Key clinical point: Topical basil essential oil at higher doses can effectively reduce the severity of pain intensity and frequency of migraine attacks.
Major Finding: The interaction between dose and time factors was significantly associated with both pain intensity and frequency of attack ( P less than .001 for both). The odds of higher pain intensity and rates of higher frequency of migraine attacks in the basil essential oil vs placebo group decreased over time.
Study details: In a triple-blind study, 144 patients with migraine were randomly assigned to basil essential oil 2%, 4%, 6%, and placebo groups (1:1:1:1) by a stratified method.
Disclosures: This study was supported by the Lorestan University of Medical Sciences, Khorramabad, Iran. The authors declared no conflicts of interest.
Citation: Ahmadifard M et al. Complement Med Res. 2020 Mar 10. doi: 10.1159/000506349.