Article Type
Changed
Tue, 08/28/2018 - 11:05
Display Headline
Does tight control of hypertension in pregnancy produce better perinatal outcomes?

The question of degree of control of hypertension during pregnancy has been debated for many years. The primary concern, which is mainly theoretical, is that tight control of hypertension may lead to underperfusion of the uterus, ultimately resulting in fetal growth restriction. This study adds to the available body of literature on this subject.

Details of the trial
In this pragmatic randomized clinical trial, 987 women with office diastolic BP of 90 to 105 mm Hg (or 85 to 105 mm Hg if they were taking a hypertensive medication) between 14 weeks, zero days of gestation and 33 weeks, 6 days of gestation were randomized to tight (n = 488) versus less-tight control of hypertension (n = 493).

Practitioners were encouraged to use labetalol for treatment. The primary outcome was pregnancy loss (miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, or neonatal death) or the need for high-level neonatal care (defined as greater than normal newborn care for more than 48 hours until 28 days of life or discharge home). Secondary outcomes included serious maternal morbidity as late as 6 weeks postpartum. Statistical analysis was based on the intent-to-treat principle.

Adherence to assigned treatment was good, at approximately 75% in each arm. As stated above, the study found no differences in the combined primary endpoint between the two groups. It also found no differences in other perinatal outcomes, including small size for gestational age or other adverse neonatal outcomes. Maternal complications generally were similar as well, with the exception of severe hypertension, which was more common in the less-tight control group.

Strengths and weaknesses of the study
This trial has several important strengths, including its pragmatic design, making it more applicable to everyday practice. Other strengths include rigorous methods and a large sample size.

Two main weaknesses hamper the study, however:

  • the inclusion of both chronic hypertension and gestational hypertension. In my opinion, the much more clinically relevant question concerns women with chronic hypertension, who have a long duration of treatment.
  • the choice of high-level neonatal care as part of the composite endpoint. This aspect of the composite outcome drove the endpoint in terms of numbers, but it is unclear to me what its clinical relevance is. In my opinion, it is a poor surrogate for the neonatal outcomes we really care about.

What this evidence means for practice
This study does not establish a foundation for a change in clinical practice. At best, it supports the maternal safety of less-tight control of hypertension in pregnancy. That aspect of the trial may find its way into counseling of the patient. 
George Macones, MD

Share your thoughts on this article! Send your Letter to the Editor to rbarbieri@frontlinemedcom.com. Please include your name and the city and state in which you practice.

References

Article PDF
Author and Disclosure Information

EXPERT COMMENTARY

‡‡George Macones, MD
Professor and Chair, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

The author reports no financial relationships relevant to this article.

Issue
OBG Management - 27(3)
Publications
Topics
Page Number
52,51
Legacy Keywords
George Macones MD, Examining the Evidence, tight control of hypertension in pregnancy, better perinatal outcomes, nonproteinuric hypertension, gestational hypertension, blood pressure, high-level neonatal care, less-tight control of hypertension, miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, neonatal death, high-level neonatal care
Sections
Author and Disclosure Information

EXPERT COMMENTARY

‡‡George Macones, MD
Professor and Chair, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

The author reports no financial relationships relevant to this article.

Author and Disclosure Information

EXPERT COMMENTARY

‡‡George Macones, MD
Professor and Chair, Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, Missouri.

The author reports no financial relationships relevant to this article.

Article PDF
Article PDF
Related Articles

The question of degree of control of hypertension during pregnancy has been debated for many years. The primary concern, which is mainly theoretical, is that tight control of hypertension may lead to underperfusion of the uterus, ultimately resulting in fetal growth restriction. This study adds to the available body of literature on this subject.

Details of the trial
In this pragmatic randomized clinical trial, 987 women with office diastolic BP of 90 to 105 mm Hg (or 85 to 105 mm Hg if they were taking a hypertensive medication) between 14 weeks, zero days of gestation and 33 weeks, 6 days of gestation were randomized to tight (n = 488) versus less-tight control of hypertension (n = 493).

Practitioners were encouraged to use labetalol for treatment. The primary outcome was pregnancy loss (miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, or neonatal death) or the need for high-level neonatal care (defined as greater than normal newborn care for more than 48 hours until 28 days of life or discharge home). Secondary outcomes included serious maternal morbidity as late as 6 weeks postpartum. Statistical analysis was based on the intent-to-treat principle.

Adherence to assigned treatment was good, at approximately 75% in each arm. As stated above, the study found no differences in the combined primary endpoint between the two groups. It also found no differences in other perinatal outcomes, including small size for gestational age or other adverse neonatal outcomes. Maternal complications generally were similar as well, with the exception of severe hypertension, which was more common in the less-tight control group.

Strengths and weaknesses of the study
This trial has several important strengths, including its pragmatic design, making it more applicable to everyday practice. Other strengths include rigorous methods and a large sample size.

Two main weaknesses hamper the study, however:

  • the inclusion of both chronic hypertension and gestational hypertension. In my opinion, the much more clinically relevant question concerns women with chronic hypertension, who have a long duration of treatment.
  • the choice of high-level neonatal care as part of the composite endpoint. This aspect of the composite outcome drove the endpoint in terms of numbers, but it is unclear to me what its clinical relevance is. In my opinion, it is a poor surrogate for the neonatal outcomes we really care about.

What this evidence means for practice
This study does not establish a foundation for a change in clinical practice. At best, it supports the maternal safety of less-tight control of hypertension in pregnancy. That aspect of the trial may find its way into counseling of the patient. 
George Macones, MD

Share your thoughts on this article! Send your Letter to the Editor to rbarbieri@frontlinemedcom.com. Please include your name and the city and state in which you practice.

The question of degree of control of hypertension during pregnancy has been debated for many years. The primary concern, which is mainly theoretical, is that tight control of hypertension may lead to underperfusion of the uterus, ultimately resulting in fetal growth restriction. This study adds to the available body of literature on this subject.

Details of the trial
In this pragmatic randomized clinical trial, 987 women with office diastolic BP of 90 to 105 mm Hg (or 85 to 105 mm Hg if they were taking a hypertensive medication) between 14 weeks, zero days of gestation and 33 weeks, 6 days of gestation were randomized to tight (n = 488) versus less-tight control of hypertension (n = 493).

Practitioners were encouraged to use labetalol for treatment. The primary outcome was pregnancy loss (miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, or neonatal death) or the need for high-level neonatal care (defined as greater than normal newborn care for more than 48 hours until 28 days of life or discharge home). Secondary outcomes included serious maternal morbidity as late as 6 weeks postpartum. Statistical analysis was based on the intent-to-treat principle.

Adherence to assigned treatment was good, at approximately 75% in each arm. As stated above, the study found no differences in the combined primary endpoint between the two groups. It also found no differences in other perinatal outcomes, including small size for gestational age or other adverse neonatal outcomes. Maternal complications generally were similar as well, with the exception of severe hypertension, which was more common in the less-tight control group.

Strengths and weaknesses of the study
This trial has several important strengths, including its pragmatic design, making it more applicable to everyday practice. Other strengths include rigorous methods and a large sample size.

Two main weaknesses hamper the study, however:

  • the inclusion of both chronic hypertension and gestational hypertension. In my opinion, the much more clinically relevant question concerns women with chronic hypertension, who have a long duration of treatment.
  • the choice of high-level neonatal care as part of the composite endpoint. This aspect of the composite outcome drove the endpoint in terms of numbers, but it is unclear to me what its clinical relevance is. In my opinion, it is a poor surrogate for the neonatal outcomes we really care about.

What this evidence means for practice
This study does not establish a foundation for a change in clinical practice. At best, it supports the maternal safety of less-tight control of hypertension in pregnancy. That aspect of the trial may find its way into counseling of the patient. 
George Macones, MD

Share your thoughts on this article! Send your Letter to the Editor to rbarbieri@frontlinemedcom.com. Please include your name and the city and state in which you practice.

References

References

Issue
OBG Management - 27(3)
Issue
OBG Management - 27(3)
Page Number
52,51
Page Number
52,51
Publications
Publications
Topics
Article Type
Display Headline
Does tight control of hypertension in pregnancy produce better perinatal outcomes?
Display Headline
Does tight control of hypertension in pregnancy produce better perinatal outcomes?
Legacy Keywords
George Macones MD, Examining the Evidence, tight control of hypertension in pregnancy, better perinatal outcomes, nonproteinuric hypertension, gestational hypertension, blood pressure, high-level neonatal care, less-tight control of hypertension, miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, neonatal death, high-level neonatal care
Legacy Keywords
George Macones MD, Examining the Evidence, tight control of hypertension in pregnancy, better perinatal outcomes, nonproteinuric hypertension, gestational hypertension, blood pressure, high-level neonatal care, less-tight control of hypertension, miscarriage, ectopic pregnancy, pregnancy termination, stillbirth, neonatal death, high-level neonatal care
Sections
Article Source

PURLs Copyright

Inside the Article

Article PDF Media