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Cardiac rehabilitation: A class 1 recommendation
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Margo Simon, DO
Kaitlyn Korn, DO
Leslie Cho, MD
Gordon G. Blackburn, PhD
Chad Raymond

Cardiac rehabilitation has a class 1 indication (ie, strong recommendation) after heart surgery, myocardial infarction, or coronary intervention, and for stable angina or peripheral artery disease. It has a class 2a indication (ie, moderate recommendation) for stable systolic heart failure. Yet it is still under­utilized despite its demonstrated benefits, endorsement by most recognized cardiovascular societies, and coverage by the US Centers for Medicare and Medicaid Services (CMS).

Here, we review cardiac rehabilitation—its benefits, appropriate indications, barriers to referral and enrollment, and efforts to increase its use.

EXERCISE: SLOW TO BE ADOPTED

In 1772, William Heberden (also remembered today for describing swelling of the distal interphalangeal joints in osteoarthritis) described1 a patient with angina pectoris who “set himself a task of sawing wood for half an hour every day, and was nearly cured.”

Despite early clues, it would be some time before the medical community would recognize the benefits of exercise for cardiovascular health. Before the 1930s, immobilization and extended bedrest were encouraged for up to 6 weeks after a cardiovascular event, leading to significant deconditioning.2 Things slowly began to change in the 1940s with Levine’s introduction of up-to-chair therapy,3 and short daily walks were introduced in the 1950s. Over time, the link between a sedentary lifestyle and cardiovascular disease was studied and led to greater investigation into the benefits of exercise, propelling us into the modern era.4,5

CARDIAC REHABILITATION: COMPREHENSIVE RISK REDUCTION

The American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) defines cardiac rehabilitation as the provision of comprehensive long-term services involving medical evaluation, prescriptive exercise, cardiac risk-factor modification, education, counseling, and behavioral interventions.6 CMS defines it as a physician-supervised program that furnishes physician-prescribed exercise, cardiac risk-factor modification (including education, counseling, and behavioral intervention), psychosocial assessment, outcomes assessment, and other items and services.7

In general, most cardiac rehabilitation programs provide medically supervised exercise and patient education designed to improve cardiac health and functional status. Risk factors are targeted to reduce disability and rates of morbidity and mortality, to improve functional capacity, and to alleviate activity-related symptoms.

FROM HOSPITAL TO SELF-MAINTENANCE

Phases of cardiac rehabilitation
Cardiac rehabilitation traditionally consists of 3 phases: inpatient, outpatient, and independent maintenance (Table 1). No uniform nomenclature of the phases exists, which can lead to patient, provider, and payer confusion. Some programs have 4 phases (eg, phase 2 might be considered light activity at home before beginning a formal outpatient cardiac rehabilitation program). The 3 phases, as traditionally defined, are detailed below.

Phase 1: Inpatient rehabilitation

Phase 1 typically takes place in the inpatient setting, often after open heart surgery (eg, coronary artery bypass grafting, valve repair or replacement, heart transplant), myocardial infarction, or percutaneous coronary intervention. This phase may last only a few days, especially in the current era of short hospital stays.

During phase 1, patients discuss their health situation and goals with their primary provider or cardiologist and receive education about recovery and cardiovascular risk factors. Early mobilization to prepare for discharge and to resume simple activities of daily living is emphasized. Depending on the institution, phase 1 exercise may involve simple ambulation on the ward or using equipment such as a stationary bike or treadmill.6 Phase 2 enrollment ideally is set up before discharge.

Phase 2: Limited-time outpatient rehabilitation

Phase 2 traditionally takes place in a hospital-based outpatient facility and consists of a physician-supervised multidisciplinary program. Growing evidence shows that home-based cardiac rehabilitation may be as effective as a medical facility-based program and should be an option for patients who have difficulty getting access to a traditional program.8

A phase 2 program takes a threefold approach, consisting of exercise, aggressive risk-factor modification, and education classes. A Cochrane review9 included programs that also incorporated behavioral modification and psychosocial support as a means of secondary prevention, underscoring the evolving definition of cardiac rehabilitation.

During the initial phase 2 visit, an individualized treatment plan is developed, incorporating an exercise prescription and realistic goals for secondary prevention. Sessions typically take place 3 times a week for up to 36 sessions; usually, options are available for less frequent weekly attendance for a longer period to achieve a full course. In some cases, patients may qualify for up to 72 sessions, particularly if they have not progressed as expected.

Exercise. As part of the initial evaluation, AACVPR guidelines6 suggest an exercise test­—eg, a symptom-limited exercise stress test, a 6-minute walk test, or use of a Rating of Perceived Exertion scale. Prescribed exercise generally targets moderate activity in the range of 50% to 70% of peak estimated functional capacity. In the appropriate clinical context, high-functioning patients can be offered high-intensity interval training instead of moderate exercise, as they confer similar benefits.10

Risk-factor reduction. Comprehensive risk-factor reduction can address smoking, hypertension, high cholesterol, diabetes, obesity, and diet, as well as psychosocial issues such as stress, anxiety, depression, and alcohol use. Sexual activity counseling may also be included.

Education classes are aimed at helping patients understand cardiovascular disease and empowering them to manage their medical treatment and lifestyle modifications.6

Phase 3: Lifetime maintenance

In phase 3, patients independently continue risk-factor modification and physical activity without cardiac monitoring. Most cardiac rehabilitation programs offer transition-to-maintenance classes after completion of phase 2; this may be a welcome option, particularly for those who have developed a good routine and rapport with the staff and other participants. Others may opt for an independent program, using their own home equipment or a local health club.

 

 

EXERCISE: MOSTLY SAFE, WITH PROVEN BENEFITS

The safety of cardiac rehabilitation is well established, with a low risk of major cardiovascular complications. A US study in the early 1980s of 167 cardiac rehabilitation programs found 1 cardiac arrest for every 111,996 exercise hours, 1 myocardial infarction per 293,990 exercise hours, and 1 fatality per 783,972 exercise hours.11 A 2006 study of more than 65 cardiac rehabilitation centers in France found 1 cardiac event per 8,484 exercise tests and 1.3 cardiac arrests per 1 million exercise hours.12

The benefits of cardiac rehabilitation are numerous and substantial.9,13–17 A 2016 Cochrane review and meta-analysis of 63 randomized controlled trials with 14,486 participants found a reduced rate of cardiovascular mortality (relative risk [RR] 0.74, 95% confidence interval [CI] 0.64–0.86), with a number needed to treat of 37, and fewer hospital re­admissions (RR 0.82, 95% CI 0.70–0.96).9

Reductions in mortality rates are dose-dependent. A study of more than 30,000 Medicare beneficiaries who participated in cardiac rehabilitation found that those who attended more sessions had a lower rate of morbidity and death at 4 years, particularly if they participated in more than 11 sessions. Those who attended the full 36 sessions had a mortality rate 47% lower than those who attended a single session.17 There was a 15% reduction in mortality for those who attended 36 sessions compared with 24 sessions, a 28% lower risk with attending 36 sessions compared with 12. After adjustment, each additional 6 sessions was associated with a 6% reduction in mortality. The curves continued to separate up to 4 years.

The benefits of cardiac rehabilitation go beyond risk reduction and include improved functional capacity, greater ease with activities of daily living, and improved quality of life.9 Patients receive structure and support from the management team and other participants, which may provide an additional layer of friendship and psychosocial support for making lifestyle changes.

Is the overall mortality rate improved?

In the modern era, with access to optimal medical therapy and drug-eluting stents, one might expect only small additional benefit from cardiac rehabilitation. The 2016 Cochrane review and meta-analysis found that although cardiac rehabilitation contributed to improved cardiovascular mortality rates and health-related quality of life, no significant reduction was detected in the rate of death from all causes.8 But the analysis did not necessarily support removing the claim of reduced all-cause mortality for cardiac rehabilitation: only randomized controlled trials were examined, and the quality of evidence for each outcome was deemed to be low to moderate because of a general paucity of reports, including many small trials that followed patients for less than 12 months.

A large cohort analysis15 with more than 73,000 patients who had undergone cardiac rehabilitation found a relative reduction in mortality rate of 58% at 1 year and 21% to 34% at 5 years, with elderly women gaining the most benefit. In the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) trial, with more than 2,300 patients followed for a median of 2.5 years, exercise training for heart failure was associated with reduced rates of all-cause mortality or hospitalization (HR 0.89, 95% CI 0.81–0.99; P = .03) and of cardiovascular mortality or heart failure hospitalization (HR 0.85, 95% CI 0.74–0.99; P = .03).18

Regardless of the precise reduction in all-cause mortality, the cardiovascular and health-quality outcomes of cardiac rehabilitation clearly indicate benefit. More trials with follow-up longer than 1 year are needed to definitively determine the impact of cardiac rehabilitation on the all-cause mortality rate.

WHO SHOULD BE OFFERED CARDIAC REHABILITATION?

The 2006 CMS coverage criteria listed the indications for cardiac rehabilitation as myocardial infarction within the preceding 12 months, coronary artery bypass surgery, stable angina pectoris, heart valve repair or replacement, percutaneous coronary intervention, and heart or heart-lung transplant.

Indications for cardiac rehabilitation approved by the Centers for Medicare and Medicaid Services

In 2014, stable chronic systolic heart failure was added to the list (Table 2). Qualifications include New York Heart Association class II (mild symptoms, slight limitation of activity) to class IV (severe limitations, symptoms at rest), an ejection fraction of 35% or less, and being stable on optimal medical therapy for at least 6 weeks.

In 2017, CMS approved supervised exercise therapy for peripheral arterial disease. Supervised exercise has a class 1 recommendation by the American Heart Association and American College of Cardiology for treating intermittent claudication. Supervised exercise therapy can increase walking distance by 180% and is superior to medical therapy alone. Unsupervised exercise has a class 2b recommendation.19,20

Other patients may not qualify for phase 2 cardiac rehabilitation according to CMS or private insurance but could benefit from an exercise prescription and enrollment in a local phase 3 or home exercise program. Indications might include diabetes, obesity, metabolic syndrome, atrial fibrillation, postural orthostatic tachycardia syndrome, and nonalcoholic steatohepatitis. The benefits of cardiac rehabilitation after newer, less-invasive procedures for transcatheter valve repair and replacement are not well established, and more research is needed in this area.

 

 

WHEN TO REFER

Ades et al have defined cardiac rehabilitation referral as a combination of electronic medical records order, patient-physician discussion, and receipt of an order by a cardiac rehabilitation program.21

Ideally, referral for outpatient cardiac rehabilitation should take place at the time of hospital discharge. The AACVPR endorses a “cardiovascular continuum of care” model that emphasizes a smooth transition from inpatient to outpatient programs.6 Inpatient referral is a strong predictor of cardiac rehabilitation enrollment, and lack of referral in phase 1 negatively affects enrollment rates.

Depending on the diagnosis, US and Canadian guidelines recommend cardiac rehabilitation starting within 1 to 4 weeks of the index event, with acceptable wait times up to 60 days.6,22 In the United Kingdom, referral is recommended within 24 hours of patient eligibility; assessment for a cardiovascular prevention and rehabilitation program, with a defined pathway and individual goals, is expected to be completed within 10 working days of referral.23 Such a standard is difficult to meet in the United States, where the time from hospital discharge to cardiac rehabilitation program enrollment averages 35 days.24,25

After an uncomplicated myocardial infarction or percutaneous coronary intervention, patients with a normal or mildly reduced left ventricular ejection fraction should start outpatient cardiac rehabilitation within 14 days of the index event. For such cases, cardiac rehabilitation has been shown to be safe within 1 to 2 weeks of hospital discharge and is associated with increased participation rates.

When to start phase 2 cardiac rehabilitation
After a minimally invasive open-heart procedure, many patients could likely start cardiac rehabilitation within 4 weeks. For those who underwent sternotomy, some institutions require waiting at least 6 weeks before starting phase 2, allowing time for the incision to heal and the patient to be able to drive independently, although the inpatient phase 1 of cardiac rehabilitation could start within a few days of surgery (Table 3).26–30

REHABILITATION IS STILL UNDERUSED

Despite its significant benefits, cardiac rehabilitation is underused for many reasons.

Referral rates vary

A study using the 1997 Medicare claims data­base showed national referral rates of only 14% after myocardial infarction and 31% after coronary artery bypass grafting.31

Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI)
Figure 1. Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI) established by the Centers for Medicare and Medicaid Services (P < .001 for cardiac rehabilitation referral compared with other interventions).

A later study using the National Cardiovascular Data Registry between 2009 and 2017 found that the situation had improved, with a referral rate of about 60% for patients undergoing percutaneous coronary intervention.32 Nevertheless, referral rates for cardiac rehabilitation remain highly variable and still lag behind other CMS quality measures for optimal medical therapy after acute myocardial infarction (Figure 1). Factors associated with higher referral rates included ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, care in a high-volume center for percutaneous coronary intervention, and care in a private or community hospital in a Midwestern state. Small Midwestern hospitals generally had referral rates of over 80%, while major teaching hospitals and hospital systems on the East Coast and the West Coast had referral rates of less than 20%. Unlike some studies, this study found that insurance status had little bearing on referral rates.

Other studies found lower referral rates for women and patients with comorbidities such as previous coronary artery bypass grafting, diabetes, and heart failure.33,34

In the United Kingdom, patients with heart failure made up only 5% of patients in cardiac rehabilitation; only 7% to 20% of patients with a heart failure diagnosis were referred to cardiac rehabilitation from general and cardiology wards.35

Enrollment, completion rates even lower

Rates of referral for cardiac rehabilitation do not equate to rates of enrollment or participation. Enrollment was 50% in the United Kingdom in 2016.35 A 2015 US study evaluated 58,269 older patients eligible for cardiac rehabilitation after acute myocardial infarction;  62% were referred for cardiac rehabilitation at the time of discharge, but only 23% of the total attended at least 1 session, and just 5% of the total completed 36 or more sessions.36

BARRIERS, OPPORTUNITIES TO IMPROVE

The underuse of cardiac rehabilitation in the United States has led to an American Heart Association presidential advisory on the referral, enrollment, and delivery of cardiac rehabilitation.34 Dozens of barriers are mentioned, with several standing out as having the largest impact: lack of physician referral, weak endorsement by the prescribing provider, female sex of patients, lack of program availability, work-related hardship, low socioeconomic status, and lack of or limited healthcare insurance. Copayments have also become a major barrier, often ranging from $20 to $40 per session for patients with Medicare.

The Million Hearts Initiative has established a goal of 70% cardiac rehabilitation compliance for eligible patients by 2022, a goal they estimate could save 25,000 lives and prevent 180,000 hospitalizations annually.21

Lack of physician awareness and lack of referral may be the most modifiable factors with the capacity to have the largest impact. Increasing physician awareness is a top priority not only for primary care providers, but also for cardiologists. In 2014, CMS made referral for cardiac rehabilitation a quality measure that is trackable and reportable. CMS has also proposed models that would incentivize participation by increasing reimbursement for services provided, but these models have been halted.

Additional efforts to increase cardiac rehabilitation referral and participation include automated order sets, increased caregiver education, and early morning or late evening classes, single-sex classes, home or mobile-based exercise programs, and parking and transportation assistance.34 Grace et al37 reported that referral rates rose to 86% when a cardiac rehabilitation order was integrated into the electronic medical record and combined with a hospital liaison to educate patients about their need for cardiac rehabilitation. Lowering patient copayments would also be a good idea. We have recently seen some creative ways to reduce copayments, including philanthropy and grants.

References
  1. Herberden W. Classics in cardiology: description of angina pectoris by William Herberden. Heart Views 2006; 7(3):118–119. www.heartviews.org/text.asp?2006/7/3/118/63927. Accessed May 9, 2018.
  2. Mampuya WM. Cardiac rehabilitation past, present and future: an overview. Cardiovasc Diagn Ther 2012; 2(1):38–49. doi:10.3978/j.issn.2223-3652.2012.01.02
  3. Levine SA, Lown B. The “chair” treatment of acute thrombosis. Trans Assoc Am Physicians 1951; 64:316–327. pmid:14884265
  4. Morris JN, Everitt MG, Pollard R, Chave SP, Semmence AM. Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet 1980; 2(8206):207–210. pmid:6108391
  5. Morris JN, Heady JA. Mortality in relation to the physical activity of work: a preliminary note on experience in middle age. Br J Ind Med 1953; 10(4):245–254. pmid:13106231
  6. American Association of Cardiovascular and Pulmonary Rehabilitation. Guidelines for cardiac rehabilitation and secondary prevention programs/American Association of Cardiovascular and Pulmonary Rehabilitation. 5th ed. Champaign, IL: Human Kinetics; 2013.
  7. Department of Health & Human Services (DHHS); Centers for Medicare & Medicaid Services (CMS). CMS manual system. Cardiac rehabilitation and intensive cardiac rehabilitation. www.cms.gov/Regulations-and-Guidance/Guidance/Transmittals/downloads/r126bp.pdf. Accessed May 9, 2018.
  8. Anderson L, Sharp GA, Norton RJ, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev 2017; 6:CD007130. doi:10.1002/14651858.CD007130.pub4
  9. Anderson L, Oldridge N, Thompson DR, et al. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane systematic review and meta-analysis. J Am Coll Cardiol 2016; 67(1):1–12. doi:10.1016/j.jacc.2015.10.044
  10. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med 2012; 42(7):587–605. doi:10.2165/11631910-000000000-00000
  11. Van Camp SP, Peterson RA. Cardiovascular complications of outpatient cardiac rehabilitation programs. JAMA 1986; 256(9):1160–1163. pmid:3735650
  12. Pavy B, Iliou MC, Meurin P, Tabet JY, Corone S; Functional Evaluation and Cardiac Rehabilitation Working Group of the French Society of Cardiology. Safety of exercise training for cardiac patients: results of the French registry of complications during cardiac rehabilitation. Arch Intern Med 2006; 166(21):2329–2334. doi:10.1001/archinte.166.21.2329
  13. Shaw LW. Effects of a prescribed supervised exercise program on mortality and cardiovascular morbidity in patients after a myocardial infarction: The National Exercise and Heart Disease Project. Am J Cardiol 1981; 48(1):39–46. pmid:6972693
  14. Sandesara PB, Lambert CT, Gordon NF, et al. Cardiac rehabilitation and risk reduction: time to “rebrand and reinvigorate.” J Am Coll Cardiol 2015; 65(4):389–395. doi:10.1016/j.jacc.2014.10.059
  15. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 2009; 54(1):25–33. doi:10.1016/j.jacc.2009.01.078
  16. Goel K, Lennon RJ, Tilbury RT, Squires RW, Thomas RJ. Impact of cardiac rehabilitation on mortality and cardiovascular events after percutaneous coronary intervention in the community. Circulation 2011: 123(21):2344–2352. doi:10.1161/CIRCULATIONAHA.110.983536
  17. Hammill BG, Curtis LH, Schulman KA, Whellan DJ. Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation 2010; 121(1):63–70. doi:10.1161/CIRCULATIONAHA.109.876383
  18. O’Connor CM, Whellan DJ, Lee KL, et al; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009; 301(14):1439–1450. doi:10.1001/jama.2009.454
  19. Hirsch A, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic). Circulation 2006; 113(11):463–654. doi:10.1161/CIRCULATIONAHA.106.174526
  20. Ambrosetti M. Advances in exercise rehabilitation for patients with lower extremity peripheral artery disease. Monaldi Arch Chest Dis 2016; 86(1–2):752. doi:10.4081/monaldi.2016.752
  21. Ades PA, Keteyian SJ, Wright JS, et al. Increasing cardiac rehabilitation participation from 20% to 70%: a road map from the Million Hearts Cardiac Rehabilitation Collaborative. Mayo Clin Proc 2017; 92(2):234–242. doi:10.1016/j.mayocp.2016.10.014
  22. Dafoe W, Arthur H, Stokes H, Morrin L, Beaton L; Canadian Cardiovascular Society Access to Care Working Group on Cardiac Rehabilitation. Universal access: but when? Treating the right patient at the right time: access to cardiac rehabilitation. Can J Cardiol 2006; 22(11):905–911. pmid:16971975
  23. The British Association for Cardiovascular Prevention and Rehabilitation. The BACPR standards and core components for cardiovascular disease prevention and cardiac rehabilitation 2017. www.bacpr.com/resources/6A7_BACR_Standards_and_Core_Components_2017.pdf. Accessed May 9, 2018.
  24. Zullo MD, Jackson LW, Whalen CC, Dolansky MA. Evaluation of the recommended core components of cardiac rehabilitation practice: an opportunity for quality improvement. J Cardiopulm Rehabil Prev 2012; 32(1):32–40. doi:10.1097/HCR.0b013e31823be0e2
  25. Russell KL, Holloway TM, Brum M, Caruso V, Chessex C, Grace SL. Cardiac rehabilitation wait times: effect on enrollment. J Cardiopulm Rehabil Prev 2011; 31(6):373–377. doi:10.1097/HCR.0b013e318228a32f
  26. Soga Y, Yokoi H, Ando K, et al. Safety of early exercise training after elective coronary stenting in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil 2010; 17(2):230–234. doi:10.1097/HJR.0b013e3283359c4e
  27. Scheinowitz M, Harpaz D. Safety of cardiac rehabilitation in a medically supervised, community-based program. Cardiology 2005; 103(3):113–117. doi:10.1159/000083433
  28. Goto Y, Sumida H, Ueshima K, Adachi H, Nohara R, Itoh H. Safety and implementation of exercise testing and training after coronary stenting in patients with acute myocardial infarction. Circ J 2002; 66(10):930–936. pmid:12381088
  29. Parker K, Stone JA, Arena R, et al. An early cardiac access clinic significantly improves cardiac rehabilitation participation and completion rates in low-risk ST-elevation myocardial infarction patients. Can J Cardiol 2011; 27(5):619–627. doi:10.1016/j.cjca.2010.12.076
  30. Pack QR, Mansour M, Barboza JS, et al. An early appointment to outpatient cardiac rehabilitation at hospital discharge improves attendance at orientation: a randomized, single-blind, controlled trial. Circulation 2013; 127(3):349–355. doi:10.1161/CIRCULATIONAHA.112.121996
  31. Suaya JA, Shepard DS, Normand SL, Ades PA, Prottas J, Stason WB. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007; 116(15):1653–1662. doi:10.1161/CIRCULATIONAHA.107.701466
  32. Aragam KG, Dai D, Neely ML, et al. Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States. J Am Coll Cardiol 2015; 65(19):2079–2088. doi:10.1016/j.jacc.2015.02.063
  33. Bittner V, Sanderson B, Breland J, Green D. Referral patterns to a university-based cardiac rehabilitation program. Am J Cardiol 1999; 83(2):252–255, A5. pmid:10073829
  34. Balady GJ, Ades PA, Bittner VA, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond. A presidential advisory from the American Heart Association. Circulation 2011; 124(25):2951–2960. doi:10.1161/CIR.0b013e31823b21e2
  35. British Heart Foundation. The national audit of cardiac rehabilitation annual statistical report 2016. www.cardiacrehabilitation.org.uk/docs/BHF_NACR_Report_2016.pdf. Accessed April 12, 2018.
  36. Doll JA, Hellkamp A, Ho PM, et al. Participation in cardiac rehabilitation programs among older patients after acute myocardial infarction. JAMA Intern Med 2015; 175(10):1700–1702. doi:10.1001/jamainternmed.2015.3819
  37. Grace SL, Russell KL, Reid RD, et al. Cardiac Rehabilitation Care Continuity Through Automatic Referral Evaluation (CRCARE) Investigators. Effect of cardiac rehabilitation referral strategies on utilization rates: a prospective, controlled study. Arch Intern Med 2011; 171(3):235–241. doi:10.1001/archinternmed.2010.501
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Margo Simon, DO
South Pointe Hospital, Cleveland Clinic

Kaitlyn Korn, DO
South Pointe Hospital, Cleveland Clinic

Leslie Cho, MD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic

Gordon G. Blackburn, PhD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Chad Raymond, DO
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Address: Chad Raymond, DO, Department of Cardiovascular Medicine, B-108, Cleveland Clinic, South Pointe Hospital, 20000 Harvard Road, Warrensville Heights, OH 44122; raymonc2@ccf.org

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Margo Simon, DO
Kaitlyn Korn, DO
Leslie Cho, MD
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Kaitlyn Korn, DO
Leslie Cho, MD
Gordon G. Blackburn, PhD
Chad Raymond
Author and Disclosure Information

Margo Simon, DO
South Pointe Hospital, Cleveland Clinic

Kaitlyn Korn, DO
South Pointe Hospital, Cleveland Clinic

Leslie Cho, MD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic

Gordon G. Blackburn, PhD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Chad Raymond, DO
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Address: Chad Raymond, DO, Department of Cardiovascular Medicine, B-108, Cleveland Clinic, South Pointe Hospital, 20000 Harvard Road, Warrensville Heights, OH 44122; raymonc2@ccf.org

Author and Disclosure Information

Margo Simon, DO
South Pointe Hospital, Cleveland Clinic

Kaitlyn Korn, DO
South Pointe Hospital, Cleveland Clinic

Leslie Cho, MD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic

Gordon G. Blackburn, PhD
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Adjunct Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Chad Raymond, DO
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic; Clinical Assistant Professor, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH

Address: Chad Raymond, DO, Department of Cardiovascular Medicine, B-108, Cleveland Clinic, South Pointe Hospital, 20000 Harvard Road, Warrensville Heights, OH 44122; raymonc2@ccf.org

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Related Articles
Cardiac rehabilitation: not just exercise anymore

Cardiac rehabilitation has a class 1 indication (ie, strong recommendation) after heart surgery, myocardial infarction, or coronary intervention, and for stable angina or peripheral artery disease. It has a class 2a indication (ie, moderate recommendation) for stable systolic heart failure. Yet it is still under­utilized despite its demonstrated benefits, endorsement by most recognized cardiovascular societies, and coverage by the US Centers for Medicare and Medicaid Services (CMS).

Here, we review cardiac rehabilitation—its benefits, appropriate indications, barriers to referral and enrollment, and efforts to increase its use.

EXERCISE: SLOW TO BE ADOPTED

In 1772, William Heberden (also remembered today for describing swelling of the distal interphalangeal joints in osteoarthritis) described1 a patient with angina pectoris who “set himself a task of sawing wood for half an hour every day, and was nearly cured.”

Despite early clues, it would be some time before the medical community would recognize the benefits of exercise for cardiovascular health. Before the 1930s, immobilization and extended bedrest were encouraged for up to 6 weeks after a cardiovascular event, leading to significant deconditioning.2 Things slowly began to change in the 1940s with Levine’s introduction of up-to-chair therapy,3 and short daily walks were introduced in the 1950s. Over time, the link between a sedentary lifestyle and cardiovascular disease was studied and led to greater investigation into the benefits of exercise, propelling us into the modern era.4,5

CARDIAC REHABILITATION: COMPREHENSIVE RISK REDUCTION

The American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) defines cardiac rehabilitation as the provision of comprehensive long-term services involving medical evaluation, prescriptive exercise, cardiac risk-factor modification, education, counseling, and behavioral interventions.6 CMS defines it as a physician-supervised program that furnishes physician-prescribed exercise, cardiac risk-factor modification (including education, counseling, and behavioral intervention), psychosocial assessment, outcomes assessment, and other items and services.7

In general, most cardiac rehabilitation programs provide medically supervised exercise and patient education designed to improve cardiac health and functional status. Risk factors are targeted to reduce disability and rates of morbidity and mortality, to improve functional capacity, and to alleviate activity-related symptoms.

FROM HOSPITAL TO SELF-MAINTENANCE

Phases of cardiac rehabilitation
Cardiac rehabilitation traditionally consists of 3 phases: inpatient, outpatient, and independent maintenance (Table 1). No uniform nomenclature of the phases exists, which can lead to patient, provider, and payer confusion. Some programs have 4 phases (eg, phase 2 might be considered light activity at home before beginning a formal outpatient cardiac rehabilitation program). The 3 phases, as traditionally defined, are detailed below.

Phase 1: Inpatient rehabilitation

Phase 1 typically takes place in the inpatient setting, often after open heart surgery (eg, coronary artery bypass grafting, valve repair or replacement, heart transplant), myocardial infarction, or percutaneous coronary intervention. This phase may last only a few days, especially in the current era of short hospital stays.

During phase 1, patients discuss their health situation and goals with their primary provider or cardiologist and receive education about recovery and cardiovascular risk factors. Early mobilization to prepare for discharge and to resume simple activities of daily living is emphasized. Depending on the institution, phase 1 exercise may involve simple ambulation on the ward or using equipment such as a stationary bike or treadmill.6 Phase 2 enrollment ideally is set up before discharge.

Phase 2: Limited-time outpatient rehabilitation

Phase 2 traditionally takes place in a hospital-based outpatient facility and consists of a physician-supervised multidisciplinary program. Growing evidence shows that home-based cardiac rehabilitation may be as effective as a medical facility-based program and should be an option for patients who have difficulty getting access to a traditional program.8

A phase 2 program takes a threefold approach, consisting of exercise, aggressive risk-factor modification, and education classes. A Cochrane review9 included programs that also incorporated behavioral modification and psychosocial support as a means of secondary prevention, underscoring the evolving definition of cardiac rehabilitation.

During the initial phase 2 visit, an individualized treatment plan is developed, incorporating an exercise prescription and realistic goals for secondary prevention. Sessions typically take place 3 times a week for up to 36 sessions; usually, options are available for less frequent weekly attendance for a longer period to achieve a full course. In some cases, patients may qualify for up to 72 sessions, particularly if they have not progressed as expected.

Exercise. As part of the initial evaluation, AACVPR guidelines6 suggest an exercise test­—eg, a symptom-limited exercise stress test, a 6-minute walk test, or use of a Rating of Perceived Exertion scale. Prescribed exercise generally targets moderate activity in the range of 50% to 70% of peak estimated functional capacity. In the appropriate clinical context, high-functioning patients can be offered high-intensity interval training instead of moderate exercise, as they confer similar benefits.10

Risk-factor reduction. Comprehensive risk-factor reduction can address smoking, hypertension, high cholesterol, diabetes, obesity, and diet, as well as psychosocial issues such as stress, anxiety, depression, and alcohol use. Sexual activity counseling may also be included.

Education classes are aimed at helping patients understand cardiovascular disease and empowering them to manage their medical treatment and lifestyle modifications.6

Phase 3: Lifetime maintenance

In phase 3, patients independently continue risk-factor modification and physical activity without cardiac monitoring. Most cardiac rehabilitation programs offer transition-to-maintenance classes after completion of phase 2; this may be a welcome option, particularly for those who have developed a good routine and rapport with the staff and other participants. Others may opt for an independent program, using their own home equipment or a local health club.

 

 

EXERCISE: MOSTLY SAFE, WITH PROVEN BENEFITS

The safety of cardiac rehabilitation is well established, with a low risk of major cardiovascular complications. A US study in the early 1980s of 167 cardiac rehabilitation programs found 1 cardiac arrest for every 111,996 exercise hours, 1 myocardial infarction per 293,990 exercise hours, and 1 fatality per 783,972 exercise hours.11 A 2006 study of more than 65 cardiac rehabilitation centers in France found 1 cardiac event per 8,484 exercise tests and 1.3 cardiac arrests per 1 million exercise hours.12

The benefits of cardiac rehabilitation are numerous and substantial.9,13–17 A 2016 Cochrane review and meta-analysis of 63 randomized controlled trials with 14,486 participants found a reduced rate of cardiovascular mortality (relative risk [RR] 0.74, 95% confidence interval [CI] 0.64–0.86), with a number needed to treat of 37, and fewer hospital re­admissions (RR 0.82, 95% CI 0.70–0.96).9

Reductions in mortality rates are dose-dependent. A study of more than 30,000 Medicare beneficiaries who participated in cardiac rehabilitation found that those who attended more sessions had a lower rate of morbidity and death at 4 years, particularly if they participated in more than 11 sessions. Those who attended the full 36 sessions had a mortality rate 47% lower than those who attended a single session.17 There was a 15% reduction in mortality for those who attended 36 sessions compared with 24 sessions, a 28% lower risk with attending 36 sessions compared with 12. After adjustment, each additional 6 sessions was associated with a 6% reduction in mortality. The curves continued to separate up to 4 years.

The benefits of cardiac rehabilitation go beyond risk reduction and include improved functional capacity, greater ease with activities of daily living, and improved quality of life.9 Patients receive structure and support from the management team and other participants, which may provide an additional layer of friendship and psychosocial support for making lifestyle changes.

Is the overall mortality rate improved?

In the modern era, with access to optimal medical therapy and drug-eluting stents, one might expect only small additional benefit from cardiac rehabilitation. The 2016 Cochrane review and meta-analysis found that although cardiac rehabilitation contributed to improved cardiovascular mortality rates and health-related quality of life, no significant reduction was detected in the rate of death from all causes.8 But the analysis did not necessarily support removing the claim of reduced all-cause mortality for cardiac rehabilitation: only randomized controlled trials were examined, and the quality of evidence for each outcome was deemed to be low to moderate because of a general paucity of reports, including many small trials that followed patients for less than 12 months.

A large cohort analysis15 with more than 73,000 patients who had undergone cardiac rehabilitation found a relative reduction in mortality rate of 58% at 1 year and 21% to 34% at 5 years, with elderly women gaining the most benefit. In the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) trial, with more than 2,300 patients followed for a median of 2.5 years, exercise training for heart failure was associated with reduced rates of all-cause mortality or hospitalization (HR 0.89, 95% CI 0.81–0.99; P = .03) and of cardiovascular mortality or heart failure hospitalization (HR 0.85, 95% CI 0.74–0.99; P = .03).18

Regardless of the precise reduction in all-cause mortality, the cardiovascular and health-quality outcomes of cardiac rehabilitation clearly indicate benefit. More trials with follow-up longer than 1 year are needed to definitively determine the impact of cardiac rehabilitation on the all-cause mortality rate.

WHO SHOULD BE OFFERED CARDIAC REHABILITATION?

The 2006 CMS coverage criteria listed the indications for cardiac rehabilitation as myocardial infarction within the preceding 12 months, coronary artery bypass surgery, stable angina pectoris, heart valve repair or replacement, percutaneous coronary intervention, and heart or heart-lung transplant.

Indications for cardiac rehabilitation approved by the Centers for Medicare and Medicaid Services

In 2014, stable chronic systolic heart failure was added to the list (Table 2). Qualifications include New York Heart Association class II (mild symptoms, slight limitation of activity) to class IV (severe limitations, symptoms at rest), an ejection fraction of 35% or less, and being stable on optimal medical therapy for at least 6 weeks.

In 2017, CMS approved supervised exercise therapy for peripheral arterial disease. Supervised exercise has a class 1 recommendation by the American Heart Association and American College of Cardiology for treating intermittent claudication. Supervised exercise therapy can increase walking distance by 180% and is superior to medical therapy alone. Unsupervised exercise has a class 2b recommendation.19,20

Other patients may not qualify for phase 2 cardiac rehabilitation according to CMS or private insurance but could benefit from an exercise prescription and enrollment in a local phase 3 or home exercise program. Indications might include diabetes, obesity, metabolic syndrome, atrial fibrillation, postural orthostatic tachycardia syndrome, and nonalcoholic steatohepatitis. The benefits of cardiac rehabilitation after newer, less-invasive procedures for transcatheter valve repair and replacement are not well established, and more research is needed in this area.

 

 

WHEN TO REFER

Ades et al have defined cardiac rehabilitation referral as a combination of electronic medical records order, patient-physician discussion, and receipt of an order by a cardiac rehabilitation program.21

Ideally, referral for outpatient cardiac rehabilitation should take place at the time of hospital discharge. The AACVPR endorses a “cardiovascular continuum of care” model that emphasizes a smooth transition from inpatient to outpatient programs.6 Inpatient referral is a strong predictor of cardiac rehabilitation enrollment, and lack of referral in phase 1 negatively affects enrollment rates.

Depending on the diagnosis, US and Canadian guidelines recommend cardiac rehabilitation starting within 1 to 4 weeks of the index event, with acceptable wait times up to 60 days.6,22 In the United Kingdom, referral is recommended within 24 hours of patient eligibility; assessment for a cardiovascular prevention and rehabilitation program, with a defined pathway and individual goals, is expected to be completed within 10 working days of referral.23 Such a standard is difficult to meet in the United States, where the time from hospital discharge to cardiac rehabilitation program enrollment averages 35 days.24,25

After an uncomplicated myocardial infarction or percutaneous coronary intervention, patients with a normal or mildly reduced left ventricular ejection fraction should start outpatient cardiac rehabilitation within 14 days of the index event. For such cases, cardiac rehabilitation has been shown to be safe within 1 to 2 weeks of hospital discharge and is associated with increased participation rates.

When to start phase 2 cardiac rehabilitation
After a minimally invasive open-heart procedure, many patients could likely start cardiac rehabilitation within 4 weeks. For those who underwent sternotomy, some institutions require waiting at least 6 weeks before starting phase 2, allowing time for the incision to heal and the patient to be able to drive independently, although the inpatient phase 1 of cardiac rehabilitation could start within a few days of surgery (Table 3).26–30

REHABILITATION IS STILL UNDERUSED

Despite its significant benefits, cardiac rehabilitation is underused for many reasons.

Referral rates vary

A study using the 1997 Medicare claims data­base showed national referral rates of only 14% after myocardial infarction and 31% after coronary artery bypass grafting.31

Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI)
Figure 1. Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI) established by the Centers for Medicare and Medicaid Services (P < .001 for cardiac rehabilitation referral compared with other interventions).

A later study using the National Cardiovascular Data Registry between 2009 and 2017 found that the situation had improved, with a referral rate of about 60% for patients undergoing percutaneous coronary intervention.32 Nevertheless, referral rates for cardiac rehabilitation remain highly variable and still lag behind other CMS quality measures for optimal medical therapy after acute myocardial infarction (Figure 1). Factors associated with higher referral rates included ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, care in a high-volume center for percutaneous coronary intervention, and care in a private or community hospital in a Midwestern state. Small Midwestern hospitals generally had referral rates of over 80%, while major teaching hospitals and hospital systems on the East Coast and the West Coast had referral rates of less than 20%. Unlike some studies, this study found that insurance status had little bearing on referral rates.

Other studies found lower referral rates for women and patients with comorbidities such as previous coronary artery bypass grafting, diabetes, and heart failure.33,34

In the United Kingdom, patients with heart failure made up only 5% of patients in cardiac rehabilitation; only 7% to 20% of patients with a heart failure diagnosis were referred to cardiac rehabilitation from general and cardiology wards.35

Enrollment, completion rates even lower

Rates of referral for cardiac rehabilitation do not equate to rates of enrollment or participation. Enrollment was 50% in the United Kingdom in 2016.35 A 2015 US study evaluated 58,269 older patients eligible for cardiac rehabilitation after acute myocardial infarction;  62% were referred for cardiac rehabilitation at the time of discharge, but only 23% of the total attended at least 1 session, and just 5% of the total completed 36 or more sessions.36

BARRIERS, OPPORTUNITIES TO IMPROVE

The underuse of cardiac rehabilitation in the United States has led to an American Heart Association presidential advisory on the referral, enrollment, and delivery of cardiac rehabilitation.34 Dozens of barriers are mentioned, with several standing out as having the largest impact: lack of physician referral, weak endorsement by the prescribing provider, female sex of patients, lack of program availability, work-related hardship, low socioeconomic status, and lack of or limited healthcare insurance. Copayments have also become a major barrier, often ranging from $20 to $40 per session for patients with Medicare.

The Million Hearts Initiative has established a goal of 70% cardiac rehabilitation compliance for eligible patients by 2022, a goal they estimate could save 25,000 lives and prevent 180,000 hospitalizations annually.21

Lack of physician awareness and lack of referral may be the most modifiable factors with the capacity to have the largest impact. Increasing physician awareness is a top priority not only for primary care providers, but also for cardiologists. In 2014, CMS made referral for cardiac rehabilitation a quality measure that is trackable and reportable. CMS has also proposed models that would incentivize participation by increasing reimbursement for services provided, but these models have been halted.

Additional efforts to increase cardiac rehabilitation referral and participation include automated order sets, increased caregiver education, and early morning or late evening classes, single-sex classes, home or mobile-based exercise programs, and parking and transportation assistance.34 Grace et al37 reported that referral rates rose to 86% when a cardiac rehabilitation order was integrated into the electronic medical record and combined with a hospital liaison to educate patients about their need for cardiac rehabilitation. Lowering patient copayments would also be a good idea. We have recently seen some creative ways to reduce copayments, including philanthropy and grants.

Cardiac rehabilitation has a class 1 indication (ie, strong recommendation) after heart surgery, myocardial infarction, or coronary intervention, and for stable angina or peripheral artery disease. It has a class 2a indication (ie, moderate recommendation) for stable systolic heart failure. Yet it is still under­utilized despite its demonstrated benefits, endorsement by most recognized cardiovascular societies, and coverage by the US Centers for Medicare and Medicaid Services (CMS).

Here, we review cardiac rehabilitation—its benefits, appropriate indications, barriers to referral and enrollment, and efforts to increase its use.

EXERCISE: SLOW TO BE ADOPTED

In 1772, William Heberden (also remembered today for describing swelling of the distal interphalangeal joints in osteoarthritis) described1 a patient with angina pectoris who “set himself a task of sawing wood for half an hour every day, and was nearly cured.”

Despite early clues, it would be some time before the medical community would recognize the benefits of exercise for cardiovascular health. Before the 1930s, immobilization and extended bedrest were encouraged for up to 6 weeks after a cardiovascular event, leading to significant deconditioning.2 Things slowly began to change in the 1940s with Levine’s introduction of up-to-chair therapy,3 and short daily walks were introduced in the 1950s. Over time, the link between a sedentary lifestyle and cardiovascular disease was studied and led to greater investigation into the benefits of exercise, propelling us into the modern era.4,5

CARDIAC REHABILITATION: COMPREHENSIVE RISK REDUCTION

The American Association of Cardiovascular and Pulmonary Rehabilitation (AACVPR) defines cardiac rehabilitation as the provision of comprehensive long-term services involving medical evaluation, prescriptive exercise, cardiac risk-factor modification, education, counseling, and behavioral interventions.6 CMS defines it as a physician-supervised program that furnishes physician-prescribed exercise, cardiac risk-factor modification (including education, counseling, and behavioral intervention), psychosocial assessment, outcomes assessment, and other items and services.7

In general, most cardiac rehabilitation programs provide medically supervised exercise and patient education designed to improve cardiac health and functional status. Risk factors are targeted to reduce disability and rates of morbidity and mortality, to improve functional capacity, and to alleviate activity-related symptoms.

FROM HOSPITAL TO SELF-MAINTENANCE

Phases of cardiac rehabilitation
Cardiac rehabilitation traditionally consists of 3 phases: inpatient, outpatient, and independent maintenance (Table 1). No uniform nomenclature of the phases exists, which can lead to patient, provider, and payer confusion. Some programs have 4 phases (eg, phase 2 might be considered light activity at home before beginning a formal outpatient cardiac rehabilitation program). The 3 phases, as traditionally defined, are detailed below.

Phase 1: Inpatient rehabilitation

Phase 1 typically takes place in the inpatient setting, often after open heart surgery (eg, coronary artery bypass grafting, valve repair or replacement, heart transplant), myocardial infarction, or percutaneous coronary intervention. This phase may last only a few days, especially in the current era of short hospital stays.

During phase 1, patients discuss their health situation and goals with their primary provider or cardiologist and receive education about recovery and cardiovascular risk factors. Early mobilization to prepare for discharge and to resume simple activities of daily living is emphasized. Depending on the institution, phase 1 exercise may involve simple ambulation on the ward or using equipment such as a stationary bike or treadmill.6 Phase 2 enrollment ideally is set up before discharge.

Phase 2: Limited-time outpatient rehabilitation

Phase 2 traditionally takes place in a hospital-based outpatient facility and consists of a physician-supervised multidisciplinary program. Growing evidence shows that home-based cardiac rehabilitation may be as effective as a medical facility-based program and should be an option for patients who have difficulty getting access to a traditional program.8

A phase 2 program takes a threefold approach, consisting of exercise, aggressive risk-factor modification, and education classes. A Cochrane review9 included programs that also incorporated behavioral modification and psychosocial support as a means of secondary prevention, underscoring the evolving definition of cardiac rehabilitation.

During the initial phase 2 visit, an individualized treatment plan is developed, incorporating an exercise prescription and realistic goals for secondary prevention. Sessions typically take place 3 times a week for up to 36 sessions; usually, options are available for less frequent weekly attendance for a longer period to achieve a full course. In some cases, patients may qualify for up to 72 sessions, particularly if they have not progressed as expected.

Exercise. As part of the initial evaluation, AACVPR guidelines6 suggest an exercise test­—eg, a symptom-limited exercise stress test, a 6-minute walk test, or use of a Rating of Perceived Exertion scale. Prescribed exercise generally targets moderate activity in the range of 50% to 70% of peak estimated functional capacity. In the appropriate clinical context, high-functioning patients can be offered high-intensity interval training instead of moderate exercise, as they confer similar benefits.10

Risk-factor reduction. Comprehensive risk-factor reduction can address smoking, hypertension, high cholesterol, diabetes, obesity, and diet, as well as psychosocial issues such as stress, anxiety, depression, and alcohol use. Sexual activity counseling may also be included.

Education classes are aimed at helping patients understand cardiovascular disease and empowering them to manage their medical treatment and lifestyle modifications.6

Phase 3: Lifetime maintenance

In phase 3, patients independently continue risk-factor modification and physical activity without cardiac monitoring. Most cardiac rehabilitation programs offer transition-to-maintenance classes after completion of phase 2; this may be a welcome option, particularly for those who have developed a good routine and rapport with the staff and other participants. Others may opt for an independent program, using their own home equipment or a local health club.

 

 

EXERCISE: MOSTLY SAFE, WITH PROVEN BENEFITS

The safety of cardiac rehabilitation is well established, with a low risk of major cardiovascular complications. A US study in the early 1980s of 167 cardiac rehabilitation programs found 1 cardiac arrest for every 111,996 exercise hours, 1 myocardial infarction per 293,990 exercise hours, and 1 fatality per 783,972 exercise hours.11 A 2006 study of more than 65 cardiac rehabilitation centers in France found 1 cardiac event per 8,484 exercise tests and 1.3 cardiac arrests per 1 million exercise hours.12

The benefits of cardiac rehabilitation are numerous and substantial.9,13–17 A 2016 Cochrane review and meta-analysis of 63 randomized controlled trials with 14,486 participants found a reduced rate of cardiovascular mortality (relative risk [RR] 0.74, 95% confidence interval [CI] 0.64–0.86), with a number needed to treat of 37, and fewer hospital re­admissions (RR 0.82, 95% CI 0.70–0.96).9

Reductions in mortality rates are dose-dependent. A study of more than 30,000 Medicare beneficiaries who participated in cardiac rehabilitation found that those who attended more sessions had a lower rate of morbidity and death at 4 years, particularly if they participated in more than 11 sessions. Those who attended the full 36 sessions had a mortality rate 47% lower than those who attended a single session.17 There was a 15% reduction in mortality for those who attended 36 sessions compared with 24 sessions, a 28% lower risk with attending 36 sessions compared with 12. After adjustment, each additional 6 sessions was associated with a 6% reduction in mortality. The curves continued to separate up to 4 years.

The benefits of cardiac rehabilitation go beyond risk reduction and include improved functional capacity, greater ease with activities of daily living, and improved quality of life.9 Patients receive structure and support from the management team and other participants, which may provide an additional layer of friendship and psychosocial support for making lifestyle changes.

Is the overall mortality rate improved?

In the modern era, with access to optimal medical therapy and drug-eluting stents, one might expect only small additional benefit from cardiac rehabilitation. The 2016 Cochrane review and meta-analysis found that although cardiac rehabilitation contributed to improved cardiovascular mortality rates and health-related quality of life, no significant reduction was detected in the rate of death from all causes.8 But the analysis did not necessarily support removing the claim of reduced all-cause mortality for cardiac rehabilitation: only randomized controlled trials were examined, and the quality of evidence for each outcome was deemed to be low to moderate because of a general paucity of reports, including many small trials that followed patients for less than 12 months.

A large cohort analysis15 with more than 73,000 patients who had undergone cardiac rehabilitation found a relative reduction in mortality rate of 58% at 1 year and 21% to 34% at 5 years, with elderly women gaining the most benefit. In the Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) trial, with more than 2,300 patients followed for a median of 2.5 years, exercise training for heart failure was associated with reduced rates of all-cause mortality or hospitalization (HR 0.89, 95% CI 0.81–0.99; P = .03) and of cardiovascular mortality or heart failure hospitalization (HR 0.85, 95% CI 0.74–0.99; P = .03).18

Regardless of the precise reduction in all-cause mortality, the cardiovascular and health-quality outcomes of cardiac rehabilitation clearly indicate benefit. More trials with follow-up longer than 1 year are needed to definitively determine the impact of cardiac rehabilitation on the all-cause mortality rate.

WHO SHOULD BE OFFERED CARDIAC REHABILITATION?

The 2006 CMS coverage criteria listed the indications for cardiac rehabilitation as myocardial infarction within the preceding 12 months, coronary artery bypass surgery, stable angina pectoris, heart valve repair or replacement, percutaneous coronary intervention, and heart or heart-lung transplant.

Indications for cardiac rehabilitation approved by the Centers for Medicare and Medicaid Services

In 2014, stable chronic systolic heart failure was added to the list (Table 2). Qualifications include New York Heart Association class II (mild symptoms, slight limitation of activity) to class IV (severe limitations, symptoms at rest), an ejection fraction of 35% or less, and being stable on optimal medical therapy for at least 6 weeks.

In 2017, CMS approved supervised exercise therapy for peripheral arterial disease. Supervised exercise has a class 1 recommendation by the American Heart Association and American College of Cardiology for treating intermittent claudication. Supervised exercise therapy can increase walking distance by 180% and is superior to medical therapy alone. Unsupervised exercise has a class 2b recommendation.19,20

Other patients may not qualify for phase 2 cardiac rehabilitation according to CMS or private insurance but could benefit from an exercise prescription and enrollment in a local phase 3 or home exercise program. Indications might include diabetes, obesity, metabolic syndrome, atrial fibrillation, postural orthostatic tachycardia syndrome, and nonalcoholic steatohepatitis. The benefits of cardiac rehabilitation after newer, less-invasive procedures for transcatheter valve repair and replacement are not well established, and more research is needed in this area.

 

 

WHEN TO REFER

Ades et al have defined cardiac rehabilitation referral as a combination of electronic medical records order, patient-physician discussion, and receipt of an order by a cardiac rehabilitation program.21

Ideally, referral for outpatient cardiac rehabilitation should take place at the time of hospital discharge. The AACVPR endorses a “cardiovascular continuum of care” model that emphasizes a smooth transition from inpatient to outpatient programs.6 Inpatient referral is a strong predictor of cardiac rehabilitation enrollment, and lack of referral in phase 1 negatively affects enrollment rates.

Depending on the diagnosis, US and Canadian guidelines recommend cardiac rehabilitation starting within 1 to 4 weeks of the index event, with acceptable wait times up to 60 days.6,22 In the United Kingdom, referral is recommended within 24 hours of patient eligibility; assessment for a cardiovascular prevention and rehabilitation program, with a defined pathway and individual goals, is expected to be completed within 10 working days of referral.23 Such a standard is difficult to meet in the United States, where the time from hospital discharge to cardiac rehabilitation program enrollment averages 35 days.24,25

After an uncomplicated myocardial infarction or percutaneous coronary intervention, patients with a normal or mildly reduced left ventricular ejection fraction should start outpatient cardiac rehabilitation within 14 days of the index event. For such cases, cardiac rehabilitation has been shown to be safe within 1 to 2 weeks of hospital discharge and is associated with increased participation rates.

When to start phase 2 cardiac rehabilitation
After a minimally invasive open-heart procedure, many patients could likely start cardiac rehabilitation within 4 weeks. For those who underwent sternotomy, some institutions require waiting at least 6 weeks before starting phase 2, allowing time for the incision to heal and the patient to be able to drive independently, although the inpatient phase 1 of cardiac rehabilitation could start within a few days of surgery (Table 3).26–30

REHABILITATION IS STILL UNDERUSED

Despite its significant benefits, cardiac rehabilitation is underused for many reasons.

Referral rates vary

A study using the 1997 Medicare claims data­base showed national referral rates of only 14% after myocardial infarction and 31% after coronary artery bypass grafting.31

Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI)
Figure 1. Rates of referral to cardiac rehabilitation compared with other quality measures for acute myocardial infarction (MI) established by the Centers for Medicare and Medicaid Services (P < .001 for cardiac rehabilitation referral compared with other interventions).

A later study using the National Cardiovascular Data Registry between 2009 and 2017 found that the situation had improved, with a referral rate of about 60% for patients undergoing percutaneous coronary intervention.32 Nevertheless, referral rates for cardiac rehabilitation remain highly variable and still lag behind other CMS quality measures for optimal medical therapy after acute myocardial infarction (Figure 1). Factors associated with higher referral rates included ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, care in a high-volume center for percutaneous coronary intervention, and care in a private or community hospital in a Midwestern state. Small Midwestern hospitals generally had referral rates of over 80%, while major teaching hospitals and hospital systems on the East Coast and the West Coast had referral rates of less than 20%. Unlike some studies, this study found that insurance status had little bearing on referral rates.

Other studies found lower referral rates for women and patients with comorbidities such as previous coronary artery bypass grafting, diabetes, and heart failure.33,34

In the United Kingdom, patients with heart failure made up only 5% of patients in cardiac rehabilitation; only 7% to 20% of patients with a heart failure diagnosis were referred to cardiac rehabilitation from general and cardiology wards.35

Enrollment, completion rates even lower

Rates of referral for cardiac rehabilitation do not equate to rates of enrollment or participation. Enrollment was 50% in the United Kingdom in 2016.35 A 2015 US study evaluated 58,269 older patients eligible for cardiac rehabilitation after acute myocardial infarction;  62% were referred for cardiac rehabilitation at the time of discharge, but only 23% of the total attended at least 1 session, and just 5% of the total completed 36 or more sessions.36

BARRIERS, OPPORTUNITIES TO IMPROVE

The underuse of cardiac rehabilitation in the United States has led to an American Heart Association presidential advisory on the referral, enrollment, and delivery of cardiac rehabilitation.34 Dozens of barriers are mentioned, with several standing out as having the largest impact: lack of physician referral, weak endorsement by the prescribing provider, female sex of patients, lack of program availability, work-related hardship, low socioeconomic status, and lack of or limited healthcare insurance. Copayments have also become a major barrier, often ranging from $20 to $40 per session for patients with Medicare.

The Million Hearts Initiative has established a goal of 70% cardiac rehabilitation compliance for eligible patients by 2022, a goal they estimate could save 25,000 lives and prevent 180,000 hospitalizations annually.21

Lack of physician awareness and lack of referral may be the most modifiable factors with the capacity to have the largest impact. Increasing physician awareness is a top priority not only for primary care providers, but also for cardiologists. In 2014, CMS made referral for cardiac rehabilitation a quality measure that is trackable and reportable. CMS has also proposed models that would incentivize participation by increasing reimbursement for services provided, but these models have been halted.

Additional efforts to increase cardiac rehabilitation referral and participation include automated order sets, increased caregiver education, and early morning or late evening classes, single-sex classes, home or mobile-based exercise programs, and parking and transportation assistance.34 Grace et al37 reported that referral rates rose to 86% when a cardiac rehabilitation order was integrated into the electronic medical record and combined with a hospital liaison to educate patients about their need for cardiac rehabilitation. Lowering patient copayments would also be a good idea. We have recently seen some creative ways to reduce copayments, including philanthropy and grants.

References
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  2. Mampuya WM. Cardiac rehabilitation past, present and future: an overview. Cardiovasc Diagn Ther 2012; 2(1):38–49. doi:10.3978/j.issn.2223-3652.2012.01.02
  3. Levine SA, Lown B. The “chair” treatment of acute thrombosis. Trans Assoc Am Physicians 1951; 64:316–327. pmid:14884265
  4. Morris JN, Everitt MG, Pollard R, Chave SP, Semmence AM. Vigorous exercise in leisure-time: protection against coronary heart disease. Lancet 1980; 2(8206):207–210. pmid:6108391
  5. Morris JN, Heady JA. Mortality in relation to the physical activity of work: a preliminary note on experience in middle age. Br J Ind Med 1953; 10(4):245–254. pmid:13106231
  6. American Association of Cardiovascular and Pulmonary Rehabilitation. Guidelines for cardiac rehabilitation and secondary prevention programs/American Association of Cardiovascular and Pulmonary Rehabilitation. 5th ed. Champaign, IL: Human Kinetics; 2013.
  7. Department of Health & Human Services (DHHS); Centers for Medicare & Medicaid Services (CMS). CMS manual system. Cardiac rehabilitation and intensive cardiac rehabilitation. www.cms.gov/Regulations-and-Guidance/Guidance/Transmittals/downloads/r126bp.pdf. Accessed May 9, 2018.
  8. Anderson L, Sharp GA, Norton RJ, et al. Home-based versus centre-based cardiac rehabilitation. Cochrane Database Syst Rev 2017; 6:CD007130. doi:10.1002/14651858.CD007130.pub4
  9. Anderson L, Oldridge N, Thompson DR, et al. Exercise-based cardiac rehabilitation for coronary heart disease: Cochrane systematic review and meta-analysis. J Am Coll Cardiol 2016; 67(1):1–12. doi:10.1016/j.jacc.2015.10.044
  10. Guiraud T, Nigam A, Gremeaux V, Meyer P, Juneau M, Bosquet L. High-intensity interval training in cardiac rehabilitation. Sports Med 2012; 42(7):587–605. doi:10.2165/11631910-000000000-00000
  11. Van Camp SP, Peterson RA. Cardiovascular complications of outpatient cardiac rehabilitation programs. JAMA 1986; 256(9):1160–1163. pmid:3735650
  12. Pavy B, Iliou MC, Meurin P, Tabet JY, Corone S; Functional Evaluation and Cardiac Rehabilitation Working Group of the French Society of Cardiology. Safety of exercise training for cardiac patients: results of the French registry of complications during cardiac rehabilitation. Arch Intern Med 2006; 166(21):2329–2334. doi:10.1001/archinte.166.21.2329
  13. Shaw LW. Effects of a prescribed supervised exercise program on mortality and cardiovascular morbidity in patients after a myocardial infarction: The National Exercise and Heart Disease Project. Am J Cardiol 1981; 48(1):39–46. pmid:6972693
  14. Sandesara PB, Lambert CT, Gordon NF, et al. Cardiac rehabilitation and risk reduction: time to “rebrand and reinvigorate.” J Am Coll Cardiol 2015; 65(4):389–395. doi:10.1016/j.jacc.2014.10.059
  15. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 2009; 54(1):25–33. doi:10.1016/j.jacc.2009.01.078
  16. Goel K, Lennon RJ, Tilbury RT, Squires RW, Thomas RJ. Impact of cardiac rehabilitation on mortality and cardiovascular events after percutaneous coronary intervention in the community. Circulation 2011: 123(21):2344–2352. doi:10.1161/CIRCULATIONAHA.110.983536
  17. Hammill BG, Curtis LH, Schulman KA, Whellan DJ. Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation 2010; 121(1):63–70. doi:10.1161/CIRCULATIONAHA.109.876383
  18. O’Connor CM, Whellan DJ, Lee KL, et al; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009; 301(14):1439–1450. doi:10.1001/jama.2009.454
  19. Hirsch A, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic). Circulation 2006; 113(11):463–654. doi:10.1161/CIRCULATIONAHA.106.174526
  20. Ambrosetti M. Advances in exercise rehabilitation for patients with lower extremity peripheral artery disease. Monaldi Arch Chest Dis 2016; 86(1–2):752. doi:10.4081/monaldi.2016.752
  21. Ades PA, Keteyian SJ, Wright JS, et al. Increasing cardiac rehabilitation participation from 20% to 70%: a road map from the Million Hearts Cardiac Rehabilitation Collaborative. Mayo Clin Proc 2017; 92(2):234–242. doi:10.1016/j.mayocp.2016.10.014
  22. Dafoe W, Arthur H, Stokes H, Morrin L, Beaton L; Canadian Cardiovascular Society Access to Care Working Group on Cardiac Rehabilitation. Universal access: but when? Treating the right patient at the right time: access to cardiac rehabilitation. Can J Cardiol 2006; 22(11):905–911. pmid:16971975
  23. The British Association for Cardiovascular Prevention and Rehabilitation. The BACPR standards and core components for cardiovascular disease prevention and cardiac rehabilitation 2017. www.bacpr.com/resources/6A7_BACR_Standards_and_Core_Components_2017.pdf. Accessed May 9, 2018.
  24. Zullo MD, Jackson LW, Whalen CC, Dolansky MA. Evaluation of the recommended core components of cardiac rehabilitation practice: an opportunity for quality improvement. J Cardiopulm Rehabil Prev 2012; 32(1):32–40. doi:10.1097/HCR.0b013e31823be0e2
  25. Russell KL, Holloway TM, Brum M, Caruso V, Chessex C, Grace SL. Cardiac rehabilitation wait times: effect on enrollment. J Cardiopulm Rehabil Prev 2011; 31(6):373–377. doi:10.1097/HCR.0b013e318228a32f
  26. Soga Y, Yokoi H, Ando K, et al. Safety of early exercise training after elective coronary stenting in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil 2010; 17(2):230–234. doi:10.1097/HJR.0b013e3283359c4e
  27. Scheinowitz M, Harpaz D. Safety of cardiac rehabilitation in a medically supervised, community-based program. Cardiology 2005; 103(3):113–117. doi:10.1159/000083433
  28. Goto Y, Sumida H, Ueshima K, Adachi H, Nohara R, Itoh H. Safety and implementation of exercise testing and training after coronary stenting in patients with acute myocardial infarction. Circ J 2002; 66(10):930–936. pmid:12381088
  29. Parker K, Stone JA, Arena R, et al. An early cardiac access clinic significantly improves cardiac rehabilitation participation and completion rates in low-risk ST-elevation myocardial infarction patients. Can J Cardiol 2011; 27(5):619–627. doi:10.1016/j.cjca.2010.12.076
  30. Pack QR, Mansour M, Barboza JS, et al. An early appointment to outpatient cardiac rehabilitation at hospital discharge improves attendance at orientation: a randomized, single-blind, controlled trial. Circulation 2013; 127(3):349–355. doi:10.1161/CIRCULATIONAHA.112.121996
  31. Suaya JA, Shepard DS, Normand SL, Ades PA, Prottas J, Stason WB. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007; 116(15):1653–1662. doi:10.1161/CIRCULATIONAHA.107.701466
  32. Aragam KG, Dai D, Neely ML, et al. Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States. J Am Coll Cardiol 2015; 65(19):2079–2088. doi:10.1016/j.jacc.2015.02.063
  33. Bittner V, Sanderson B, Breland J, Green D. Referral patterns to a university-based cardiac rehabilitation program. Am J Cardiol 1999; 83(2):252–255, A5. pmid:10073829
  34. Balady GJ, Ades PA, Bittner VA, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond. A presidential advisory from the American Heart Association. Circulation 2011; 124(25):2951–2960. doi:10.1161/CIR.0b013e31823b21e2
  35. British Heart Foundation. The national audit of cardiac rehabilitation annual statistical report 2016. www.cardiacrehabilitation.org.uk/docs/BHF_NACR_Report_2016.pdf. Accessed April 12, 2018.
  36. Doll JA, Hellkamp A, Ho PM, et al. Participation in cardiac rehabilitation programs among older patients after acute myocardial infarction. JAMA Intern Med 2015; 175(10):1700–1702. doi:10.1001/jamainternmed.2015.3819
  37. Grace SL, Russell KL, Reid RD, et al. Cardiac Rehabilitation Care Continuity Through Automatic Referral Evaluation (CRCARE) Investigators. Effect of cardiac rehabilitation referral strategies on utilization rates: a prospective, controlled study. Arch Intern Med 2011; 171(3):235–241. doi:10.1001/archinternmed.2010.501
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  13. Shaw LW. Effects of a prescribed supervised exercise program on mortality and cardiovascular morbidity in patients after a myocardial infarction: The National Exercise and Heart Disease Project. Am J Cardiol 1981; 48(1):39–46. pmid:6972693
  14. Sandesara PB, Lambert CT, Gordon NF, et al. Cardiac rehabilitation and risk reduction: time to “rebrand and reinvigorate.” J Am Coll Cardiol 2015; 65(4):389–395. doi:10.1016/j.jacc.2014.10.059
  15. Suaya JA, Stason WB, Ades PA, Normand SL, Shepard DS. Cardiac rehabilitation and survival in older coronary patients. J Am Coll Cardiol 2009; 54(1):25–33. doi:10.1016/j.jacc.2009.01.078
  16. Goel K, Lennon RJ, Tilbury RT, Squires RW, Thomas RJ. Impact of cardiac rehabilitation on mortality and cardiovascular events after percutaneous coronary intervention in the community. Circulation 2011: 123(21):2344–2352. doi:10.1161/CIRCULATIONAHA.110.983536
  17. Hammill BG, Curtis LH, Schulman KA, Whellan DJ. Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation 2010; 121(1):63–70. doi:10.1161/CIRCULATIONAHA.109.876383
  18. O’Connor CM, Whellan DJ, Lee KL, et al; HF-ACTION Investigators. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA 2009; 301(14):1439–1450. doi:10.1001/jama.2009.454
  19. Hirsch A, Haskal ZJ, Hertzer NR, et al. ACC/AHA 2005 practice guidelines for the management of patients with peripheral arterial disease (lower extremity, renal, mesenteric, and abdominal aortic). Circulation 2006; 113(11):463–654. doi:10.1161/CIRCULATIONAHA.106.174526
  20. Ambrosetti M. Advances in exercise rehabilitation for patients with lower extremity peripheral artery disease. Monaldi Arch Chest Dis 2016; 86(1–2):752. doi:10.4081/monaldi.2016.752
  21. Ades PA, Keteyian SJ, Wright JS, et al. Increasing cardiac rehabilitation participation from 20% to 70%: a road map from the Million Hearts Cardiac Rehabilitation Collaborative. Mayo Clin Proc 2017; 92(2):234–242. doi:10.1016/j.mayocp.2016.10.014
  22. Dafoe W, Arthur H, Stokes H, Morrin L, Beaton L; Canadian Cardiovascular Society Access to Care Working Group on Cardiac Rehabilitation. Universal access: but when? Treating the right patient at the right time: access to cardiac rehabilitation. Can J Cardiol 2006; 22(11):905–911. pmid:16971975
  23. The British Association for Cardiovascular Prevention and Rehabilitation. The BACPR standards and core components for cardiovascular disease prevention and cardiac rehabilitation 2017. www.bacpr.com/resources/6A7_BACR_Standards_and_Core_Components_2017.pdf. Accessed May 9, 2018.
  24. Zullo MD, Jackson LW, Whalen CC, Dolansky MA. Evaluation of the recommended core components of cardiac rehabilitation practice: an opportunity for quality improvement. J Cardiopulm Rehabil Prev 2012; 32(1):32–40. doi:10.1097/HCR.0b013e31823be0e2
  25. Russell KL, Holloway TM, Brum M, Caruso V, Chessex C, Grace SL. Cardiac rehabilitation wait times: effect on enrollment. J Cardiopulm Rehabil Prev 2011; 31(6):373–377. doi:10.1097/HCR.0b013e318228a32f
  26. Soga Y, Yokoi H, Ando K, et al. Safety of early exercise training after elective coronary stenting in patients with stable coronary artery disease. Eur J Cardiovasc Prev Rehabil 2010; 17(2):230–234. doi:10.1097/HJR.0b013e3283359c4e
  27. Scheinowitz M, Harpaz D. Safety of cardiac rehabilitation in a medically supervised, community-based program. Cardiology 2005; 103(3):113–117. doi:10.1159/000083433
  28. Goto Y, Sumida H, Ueshima K, Adachi H, Nohara R, Itoh H. Safety and implementation of exercise testing and training after coronary stenting in patients with acute myocardial infarction. Circ J 2002; 66(10):930–936. pmid:12381088
  29. Parker K, Stone JA, Arena R, et al. An early cardiac access clinic significantly improves cardiac rehabilitation participation and completion rates in low-risk ST-elevation myocardial infarction patients. Can J Cardiol 2011; 27(5):619–627. doi:10.1016/j.cjca.2010.12.076
  30. Pack QR, Mansour M, Barboza JS, et al. An early appointment to outpatient cardiac rehabilitation at hospital discharge improves attendance at orientation: a randomized, single-blind, controlled trial. Circulation 2013; 127(3):349–355. doi:10.1161/CIRCULATIONAHA.112.121996
  31. Suaya JA, Shepard DS, Normand SL, Ades PA, Prottas J, Stason WB. Use of cardiac rehabilitation by Medicare beneficiaries after myocardial infarction or coronary bypass surgery. Circulation 2007; 116(15):1653–1662. doi:10.1161/CIRCULATIONAHA.107.701466
  32. Aragam KG, Dai D, Neely ML, et al. Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States. J Am Coll Cardiol 2015; 65(19):2079–2088. doi:10.1016/j.jacc.2015.02.063
  33. Bittner V, Sanderson B, Breland J, Green D. Referral patterns to a university-based cardiac rehabilitation program. Am J Cardiol 1999; 83(2):252–255, A5. pmid:10073829
  34. Balady GJ, Ades PA, Bittner VA, et al. Referral, enrollment, and delivery of cardiac rehabilitation/secondary prevention programs at clinical centers and beyond. A presidential advisory from the American Heart Association. Circulation 2011; 124(25):2951–2960. doi:10.1161/CIR.0b013e31823b21e2
  35. British Heart Foundation. The national audit of cardiac rehabilitation annual statistical report 2016. www.cardiacrehabilitation.org.uk/docs/BHF_NACR_Report_2016.pdf. Accessed April 12, 2018.
  36. Doll JA, Hellkamp A, Ho PM, et al. Participation in cardiac rehabilitation programs among older patients after acute myocardial infarction. JAMA Intern Med 2015; 175(10):1700–1702. doi:10.1001/jamainternmed.2015.3819
  37. Grace SL, Russell KL, Reid RD, et al. Cardiac Rehabilitation Care Continuity Through Automatic Referral Evaluation (CRCARE) Investigators. Effect of cardiac rehabilitation referral strategies on utilization rates: a prospective, controlled study. Arch Intern Med 2011; 171(3):235–241. doi:10.1001/archinternmed.2010.501
Issue
Cleveland Clinic Journal of Medicine - 85(7)
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Cleveland Clinic Journal of Medicine - 85(7)
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551-558
Page Number
551-558
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Cleveland Clinic Journal of Medicine
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Cleveland Clinic Journal of Medicine
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Cardiology
Geriatrics
Hospital Medicine
Preventive Care
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Cardiac rehabilitation: A class 1 recommendation
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Cardiac rehabilitation: A class 1 recommendation
Legacy Keywords
cardiac rehabilitation, exercise, risk modification, myocardial infarction, Medicare, CMS, Margo Simon, Kaitlyn Korn, Leslie Cho, Gordon Blackburn, Chad Raymond
Legacy Keywords
cardiac rehabilitation, exercise, risk modification, myocardial infarction, Medicare, CMS, Margo Simon, Kaitlyn Korn, Leslie Cho, Gordon Blackburn, Chad Raymond
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KEY POINTS

  • Cardiac rehabilitation should begin in the hospital after heart surgery or myocardial infarction, should continue with a hospital-centered 36-session program, and should be maintained independently by the patient for life. 
  • Exercise in a cardiac rehabilitation program entails little risk and many proven benefits.
  • Cardiac rehabilitation is indicated and covered by the Centers for Medicare and Medicaid Services (CMS) for a number of cardiovascular conditions.
  • Utilization of cardiac rehabilitation could be improved through CMS reimbursement incentives, electronic medical record prompts, lower copayments for participation, and home-based programs for patients who live far from medical centers.
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