Do Organophosphate Esters Increase Thyroid Disease Risk?

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All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>Exposure to organophosphate ester (OPE) metabolites, a newer group of widely used chemical flame retardants, is linked to a higher risk for thyroid disease</metaDescription> <articlePDF/> <teaserImage/> <teaser>Chemicals found in flame retardants were linked to increased risk for thyroid disease, study finds.</teaser> <title>Do Organophosphate Esters Increase Thyroid Disease Risk?</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>endo</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term>15</term> <term>21</term> <term canonical="true">34</term> </publications> <sections> <term canonical="true">39313</term> </sections> <topics> <term canonical="true">277</term> <term>206</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Do Organophosphate Esters Increase Thyroid Disease Risk?</title> <deck/> </itemMeta> <itemContent> <h2> <span class="Strong">TOPLINE:</span> </h2> <p><span class="tag metaDescription">Exposure to organophosphate ester (OPE) metabolites, a newer group of widely used chemical flame retardants, is linked to a higher risk for thyroid disease</span>, bis(2-chloroethyl) phosphate (BCEP) being the main contributor.</p> <h2> <span class="Strong">METHODOLOGY:</span> </h2> <ul class="body"> <li>Prior studies have reported that OPEs — used in building materials, electronic products, furniture, and textiles — may interfere with thyroid function, hinting at a possible association of OPEs with thyroid disease.</li> <li>Researchers assessed the association between OPE exposure and the risk for thyroid disease using data from the 2011-2014 US National Health and Nutrition Examination Survey cycle.</li> <li>They included 2449 participants (mean age, 46 years; half of whom were women) who had complete values for seven OPE metabolites through urinalysis and completed questionnaires regarding the presence of thyroid disease.</li> <li>The seven OPE metabolites assessed in this study were diphenyl phosphate (DPHP), bis(1,3-dichloro-2-propyl) phosphate, bis(1-chloro-2-propyl) phosphate, BCEP, dibutyl phosphate, dibenzyl phosphate, and 2,3,4,5-tetrabromobenzoic acid.</li> <li>Several mixed exposure models were used to investigate the associations between the risk for thyroid disease and exposure to individual and mixed OPEs.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>A history of thyroid disease was self-reported by 228 participants.</li> <li>In one model, the risk for thyroid disease was 57% higher in people in the highest vs the lowest tertile of BCEP exposure (<span class="Emphasis">P</span> = .005).</li> <li>A newer method confirmed the positive association between exposure to mixed OPE metabolites and a higher risk for thyroid disease (odds ratio, 1.03; <span class="Emphasis">P</span> = .013), with BCEP (65%) being the main contributing factor, followed by DPHP (35%).</li> <li>A model from another new method showed a J-shaped relationship between the risk for thyroid disease and increasing levels of BCEP exposure, in which the risk first dropped but then rose with increasing exposure.</li> </ul> <h2> <span class="Strong">IN PRACTICE:</span> </h2> <p>“The three models in our study provided similar results, with exposure to mixed OPEs having a tendency to increase the risk of thyroid disease and pointing to BCEP as the most significant compound responsible for this trend,” wrote the authors.</p> <h2> <span class="Strong">SOURCE:</span> </h2> <p>This study was led by Yuxin Lin, from the Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China, and published <span class="Hyperlink"><a href="https://doi.org/10.3389/fendo.2024.1329247">online</a></span> in <span class="Emphasis">Frontiers in Endocrinology</span>.</p> <h2> <span class="Strong">LIMITATIONS:</span> </h2> <p>The cross-sectional design cannot establish a causal relationship between OPE exposure and thyroid disease. The study used unweighted data, which could have limited the generalizability of the findings. Moreover, urine sample measurements were performed only once.</p> <h2> <span class="Strong">DISCLOSURES:</span> </h2> <p>The study was supported by the Fujian Natural Science Foundation Program and the Scientific Research Program of High-level Talents of Fujian Medical University. The authors declared no potential conflicts of interest.<span class="end"/></p> <p> <em>A version of this article first appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/do-organophosphate-esters-increase-thyroid-disease-risk-2024a10004ct">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> </itemContent> </newsItem> </itemSet></root>