Brennan McCullar is a Hospitalist at Baptist Medical Group in Memphis, Tennessee. Bradford Waters is a Hepatologist, John Phillips is a Radiologist, Alan Appelbaum is a Radiologist, David Archie is a Radiologist, and Alva Weir is an Oncologist, all at Memphis Veterans Affairs Medical Center in Tennessee. Vikki Nolan is an Assistant Professor of epidemiology and Alva Weir is the Director of the hematology-oncology fellowship program, both at University of Tennessee Health Science Center in Memphis. Correspondence: Brennan McCullar (bpalazo@gmail.com)
Author disclosures The authors report no actual or potential conflicts of interest with regard to this article.
Disclaimer The opinions expressed herein are those of the authors and do not necessarily reflect those of Federal Practitioner, Frontline Medical Communications Inc., the US Government, or any of its agencies.
Limitations to our study occurred because radiologist 3 did not review all of the images nor score them. Radiologist 3 was limited to 12 images where there was disagreement and was limited to 2 scores to choose from for each image. Further limitations include that this study was performed at a single center. Our study focused on one imaging modality and did not include ultrasounds or MRIs. We did not compare the demographics of our patients with those of other VA hospitals. The radiologists interpreted the images individually, and their subjectivity was another limitation.
Conclusion
In the MVAMC population, LI-RADS showed a good sensitivity, specificity, and diagnostic accuracy for CT surveillance scans in patient at high risk for HCC at an earlier time point than did standard evaluation by very experienced CT radiologists. Higher LI-RADS scores on surveillance CTs had good diagnostic accuracy for the probable future diagnosis of HCC, whereas lower LI-RADS scores had a good diagnostic accuracy for probable benign nodules. Utilizing the LI-RADS algorithm on all surveillance CTs in patients at high risk for HCC may lead to obtaining MRIs or follow-up CTs sooner for suspicious nodules, leading to an earlier diagnosis of HCC and possible earlier and more effective intervention.
