Periodontal inflammation is associated with increased circulating levels of calcitonin gene-related peptide (CGRP) in patients with chronic migraine, a new study found. The cohort included 102 chronic migraineurs and 77 age- and sex-matched individuals free of headache/migraine. Full-mouth periodontal parameters were recorded and the periodontal inflamed surface area (PISA) was calculated to quantify the periodontal inflammatory status for each participant. Researchers found:
- In the chronic migraine group, patients with periodontitis had greater levels of serum CGRP and IL-6, while nonsignificant differences were observed with IL-10 concentrations vs those without periodontitis.
- PISA was independently associated with CGRP in patients with chronic migraine.
Leira Y, et al. Periodontal inflammation is related to increased serum calcitonin gene-related peptide (CGRP) levels in patients with chronic migraine. [Published online ahead of print May 9, 2019]. J Periodontol. doi: 10.1002/JPER.19-0051.