ZUMA-5: Axi-cel yields high response rate in indolent NHL

Adverse effects

The incidence of grade 3 or greater neurologic events was lower in FL patients (15%), compared with MZL patients (41%), according to Dr. Jacobson.

While CRS occurred in 82% of patients, rates of grade 3 or greater CRS occurred in just 6% of FL patients and 9% of MZL patients, the investigator said.

There were no grade 5 neurologic events, and one grade 5 CRS was observed, she noted in her presentation.

The median time to onset of CRS was 4 days, compared with 2 days in the ZUMA-1 trial. “This may have implications for the possibility of outpatient therapy,” she said.

A study is planned to look at outpatient administration of axi-cel in patients with indolent NHL, she added.

Dr. Jacobson said she had no conflicts of interest to declare. Coauthors reported disclosures related to Kite, a Gilead Company; Genentech; Epizyme; Verastem; Novartis; and Pfizer, among others.

Correction, 12/7/20: An earlier version of this article misattributed some aspects of the ZUMA-5 trial to ZUMA-1.

SOURCE: Jacobson CA et al. ASH 2020, Abstract 700.