Immunization Intervention Targets High-Risk Urban Teens

Major Finding: Adolescents assigned to a stepped intervention were 1.8 times more likely to receive new vaccines and 1.7 times more likely to have a recent well-child visit than those given usual care.

Data Source: Randomized controlled trial involving 6,684 high-risk adolescents.

Disclosures: Dr. Szilagyi reported that he had no conflicts of interest related to the study.

VANCOUVER, B.C. — A stepped intervention in primary care practices can improve rates of immunization and well-child visits among urban adolescents at high risk for poor health outcomes.

Data from a randomized trial conducted in Rochester, N.Y., showed that adolescents assigned to the intervention were 1.8 times more likely to receive new vaccines than were their peers assigned to usual care. In addition, they were 1.7 times more likely to have made a well-child visit in the past year.

“A stepped tracking-reminder-recall-outreach program can improve immunization rates for high-risk urban adolescents, and it has spillover benefits on improving preventive care visits,” said Dr. Peter G. Szilagyi, professor and chief of the division of general pediatrics and professor at the center for community health at the University of Rochester.

The 15-month trial was conducted in eight primary care practices among adolescents aged 11–15 years. Within each practice, the adolescents were randomized to an intervention group or a control group given usual care.

In the intervention group, outreach workers tracked all adolescents to monitor their immunization status. For those identified as being behind, progressively intense measures were used until they were up to date: reminders, then recalls, and finally outreach in the form of a home visit, which was used to assess barriers, link the families with social services, and stress the importance of a medical home.

Outreach workers mainly targeted the parents but often did speak with the adolescents. “Reaching them is a constant problem,” he commented. “This is why we put human beings here rather than computers or auto-dialers.”

The researchers assessed rates of receipt for three new vaccines for adolescents—meningococcal conjugate (MCV4); tetanus, diphtheria, and pertussis (Tdap); and human papillomavirus (HPV) vaccines—and rates of well-child care visits.

Analyses were based on 3,365 adolescents in the intervention group and 3,319 adolescents in the control group. They were a mean 13.5 years old, and half were male. Most were either black (63%) or Hispanic (23%) and most had Medicaid (73%).

Results showed that in the intervention group, 71% of adolescents needed reminders and recall, and 12% needed home visits.

After adjustment for potential confounders, relative to their peers in the control group, adolescents in the intervention group were 1.8-fold more likely to have received all three vaccines at the study's end (P less than .001), Dr. Szilagyi said.

In absolute terms, 44% of adolescents in the intervention group were fully immunized at that point, compared with 32% in the control group. Differences were significant for each vaccine as well.

Similarly, after statistical adjustment, adolescents in the intervention group were 1.7-fold more likely to have had a well-child visit in the past year at the study's end (P less than .001), he said.

In absolute terms, 67% in the intervention group had made such a visit, compared with 55% in the control group.

The difference in immunization rates between groups was significant within each of the eight practices, and the difference between groups in well-child visits was significant within all but one, Dr. Szilagyi noted. Furthermore, improvements in rates of these outcomes were similar by age, sex, race/ethnicity, and type of insurance.

The cost of the intervention (excluding research costs) was $43 per year per adolescent. The cost per additional fully vaccinated adolescent was $465, and the cost per additional adolescent with a recent well-child visit was $417. The number needed to treat (enroll in the intervention) was nine for an additional adolescent to be fully vaccinated and nine for an additional adolescent to have a well-child visit.

Major Finding: Adolescents assigned to a stepped intervention were 1.8 times more likely to receive new vaccines and 1.7 times more likely to have a recent well-child visit than those given usual care.

Data Source: Randomized controlled trial involving 6,684 high-risk adolescents.

Disclosures: Dr. Szilagyi reported that he had no conflicts of interest related to the study.

VANCOUVER, B.C. — A stepped intervention in primary care practices can improve rates of immunization and well-child visits among urban adolescents at high risk for poor health outcomes.

Data from a randomized trial conducted in Rochester, N.Y., showed that adolescents assigned to the intervention were 1.8 times more likely to receive new vaccines than were their peers assigned to usual care. In addition, they were 1.7 times more likely to have made a well-child visit in the past year.

“A stepped tracking-reminder-recall-outreach program can improve immunization rates for high-risk urban adolescents, and it has spillover benefits on improving preventive care visits,” said Dr. Peter G. Szilagyi, professor and chief of the division of general pediatrics and professor at the center for community health at the University of Rochester.

The 15-month trial was conducted in eight primary care practices among adolescents aged 11–15 years. Within each practice, the adolescents were randomized to an intervention group or a control group given usual care.

In the intervention group, outreach workers tracked all adolescents to monitor their immunization status. For those identified as being behind, progressively intense measures were used until they were up to date: reminders, then recalls, and finally outreach in the form of a home visit, which was used to assess barriers, link the families with social services, and stress the importance of a medical home.

Outreach workers mainly targeted the parents but often did speak with the adolescents. “Reaching them is a constant problem,” he commented. “This is why we put human beings here rather than computers or auto-dialers.”

The researchers assessed rates of receipt for three new vaccines for adolescents—meningococcal conjugate (MCV4); tetanus, diphtheria, and pertussis (Tdap); and human papillomavirus (HPV) vaccines—and rates of well-child care visits.

Analyses were based on 3,365 adolescents in the intervention group and 3,319 adolescents in the control group. They were a mean 13.5 years old, and half were male. Most were either black (63%) or Hispanic (23%) and most had Medicaid (73%).

Results showed that in the intervention group, 71% of adolescents needed reminders and recall, and 12% needed home visits.

After adjustment for potential confounders, relative to their peers in the control group, adolescents in the intervention group were 1.8-fold more likely to have received all three vaccines at the study's end (P less than .001), Dr. Szilagyi said.

In absolute terms, 44% of adolescents in the intervention group were fully immunized at that point, compared with 32% in the control group. Differences were significant for each vaccine as well.

Similarly, after statistical adjustment, adolescents in the intervention group were 1.7-fold more likely to have had a well-child visit in the past year at the study's end (P less than .001), he said.

In absolute terms, 67% in the intervention group had made such a visit, compared with 55% in the control group.

The difference in immunization rates between groups was significant within each of the eight practices, and the difference between groups in well-child visits was significant within all but one, Dr. Szilagyi noted. Furthermore, improvements in rates of these outcomes were similar by age, sex, race/ethnicity, and type of insurance.

The cost of the intervention (excluding research costs) was $43 per year per adolescent. The cost per additional fully vaccinated adolescent was $465, and the cost per additional adolescent with a recent well-child visit was $417. The number needed to treat (enroll in the intervention) was nine for an additional adolescent to be fully vaccinated and nine for an additional adolescent to have a well-child visit.

Major Finding: Adolescents assigned to a stepped intervention were 1.8 times more likely to receive new vaccines and 1.7 times more likely to have a recent well-child visit than those given usual care.

Data Source: Randomized controlled trial involving 6,684 high-risk adolescents.

Disclosures: Dr. Szilagyi reported that he had no conflicts of interest related to the study.

VANCOUVER, B.C. — A stepped intervention in primary care practices can improve rates of immunization and well-child visits among urban adolescents at high risk for poor health outcomes.

Data from a randomized trial conducted in Rochester, N.Y., showed that adolescents assigned to the intervention were 1.8 times more likely to receive new vaccines than were their peers assigned to usual care. In addition, they were 1.7 times more likely to have made a well-child visit in the past year.

“A stepped tracking-reminder-recall-outreach program can improve immunization rates for high-risk urban adolescents, and it has spillover benefits on improving preventive care visits,” said Dr. Peter G. Szilagyi, professor and chief of the division of general pediatrics and professor at the center for community health at the University of Rochester.

The 15-month trial was conducted in eight primary care practices among adolescents aged 11–15 years. Within each practice, the adolescents were randomized to an intervention group or a control group given usual care.

In the intervention group, outreach workers tracked all adolescents to monitor their immunization status. For those identified as being behind, progressively intense measures were used until they were up to date: reminders, then recalls, and finally outreach in the form of a home visit, which was used to assess barriers, link the families with social services, and stress the importance of a medical home.

Outreach workers mainly targeted the parents but often did speak with the adolescents. “Reaching them is a constant problem,” he commented. “This is why we put human beings here rather than computers or auto-dialers.”

The researchers assessed rates of receipt for three new vaccines for adolescents—meningococcal conjugate (MCV4); tetanus, diphtheria, and pertussis (Tdap); and human papillomavirus (HPV) vaccines—and rates of well-child care visits.

Analyses were based on 3,365 adolescents in the intervention group and 3,319 adolescents in the control group. They were a mean 13.5 years old, and half were male. Most were either black (63%) or Hispanic (23%) and most had Medicaid (73%).

Results showed that in the intervention group, 71% of adolescents needed reminders and recall, and 12% needed home visits.

After adjustment for potential confounders, relative to their peers in the control group, adolescents in the intervention group were 1.8-fold more likely to have received all three vaccines at the study's end (P less than .001), Dr. Szilagyi said.

In absolute terms, 44% of adolescents in the intervention group were fully immunized at that point, compared with 32% in the control group. Differences were significant for each vaccine as well.

Similarly, after statistical adjustment, adolescents in the intervention group were 1.7-fold more likely to have had a well-child visit in the past year at the study's end (P less than .001), he said.

In absolute terms, 67% in the intervention group had made such a visit, compared with 55% in the control group.

The difference in immunization rates between groups was significant within each of the eight practices, and the difference between groups in well-child visits was significant within all but one, Dr. Szilagyi noted. Furthermore, improvements in rates of these outcomes were similar by age, sex, race/ethnicity, and type of insurance.

The cost of the intervention (excluding research costs) was $43 per year per adolescent. The cost per additional fully vaccinated adolescent was $465, and the cost per additional adolescent with a recent well-child visit was $417. The number needed to treat (enroll in the intervention) was nine for an additional adolescent to be fully vaccinated and nine for an additional adolescent to have a well-child visit.