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Key clinical point: Women with uterine fibroids, especially those with pain symptoms or who have had a hysterectomy, may have an increased risk for certain mental health outcomes.
Major finding: After adjusting for confounders, women with uterine fibroids vs those without had higher rates of depression (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.10-1.13), anxiety (HR, 1.12; 95% CI, 1.10-1.13), and self-directed violence (HR, 1.46; 95% CI, 1.29-1.64). These associations were more pronounced in women experiencing pain symptoms and in those who underwent a hysterectomy.
Study details: The data come from a cohort study of 313,754 women aged 18-50 years with diagnosed uterine fibroids who were matched to 627,539 women without uterine fibroids.
Disclosures: The research was funded by AbbVie, and Aetion received funding for conducting the study. SE Chiuve, C Huisingh, and C Owens are employees of AbbVie receiving stock and/or stock options. N Petruski-Ivleva was an employee of Aetion when the study was being conducted and may hold stock options at Aetion. W Kuohung and LA Wise received consultancy fees from AbbVie, but did not receive payment for authorship.
Source: Chiuve SE et al. J Epidemiol Community Health. 2021 Jul 22. doi: 10.1136/jech-2020-214565.
Key clinical point: Women with uterine fibroids, especially those with pain symptoms or who have had a hysterectomy, may have an increased risk for certain mental health outcomes.
Major finding: After adjusting for confounders, women with uterine fibroids vs those without had higher rates of depression (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.10-1.13), anxiety (HR, 1.12; 95% CI, 1.10-1.13), and self-directed violence (HR, 1.46; 95% CI, 1.29-1.64). These associations were more pronounced in women experiencing pain symptoms and in those who underwent a hysterectomy.
Study details: The data come from a cohort study of 313,754 women aged 18-50 years with diagnosed uterine fibroids who were matched to 627,539 women without uterine fibroids.
Disclosures: The research was funded by AbbVie, and Aetion received funding for conducting the study. SE Chiuve, C Huisingh, and C Owens are employees of AbbVie receiving stock and/or stock options. N Petruski-Ivleva was an employee of Aetion when the study was being conducted and may hold stock options at Aetion. W Kuohung and LA Wise received consultancy fees from AbbVie, but did not receive payment for authorship.
Source: Chiuve SE et al. J Epidemiol Community Health. 2021 Jul 22. doi: 10.1136/jech-2020-214565.
Key clinical point: Women with uterine fibroids, especially those with pain symptoms or who have had a hysterectomy, may have an increased risk for certain mental health outcomes.
Major finding: After adjusting for confounders, women with uterine fibroids vs those without had higher rates of depression (hazard ratio [HR], 1.12; 95% confidence interval [CI], 1.10-1.13), anxiety (HR, 1.12; 95% CI, 1.10-1.13), and self-directed violence (HR, 1.46; 95% CI, 1.29-1.64). These associations were more pronounced in women experiencing pain symptoms and in those who underwent a hysterectomy.
Study details: The data come from a cohort study of 313,754 women aged 18-50 years with diagnosed uterine fibroids who were matched to 627,539 women without uterine fibroids.
Disclosures: The research was funded by AbbVie, and Aetion received funding for conducting the study. SE Chiuve, C Huisingh, and C Owens are employees of AbbVie receiving stock and/or stock options. N Petruski-Ivleva was an employee of Aetion when the study was being conducted and may hold stock options at Aetion. W Kuohung and LA Wise received consultancy fees from AbbVie, but did not receive payment for authorship.
Source: Chiuve SE et al. J Epidemiol Community Health. 2021 Jul 22. doi: 10.1136/jech-2020-214565.