Gastric Bypass' Metabolic Gains Persist at 6 Years : Rate of diabetes remission was 75% in surgical group, 1% among controls.

Major Finding: Six years after gastric bypass surgery, the rate of diabetes remission in a cohort of morbidly obese patients was 75%, compared with 1% among those who did not undergo the procedure. The average weight loss from baseline was 28%.

Data Source: Longitudinal controlled prospective study evaluating the long-term weight and health outcomes of gastric bypass surgery in 418 morbidly obese patients.

Disclosures: Dr. Adams had no financial conflicts of interest to disclose.

ORLANDO – Cardiometabolic improvements following gastric bypass surgery persist over time, according to findings from the first prospective, long-term controlled trial to focus on gastric bypass patients.

After 6 years of follow-up, patients in the Utah Obesity Study who underwent the bariatric procedure maintained significant total weight loss and significant improvements in cardiovascular and metabolic measures and other disease end points relative to severely obese patients in the control group who did not undergo the surgery, according to Dr. Ted D. Adams of the University of Utah in Salt Lake City.

Of the 1,156 morbidly obese subjects enrolled in the study, 418 underwent gastric bypass surgery; 417 sought the procedure but were unable to have it, primarily because of lack of health insurance; and 321 were randomly selected as community controls from the Utah Health Family Tree program.

All of the participants underwent physical examinations and health evaluations at baseline, 2 years, and 6 years, including a physician interview and detailed medical history; resting electro- and echocardiograms; a submaximal exercise treadmill test and electrocardiogram; pulmonary function; limited polysomnography; resting metabolic rate; anthropometry; resting and exercise blood pressure; comprehensive blood chemistry; urinalysis; and dietary, quality of life, and physical activity questionnaires, Dr. Adams stated, noting that the 6-year follow-up was “excellent,” at 97%.

“In the surgical group, nearly all of the clinical measures improved significantly between the baseline and 2-year exams, and they remained significantly improved, compared with baseline at 6 years,” Dr. Adams said. In contrast, he noted, “the clinical variables in the combined control groups changed minimally if at all over the 6-year period.”

With respect to weight loss, the total weight reduction from baseline in the surgery group was 35% at 2 years and 28% at 6 years, while the average weight loss in the nonsurgical control subjects was negligible, Dr. Adams reported.

Further, the rate of diabetes remission at 6 years was 75% in the surgical group and 1% in the combined controls, and the incidence of diabetes in the surgical and control groups at 6 years was 2% and 16%, respectively, he said.

Cardiac morphology measures were also significantly improved at 6 months in the surgical group, Dr. Adams said. Echocardiography showed reduced left atrial volume and left ventricular mass, improvements that could potentially lead to reduction in obesity-related heart failure over time, he pointed out. The left atrial volume increased in the control group. Significant reductions in waist circumference, systolic blood pressure, heart rate, triglycerides, low-density lipoprotein cholesterol, and insulin resistance were maintained at 6 years in the surgical group, as were higher levels of high-density lipoprotein cholesterol, he said.

The findings complement other cohort studies in bariatric surgery, Dr. Adams stated.

The cohort will continue to be followed to provide additional insight in the long-term durability of the improvements, he said.

Major Finding: Six years after gastric bypass surgery, the rate of diabetes remission in a cohort of morbidly obese patients was 75%, compared with 1% among those who did not undergo the procedure. The average weight loss from baseline was 28%.

Data Source: Longitudinal controlled prospective study evaluating the long-term weight and health outcomes of gastric bypass surgery in 418 morbidly obese patients.

Disclosures: Dr. Adams had no financial conflicts of interest to disclose.

ORLANDO – Cardiometabolic improvements following gastric bypass surgery persist over time, according to findings from the first prospective, long-term controlled trial to focus on gastric bypass patients.

After 6 years of follow-up, patients in the Utah Obesity Study who underwent the bariatric procedure maintained significant total weight loss and significant improvements in cardiovascular and metabolic measures and other disease end points relative to severely obese patients in the control group who did not undergo the surgery, according to Dr. Ted D. Adams of the University of Utah in Salt Lake City.

Of the 1,156 morbidly obese subjects enrolled in the study, 418 underwent gastric bypass surgery; 417 sought the procedure but were unable to have it, primarily because of lack of health insurance; and 321 were randomly selected as community controls from the Utah Health Family Tree program.

All of the participants underwent physical examinations and health evaluations at baseline, 2 years, and 6 years, including a physician interview and detailed medical history; resting electro- and echocardiograms; a submaximal exercise treadmill test and electrocardiogram; pulmonary function; limited polysomnography; resting metabolic rate; anthropometry; resting and exercise blood pressure; comprehensive blood chemistry; urinalysis; and dietary, quality of life, and physical activity questionnaires, Dr. Adams stated, noting that the 6-year follow-up was “excellent,” at 97%.

“In the surgical group, nearly all of the clinical measures improved significantly between the baseline and 2-year exams, and they remained significantly improved, compared with baseline at 6 years,” Dr. Adams said. In contrast, he noted, “the clinical variables in the combined control groups changed minimally if at all over the 6-year period.”

With respect to weight loss, the total weight reduction from baseline in the surgery group was 35% at 2 years and 28% at 6 years, while the average weight loss in the nonsurgical control subjects was negligible, Dr. Adams reported.

Further, the rate of diabetes remission at 6 years was 75% in the surgical group and 1% in the combined controls, and the incidence of diabetes in the surgical and control groups at 6 years was 2% and 16%, respectively, he said.

Cardiac morphology measures were also significantly improved at 6 months in the surgical group, Dr. Adams said. Echocardiography showed reduced left atrial volume and left ventricular mass, improvements that could potentially lead to reduction in obesity-related heart failure over time, he pointed out. The left atrial volume increased in the control group. Significant reductions in waist circumference, systolic blood pressure, heart rate, triglycerides, low-density lipoprotein cholesterol, and insulin resistance were maintained at 6 years in the surgical group, as were higher levels of high-density lipoprotein cholesterol, he said.

The findings complement other cohort studies in bariatric surgery, Dr. Adams stated.

The cohort will continue to be followed to provide additional insight in the long-term durability of the improvements, he said.

Major Finding: Six years after gastric bypass surgery, the rate of diabetes remission in a cohort of morbidly obese patients was 75%, compared with 1% among those who did not undergo the procedure. The average weight loss from baseline was 28%.

Data Source: Longitudinal controlled prospective study evaluating the long-term weight and health outcomes of gastric bypass surgery in 418 morbidly obese patients.

Disclosures: Dr. Adams had no financial conflicts of interest to disclose.

ORLANDO – Cardiometabolic improvements following gastric bypass surgery persist over time, according to findings from the first prospective, long-term controlled trial to focus on gastric bypass patients.

After 6 years of follow-up, patients in the Utah Obesity Study who underwent the bariatric procedure maintained significant total weight loss and significant improvements in cardiovascular and metabolic measures and other disease end points relative to severely obese patients in the control group who did not undergo the surgery, according to Dr. Ted D. Adams of the University of Utah in Salt Lake City.

Of the 1,156 morbidly obese subjects enrolled in the study, 418 underwent gastric bypass surgery; 417 sought the procedure but were unable to have it, primarily because of lack of health insurance; and 321 were randomly selected as community controls from the Utah Health Family Tree program.

All of the participants underwent physical examinations and health evaluations at baseline, 2 years, and 6 years, including a physician interview and detailed medical history; resting electro- and echocardiograms; a submaximal exercise treadmill test and electrocardiogram; pulmonary function; limited polysomnography; resting metabolic rate; anthropometry; resting and exercise blood pressure; comprehensive blood chemistry; urinalysis; and dietary, quality of life, and physical activity questionnaires, Dr. Adams stated, noting that the 6-year follow-up was “excellent,” at 97%.

“In the surgical group, nearly all of the clinical measures improved significantly between the baseline and 2-year exams, and they remained significantly improved, compared with baseline at 6 years,” Dr. Adams said. In contrast, he noted, “the clinical variables in the combined control groups changed minimally if at all over the 6-year period.”

With respect to weight loss, the total weight reduction from baseline in the surgery group was 35% at 2 years and 28% at 6 years, while the average weight loss in the nonsurgical control subjects was negligible, Dr. Adams reported.

Further, the rate of diabetes remission at 6 years was 75% in the surgical group and 1% in the combined controls, and the incidence of diabetes in the surgical and control groups at 6 years was 2% and 16%, respectively, he said.

Cardiac morphology measures were also significantly improved at 6 months in the surgical group, Dr. Adams said. Echocardiography showed reduced left atrial volume and left ventricular mass, improvements that could potentially lead to reduction in obesity-related heart failure over time, he pointed out. The left atrial volume increased in the control group. Significant reductions in waist circumference, systolic blood pressure, heart rate, triglycerides, low-density lipoprotein cholesterol, and insulin resistance were maintained at 6 years in the surgical group, as were higher levels of high-density lipoprotein cholesterol, he said.

The findings complement other cohort studies in bariatric surgery, Dr. Adams stated.

The cohort will continue to be followed to provide additional insight in the long-term durability of the improvements, he said.