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David Henry's JCSO podcast, February 2016

For the February podcast for The Journal of Community and Supportive Oncology, Editor-in-Chief Dr David Henry examines two Original Reports, one on a collaborative investigation by scientists and members of a social network into fluoroquinolone-related neuropsychiatric and mitochondrial toxicity and another on the prognostic value of complete remission with superior platelet counts in patients with acute myeloid leukemia. The Case Reports this month focus on rare tumors: in one case, it is a metastatic primary bladder adenocarcinoma for which a novel treatment approach prolonged survival; and in a second, an 18-year follow-up on a rare, indolent form of T-cell prolymphocytic leukemia. The Community Translations column features the novel MEK inhibitor, cobimetinib, which was approved last year in combination with the BRAF inhibitor, vemurafenib, for metastatic melanoma with BRAF V600E or V600K mutation. Dr Henry also discusses articles on new therapies for gastrointestinal cancers and on selected practice-changing presentations from the 2015 annual meeting of the San Antonio Breast Cancer Symposium in Orlando last year. 

 

Listen to the podcast below.

 

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Legacy Keywords
breast cancer, immunotherapy, avelumab, pembrolizumab, HER2-negative, HER2-positive, docetaxel, carboplatin, trastuzumab, TCH, doxorubicin, cyclophosphamide, paclitaxel, AC-TH, mammogram, cobimetinib, MEK inhibitor, BRAF inhibitor, vemurafenib, melanoma, BRAF V600E, BRAF V600K, fluoroquinolones, anitibiotics, neuropsychiatric toxicity, mitochondrial toxicity, ciprofoxacin, levofoxacin, mofoxacin, acute myeloid leukemia, AML, leukemic blast cells, platelet count, prognostication, primary bladder adenocarcinoma, PBA, urothelial carcinoma, bladder exstrophy, ectopia vesicae, wild-type KRAS, T-cell prolymphocytic leukemia, T-PLL, lymphoid neoplasms, gastrointestinal malignancies, gastrointestinal stromal tumors, GIST, imatinib, colorectal cancers, CRC, HER1/EGFR, monoclonal antibody, mAb, trastuzumab, ado-trastuzumab emtansine, erlotinib, gemcitabine, pancreatic cancer, mAbs, panitumumab, cetuximab, KRAS, onartuzumab, mFOLFOX, avelumab, metastatic breast cancer, programmed death-ligand 1, PD-L1, immune checkpoint inhibitor, triple-negative breast cancer, TNBC, pembrolizumab, estrogen receptor-positive, human epidermal growth factor receptor 2, HER2, trastuzumab, cardiac toxicity, neratinib, disease-free survival, DFS
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For the February podcast for The Journal of Community and Supportive Oncology, Editor-in-Chief Dr David Henry examines two Original Reports, one on a collaborative investigation by scientists and members of a social network into fluoroquinolone-related neuropsychiatric and mitochondrial toxicity and another on the prognostic value of complete remission with superior platelet counts in patients with acute myeloid leukemia. The Case Reports this month focus on rare tumors: in one case, it is a metastatic primary bladder adenocarcinoma for which a novel treatment approach prolonged survival; and in a second, an 18-year follow-up on a rare, indolent form of T-cell prolymphocytic leukemia. The Community Translations column features the novel MEK inhibitor, cobimetinib, which was approved last year in combination with the BRAF inhibitor, vemurafenib, for metastatic melanoma with BRAF V600E or V600K mutation. Dr Henry also discusses articles on new therapies for gastrointestinal cancers and on selected practice-changing presentations from the 2015 annual meeting of the San Antonio Breast Cancer Symposium in Orlando last year. 

 

Listen to the podcast below.

 

For the February podcast for The Journal of Community and Supportive Oncology, Editor-in-Chief Dr David Henry examines two Original Reports, one on a collaborative investigation by scientists and members of a social network into fluoroquinolone-related neuropsychiatric and mitochondrial toxicity and another on the prognostic value of complete remission with superior platelet counts in patients with acute myeloid leukemia. The Case Reports this month focus on rare tumors: in one case, it is a metastatic primary bladder adenocarcinoma for which a novel treatment approach prolonged survival; and in a second, an 18-year follow-up on a rare, indolent form of T-cell prolymphocytic leukemia. The Community Translations column features the novel MEK inhibitor, cobimetinib, which was approved last year in combination with the BRAF inhibitor, vemurafenib, for metastatic melanoma with BRAF V600E or V600K mutation. Dr Henry also discusses articles on new therapies for gastrointestinal cancers and on selected practice-changing presentations from the 2015 annual meeting of the San Antonio Breast Cancer Symposium in Orlando last year. 

 

Listen to the podcast below.

 

Publications
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David Henry's JCSO podcast, February 2016
Display Headline
David Henry's JCSO podcast, February 2016
Legacy Keywords
breast cancer, immunotherapy, avelumab, pembrolizumab, HER2-negative, HER2-positive, docetaxel, carboplatin, trastuzumab, TCH, doxorubicin, cyclophosphamide, paclitaxel, AC-TH, mammogram, cobimetinib, MEK inhibitor, BRAF inhibitor, vemurafenib, melanoma, BRAF V600E, BRAF V600K, fluoroquinolones, anitibiotics, neuropsychiatric toxicity, mitochondrial toxicity, ciprofoxacin, levofoxacin, mofoxacin, acute myeloid leukemia, AML, leukemic blast cells, platelet count, prognostication, primary bladder adenocarcinoma, PBA, urothelial carcinoma, bladder exstrophy, ectopia vesicae, wild-type KRAS, T-cell prolymphocytic leukemia, T-PLL, lymphoid neoplasms, gastrointestinal malignancies, gastrointestinal stromal tumors, GIST, imatinib, colorectal cancers, CRC, HER1/EGFR, monoclonal antibody, mAb, trastuzumab, ado-trastuzumab emtansine, erlotinib, gemcitabine, pancreatic cancer, mAbs, panitumumab, cetuximab, KRAS, onartuzumab, mFOLFOX, avelumab, metastatic breast cancer, programmed death-ligand 1, PD-L1, immune checkpoint inhibitor, triple-negative breast cancer, TNBC, pembrolizumab, estrogen receptor-positive, human epidermal growth factor receptor 2, HER2, trastuzumab, cardiac toxicity, neratinib, disease-free survival, DFS
Legacy Keywords
breast cancer, immunotherapy, avelumab, pembrolizumab, HER2-negative, HER2-positive, docetaxel, carboplatin, trastuzumab, TCH, doxorubicin, cyclophosphamide, paclitaxel, AC-TH, mammogram, cobimetinib, MEK inhibitor, BRAF inhibitor, vemurafenib, melanoma, BRAF V600E, BRAF V600K, fluoroquinolones, anitibiotics, neuropsychiatric toxicity, mitochondrial toxicity, ciprofoxacin, levofoxacin, mofoxacin, acute myeloid leukemia, AML, leukemic blast cells, platelet count, prognostication, primary bladder adenocarcinoma, PBA, urothelial carcinoma, bladder exstrophy, ectopia vesicae, wild-type KRAS, T-cell prolymphocytic leukemia, T-PLL, lymphoid neoplasms, gastrointestinal malignancies, gastrointestinal stromal tumors, GIST, imatinib, colorectal cancers, CRC, HER1/EGFR, monoclonal antibody, mAb, trastuzumab, ado-trastuzumab emtansine, erlotinib, gemcitabine, pancreatic cancer, mAbs, panitumumab, cetuximab, KRAS, onartuzumab, mFOLFOX, avelumab, metastatic breast cancer, programmed death-ligand 1, PD-L1, immune checkpoint inhibitor, triple-negative breast cancer, TNBC, pembrolizumab, estrogen receptor-positive, human epidermal growth factor receptor 2, HER2, trastuzumab, cardiac toxicity, neratinib, disease-free survival, DFS
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