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TOPLINE:
A clinically significant association exists between fructose and fructan malabsorption in certain patients with irritable bowel syndrome (IBS), indicating that some may benefit from eliminating both carbohydrates.
METHODOLOGY:
- Previous research has focused on fructose or fructan malabsorption separately in patients with IBS, rather than together in the same cohort.
- Researchers conducted a retrospective review of electronic medical records obtained from January 2017 to June 2022 at a single US medical clinic from patients with IBS who had undergone fructose and fructan hydrogen breath tests (HBTs).
- Patients were advised to have a low-carbohydrate dinner the day before, and fast for at least 12 hours prior to the HBT.
- Separate fructose and fructan HBTs were performed at baseline and again on separate days (minimum 1 day between HBTs) by administering a 25-g fructose or 10-g insulin solution and noting the breath hydrogen readings every 30 minutes for 3 hours. Breath hydrogen levels ≥ 20 ppm indicated a positive malabsorption result for either of the carbohydrates.
- The HBT results were compared to study the association between fructose and fructan malabsorption.
TAKEAWAY:
- Among 186 patients (median age, 36.7 years; 37.6% men), 38.2% tested positive for fructose malabsorption, 48.9% for fructan malabsorption, and 22.6% for both.
- There was a significant association between positive fructose and positive fructan HBT readings (P = .0283).
- Patients who tested positive for fructose or fructan malabsorption had a 1.951 times higher likelihood of testing positive for the other carbohydrate (95% CI, 1.072-3.476).
IN PRACTICE:
“The positive association between fructose and fructan malabsorption in patients with IBS suggests that fructan malabsorption should be suspected in a patient who tests positive for fructose malabsorption, and vice versa,” the authors wrote.
SOURCE:
The study, led by Twan Sia, MD, Boston Specialists, Boston, was published online in BMC Gastroenterology.
LIMITATIONS:
The findings may have limited generalizability, as it included patients primarily from the northeastern region of the United States. The study limited HBT to 3 hours, beyond which rises in hydrogen gas might have been missed. Moreover, the use of an absolute hydrogen threshold of 20 ppm differs from that used in most other studies.
DISCLOSURES:
This study did not receive any specific grant from any funding agencies. One of the authors declared being a consultant for various pharmaceutical companies.
A version of this article appeared on Medscape.com.
TOPLINE:
A clinically significant association exists between fructose and fructan malabsorption in certain patients with irritable bowel syndrome (IBS), indicating that some may benefit from eliminating both carbohydrates.
METHODOLOGY:
- Previous research has focused on fructose or fructan malabsorption separately in patients with IBS, rather than together in the same cohort.
- Researchers conducted a retrospective review of electronic medical records obtained from January 2017 to June 2022 at a single US medical clinic from patients with IBS who had undergone fructose and fructan hydrogen breath tests (HBTs).
- Patients were advised to have a low-carbohydrate dinner the day before, and fast for at least 12 hours prior to the HBT.
- Separate fructose and fructan HBTs were performed at baseline and again on separate days (minimum 1 day between HBTs) by administering a 25-g fructose or 10-g insulin solution and noting the breath hydrogen readings every 30 minutes for 3 hours. Breath hydrogen levels ≥ 20 ppm indicated a positive malabsorption result for either of the carbohydrates.
- The HBT results were compared to study the association between fructose and fructan malabsorption.
TAKEAWAY:
- Among 186 patients (median age, 36.7 years; 37.6% men), 38.2% tested positive for fructose malabsorption, 48.9% for fructan malabsorption, and 22.6% for both.
- There was a significant association between positive fructose and positive fructan HBT readings (P = .0283).
- Patients who tested positive for fructose or fructan malabsorption had a 1.951 times higher likelihood of testing positive for the other carbohydrate (95% CI, 1.072-3.476).
IN PRACTICE:
“The positive association between fructose and fructan malabsorption in patients with IBS suggests that fructan malabsorption should be suspected in a patient who tests positive for fructose malabsorption, and vice versa,” the authors wrote.
SOURCE:
The study, led by Twan Sia, MD, Boston Specialists, Boston, was published online in BMC Gastroenterology.
LIMITATIONS:
The findings may have limited generalizability, as it included patients primarily from the northeastern region of the United States. The study limited HBT to 3 hours, beyond which rises in hydrogen gas might have been missed. Moreover, the use of an absolute hydrogen threshold of 20 ppm differs from that used in most other studies.
DISCLOSURES:
This study did not receive any specific grant from any funding agencies. One of the authors declared being a consultant for various pharmaceutical companies.
A version of this article appeared on Medscape.com.
TOPLINE:
A clinically significant association exists between fructose and fructan malabsorption in certain patients with irritable bowel syndrome (IBS), indicating that some may benefit from eliminating both carbohydrates.
METHODOLOGY:
- Previous research has focused on fructose or fructan malabsorption separately in patients with IBS, rather than together in the same cohort.
- Researchers conducted a retrospective review of electronic medical records obtained from January 2017 to June 2022 at a single US medical clinic from patients with IBS who had undergone fructose and fructan hydrogen breath tests (HBTs).
- Patients were advised to have a low-carbohydrate dinner the day before, and fast for at least 12 hours prior to the HBT.
- Separate fructose and fructan HBTs were performed at baseline and again on separate days (minimum 1 day between HBTs) by administering a 25-g fructose or 10-g insulin solution and noting the breath hydrogen readings every 30 minutes for 3 hours. Breath hydrogen levels ≥ 20 ppm indicated a positive malabsorption result for either of the carbohydrates.
- The HBT results were compared to study the association between fructose and fructan malabsorption.
TAKEAWAY:
- Among 186 patients (median age, 36.7 years; 37.6% men), 38.2% tested positive for fructose malabsorption, 48.9% for fructan malabsorption, and 22.6% for both.
- There was a significant association between positive fructose and positive fructan HBT readings (P = .0283).
- Patients who tested positive for fructose or fructan malabsorption had a 1.951 times higher likelihood of testing positive for the other carbohydrate (95% CI, 1.072-3.476).
IN PRACTICE:
“The positive association between fructose and fructan malabsorption in patients with IBS suggests that fructan malabsorption should be suspected in a patient who tests positive for fructose malabsorption, and vice versa,” the authors wrote.
SOURCE:
The study, led by Twan Sia, MD, Boston Specialists, Boston, was published online in BMC Gastroenterology.
LIMITATIONS:
The findings may have limited generalizability, as it included patients primarily from the northeastern region of the United States. The study limited HBT to 3 hours, beyond which rises in hydrogen gas might have been missed. Moreover, the use of an absolute hydrogen threshold of 20 ppm differs from that used in most other studies.
DISCLOSURES:
This study did not receive any specific grant from any funding agencies. One of the authors declared being a consultant for various pharmaceutical companies.
A version of this article appeared on Medscape.com.
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All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>A clinically significant association exists between fructose and fructan malabsorption in certain patients with irritable bowel syndrome (IBS), indicating that </metaDescription> <articlePDF/> <teaserImage/> <teaser>Patients who tested positive for fructose or fructan malabsorption had a 1.951 times higher likelihood of testing positive for the other carbohydrate.</teaser> <title>Fructose and Fructan Malabsorption Strongly Linked in IBS</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>GIHOLD</publicationCode> <pubIssueName>January 2014</pubIssueName> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> <journalTitle/> <journalFullTitle/> <copyrightStatement/> </publicationData> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term>15</term> <term canonical="true">21</term> </publications> <sections> <term>27970</term> <term canonical="true">39313</term> </sections> <topics> <term canonical="true">213</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Fructose and Fructan Malabsorption Strongly Linked in IBS</title> <deck/> </itemMeta> <itemContent> <h2>TOPLINE:</h2> <p>A clinically significant association exists between fructose and fructan <span class="Hyperlink">malabsorption</span> in certain patients with <span class="Hyperlink">irritable bowel syndrome</span> (IBS), indicating that some may benefit from eliminating both carbohydrates.</p> <h2>METHODOLOGY:</h2> <ul class="body"> <li>Previous research has focused on fructose or fructan malabsorption separately in patients with IBS, rather than together in the same cohort.</li> <li>Researchers conducted a retrospective review of electronic medical records obtained from January 2017 to June 2022 at a single US medical clinic from patients with IBS who had undergone fructose and fructan hydrogen breath tests (HBTs).</li> <li>Patients were advised to have a low-carbohydrate dinner the day before, and fast for at least 12 hours prior to the HBT.</li> <li>Separate fructose and fructan HBTs were performed at baseline and again on separate days (minimum 1 day between HBTs) by administering a 25-g fructose or 10-g <span class="Hyperlink">insulin</span> solution and noting the breath hydrogen readings every 30 minutes for 3 hours. Breath hydrogen levels ≥ 20 ppm indicated a positive malabsorption result for either of the carbohydrates.</li> <li>The HBT results were compared to study the association between fructose and fructan malabsorption.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>Among 186 patients (median age, 36.7 years; 37.6% men), 38.2% tested positive for fructose malabsorption, 48.9% for fructan malabsorption, and 22.6% for both.</li> <li>There was a significant association between positive fructose and positive fructan HBT readings (<em>P</em> = .0283).</li> <li>Patients who tested positive for fructose or fructan malabsorption had a 1.951 times higher likelihood of testing positive for the other carbohydrate (95% CI, 1.072-3.476).</li> </ul> <h2>IN PRACTICE:</h2> <p>“The positive association between fructose and fructan malabsorption in patients with IBS suggests that fructan malabsorption should be suspected in a patient who tests positive for fructose malabsorption, and vice versa,” the authors wrote.</p> <h2>SOURCE:</h2> <p>The study, led by Twan Sia, MD, Boston Specialists, Boston, was <span class="Hyperlink"><a href="https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-024-03230-x">published online</a></span> in <em>BMC Gastroenterology</em>.</p> <h2>LIMITATIONS:</h2> <p>The findings may have limited generalizability, as it included patients primarily from the northeastern region of the United States. The study limited HBT to 3 hours, beyond which rises in hydrogen gas might have been missed. Moreover, the use of an absolute hydrogen threshold of 20 ppm differs from that used in most other studies.</p> <h2>DISCLOSURES:</h2> <p>This study did not receive any specific grant from any funding agencies. One of the authors declared being a consultant for various pharmaceutical companies.<br/><br/></p> <p> <em>A version of this article appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/fructose-and-fructan-malabsorption-strongly-linked-ibs-2024a1000b6w">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> </itemContent> </newsItem> </itemSet></root>