Interactions of the public and private sectors in drug development: Boundaries to protect scientific values while preserving innovation

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Gail H. Cassell, PhD, DSc (hon)
Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Correspondence: Gail H. Cassell, PhD, DSc (hon), Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285; G.cassell@Lilly.com

Acknowledgment: The author gratefully acknowledges helpful discussions with H. Heath, A. Norris, L.E. Van Campen, M.C. Jones, G. Geipel, and S.M. Paul of Eli Lilly and Company; E. Holmes of the University of California, San Diego; and M.G. Edwards of Recombinant Capital.

Dr. Cassell reported that she has no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article apart from her employment with Eli Lilly and Company, through which she receives a salary, grant/research support, and stock options.

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Gail H. Cassell, PhD, DSc (hon)
Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Correspondence: Gail H. Cassell, PhD, DSc (hon), Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285; G.cassell@Lilly.com

Acknowledgment: The author gratefully acknowledges helpful discussions with H. Heath, A. Norris, L.E. Van Campen, M.C. Jones, G. Geipel, and S.M. Paul of Eli Lilly and Company; E. Holmes of the University of California, San Diego; and M.G. Edwards of Recombinant Capital.

Dr. Cassell reported that she has no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article apart from her employment with Eli Lilly and Company, through which she receives a salary, grant/research support, and stock options.

Author and Disclosure Information

Gail H. Cassell, PhD, DSc (hon)
Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Correspondence: Gail H. Cassell, PhD, DSc (hon), Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285; G.cassell@Lilly.com

Acknowledgment: The author gratefully acknowledges helpful discussions with H. Heath, A. Norris, L.E. Van Campen, M.C. Jones, G. Geipel, and S.M. Paul of Eli Lilly and Company; E. Holmes of the University of California, San Diego; and M.G. Edwards of Recombinant Capital.

Dr. Cassell reported that she has no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article apart from her employment with Eli Lilly and Company, through which she receives a salary, grant/research support, and stock options.

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Interactions of the public and private sectors in drug development: Boundaries to protect scientific values while preserving innovation
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Cleveland Clinic Journal of Medicine 2007 March;74(suppl 2):S45-S48
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Applications in the real world: Case studies in defining boundaries and managing innovation

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Moderator and Author of Case Study 2
Claudia R. Adkison, JD, PhD

Executive Associate Dean, Administration and Faculty Affairs, Emory University School of Medicine, Atlanta, GA

Author of Case Study 1
Michael J. Meehan, Esq

Senior Counsel and Corporate Assistant Secretary, Cleveland Clinic, Cleveland, OH

Panelists
Gail H. Cassell, PhD, DSc (hon)

Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Jeffrey P. Kahn, PhD, MPH
Maas Family Chair in Bioethics and Director, Center for Bioethics, University of Minnesota, Minneapolis, MN

Philip A. Pizzo, MD
Dean and Professor of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA

Thomas P. Stossel, MD
Professor of Medicine, Harvard Medical School, Boston, MA

Dr. Cassell reported that she receives a salary, grant/research support, and stock options through her employment with Eli Lilly and Company.

Dr. Stossel reported that he has ownership interests in ZymeQuest, Inc., and in Critical Biologics Corp.; has intellectual property rights in Critical Biologics Corp.; has received consulting/advisory fees from Merck, Inc.; has received honoraria from Pfizer, Inc.; and has received royalties from Lippincott Williams & Wilkins.

All other participants reported that they have no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article.

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S51-S59
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Moderator and Author of Case Study 2
Claudia R. Adkison, JD, PhD

Executive Associate Dean, Administration and Faculty Affairs, Emory University School of Medicine, Atlanta, GA

Author of Case Study 1
Michael J. Meehan, Esq

Senior Counsel and Corporate Assistant Secretary, Cleveland Clinic, Cleveland, OH

Panelists
Gail H. Cassell, PhD, DSc (hon)

Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Jeffrey P. Kahn, PhD, MPH
Maas Family Chair in Bioethics and Director, Center for Bioethics, University of Minnesota, Minneapolis, MN

Philip A. Pizzo, MD
Dean and Professor of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA

Thomas P. Stossel, MD
Professor of Medicine, Harvard Medical School, Boston, MA

Dr. Cassell reported that she receives a salary, grant/research support, and stock options through her employment with Eli Lilly and Company.

Dr. Stossel reported that he has ownership interests in ZymeQuest, Inc., and in Critical Biologics Corp.; has intellectual property rights in Critical Biologics Corp.; has received consulting/advisory fees from Merck, Inc.; has received honoraria from Pfizer, Inc.; and has received royalties from Lippincott Williams & Wilkins.

All other participants reported that they have no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article.

Author and Disclosure Information

Moderator and Author of Case Study 2
Claudia R. Adkison, JD, PhD

Executive Associate Dean, Administration and Faculty Affairs, Emory University School of Medicine, Atlanta, GA

Author of Case Study 1
Michael J. Meehan, Esq

Senior Counsel and Corporate Assistant Secretary, Cleveland Clinic, Cleveland, OH

Panelists
Gail H. Cassell, PhD, DSc (hon)

Vice President, Scientific Affairs, and Distinguished Lilly Research Scholar for Infectious Diseases, Eli Lilly and Company, Indianapolis, IN

Jeffrey P. Kahn, PhD, MPH
Maas Family Chair in Bioethics and Director, Center for Bioethics, University of Minnesota, Minneapolis, MN

Philip A. Pizzo, MD
Dean and Professor of Pediatrics and of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA

Thomas P. Stossel, MD
Professor of Medicine, Harvard Medical School, Boston, MA

Dr. Cassell reported that she receives a salary, grant/research support, and stock options through her employment with Eli Lilly and Company.

Dr. Stossel reported that he has ownership interests in ZymeQuest, Inc., and in Critical Biologics Corp.; has intellectual property rights in Critical Biologics Corp.; has received consulting/advisory fees from Merck, Inc.; has received honoraria from Pfizer, Inc.; and has received royalties from Lippincott Williams & Wilkins.

All other participants reported that they have no financial interests, relationships, or affiliations that pose a potential conflict of interest with this article.

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Applications in the real world: Case studies in defining boundaries and managing innovation
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