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Program Chairmen and Editors:
Gary S. Hoffman, MD, and John H. Stone, MD, MPH
Contents
I. PATHOGENESIS
A. Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Moderators: Coen Stegeman and Herbert Virgin
Keynote Presentation
Host and viral genes that control herpesvirus vasculitis
Herbert W. Virgin IV
Plenary Session Abstracts (1-3)
1-090. Induction of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) by intravenous administration of anti-myeloperoxidase (anti-MPO) antibodies to recombinase activating gene-2 deficient (RAG-2 -/-) mice
J.C. Jennette, H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk
2-091. Induction of necrotizing and crescentic glomerulonephritis (NCGN) and small-vessel vasculitis (SVV) by adoptive transfer of anti-myeloperoxidase (anti-MPO) lymphocytes into recombinase activating gene-2 deficient (RAG-2 -/-) mice
H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk, J.C. Jennette
3-049. Contribution of activated neurotrophils and MPO-ANCA to the development of crescentic glomerulonephritis in SCG/KJ mice
A. Ishida-Okawara, T. Ito-Ihara, T. Ono, E. Muso, K. Saiga, K. Nemoto, K. Suzuki
Keynote Presentations
Known causes of vasculitis in man
Stanley J. Naides
HCV and cryoglobulinemic vasculitis
Clodoveo Ferri, A.L. Zignego, D. Giuggioli, M. Sebastiani, M. Cazzato, A. Antonelli, L. La Civita, P. Fadda, G. Longombardo, and S. Pileri
Infections in primary vasculitides
Jan W. Cohen Tervaert
Plenary session Abstracts (4-5)
4-093. Staphylococcal toxic-shock-syndrome-toxin-1 (TSST-1) is a risk factor for disease relapse in Wegener's granulomatosis
E.R. Popa, B. van der Meer, J. Arends, W.M. Manson, N.A. Bos, C.G.M. Kallenberg, J.W. Cohen Tervaert, C.A. Stegeman
5-104.Chlamydia pneumoniae and giant-cell arteritis: Failure to detect Chlamydia pneumoniae in temporal artery biopsies by polymerase chain reaction
M.J. Regan, B.J. Wood, Y.-H. Hsieh, M.L. Theodore, T.C. Quinn, D.B. Hellmann, W.R. Green, C.A. Gaydos, J.H. Stone
B. Patterns of Injury: Implications for Pathogenesis
Moderators: Loïc Guillevin and Cornelia Weyand
Keynote Presentations
Pathogenic mechanisms in giant cell arteritis
Cornelia M. Weyand and Jörg J. Goronzy
Implications for pathogenesis of patterns of injury in small- and medium-sized-vessel vasculitis
J. Charles Jennette
Plenary Session Abstracts (6-7)
6-037. Superantigenic activation of T lymphocytes and endothelial cells: A mechanism for superantigen-induced vasculitis
P.A. Brogan, V. Shah, N. Klein, M.J. Dillon
7-108. Analysis of autoantibody repertoires in small and medium sized vessel vasculitis: Evidence for disease-specific perturbations in classic polyarteritis nodosa (PAN), micropolyangiitis (MPA), Churg-Strauss syndrome (CSS) and Wegener's granulomatosis (WG)
Y. Chanseaud, L. Guillevin, M. Kambouchner, M.C. Boissier, L. Mouthon
Keynote Presentation
Granuloma formation, implications for the pathogenesis of vasculitis
Michael C. Sneller
Plenary Session Abstracts (8-9)
8-052. Chemokine receptor expression on CD4+ and CD8+ memory T-cells and in granulomas in Wegener's granulomatosis
P. Lamprecht, A. Erdmann, A. Mueller, E. Csernok, H. Bruehl, W.L. Gross, M. Mack
9-016. Genetic resistance to Wegener's granulomatosis—a role for CCR5 in patients without antineutrophil cytoplasmic antibodies
Y. Zhou, D. Huang, C. Farver, G. Hoffman
Keynote Presentation
Endothelial cell biology, perivascular inflammation, and vasculitis
Maria C. Cid
Plenary Session Abstract (10)
10-023. Novel effects of inflammatory cell proteases on vascular endothelia
G.A. Preston, W.F. Pendergraft, J.J. Yang, J.C. Jennette, R.J. Falk
C. Possible Role of ANCA and AECA in Select Forms of Systemic Vasculitis
Moderators: Wolfgang Gross and Caroline Savage
Keynote Presentation
Understanding the pathogenesis of ANCA: Where are we today?
Gloria A. Preston, Jia Jin Yang, Hong Xiao, and Ronald J. Falk
Plenary Session Abstracts (11-12)
11-027. TNF-alpha accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism
R. Kettritz, J. Scheumann, Y. Xu, F.C. Luft, H. Haller
12-071. Membrane expression of neurotrophil proteinase 3 (PR3) is associated with relapse in PR3-ANCA related vasculitis
A.A. Rarok, C.A. Stegeman, P.C. Limburg, C.G.M. Kallenberg
Keynote Presentation
ANCA subsets: Influence on disease phenotype
Ulrich Specks
Plenary Session Abstract (13)
13-096. Sequential epitope mapping of the myeloperoxidase antigen
D.M. Wynn, J.A. James
Keynote Presentation
Genetics of ANCA-associated vasculitis
Cees G.M. Kallenberg, Agnieszka Rarok, and Coen A. Stegeman
Plenary Session Abstracts (14-15)
14-028. Membrane expression of proteinase 3 is genetically controlled
A. Schreiber, A. Bushjahn, F.C. Luft, R. Kettritz
15-015. Genetic polymorphisms in TNF, IL-1, IL-6 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in Wegener's granulomatosis (WG)
Y. Zhou, D. Huang, G.S. Hoffman
Keynote Presentation
Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications
Yehuda Shoenfeld
Plenary Session Abstract (16)
16-029. HMG-COA reductase inhibitors decrease ANCA-mediated activation of human neutrophils
M. Choi, S. Rolle M. Rane, H. Haller, F.C. Luft, R. Kettritz
II. EPIDEMIOLOGY OF VASCULITIS
Moderators: Miguel Gonzalez-Gay and Gene Hunder
Keynote Presentations
Kawasaki disease: Etiology, pathogenesis, and treatment
Karyl S. Barron
Epidemiology of giant-cell arteritis
Gene G. Hunder
Plenary Session Abstract (17)
17-102. Ethnic disparity in the incidence of temporal arteritis: A 32-year experience at an urban medical center
M.J. Regan, W.R. Green, J.H. Stone
Keynote Presentations
Epidemiology of Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome
Richard A. Watts, David G.I. Scott, and Suzanne E. Lane
Epidemiology of Henoch-Schönlein purpura
Frank Saulsbury
Plenary Session Abstract (18)
18-010. Henoch-Schönlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations
M.M. Amoli, W. Thomson, A.H. Hajeer, M.C. Calviño, C. Garcia-Porrua, W.E.R. Ollier, M.A. Gonzalez-Gay
III. DIAGNOSTIC MODALITIES, SURROGATE MARKERS OF DISEASE ACTIVITY, AND TOOLS FOR OUTCOME MEASUREMENTS
Moderators: Carol Langford and Raashid Luqmani
Keynote Presentations
Cytokines in giant-cell arteritis
Jörg J. Goronzy and Cornelia M. Weyand
Utility of imaging studies in assessment of vascular inflammation
Daniël Blockmans
Measuring disease activity and outcomes in clinical studies
Raashid Luqmani
Plenary Session Abstracts (19-21)
19-022. Increases of PR3 and MPO gene transcription in circulating leukocyte of ANCA-associated disease correlate with disease activity
J.J. Yang, G.A. Preston, D.A. Alcorta, B.D. Phillips, R.P. Thomas, S.L. Hogan, J.C. Jennette, R.J. Falk
20-119. Cardiac involvement in Wegener's granulomatosis: Echocardiographic features and clinical outcomes
G.H.M. Oliveira, J.B. Seward, U. Specks
21-041. Endothelial microparticles: Just blood "dust," or a "must" for the diagnosis and monitoring of disease activity in childhood vasculitides?
P.A. Brogan, V. Shah, C. Brachet, N. Klein, M.J. Dillon
Keynote Presentation
Diagnostic strategies in vasculitis affecting the central nervous system
Leonard H. Calabrese
Plenary Session Abstracts (22-23)
Moderator: Leonard Calabrese
22-082. Circulating endothelial cells and vasculitis
A. Woywodt, F. Streiber, K. de Groot, H. Haller, M. Haubitz
23-051. Diffuse endothelial dysfunction is a common feature of SNV
P.A. Bacon, D.M. Carruthers, A.D. Diler, K. Raza, J. Townend
IV. TREATMENT AND OUTCOMES
Moderators: Charles Pusey and Fokko van der Woude
Keynote Presentation
Conventional treatment and outcome of Wegener's granulomatosis and microscopic polyangiitis
David R.W. Jayne
Plenary Session Abstract (24)
24-012. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in "non-renal" ANCA-associated vasculitis
K. de Groot, N. Rasmussen, J.W. Cohen Tervaert, D.R.W. Jayne for EUVAS (European Vasculitis Study Group)
Keynote Presentations
Treatment of giant-cell arteritis: Where we have been and why we must move on
Gary S. Hoffman
Henoch-Schönlein purpura (treatment and outcome)
Michael J. Dillon
Targeted therapies in systemic vasculitis
John H. Stone
Plenary Session Abstract (25)
25-070. Campath 1-H (anti-CD52) for refractory vasculitis: Retrospective Cambridge experience 1989-1999
D.R.W. Jayne
V. TREATING THE PERMANENT SEQUELAE OF VASCULITIS
Moderators: Robert Kimberly and John Stone
Keynote Presentations
Inflammation in acute coronary syndromes
Mark Robbins and Eric J. Topol
Kidney transplantation and ANCA-associated vasculitis
Fokko J. van der Woude
Surgical treatment of Takayasu's disease
Joseph M. Giordano
New approaches to the management of subglottic stenosis in Wegener's granulomatosis
Isaac Eliachar, James Chan, and Lee Akst
Sinonasal complications of vasculitic diseases
Robert S. Lebovics
Pathogenesis—Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Pathogenesis—Patterns of Injury: Implications for Pathogenesis
Pathogenesis—Possible Role of ANCA and AECA in Selected Forms of Systemic Vasculitis
Epidemiology of Vasculitis
Diagnostic Modalities, Surrogate Markers of Disease Activity, and Tools for Outcome Measurements
Treatment and Outcomes
Treating the Permanent Sequelae of Vasculitis
Program Chairmen and Editors:
Gary S. Hoffman, MD, and John H. Stone, MD, MPH
Contents
I. PATHOGENESIS
A. Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Moderators: Coen Stegeman and Herbert Virgin
Keynote Presentation
Host and viral genes that control herpesvirus vasculitis
Herbert W. Virgin IV
Plenary Session Abstracts (1-3)
1-090. Induction of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) by intravenous administration of anti-myeloperoxidase (anti-MPO) antibodies to recombinase activating gene-2 deficient (RAG-2 -/-) mice
J.C. Jennette, H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk
2-091. Induction of necrotizing and crescentic glomerulonephritis (NCGN) and small-vessel vasculitis (SVV) by adoptive transfer of anti-myeloperoxidase (anti-MPO) lymphocytes into recombinase activating gene-2 deficient (RAG-2 -/-) mice
H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk, J.C. Jennette
3-049. Contribution of activated neurotrophils and MPO-ANCA to the development of crescentic glomerulonephritis in SCG/KJ mice
A. Ishida-Okawara, T. Ito-Ihara, T. Ono, E. Muso, K. Saiga, K. Nemoto, K. Suzuki
Keynote Presentations
Known causes of vasculitis in man
Stanley J. Naides
HCV and cryoglobulinemic vasculitis
Clodoveo Ferri, A.L. Zignego, D. Giuggioli, M. Sebastiani, M. Cazzato, A. Antonelli, L. La Civita, P. Fadda, G. Longombardo, and S. Pileri
Infections in primary vasculitides
Jan W. Cohen Tervaert
Plenary session Abstracts (4-5)
4-093. Staphylococcal toxic-shock-syndrome-toxin-1 (TSST-1) is a risk factor for disease relapse in Wegener's granulomatosis
E.R. Popa, B. van der Meer, J. Arends, W.M. Manson, N.A. Bos, C.G.M. Kallenberg, J.W. Cohen Tervaert, C.A. Stegeman
5-104.Chlamydia pneumoniae and giant-cell arteritis: Failure to detect Chlamydia pneumoniae in temporal artery biopsies by polymerase chain reaction
M.J. Regan, B.J. Wood, Y.-H. Hsieh, M.L. Theodore, T.C. Quinn, D.B. Hellmann, W.R. Green, C.A. Gaydos, J.H. Stone
B. Patterns of Injury: Implications for Pathogenesis
Moderators: Loïc Guillevin and Cornelia Weyand
Keynote Presentations
Pathogenic mechanisms in giant cell arteritis
Cornelia M. Weyand and Jörg J. Goronzy
Implications for pathogenesis of patterns of injury in small- and medium-sized-vessel vasculitis
J. Charles Jennette
Plenary Session Abstracts (6-7)
6-037. Superantigenic activation of T lymphocytes and endothelial cells: A mechanism for superantigen-induced vasculitis
P.A. Brogan, V. Shah, N. Klein, M.J. Dillon
7-108. Analysis of autoantibody repertoires in small and medium sized vessel vasculitis: Evidence for disease-specific perturbations in classic polyarteritis nodosa (PAN), micropolyangiitis (MPA), Churg-Strauss syndrome (CSS) and Wegener's granulomatosis (WG)
Y. Chanseaud, L. Guillevin, M. Kambouchner, M.C. Boissier, L. Mouthon
Keynote Presentation
Granuloma formation, implications for the pathogenesis of vasculitis
Michael C. Sneller
Plenary Session Abstracts (8-9)
8-052. Chemokine receptor expression on CD4+ and CD8+ memory T-cells and in granulomas in Wegener's granulomatosis
P. Lamprecht, A. Erdmann, A. Mueller, E. Csernok, H. Bruehl, W.L. Gross, M. Mack
9-016. Genetic resistance to Wegener's granulomatosis—a role for CCR5 in patients without antineutrophil cytoplasmic antibodies
Y. Zhou, D. Huang, C. Farver, G. Hoffman
Keynote Presentation
Endothelial cell biology, perivascular inflammation, and vasculitis
Maria C. Cid
Plenary Session Abstract (10)
10-023. Novel effects of inflammatory cell proteases on vascular endothelia
G.A. Preston, W.F. Pendergraft, J.J. Yang, J.C. Jennette, R.J. Falk
C. Possible Role of ANCA and AECA in Select Forms of Systemic Vasculitis
Moderators: Wolfgang Gross and Caroline Savage
Keynote Presentation
Understanding the pathogenesis of ANCA: Where are we today?
Gloria A. Preston, Jia Jin Yang, Hong Xiao, and Ronald J. Falk
Plenary Session Abstracts (11-12)
11-027. TNF-alpha accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism
R. Kettritz, J. Scheumann, Y. Xu, F.C. Luft, H. Haller
12-071. Membrane expression of neurotrophil proteinase 3 (PR3) is associated with relapse in PR3-ANCA related vasculitis
A.A. Rarok, C.A. Stegeman, P.C. Limburg, C.G.M. Kallenberg
Keynote Presentation
ANCA subsets: Influence on disease phenotype
Ulrich Specks
Plenary Session Abstract (13)
13-096. Sequential epitope mapping of the myeloperoxidase antigen
D.M. Wynn, J.A. James
Keynote Presentation
Genetics of ANCA-associated vasculitis
Cees G.M. Kallenberg, Agnieszka Rarok, and Coen A. Stegeman
Plenary Session Abstracts (14-15)
14-028. Membrane expression of proteinase 3 is genetically controlled
A. Schreiber, A. Bushjahn, F.C. Luft, R. Kettritz
15-015. Genetic polymorphisms in TNF, IL-1, IL-6 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in Wegener's granulomatosis (WG)
Y. Zhou, D. Huang, G.S. Hoffman
Keynote Presentation
Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications
Yehuda Shoenfeld
Plenary Session Abstract (16)
16-029. HMG-COA reductase inhibitors decrease ANCA-mediated activation of human neutrophils
M. Choi, S. Rolle M. Rane, H. Haller, F.C. Luft, R. Kettritz
II. EPIDEMIOLOGY OF VASCULITIS
Moderators: Miguel Gonzalez-Gay and Gene Hunder
Keynote Presentations
Kawasaki disease: Etiology, pathogenesis, and treatment
Karyl S. Barron
Epidemiology of giant-cell arteritis
Gene G. Hunder
Plenary Session Abstract (17)
17-102. Ethnic disparity in the incidence of temporal arteritis: A 32-year experience at an urban medical center
M.J. Regan, W.R. Green, J.H. Stone
Keynote Presentations
Epidemiology of Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome
Richard A. Watts, David G.I. Scott, and Suzanne E. Lane
Epidemiology of Henoch-Schönlein purpura
Frank Saulsbury
Plenary Session Abstract (18)
18-010. Henoch-Schönlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations
M.M. Amoli, W. Thomson, A.H. Hajeer, M.C. Calviño, C. Garcia-Porrua, W.E.R. Ollier, M.A. Gonzalez-Gay
III. DIAGNOSTIC MODALITIES, SURROGATE MARKERS OF DISEASE ACTIVITY, AND TOOLS FOR OUTCOME MEASUREMENTS
Moderators: Carol Langford and Raashid Luqmani
Keynote Presentations
Cytokines in giant-cell arteritis
Jörg J. Goronzy and Cornelia M. Weyand
Utility of imaging studies in assessment of vascular inflammation
Daniël Blockmans
Measuring disease activity and outcomes in clinical studies
Raashid Luqmani
Plenary Session Abstracts (19-21)
19-022. Increases of PR3 and MPO gene transcription in circulating leukocyte of ANCA-associated disease correlate with disease activity
J.J. Yang, G.A. Preston, D.A. Alcorta, B.D. Phillips, R.P. Thomas, S.L. Hogan, J.C. Jennette, R.J. Falk
20-119. Cardiac involvement in Wegener's granulomatosis: Echocardiographic features and clinical outcomes
G.H.M. Oliveira, J.B. Seward, U. Specks
21-041. Endothelial microparticles: Just blood "dust," or a "must" for the diagnosis and monitoring of disease activity in childhood vasculitides?
P.A. Brogan, V. Shah, C. Brachet, N. Klein, M.J. Dillon
Keynote Presentation
Diagnostic strategies in vasculitis affecting the central nervous system
Leonard H. Calabrese
Plenary Session Abstracts (22-23)
Moderator: Leonard Calabrese
22-082. Circulating endothelial cells and vasculitis
A. Woywodt, F. Streiber, K. de Groot, H. Haller, M. Haubitz
23-051. Diffuse endothelial dysfunction is a common feature of SNV
P.A. Bacon, D.M. Carruthers, A.D. Diler, K. Raza, J. Townend
IV. TREATMENT AND OUTCOMES
Moderators: Charles Pusey and Fokko van der Woude
Keynote Presentation
Conventional treatment and outcome of Wegener's granulomatosis and microscopic polyangiitis
David R.W. Jayne
Plenary Session Abstract (24)
24-012. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in "non-renal" ANCA-associated vasculitis
K. de Groot, N. Rasmussen, J.W. Cohen Tervaert, D.R.W. Jayne for EUVAS (European Vasculitis Study Group)
Keynote Presentations
Treatment of giant-cell arteritis: Where we have been and why we must move on
Gary S. Hoffman
Henoch-Schönlein purpura (treatment and outcome)
Michael J. Dillon
Targeted therapies in systemic vasculitis
John H. Stone
Plenary Session Abstract (25)
25-070. Campath 1-H (anti-CD52) for refractory vasculitis: Retrospective Cambridge experience 1989-1999
D.R.W. Jayne
V. TREATING THE PERMANENT SEQUELAE OF VASCULITIS
Moderators: Robert Kimberly and John Stone
Keynote Presentations
Inflammation in acute coronary syndromes
Mark Robbins and Eric J. Topol
Kidney transplantation and ANCA-associated vasculitis
Fokko J. van der Woude
Surgical treatment of Takayasu's disease
Joseph M. Giordano
New approaches to the management of subglottic stenosis in Wegener's granulomatosis
Isaac Eliachar, James Chan, and Lee Akst
Sinonasal complications of vasculitic diseases
Robert S. Lebovics
Pathogenesis—Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Pathogenesis—Patterns of Injury: Implications for Pathogenesis
Pathogenesis—Possible Role of ANCA and AECA in Selected Forms of Systemic Vasculitis
Epidemiology of Vasculitis
Diagnostic Modalities, Surrogate Markers of Disease Activity, and Tools for Outcome Measurements
Treatment and Outcomes
Treating the Permanent Sequelae of Vasculitis
Program Chairmen and Editors:
Gary S. Hoffman, MD, and John H. Stone, MD, MPH
Contents
I. PATHOGENESIS
A. Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Moderators: Coen Stegeman and Herbert Virgin
Keynote Presentation
Host and viral genes that control herpesvirus vasculitis
Herbert W. Virgin IV
Plenary Session Abstracts (1-3)
1-090. Induction of pauci-immune necrotizing and crescentic glomerulonephritis (NCGN) by intravenous administration of anti-myeloperoxidase (anti-MPO) antibodies to recombinase activating gene-2 deficient (RAG-2 -/-) mice
J.C. Jennette, H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk
2-091. Induction of necrotizing and crescentic glomerulonephritis (NCGN) and small-vessel vasculitis (SVV) by adoptive transfer of anti-myeloperoxidase (anti-MPO) lymphocytes into recombinase activating gene-2 deficient (RAG-2 -/-) mice
H. Xiao, P. Heeringa, Z. Liu, P. Hu, M. Zhao, Y. Aratani, R.J. Falk, J.C. Jennette
3-049. Contribution of activated neurotrophils and MPO-ANCA to the development of crescentic glomerulonephritis in SCG/KJ mice
A. Ishida-Okawara, T. Ito-Ihara, T. Ono, E. Muso, K. Saiga, K. Nemoto, K. Suzuki
Keynote Presentations
Known causes of vasculitis in man
Stanley J. Naides
HCV and cryoglobulinemic vasculitis
Clodoveo Ferri, A.L. Zignego, D. Giuggioli, M. Sebastiani, M. Cazzato, A. Antonelli, L. La Civita, P. Fadda, G. Longombardo, and S. Pileri
Infections in primary vasculitides
Jan W. Cohen Tervaert
Plenary session Abstracts (4-5)
4-093. Staphylococcal toxic-shock-syndrome-toxin-1 (TSST-1) is a risk factor for disease relapse in Wegener's granulomatosis
E.R. Popa, B. van der Meer, J. Arends, W.M. Manson, N.A. Bos, C.G.M. Kallenberg, J.W. Cohen Tervaert, C.A. Stegeman
5-104.Chlamydia pneumoniae and giant-cell arteritis: Failure to detect Chlamydia pneumoniae in temporal artery biopsies by polymerase chain reaction
M.J. Regan, B.J. Wood, Y.-H. Hsieh, M.L. Theodore, T.C. Quinn, D.B. Hellmann, W.R. Green, C.A. Gaydos, J.H. Stone
B. Patterns of Injury: Implications for Pathogenesis
Moderators: Loïc Guillevin and Cornelia Weyand
Keynote Presentations
Pathogenic mechanisms in giant cell arteritis
Cornelia M. Weyand and Jörg J. Goronzy
Implications for pathogenesis of patterns of injury in small- and medium-sized-vessel vasculitis
J. Charles Jennette
Plenary Session Abstracts (6-7)
6-037. Superantigenic activation of T lymphocytes and endothelial cells: A mechanism for superantigen-induced vasculitis
P.A. Brogan, V. Shah, N. Klein, M.J. Dillon
7-108. Analysis of autoantibody repertoires in small and medium sized vessel vasculitis: Evidence for disease-specific perturbations in classic polyarteritis nodosa (PAN), micropolyangiitis (MPA), Churg-Strauss syndrome (CSS) and Wegener's granulomatosis (WG)
Y. Chanseaud, L. Guillevin, M. Kambouchner, M.C. Boissier, L. Mouthon
Keynote Presentation
Granuloma formation, implications for the pathogenesis of vasculitis
Michael C. Sneller
Plenary Session Abstracts (8-9)
8-052. Chemokine receptor expression on CD4+ and CD8+ memory T-cells and in granulomas in Wegener's granulomatosis
P. Lamprecht, A. Erdmann, A. Mueller, E. Csernok, H. Bruehl, W.L. Gross, M. Mack
9-016. Genetic resistance to Wegener's granulomatosis—a role for CCR5 in patients without antineutrophil cytoplasmic antibodies
Y. Zhou, D. Huang, C. Farver, G. Hoffman
Keynote Presentation
Endothelial cell biology, perivascular inflammation, and vasculitis
Maria C. Cid
Plenary Session Abstract (10)
10-023. Novel effects of inflammatory cell proteases on vascular endothelia
G.A. Preston, W.F. Pendergraft, J.J. Yang, J.C. Jennette, R.J. Falk
C. Possible Role of ANCA and AECA in Select Forms of Systemic Vasculitis
Moderators: Wolfgang Gross and Caroline Savage
Keynote Presentation
Understanding the pathogenesis of ANCA: Where are we today?
Gloria A. Preston, Jia Jin Yang, Hong Xiao, and Ronald J. Falk
Plenary Session Abstracts (11-12)
11-027. TNF-alpha accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism
R. Kettritz, J. Scheumann, Y. Xu, F.C. Luft, H. Haller
12-071. Membrane expression of neurotrophil proteinase 3 (PR3) is associated with relapse in PR3-ANCA related vasculitis
A.A. Rarok, C.A. Stegeman, P.C. Limburg, C.G.M. Kallenberg
Keynote Presentation
ANCA subsets: Influence on disease phenotype
Ulrich Specks
Plenary Session Abstract (13)
13-096. Sequential epitope mapping of the myeloperoxidase antigen
D.M. Wynn, J.A. James
Keynote Presentation
Genetics of ANCA-associated vasculitis
Cees G.M. Kallenberg, Agnieszka Rarok, and Coen A. Stegeman
Plenary Session Abstracts (14-15)
14-028. Membrane expression of proteinase 3 is genetically controlled
A. Schreiber, A. Bushjahn, F.C. Luft, R. Kettritz
15-015. Genetic polymorphisms in TNF, IL-1, IL-6 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) in Wegener's granulomatosis (WG)
Y. Zhou, D. Huang, G.S. Hoffman
Keynote Presentation
Classification of anti-endothelial cell antibodies into antibodies against microvascular and macrovascular endothelial cells: The pathogenic and diagnostic implications
Yehuda Shoenfeld
Plenary Session Abstract (16)
16-029. HMG-COA reductase inhibitors decrease ANCA-mediated activation of human neutrophils
M. Choi, S. Rolle M. Rane, H. Haller, F.C. Luft, R. Kettritz
II. EPIDEMIOLOGY OF VASCULITIS
Moderators: Miguel Gonzalez-Gay and Gene Hunder
Keynote Presentations
Kawasaki disease: Etiology, pathogenesis, and treatment
Karyl S. Barron
Epidemiology of giant-cell arteritis
Gene G. Hunder
Plenary Session Abstract (17)
17-102. Ethnic disparity in the incidence of temporal arteritis: A 32-year experience at an urban medical center
M.J. Regan, W.R. Green, J.H. Stone
Keynote Presentations
Epidemiology of Wegener's granulomatosis, microscopic polyangiitis, and Churg-Strauss syndrome
Richard A. Watts, David G.I. Scott, and Suzanne E. Lane
Epidemiology of Henoch-Schönlein purpura
Frank Saulsbury
Plenary Session Abstract (18)
18-010. Henoch-Schönlein purpura and cutaneous leukocytoclastic angiitis exhibit different HLA-DRB1 associations
M.M. Amoli, W. Thomson, A.H. Hajeer, M.C. Calviño, C. Garcia-Porrua, W.E.R. Ollier, M.A. Gonzalez-Gay
III. DIAGNOSTIC MODALITIES, SURROGATE MARKERS OF DISEASE ACTIVITY, AND TOOLS FOR OUTCOME MEASUREMENTS
Moderators: Carol Langford and Raashid Luqmani
Keynote Presentations
Cytokines in giant-cell arteritis
Jörg J. Goronzy and Cornelia M. Weyand
Utility of imaging studies in assessment of vascular inflammation
Daniël Blockmans
Measuring disease activity and outcomes in clinical studies
Raashid Luqmani
Plenary Session Abstracts (19-21)
19-022. Increases of PR3 and MPO gene transcription in circulating leukocyte of ANCA-associated disease correlate with disease activity
J.J. Yang, G.A. Preston, D.A. Alcorta, B.D. Phillips, R.P. Thomas, S.L. Hogan, J.C. Jennette, R.J. Falk
20-119. Cardiac involvement in Wegener's granulomatosis: Echocardiographic features and clinical outcomes
G.H.M. Oliveira, J.B. Seward, U. Specks
21-041. Endothelial microparticles: Just blood "dust," or a "must" for the diagnosis and monitoring of disease activity in childhood vasculitides?
P.A. Brogan, V. Shah, C. Brachet, N. Klein, M.J. Dillon
Keynote Presentation
Diagnostic strategies in vasculitis affecting the central nervous system
Leonard H. Calabrese
Plenary Session Abstracts (22-23)
Moderator: Leonard Calabrese
22-082. Circulating endothelial cells and vasculitis
A. Woywodt, F. Streiber, K. de Groot, H. Haller, M. Haubitz
23-051. Diffuse endothelial dysfunction is a common feature of SNV
P.A. Bacon, D.M. Carruthers, A.D. Diler, K. Raza, J. Townend
IV. TREATMENT AND OUTCOMES
Moderators: Charles Pusey and Fokko van der Woude
Keynote Presentation
Conventional treatment and outcome of Wegener's granulomatosis and microscopic polyangiitis
David R.W. Jayne
Plenary Session Abstract (24)
24-012. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in "non-renal" ANCA-associated vasculitis
K. de Groot, N. Rasmussen, J.W. Cohen Tervaert, D.R.W. Jayne for EUVAS (European Vasculitis Study Group)
Keynote Presentations
Treatment of giant-cell arteritis: Where we have been and why we must move on
Gary S. Hoffman
Henoch-Schönlein purpura (treatment and outcome)
Michael J. Dillon
Targeted therapies in systemic vasculitis
John H. Stone
Plenary Session Abstract (25)
25-070. Campath 1-H (anti-CD52) for refractory vasculitis: Retrospective Cambridge experience 1989-1999
D.R.W. Jayne
V. TREATING THE PERMANENT SEQUELAE OF VASCULITIS
Moderators: Robert Kimberly and John Stone
Keynote Presentations
Inflammation in acute coronary syndromes
Mark Robbins and Eric J. Topol
Kidney transplantation and ANCA-associated vasculitis
Fokko J. van der Woude
Surgical treatment of Takayasu's disease
Joseph M. Giordano
New approaches to the management of subglottic stenosis in Wegener's granulomatosis
Isaac Eliachar, James Chan, and Lee Akst
Sinonasal complications of vasculitic diseases
Robert S. Lebovics
Pathogenesis—Immune Predisposition and Infectious Etiology of Systemic Vasculitis
Pathogenesis—Patterns of Injury: Implications for Pathogenesis
Pathogenesis—Possible Role of ANCA and AECA in Selected Forms of Systemic Vasculitis
Epidemiology of Vasculitis
Diagnostic Modalities, Surrogate Markers of Disease Activity, and Tools for Outcome Measurements
Treatment and Outcomes
Treating the Permanent Sequelae of Vasculitis
