Concussion in adolescents tied to MS risk

Key clinical point: Concussions in adolescents correlate to an elevated risk for multiple sclerosis (MS).

Major finding: The risk for MS was higher among patients exposed to a concussion in adolescence (hazard ratio [HR], 1.29; P = .03). Sex-specific analysis revealed a higher risk for MS only in males who sustained a concussion in adolescence (HR, 1.41; P = 0.04).

Study details: Retrospective study included 97,965 patients (age, 11-18 years) exposed to a concussion who were matched to 293,895 unexposed patients; primary outcome was MS diagnosis.

Disclosures: This study was funded by an unrestricted investigator-initiated trial grant from Roche Canada and supported by ICES. The corresponding author has served on advisory boards for Biogen Idec, EMD Serono, Genzyme Canada, Novartis, and Roche; has received Investigator Initiated Grant Funds from Biogen Idec, Novartis, and Roche; and has acted as site PI for multicenter trials funded by Novartis, Genzyme, Roche, and AbbVie. All other authors declared no conflicts of interest.

Citation: Povolo CA et al. Mult Scler. 2020 Feb 24. doi: 10.1177/1352458520908037. 

Key clinical point: Concussions in adolescents correlate to an elevated risk for multiple sclerosis (MS).

Major finding: The risk for MS was higher among patients exposed to a concussion in adolescence (hazard ratio [HR], 1.29; P = .03). Sex-specific analysis revealed a higher risk for MS only in males who sustained a concussion in adolescence (HR, 1.41; P = 0.04).

Study details: Retrospective study included 97,965 patients (age, 11-18 years) exposed to a concussion who were matched to 293,895 unexposed patients; primary outcome was MS diagnosis.

Disclosures: This study was funded by an unrestricted investigator-initiated trial grant from Roche Canada and supported by ICES. The corresponding author has served on advisory boards for Biogen Idec, EMD Serono, Genzyme Canada, Novartis, and Roche; has received Investigator Initiated Grant Funds from Biogen Idec, Novartis, and Roche; and has acted as site PI for multicenter trials funded by Novartis, Genzyme, Roche, and AbbVie. All other authors declared no conflicts of interest.

Citation: Povolo CA et al. Mult Scler. 2020 Feb 24. doi: 10.1177/1352458520908037. 

Key clinical point: Concussions in adolescents correlate to an elevated risk for multiple sclerosis (MS).

Major finding: The risk for MS was higher among patients exposed to a concussion in adolescence (hazard ratio [HR], 1.29; P = .03). Sex-specific analysis revealed a higher risk for MS only in males who sustained a concussion in adolescence (HR, 1.41; P = 0.04).

Study details: Retrospective study included 97,965 patients (age, 11-18 years) exposed to a concussion who were matched to 293,895 unexposed patients; primary outcome was MS diagnosis.

Disclosures: This study was funded by an unrestricted investigator-initiated trial grant from Roche Canada and supported by ICES. The corresponding author has served on advisory boards for Biogen Idec, EMD Serono, Genzyme Canada, Novartis, and Roche; has received Investigator Initiated Grant Funds from Biogen Idec, Novartis, and Roche; and has acted as site PI for multicenter trials funded by Novartis, Genzyme, Roche, and AbbVie. All other authors declared no conflicts of interest.

Citation: Povolo CA et al. Mult Scler. 2020 Feb 24. doi: 10.1177/1352458520908037.