Boosting Vitamin E Intake May Protect Against MASLD

<?xml version="1.0" encoding="UTF-8"?>
<!--$RCSfile: InCopy_agile.xsl,v $ $Revision: 1.35 $-->
<!--$RCSfile: drupal.xsl,v $ $Revision: 1.7 $-->
<root generator="drupal.xsl" gversion="1.7"> <header> <fileName>167047</fileName> <TBEID>0C04EB61.SIG</TBEID> <TBUniqueIdentifier>MD_0C04EB61</TBUniqueIdentifier> <newsOrJournal>News</newsOrJournal> <publisherName>Frontline Medical Communications</publisherName> <storyname/> <articleType>2</articleType> <TBLocation>QC Done-All Pubs</TBLocation> <QCDate>20240223T112948</QCDate> <firstPublished>20240223T113123</firstPublished> <LastPublished>20240223T113123</LastPublished> <pubStatus qcode="stat:"/> <embargoDate/> <killDate/> <CMSDate>20240223T113123</CMSDate> <articleSource/> <facebookInfo/> <meetingNumber/> <byline>Megan Brooks</byline> <bylineText>MEGAN BROOKS</bylineText> <bylineFull>MEGAN BROOKS</bylineFull> <bylineTitleText/> <USOrGlobal/> <wireDocType/> <newsDocType>News</newsDocType> <journalDocType/> <linkLabel/> <pageRange/> <citation/> <quizID/> <indexIssueDate/> <itemClass qcode="ninat:text"/> <provider qcode="provider:imng"> <name>IMNG Medical Media</name> <rightsInfo> <copyrightHolder> <name>Frontline Medical News</name> </copyrightHolder> <copyrightNotice>Copyright (c) 2015 Frontline Medical News, a Frontline Medical Communications Inc. company. All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>Augmenting an intake of vitamin E, via both diet and supplements, may help prevent metabolic dysfunction–associated steatotic liver disease (MASLD)</metaDescription> <articlePDF/> <teaserImage/> <title>Boosting Vitamin E Intake May Protect Against MASLD</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term>15</term> <term canonical="true">21</term> </publications> <sections> <term canonical="true">39313</term> </sections> <topics> <term canonical="true">226</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Boosting Vitamin E Intake May Protect Against MASLD</title> <deck/> </itemMeta> <itemContent> <h2>TOPLINE:</h2> <p><span class="tag metaDescription">Augmenting an intake of vitamin E, via both diet and supplements, may help prevent metabolic dysfunction–associated steatotic liver disease (MASLD)</span>, particularly in adults without hyperlipidemia, new data showed.</p> <h2>METHODOLOGY:</h2> <ul class="body"> <li>MASLD (formerly known as nonalcoholic fatty liver disease) is a common chronic liver disease, and its severe form — metabolic dysfunction–associated steatohepatitis (formerly nonalcoholic steatohepatitis) — is associated with oxidative stress. As an antioxidant, vitamin E may protect against MASLD.</li> <li>Researchers analyzed data for 6122 adults from the National Health and Nutrition Examination Survey from 2017 to 2020.</li> <li>Information on dietary, supplementary, and total vitamin E intake was obtained from two 24-hour dietary recall interviews.</li> <li>The extent of hepatic steatosis was measured by liver ultrasound transient elastography, with MASLD defined as a controlled attenuated parameter threshold of ≥ 288 dB/m.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>After adjustment for sociodemographic characteristics, adults with MASLD had lower dietary and total intake of vitamin E, and dietary and total vitamin E intake was inversely associated with MASLD outcome.</li> <li>Adults in the top quartile of dietary vitamin E intake had approximately 40% lower odds of MASLD (odds ratio [OR], 0.60; <em>P</em> = .0091).</li> <li>Vitamin E supplement use was associated with 34% reduced odds of MASLD (OR, 0.66; <em>P</em> = .0249), whereas adults in the top quartile of total vitamin E intake had a 33% lower likelihood of MASLD (OR, 0.67; <em>P</em> = .0538).</li> <li>The findings were robust to sensitivity analysis, and the effects were stronger in those without hyperlipidemia.</li> </ul> <h2>IN PRACTICE:</h2> <p>“Increasing dietary sources of vitamin E is beneficial for preventing [MASLD], particularly in individuals without hyperlipidemia,” the researchers concluded.</p> <h2>SOURCE:</h2> <p>The study, with first author Xiangjun Qi, Guangzhou University of Chinese Medicine, Guangzhou, China, was <a href="https://doi.org/10.1038/s41598-024-52482-w">published online</a> in <em>Scientific Reports</em>.</p> <h2>LIMITATIONS:</h2> <p>Causality cannot be determined due to the cross-sectional study design. Dietary recalls may not fully reflect the dietary status of participants, which may influence assessment of exposure to some extent.</p> <h2>DISCLOSURES:</h2> <p>The study had no specific funding. The authors declared no conflicts of interest.</p> <p> <em>A version of this article appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/boosting-vitamin-e-intake-may-protect-against-masld-2024a10003lp">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> <p>Increased vitamin E, through diet or supplements, may help keep MASLD at bay, study finds.</p> </itemContent> </newsItem> </itemSet></root>