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Managing chronic pain: What’s the best approach?
Practice recommendations for management of chronic pain

Grade A recommendations

  • Develop a physician-patient partnership. This should include a plan of care and realistic goal-setting.
  • Begin physical rehabilitation and psychosocial management. This includes an exercise fitness program, cognitive-behavioral therapy, and self-management.

Grade B Recommendations

  • Obtain a general history, including psychological assessment and spirituality evaluation, and identify barriers to treatment.
  • Obtain a thorough pain history.
  • Perform a physical examination, including a focused musculoskeletal and neurologic evaluation.
  • Perform diagnostic testing as indicated. X-rays, computed tomography, magnetic resonance imaging, electromyography, and nerve conduction studies can help differentiate the biological mechanisms of pain.
  • Teach patients to use pain scales for self-reporting.

Grade C recommendations

  • Categorize the 4 biological mechanisms of pain (inflammatory, mechanical, musculoskeletal, or neuropathic).
  • Consider the following pharmacologic options for Level I care:
    Nonopioid analgesics
    Nonsteroidal anti-inflammatory drugs
    Antidepressants, including tricyclics
    Anticonvulsants
    Topical agents
    Muscle relaxants
    Anxiolytics
    Drugs for insomnia
    Opioids (last line)
  • Consider the following Level I therapeutic procedures:
    Facet joint injection
    Percutaneous radiofrequency neurotomy
    Intradiscal electrothermal therapy
    Epidural corticosteroid injections
    Vertebroplasty and kyphoplasty
    Acupuncture
  • Consider the following Level II interventions:
    Referral to an interdisciplinary team and pain specialist
    Surgery
    Palliative interventions (nucleoplasty, spinal cord stimulation, intrathecal medication delivery systems)
    Multidisciplinary pain rehabilitation

Strength of recommendation (SOR)

  1. Good quality patient-oriented evidence
  2. Inconsistent or limited-quality patient-oriented evidence
  3. Consensus, usual practice, opinion, disease-oriented evidence, case series
  • What are the critical steps in assessing a patient with chronic pain?
  • What are the 4 biological mechanisms of pain?
  • When is referral to a pain specialist recommended?
 

The answers to these questions are summarized at right and in the 2008 edition of Assessment and Management of Chronic Pain. Originally developed in 2005, the guideline was funded and published by the Institute for Clinical Systems Improvement (ICSI), a collaboration of 57 medical groups sponsored by 6 Minnesota health plans. A 3rd edition, released in August, summarizes the current evidence in the assessment and treatment of chronic pain in mature adolescents (ages 16-18 years) and adults.

Chronic pain—a persistent, life-altering condition—is one of the most challenging clinical disorders for primary care physicians to treat. Unlike acute pain, where we seek to cure the underlying biological condition, the goal of chronic pain management is to improve patient function in the face of pain that may never completely resolve.

Achieving that goal, according to the new guideline, requires a patient-centered, multifaceted approach—often involving a health care team that includes specialists in behavioral health and physical rehabilitation—that is co-ordinated by a primary care physician. An effective treatment plan must address biopsychosocial factors as well as spiritual and cultural issues. Patients must be taught self-management skills focused on fitness, stress reduction, and maintaining a healthy lifestyle ( TABLE ). Medications may be part of the treatment plan but should not be the sole focus, according to the guideline. Opioids are an option when other therapies fail.

ICSI’s new guideline also addresses the effects of various therapies, the role of psychosocial factors, and the identification of barriers to treatment. The comprehensive guideline, which has 172 references and 9 appendices, also features 2 easy-to-use algorithms. One algorithm addresses the assessment of chronic pain ( FIGURE 1 ) and the other deals with chronic pain management ( FIGURE 2 ). Both algorithms identify level I and level II strategies. And both can be readily adapted to primary care practice, and are extremely helpful to physicians who are evaluating and developing care plans for patients with chronic pain.

FIGURE 1
Chronic pain assessment algorithm


HIV, human immunodeficiency virus; ICSI, Institute for Clinical Systems Improvement; MS, multiple sclerosis.
*Pain types and contributing factors are not mutually exclusive. Patients frequently have more than one type of pain, as well as overlapping contributing factors.
Source: Institute for Clinical Systems Improvement. Reprinted with permission.

4 objectives

This latest guideline was developed to:

  • Improve the treatment of adult chronic pain patients by encouraging physicians to complete an appropriate biopsychosocial assessment (and reassessment).
  • Improve patient function by recommending the development and use of a comprehensive treatment plan that includes a multispecialty team.
  • Improve the use of Level I and Level II treatment approaches to chronic pain.
  • Provide guidance on the most effective use of nonopioid and opioid medications in the treatment of chronic pain.

With these objectives in mind, the ICSI work group conducted a comprehensive literature review, giving priority to randomized controlled trials (RCTs), meta-analyses, and systematic reviews. The work group used a 7-tier grading system to rate the evidence and a 3-category system for the worksheets in the appendix. For this article, we have converted the evidence ratings into SORT taxonomy.1

What’s changed?

In addition to reflecting the latest research, the new guideline contains a number of clarifications. For example, the update states that medications are not the “sole” focus of treatment and should be used, when necessary, as part of an overall approach to pain management. The previous version noted that medications were not the “primary” focus.

 

 

 

The management algorithm ( FIGURE 2 ) now leads with “core principles”—a term suggesting greater importance than the former term, “general management,” implied. Clinical highlights, a synthesis of key recommendations, have been revised to better align with the guideline’s main components—assessment, functional goals, patient-centered/biopsychosocial care planning, Level I vs Level II approaches, and medication and patient selection.

Other changes in the guideline may contribute to clinicians’ understanding of chronic pain and its complex presentation. The guideline now includes a statement about allodynia and hyperalgesia to indicate that both may play an important role in any pain syndrome—not just complex regional pain syndrome. Information about fibromyalgia symptoms and myofascial pain has been added. The definitions page now has an entry for “biopsychosocial model,” as well as language designed to stress the differences between untreated acute pain and ongoing chronic pain.

 

FIGURE 2
Chronic pain management algorithm 


DIRE, diagnosis, intractability, risk, efficacy.
Source: Institute for Clinical System Improvement. Reprinted with permission.

A limitation, an improvement

A limitation of the guideline is the lack of studies addressing the effectiveness of a comprehensive, multidisciplinary treatment approach to chronic pain management. Most studies consider single therapies.

An improvement in this guideline is that the evidence levels of each strategy are now listed within the section describing it—a notable change that makes it far easier to identify the quality of individual recommendations.

As has been the case in the past, this latest edition of the guideline offers a number of tools for physicians. The assessment and management algorithms ( FIGURES 1 AND 2 , respectively) walk clinicians through the decision-making process. In addition, the following 9 appendices provide practical guidance to physicians in various aspects of patient evaluation and care:

  • Brief Pain Inventory (Short Form)
  • Patient Health Questionnaire (PHQ-9)
  • Functional Ability Questionnaire
  • Personal Care Plan for Chronic Pain
  • DIRE (diagnosis, intractability, risk, efficacy) Score: Patient Selection for Chronic Opioid Analgesia
  • Opioid Agreement Form
  • Opioid Analgesics
  • Pharmaceutical Interventions for Neuropathic Pain
  • Neuropathic Pain Treatment Diagram.

Source for this guideline

Institute for Clinical Systems Improvement (ICSI). Assessment and Management of Chronic Pain. 3rd ed. Bloomington (Minn): Institute for Clinical Systems Improvement (ICSI); 2008 July. Available at: http://www.icsi.org/pain__chronic__assessment_and_management_of_14399/pain__chronic__assessment_and_management_of__guideline.html. Accessed September 9, 2008.

References

1. Ebell M, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature. J Fam Pract. 2004;53:111-120.

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Keith B. Holten, MD, Editor
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio
keholtenmd@cmhregional.com

Gilbert D. Veasey, Sr, MD, MS
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio

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Keith B. Holten, MD, Editor
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio
keholtenmd@cmhregional.com

Gilbert D. Veasey, Sr, MD, MS
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio

Author and Disclosure Information

Keith B. Holten, MD, Editor
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio
keholtenmd@cmhregional.com

Gilbert D. Veasey, Sr, MD, MS
Clinton Memorial Hospital/University of Cincinnati Family Medicine Residency, Wilmington, Ohio

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Practice recommendations for management of chronic pain

Grade A recommendations

  • Develop a physician-patient partnership. This should include a plan of care and realistic goal-setting.
  • Begin physical rehabilitation and psychosocial management. This includes an exercise fitness program, cognitive-behavioral therapy, and self-management.

Grade B Recommendations

  • Obtain a general history, including psychological assessment and spirituality evaluation, and identify barriers to treatment.
  • Obtain a thorough pain history.
  • Perform a physical examination, including a focused musculoskeletal and neurologic evaluation.
  • Perform diagnostic testing as indicated. X-rays, computed tomography, magnetic resonance imaging, electromyography, and nerve conduction studies can help differentiate the biological mechanisms of pain.
  • Teach patients to use pain scales for self-reporting.

Grade C recommendations

  • Categorize the 4 biological mechanisms of pain (inflammatory, mechanical, musculoskeletal, or neuropathic).
  • Consider the following pharmacologic options for Level I care:
    Nonopioid analgesics
    Nonsteroidal anti-inflammatory drugs
    Antidepressants, including tricyclics
    Anticonvulsants
    Topical agents
    Muscle relaxants
    Anxiolytics
    Drugs for insomnia
    Opioids (last line)
  • Consider the following Level I therapeutic procedures:
    Facet joint injection
    Percutaneous radiofrequency neurotomy
    Intradiscal electrothermal therapy
    Epidural corticosteroid injections
    Vertebroplasty and kyphoplasty
    Acupuncture
  • Consider the following Level II interventions:
    Referral to an interdisciplinary team and pain specialist
    Surgery
    Palliative interventions (nucleoplasty, spinal cord stimulation, intrathecal medication delivery systems)
    Multidisciplinary pain rehabilitation

Strength of recommendation (SOR)

  1. Good quality patient-oriented evidence
  2. Inconsistent or limited-quality patient-oriented evidence
  3. Consensus, usual practice, opinion, disease-oriented evidence, case series
  • What are the critical steps in assessing a patient with chronic pain?
  • What are the 4 biological mechanisms of pain?
  • When is referral to a pain specialist recommended?
 

The answers to these questions are summarized at right and in the 2008 edition of Assessment and Management of Chronic Pain. Originally developed in 2005, the guideline was funded and published by the Institute for Clinical Systems Improvement (ICSI), a collaboration of 57 medical groups sponsored by 6 Minnesota health plans. A 3rd edition, released in August, summarizes the current evidence in the assessment and treatment of chronic pain in mature adolescents (ages 16-18 years) and adults.

Chronic pain—a persistent, life-altering condition—is one of the most challenging clinical disorders for primary care physicians to treat. Unlike acute pain, where we seek to cure the underlying biological condition, the goal of chronic pain management is to improve patient function in the face of pain that may never completely resolve.

Achieving that goal, according to the new guideline, requires a patient-centered, multifaceted approach—often involving a health care team that includes specialists in behavioral health and physical rehabilitation—that is co-ordinated by a primary care physician. An effective treatment plan must address biopsychosocial factors as well as spiritual and cultural issues. Patients must be taught self-management skills focused on fitness, stress reduction, and maintaining a healthy lifestyle ( TABLE ). Medications may be part of the treatment plan but should not be the sole focus, according to the guideline. Opioids are an option when other therapies fail.

ICSI’s new guideline also addresses the effects of various therapies, the role of psychosocial factors, and the identification of barriers to treatment. The comprehensive guideline, which has 172 references and 9 appendices, also features 2 easy-to-use algorithms. One algorithm addresses the assessment of chronic pain ( FIGURE 1 ) and the other deals with chronic pain management ( FIGURE 2 ). Both algorithms identify level I and level II strategies. And both can be readily adapted to primary care practice, and are extremely helpful to physicians who are evaluating and developing care plans for patients with chronic pain.

FIGURE 1
Chronic pain assessment algorithm


HIV, human immunodeficiency virus; ICSI, Institute for Clinical Systems Improvement; MS, multiple sclerosis.
*Pain types and contributing factors are not mutually exclusive. Patients frequently have more than one type of pain, as well as overlapping contributing factors.
Source: Institute for Clinical Systems Improvement. Reprinted with permission.

4 objectives

This latest guideline was developed to:

  • Improve the treatment of adult chronic pain patients by encouraging physicians to complete an appropriate biopsychosocial assessment (and reassessment).
  • Improve patient function by recommending the development and use of a comprehensive treatment plan that includes a multispecialty team.
  • Improve the use of Level I and Level II treatment approaches to chronic pain.
  • Provide guidance on the most effective use of nonopioid and opioid medications in the treatment of chronic pain.

With these objectives in mind, the ICSI work group conducted a comprehensive literature review, giving priority to randomized controlled trials (RCTs), meta-analyses, and systematic reviews. The work group used a 7-tier grading system to rate the evidence and a 3-category system for the worksheets in the appendix. For this article, we have converted the evidence ratings into SORT taxonomy.1

What’s changed?

In addition to reflecting the latest research, the new guideline contains a number of clarifications. For example, the update states that medications are not the “sole” focus of treatment and should be used, when necessary, as part of an overall approach to pain management. The previous version noted that medications were not the “primary” focus.

 

 

 

The management algorithm ( FIGURE 2 ) now leads with “core principles”—a term suggesting greater importance than the former term, “general management,” implied. Clinical highlights, a synthesis of key recommendations, have been revised to better align with the guideline’s main components—assessment, functional goals, patient-centered/biopsychosocial care planning, Level I vs Level II approaches, and medication and patient selection.

Other changes in the guideline may contribute to clinicians’ understanding of chronic pain and its complex presentation. The guideline now includes a statement about allodynia and hyperalgesia to indicate that both may play an important role in any pain syndrome—not just complex regional pain syndrome. Information about fibromyalgia symptoms and myofascial pain has been added. The definitions page now has an entry for “biopsychosocial model,” as well as language designed to stress the differences between untreated acute pain and ongoing chronic pain.

 

FIGURE 2
Chronic pain management algorithm 


DIRE, diagnosis, intractability, risk, efficacy.
Source: Institute for Clinical System Improvement. Reprinted with permission.

A limitation, an improvement

A limitation of the guideline is the lack of studies addressing the effectiveness of a comprehensive, multidisciplinary treatment approach to chronic pain management. Most studies consider single therapies.

An improvement in this guideline is that the evidence levels of each strategy are now listed within the section describing it—a notable change that makes it far easier to identify the quality of individual recommendations.

As has been the case in the past, this latest edition of the guideline offers a number of tools for physicians. The assessment and management algorithms ( FIGURES 1 AND 2 , respectively) walk clinicians through the decision-making process. In addition, the following 9 appendices provide practical guidance to physicians in various aspects of patient evaluation and care:

  • Brief Pain Inventory (Short Form)
  • Patient Health Questionnaire (PHQ-9)
  • Functional Ability Questionnaire
  • Personal Care Plan for Chronic Pain
  • DIRE (diagnosis, intractability, risk, efficacy) Score: Patient Selection for Chronic Opioid Analgesia
  • Opioid Agreement Form
  • Opioid Analgesics
  • Pharmaceutical Interventions for Neuropathic Pain
  • Neuropathic Pain Treatment Diagram.

Source for this guideline

Institute for Clinical Systems Improvement (ICSI). Assessment and Management of Chronic Pain. 3rd ed. Bloomington (Minn): Institute for Clinical Systems Improvement (ICSI); 2008 July. Available at: http://www.icsi.org/pain__chronic__assessment_and_management_of_14399/pain__chronic__assessment_and_management_of__guideline.html. Accessed September 9, 2008.

Practice recommendations for management of chronic pain

Grade A recommendations

  • Develop a physician-patient partnership. This should include a plan of care and realistic goal-setting.
  • Begin physical rehabilitation and psychosocial management. This includes an exercise fitness program, cognitive-behavioral therapy, and self-management.

Grade B Recommendations

  • Obtain a general history, including psychological assessment and spirituality evaluation, and identify barriers to treatment.
  • Obtain a thorough pain history.
  • Perform a physical examination, including a focused musculoskeletal and neurologic evaluation.
  • Perform diagnostic testing as indicated. X-rays, computed tomography, magnetic resonance imaging, electromyography, and nerve conduction studies can help differentiate the biological mechanisms of pain.
  • Teach patients to use pain scales for self-reporting.

Grade C recommendations

  • Categorize the 4 biological mechanisms of pain (inflammatory, mechanical, musculoskeletal, or neuropathic).
  • Consider the following pharmacologic options for Level I care:
    Nonopioid analgesics
    Nonsteroidal anti-inflammatory drugs
    Antidepressants, including tricyclics
    Anticonvulsants
    Topical agents
    Muscle relaxants
    Anxiolytics
    Drugs for insomnia
    Opioids (last line)
  • Consider the following Level I therapeutic procedures:
    Facet joint injection
    Percutaneous radiofrequency neurotomy
    Intradiscal electrothermal therapy
    Epidural corticosteroid injections
    Vertebroplasty and kyphoplasty
    Acupuncture
  • Consider the following Level II interventions:
    Referral to an interdisciplinary team and pain specialist
    Surgery
    Palliative interventions (nucleoplasty, spinal cord stimulation, intrathecal medication delivery systems)
    Multidisciplinary pain rehabilitation

Strength of recommendation (SOR)

  1. Good quality patient-oriented evidence
  2. Inconsistent or limited-quality patient-oriented evidence
  3. Consensus, usual practice, opinion, disease-oriented evidence, case series
  • What are the critical steps in assessing a patient with chronic pain?
  • What are the 4 biological mechanisms of pain?
  • When is referral to a pain specialist recommended?
 

The answers to these questions are summarized at right and in the 2008 edition of Assessment and Management of Chronic Pain. Originally developed in 2005, the guideline was funded and published by the Institute for Clinical Systems Improvement (ICSI), a collaboration of 57 medical groups sponsored by 6 Minnesota health plans. A 3rd edition, released in August, summarizes the current evidence in the assessment and treatment of chronic pain in mature adolescents (ages 16-18 years) and adults.

Chronic pain—a persistent, life-altering condition—is one of the most challenging clinical disorders for primary care physicians to treat. Unlike acute pain, where we seek to cure the underlying biological condition, the goal of chronic pain management is to improve patient function in the face of pain that may never completely resolve.

Achieving that goal, according to the new guideline, requires a patient-centered, multifaceted approach—often involving a health care team that includes specialists in behavioral health and physical rehabilitation—that is co-ordinated by a primary care physician. An effective treatment plan must address biopsychosocial factors as well as spiritual and cultural issues. Patients must be taught self-management skills focused on fitness, stress reduction, and maintaining a healthy lifestyle ( TABLE ). Medications may be part of the treatment plan but should not be the sole focus, according to the guideline. Opioids are an option when other therapies fail.

ICSI’s new guideline also addresses the effects of various therapies, the role of psychosocial factors, and the identification of barriers to treatment. The comprehensive guideline, which has 172 references and 9 appendices, also features 2 easy-to-use algorithms. One algorithm addresses the assessment of chronic pain ( FIGURE 1 ) and the other deals with chronic pain management ( FIGURE 2 ). Both algorithms identify level I and level II strategies. And both can be readily adapted to primary care practice, and are extremely helpful to physicians who are evaluating and developing care plans for patients with chronic pain.

FIGURE 1
Chronic pain assessment algorithm


HIV, human immunodeficiency virus; ICSI, Institute for Clinical Systems Improvement; MS, multiple sclerosis.
*Pain types and contributing factors are not mutually exclusive. Patients frequently have more than one type of pain, as well as overlapping contributing factors.
Source: Institute for Clinical Systems Improvement. Reprinted with permission.

4 objectives

This latest guideline was developed to:

  • Improve the treatment of adult chronic pain patients by encouraging physicians to complete an appropriate biopsychosocial assessment (and reassessment).
  • Improve patient function by recommending the development and use of a comprehensive treatment plan that includes a multispecialty team.
  • Improve the use of Level I and Level II treatment approaches to chronic pain.
  • Provide guidance on the most effective use of nonopioid and opioid medications in the treatment of chronic pain.

With these objectives in mind, the ICSI work group conducted a comprehensive literature review, giving priority to randomized controlled trials (RCTs), meta-analyses, and systematic reviews. The work group used a 7-tier grading system to rate the evidence and a 3-category system for the worksheets in the appendix. For this article, we have converted the evidence ratings into SORT taxonomy.1

What’s changed?

In addition to reflecting the latest research, the new guideline contains a number of clarifications. For example, the update states that medications are not the “sole” focus of treatment and should be used, when necessary, as part of an overall approach to pain management. The previous version noted that medications were not the “primary” focus.

 

 

 

The management algorithm ( FIGURE 2 ) now leads with “core principles”—a term suggesting greater importance than the former term, “general management,” implied. Clinical highlights, a synthesis of key recommendations, have been revised to better align with the guideline’s main components—assessment, functional goals, patient-centered/biopsychosocial care planning, Level I vs Level II approaches, and medication and patient selection.

Other changes in the guideline may contribute to clinicians’ understanding of chronic pain and its complex presentation. The guideline now includes a statement about allodynia and hyperalgesia to indicate that both may play an important role in any pain syndrome—not just complex regional pain syndrome. Information about fibromyalgia symptoms and myofascial pain has been added. The definitions page now has an entry for “biopsychosocial model,” as well as language designed to stress the differences between untreated acute pain and ongoing chronic pain.

 

FIGURE 2
Chronic pain management algorithm 


DIRE, diagnosis, intractability, risk, efficacy.
Source: Institute for Clinical System Improvement. Reprinted with permission.

A limitation, an improvement

A limitation of the guideline is the lack of studies addressing the effectiveness of a comprehensive, multidisciplinary treatment approach to chronic pain management. Most studies consider single therapies.

An improvement in this guideline is that the evidence levels of each strategy are now listed within the section describing it—a notable change that makes it far easier to identify the quality of individual recommendations.

As has been the case in the past, this latest edition of the guideline offers a number of tools for physicians. The assessment and management algorithms ( FIGURES 1 AND 2 , respectively) walk clinicians through the decision-making process. In addition, the following 9 appendices provide practical guidance to physicians in various aspects of patient evaluation and care:

  • Brief Pain Inventory (Short Form)
  • Patient Health Questionnaire (PHQ-9)
  • Functional Ability Questionnaire
  • Personal Care Plan for Chronic Pain
  • DIRE (diagnosis, intractability, risk, efficacy) Score: Patient Selection for Chronic Opioid Analgesia
  • Opioid Agreement Form
  • Opioid Analgesics
  • Pharmaceutical Interventions for Neuropathic Pain
  • Neuropathic Pain Treatment Diagram.

Source for this guideline

Institute for Clinical Systems Improvement (ICSI). Assessment and Management of Chronic Pain. 3rd ed. Bloomington (Minn): Institute for Clinical Systems Improvement (ICSI); 2008 July. Available at: http://www.icsi.org/pain__chronic__assessment_and_management_of_14399/pain__chronic__assessment_and_management_of__guideline.html. Accessed September 9, 2008.

References

1. Ebell M, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature. J Fam Pract. 2004;53:111-120.

References

1. Ebell M, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature. J Fam Pract. 2004;53:111-120.

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Managing chronic pain: What’s the best approach?
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