How should you treat Candida vaginitis in patients on antibiotics?

Evidence summary

VVC is a common cause of vaginitis; Candida albicans accounts for 85% to 90% of cases. Risk factors include pregnancy, diabetes mellitus, and systemic antibiotics.¹ Incidence increases with onset of sexual activity, but there is no direct evidence it is sexually transmitted.¹ About 75% of women experience 1 VVC episode during their lifetime, 40% to 45% have 2 or more, and 5% to 8% have recurrent VVC (defined as 4 or more annually).^1,2

The candidiasis/antibiotics link

A 2003 systematic review found the evidence supporting the association between antibiotics and VVC limited and contradictory.³ Most were case-control or cohort studies with small sample sizes. No RCTs compare the incidence of culture-confirmed VVC among women receiving antibiotics or placebo.

Nineteen reports of 18 original studies had sufficient data to calculate a relative risk or odds ratio for antibiotic-associated VVC. Thirteen of the 19 reports showed an increase (around twofold; range, 0.43–5) in vaginal Candida prevalence; however, 3 of the 13 reports had no mycological culture data. Six studies did not show significant association between antibiotics and vaginal yeast.³

Antibiotics are thought to increase risk of VVC by killing endogenous vaginal flora (particularly Lactobacillus), allowing microorganisms resistant to the antibiotics, like Candida, to flourish.¹ Yet there is evidence that numbers of genital Lactobacillus are similar for women with and without symptomatic VVC.⁴ Further, decreasing Lactobacillus does not increase the risk of VVC.⁵

Topical and oral antifungals—both do the job

For the treatment of uncomplicated VVC, both topical and oral antifungals are clinically and mycologically effective, with comparable clinical cure rates >80%.⁶ No difference in persistent symptoms between single and multiple doses, or different durations of multiple dose regimens have been found, but samples may have been too small to detect clinically significant effects. An RCT found less nausea, headache, and abdominal pain with intravaginal imidazoles, but more vulvar irritation and vaginal discharge than oral fluconazole.⁶

For treatment of recurrent VVC, RCTs have shown the effectiveness of oral fluconazole and itraconazole maintenance therapy taken for 6 months after an initial regimen.^7,8 Treating male sexual partners did not significantly improve resolution of the woman’s symptoms or reduce the rate of symptomatic relapse.⁹

Yogurt may not live up to its rep

Two poor-quality crossover RCTs provided insufficient evidence regarding effectiveness of a diet containing oral Lactobacillus yogurt to prevent recurrent VVC.⁹ A recent RCT of 278 women on short courses of antibiotics were randomized to oral lactobacilli or placebo and vaginal lactobacilli or placebo.¹⁰ The study was stopped early because there was no effect seen. Overall, 23% developed symptomatic vulvovaginitis.

Recommendations from others

The Infectious Diseases Society of America¹¹ recommends treating uncomplicated VVC with short-course of oral or topical antifungals; treating complicated VVC with antimycotic therapy for 7 days, either daily as topical therapy or as two 150-mg doses of fluconazole 72 hours apart; treating non-albicans species of Candida with topical boric acid (600 mg/day for 14 days) or topical flucytosine; and treating recurrent VVC with induction therapy with 2 weeks of a topical or oral azole followed by a maintenance regimen for 6 months (fluconazole once a week or itraconazole twice a week).¹¹

Evidence summary

VVC is a common cause of vaginitis; Candida albicans accounts for 85% to 90% of cases. Risk factors include pregnancy, diabetes mellitus, and systemic antibiotics.¹ Incidence increases with onset of sexual activity, but there is no direct evidence it is sexually transmitted.¹ About 75% of women experience 1 VVC episode during their lifetime, 40% to 45% have 2 or more, and 5% to 8% have recurrent VVC (defined as 4 or more annually).^1,2

The candidiasis/antibiotics link

A 2003 systematic review found the evidence supporting the association between antibiotics and VVC limited and contradictory.³ Most were case-control or cohort studies with small sample sizes. No RCTs compare the incidence of culture-confirmed VVC among women receiving antibiotics or placebo.

Nineteen reports of 18 original studies had sufficient data to calculate a relative risk or odds ratio for antibiotic-associated VVC. Thirteen of the 19 reports showed an increase (around twofold; range, 0.43–5) in vaginal Candida prevalence; however, 3 of the 13 reports had no mycological culture data. Six studies did not show significant association between antibiotics and vaginal yeast.³

Antibiotics are thought to increase risk of VVC by killing endogenous vaginal flora (particularly Lactobacillus), allowing microorganisms resistant to the antibiotics, like Candida, to flourish.¹ Yet there is evidence that numbers of genital Lactobacillus are similar for women with and without symptomatic VVC.⁴ Further, decreasing Lactobacillus does not increase the risk of VVC.⁵

Topical and oral antifungals—both do the job

For the treatment of uncomplicated VVC, both topical and oral antifungals are clinically and mycologically effective, with comparable clinical cure rates >80%.⁶ No difference in persistent symptoms between single and multiple doses, or different durations of multiple dose regimens have been found, but samples may have been too small to detect clinically significant effects. An RCT found less nausea, headache, and abdominal pain with intravaginal imidazoles, but more vulvar irritation and vaginal discharge than oral fluconazole.⁶

For treatment of recurrent VVC, RCTs have shown the effectiveness of oral fluconazole and itraconazole maintenance therapy taken for 6 months after an initial regimen.^7,8 Treating male sexual partners did not significantly improve resolution of the woman’s symptoms or reduce the rate of symptomatic relapse.⁹

Yogurt may not live up to its rep

Two poor-quality crossover RCTs provided insufficient evidence regarding effectiveness of a diet containing oral Lactobacillus yogurt to prevent recurrent VVC.⁹ A recent RCT of 278 women on short courses of antibiotics were randomized to oral lactobacilli or placebo and vaginal lactobacilli or placebo.¹⁰ The study was stopped early because there was no effect seen. Overall, 23% developed symptomatic vulvovaginitis.

Recommendations from others

The Infectious Diseases Society of America¹¹ recommends treating uncomplicated VVC with short-course of oral or topical antifungals; treating complicated VVC with antimycotic therapy for 7 days, either daily as topical therapy or as two 150-mg doses of fluconazole 72 hours apart; treating non-albicans species of Candida with topical boric acid (600 mg/day for 14 days) or topical flucytosine; and treating recurrent VVC with induction therapy with 2 weeks of a topical or oral azole followed by a maintenance regimen for 6 months (fluconazole once a week or itraconazole twice a week).¹¹

Evidence summary

VVC is a common cause of vaginitis; Candida albicans accounts for 85% to 90% of cases. Risk factors include pregnancy, diabetes mellitus, and systemic antibiotics.¹ Incidence increases with onset of sexual activity, but there is no direct evidence it is sexually transmitted.¹ About 75% of women experience 1 VVC episode during their lifetime, 40% to 45% have 2 or more, and 5% to 8% have recurrent VVC (defined as 4 or more annually).^1,2

The candidiasis/antibiotics link

A 2003 systematic review found the evidence supporting the association between antibiotics and VVC limited and contradictory.³ Most were case-control or cohort studies with small sample sizes. No RCTs compare the incidence of culture-confirmed VVC among women receiving antibiotics or placebo.

Nineteen reports of 18 original studies had sufficient data to calculate a relative risk or odds ratio for antibiotic-associated VVC. Thirteen of the 19 reports showed an increase (around twofold; range, 0.43–5) in vaginal Candida prevalence; however, 3 of the 13 reports had no mycological culture data. Six studies did not show significant association between antibiotics and vaginal yeast.³

Antibiotics are thought to increase risk of VVC by killing endogenous vaginal flora (particularly Lactobacillus), allowing microorganisms resistant to the antibiotics, like Candida, to flourish.¹ Yet there is evidence that numbers of genital Lactobacillus are similar for women with and without symptomatic VVC.⁴ Further, decreasing Lactobacillus does not increase the risk of VVC.⁵

Topical and oral antifungals—both do the job

For the treatment of uncomplicated VVC, both topical and oral antifungals are clinically and mycologically effective, with comparable clinical cure rates >80%.⁶ No difference in persistent symptoms between single and multiple doses, or different durations of multiple dose regimens have been found, but samples may have been too small to detect clinically significant effects. An RCT found less nausea, headache, and abdominal pain with intravaginal imidazoles, but more vulvar irritation and vaginal discharge than oral fluconazole.⁶

For treatment of recurrent VVC, RCTs have shown the effectiveness of oral fluconazole and itraconazole maintenance therapy taken for 6 months after an initial regimen.^7,8 Treating male sexual partners did not significantly improve resolution of the woman’s symptoms or reduce the rate of symptomatic relapse.⁹

Yogurt may not live up to its rep

Two poor-quality crossover RCTs provided insufficient evidence regarding effectiveness of a diet containing oral Lactobacillus yogurt to prevent recurrent VVC.⁹ A recent RCT of 278 women on short courses of antibiotics were randomized to oral lactobacilli or placebo and vaginal lactobacilli or placebo.¹⁰ The study was stopped early because there was no effect seen. Overall, 23% developed symptomatic vulvovaginitis.

Recommendations from others

The Infectious Diseases Society of America¹¹ recommends treating uncomplicated VVC with short-course of oral or topical antifungals; treating complicated VVC with antimycotic therapy for 7 days, either daily as topical therapy or as two 150-mg doses of fluconazole 72 hours apart; treating non-albicans species of Candida with topical boric acid (600 mg/day for 14 days) or topical flucytosine; and treating recurrent VVC with induction therapy with 2 weeks of a topical or oral azole followed by a maintenance regimen for 6 months (fluconazole once a week or itraconazole twice a week).¹¹