Key clinical point: Cognitive dysfunction in patients with multiple sclerosis (MS) is predictive of a higher risk for conversion from relapse-remitting MS to secondary progressive MS and a higher risk for death.
Major finding: Cognitive dysfunction was linked to a greater risk of converting from relapse-remitting course to progressive disease course (adjusted odds ratio, 2.29; P = .043) and shorter survival (adjusted hazard ratio, 3.07; P = .006).
Study details: This was a retrospective analysis of 408 patients with MS.
Disclosures: No external funding was received for this study. The authors reported no conflict of interests.
Source: Cavaco S et al. Mult Scler. 2021 Dec 30. doi: 10.1177/13524585211066598 .