The Expanded Timed Get Up and Go Test Predicts MS Disability

PARIS—The Expanded Timed Get Up and Go (ETGUG) may be a more sensitive predictor of disability in multiple sclerosis (MS) than the Timed 25-Foot Walk (T25FW), according to research presented at the Seventh Joint ECTRIMS–ACTRIMS Meeting.

Accurately assessing and predicting disability in people with MS can be challenging for clinicians. The ETGUG is an adaptation of a timed up-and-go performance test that has been used to predict fall risk in a geriatric population. Bianca Weinstock-Guttman, MD, Professor of Neurology at the University of Buffalo in New York, and colleagues sought to evaluate the utility of the ETGUG in predicting disability among a large sample of people with MS in New York State, particularly compared to other assessment measures.

The 355 study participants were part of the New York State MS Consortium, a 20-year longitudinal registry. The researchers compared the ETGUG, T25FW, and Expanded Disability Status Scale (EDSS) using Spearman’s Rank correlations. They performed receiver operating characteristic (ROC) analyses with 80% specificity to determine the ETGUG and T25FW cutoff score and associated sensitivity predicting an EDSS score of 4.0 or greater.

Of the 355 participants, 121 (34.1%) had an EDSS score of 4.0 or higher. Both ETGUG and T25FW were highly correlated with EDSS. Correlations with EDSS were stronger for ETGUG and T25FW among subjects with an EDSS score of 4.0 or greater than among people with MS with EDSS scores of less than 4.0. At the predetermined specificity, an ETGUG score of 23.5 seconds or more had a 91.7% sensitivity of identifying subjects with an EDSS of 4.0 or greater. Completing the T25FW in 6.4 seconds or more, however, had a lower sensitivity of 82.7%.

“Prospectively captured data are required to determine the sensitivity of the ETGUG to longitudinal change and its usefulness in predicting disability progression and risk of falling, especially in the patients with higher disability,” said the researchers.

PARIS—The Expanded Timed Get Up and Go (ETGUG) may be a more sensitive predictor of disability in multiple sclerosis (MS) than the Timed 25-Foot Walk (T25FW), according to research presented at the Seventh Joint ECTRIMS–ACTRIMS Meeting.

Accurately assessing and predicting disability in people with MS can be challenging for clinicians. The ETGUG is an adaptation of a timed up-and-go performance test that has been used to predict fall risk in a geriatric population. Bianca Weinstock-Guttman, MD, Professor of Neurology at the University of Buffalo in New York, and colleagues sought to evaluate the utility of the ETGUG in predicting disability among a large sample of people with MS in New York State, particularly compared to other assessment measures.

The 355 study participants were part of the New York State MS Consortium, a 20-year longitudinal registry. The researchers compared the ETGUG, T25FW, and Expanded Disability Status Scale (EDSS) using Spearman’s Rank correlations. They performed receiver operating characteristic (ROC) analyses with 80% specificity to determine the ETGUG and T25FW cutoff score and associated sensitivity predicting an EDSS score of 4.0 or greater.

Of the 355 participants, 121 (34.1%) had an EDSS score of 4.0 or higher. Both ETGUG and T25FW were highly correlated with EDSS. Correlations with EDSS were stronger for ETGUG and T25FW among subjects with an EDSS score of 4.0 or greater than among people with MS with EDSS scores of less than 4.0. At the predetermined specificity, an ETGUG score of 23.5 seconds or more had a 91.7% sensitivity of identifying subjects with an EDSS of 4.0 or greater. Completing the T25FW in 6.4 seconds or more, however, had a lower sensitivity of 82.7%.

“Prospectively captured data are required to determine the sensitivity of the ETGUG to longitudinal change and its usefulness in predicting disability progression and risk of falling, especially in the patients with higher disability,” said the researchers.

PARIS—The Expanded Timed Get Up and Go (ETGUG) may be a more sensitive predictor of disability in multiple sclerosis (MS) than the Timed 25-Foot Walk (T25FW), according to research presented at the Seventh Joint ECTRIMS–ACTRIMS Meeting.

Accurately assessing and predicting disability in people with MS can be challenging for clinicians. The ETGUG is an adaptation of a timed up-and-go performance test that has been used to predict fall risk in a geriatric population. Bianca Weinstock-Guttman, MD, Professor of Neurology at the University of Buffalo in New York, and colleagues sought to evaluate the utility of the ETGUG in predicting disability among a large sample of people with MS in New York State, particularly compared to other assessment measures.

The 355 study participants were part of the New York State MS Consortium, a 20-year longitudinal registry. The researchers compared the ETGUG, T25FW, and Expanded Disability Status Scale (EDSS) using Spearman’s Rank correlations. They performed receiver operating characteristic (ROC) analyses with 80% specificity to determine the ETGUG and T25FW cutoff score and associated sensitivity predicting an EDSS score of 4.0 or greater.

Of the 355 participants, 121 (34.1%) had an EDSS score of 4.0 or higher. Both ETGUG and T25FW were highly correlated with EDSS. Correlations with EDSS were stronger for ETGUG and T25FW among subjects with an EDSS score of 4.0 or greater than among people with MS with EDSS scores of less than 4.0. At the predetermined specificity, an ETGUG score of 23.5 seconds or more had a 91.7% sensitivity of identifying subjects with an EDSS of 4.0 or greater. Completing the T25FW in 6.4 seconds or more, however, had a lower sensitivity of 82.7%.

“Prospectively captured data are required to determine the sensitivity of the ETGUG to longitudinal change and its usefulness in predicting disability progression and risk of falling, especially in the patients with higher disability,” said the researchers.