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Antioxidant vitamins do not prevent cardiovascular disease
PRACTICE RECOMMENDATIONS

This meta-analysis of randomized controlled trials showed that neither beta-carotene nor vitamin E appears to prevent all-cause or cardiovascular mortality in patients with known heart disease or those at risk for heart disease. Similarly, use of these antioxidant vitamins did not affect number of stroke events. The use of beta-carotene and vitamin E should not be recommended for primary and secondary prevention of cardiovascular disease.

 
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Practice Recommendations from Key Studies

Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003; 361:2017–2023.

Promita Roychoudhury, MD
Kendra Schwartz, MD, MSPH
Wayne State University Family Practice Residency Program, Detroit, Mich. kensch@med.wayne.edu.

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The Journal of Family Practice - 52(10)
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747-769
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Practice Recommendations from Key Studies

Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003; 361:2017–2023.

Promita Roychoudhury, MD
Kendra Schwartz, MD, MSPH
Wayne State University Family Practice Residency Program, Detroit, Mich. kensch@med.wayne.edu.

Author and Disclosure Information

Practice Recommendations from Key Studies

Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet 2003; 361:2017–2023.

Promita Roychoudhury, MD
Kendra Schwartz, MD, MSPH
Wayne State University Family Practice Residency Program, Detroit, Mich. kensch@med.wayne.edu.

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PRACTICE RECOMMENDATIONS

This meta-analysis of randomized controlled trials showed that neither beta-carotene nor vitamin E appears to prevent all-cause or cardiovascular mortality in patients with known heart disease or those at risk for heart disease. Similarly, use of these antioxidant vitamins did not affect number of stroke events. The use of beta-carotene and vitamin E should not be recommended for primary and secondary prevention of cardiovascular disease.

 
PRACTICE RECOMMENDATIONS

This meta-analysis of randomized controlled trials showed that neither beta-carotene nor vitamin E appears to prevent all-cause or cardiovascular mortality in patients with known heart disease or those at risk for heart disease. Similarly, use of these antioxidant vitamins did not affect number of stroke events. The use of beta-carotene and vitamin E should not be recommended for primary and secondary prevention of cardiovascular disease.

 
Issue
The Journal of Family Practice - 52(10)
Issue
The Journal of Family Practice - 52(10)
Page Number
747-769
Page Number
747-769
Publications
Publications
Topics
Article Type
Display Headline
Antioxidant vitamins do not prevent cardiovascular disease
Display Headline
Antioxidant vitamins do not prevent cardiovascular disease
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