Add-On to GLP-1s Yields Greater Weight Loss

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All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>The addition of bupropion/naltrexone to glucagon-like peptide 1 (GLP-1) receptor agonists leads to a further 4%-5% total body weight loss (TBWL) in patients wit</metaDescription> <articlePDF/> <teaserImage/> <teaser>Those who received bupropion/naltrexone with GLP-1 therapy lost about 5% of body weight.</teaser> <title>Add-On to GLP-1s Yields Greater Weight Loss</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>endo</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term canonical="true">34</term> <term>15</term> <term>21</term> </publications> <sections> <term canonical="true">39313</term> </sections> <topics> <term canonical="true">261</term> <term>205</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Add-On to GLP-1s Yields Greater Weight Loss</title> <deck/> </itemMeta> <itemContent> <h2>TOPLINE:</h2> <p><span class="tag metaDescription">The addition of bupropion/naltrexone to glucagon-like peptide 1 (GLP-1) receptor agonists leads to a further 4%-5% total body weight loss (TBWL) in patients with obesity</span>, including those who show a poor response to initial GLP-1 monotherapy.</p> <h2>METHODOLOGY:</h2> <ul class="body"> <li>Some patients with obesity experience suboptimal weight loss with GLP-1 monotherapy; however, adding treatments targeting multiple pathways may offer synergistic effects and improve outcomes.</li> <li>Researchers retrospectively evaluated adult patients with body mass index (BMI) ≥ 30 who attended an obesity clinic in Vancouver, Canada, and received a GLP-1 receptor agonist (liraglutide or semaglutide) for at least 6 months.</li> <li>They compared patients who continued receiving GLP-1 monotherapy with those who received add-on bupropion/naltrexone (combination therapy).</li> <li>The percent TBWL was compared between the groups from the initiation of the GLP-1 or the addition of bupropion/naltrexone over a period of 6 and 12 months.</li> <li>Patients prescribed combination therapy were stratified into responders (≥ 5% TBWL) and nonresponders (&lt; 5% TBWL) based on their initial response to GLP-1 monotherapy.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>Researchers included 415 patients with BMI ≥ 30 (mean age, 47.3 years; 75.6% women), of whom 320 continued receiving GLP-1 monotherapy and 95 received add-on bupropion/naltrexone (combination therapy); the mean follow-up period was 510.9 days.</li> <li>At 12 months, there was no significant difference in the percent TBWL among patients receiving the GLP-1 monotherapy or combination therapy (9.6% TBWL in both).</li> <li>However, when patients were stratified by their initial GLP-1 response, combination therapy led to a greater percent TBWL than monotherapy in both responders (<em>P</em> = .002) and nonresponders (<em>P</em> &lt; .0001).</li> <li>After the addition of bupropion/naltrexone, the mean percent TBWL was 4.3% (<em>P</em> &lt; .001) and 5.3% (<em>P</em> = .009) at 6 and 12 months, respectively, among the responders, and 3.7% (<em>P</em> = .009) and 4.0% (<em>P</em> = .02) at 6 and 12 months, respectively, among the nonresponders.</li> </ul> <h2>IN PRACTICE:</h2> <p>“Specific characteristics of individuals who benefit from the bupropion/naltrexone augmentation should be examined to identify patient populations wherein this may be of greatest benefit,” the authors wrote.</p> <h2>SOURCE:</h2> <p>This study, led by James Naude, Faculty of Medicine, University of British Columbia, Vancouver, Canada, was <a href="https://www.nature.com/articles/s41366-024-01526-2">published</a> in the <em>International Journal of Obesity</em>.</p> <h2>LIMITATIONS:</h2> <p>Virtual care and self-reported weights by patients owing to the COVID-19 pandemic could have introduced bias. Some of the data on weight and medication adherence were missing. Moreover, there was no placebo control; hence, there may be confounding by indication.</p> <h2>DISCLOSURES:</h2> <p>The study was not supported by any specific funding. Two of the authors reported receiving educational grants and speaker fees, with one currently being an advisory board member to various pharma companies and the other an advisory board member to a pharma company in the past.</p> <p> <em>A version of this article appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/add-glp-1s-yields-greater-weight-loss-2024a1000a1h">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> </itemContent> </newsItem> </itemSet></root>