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SAN FRANCISCO — Obese adolescents lost significantly more weight on a high-protein, low-carbohydrate diet than on a standard low-fat diet, according to a randomized study involving 46 teens.
At the end of 12 weeks, the teens on the high-protein, low-carbohydrate (HPLC) diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg, a significant difference, Dr. Nancy F. Krebs of the University of Colorado, Denver, said at a meeting on clinical pediatrics sponsored by the University of California, San Francisco.
Moreover, adolescents in both groups tended to maintain their weight loss over an additional 24 weeks of follow-up. “My hypothesis was that [the HPLC diet] would get them to 12 weeks but they'd rebound,” possibly even ending up heavier than before.
In fact, while adolescents in the HPLC group tended to gain back a little weight within the first 3 months after the end of the diet, they still weighed less than those in the low-fat group. And the HPLC group appeared to maintain that difference for another 3 months, although those differences did not reach statistical significance.
All the adolescents in the study were severely overweight, weighing at least 175% of their ideal body weight. The teens in the HPLC group were placed on a diet limiting them to 20 g/day of carbohydrates. To ensure that they were compliant with this diet, the investigators measured ketone levels twice daily. People on HPLC diets tend to become ketonic quickly, something that can be measured easily with a urine dipstick.
Both groups of adolescents lost equivalent amounts of fat and protein and showed similar improvements in their lipid profiles, but those on the HPLC diet lowered their triglyceride levels significantly more than the low-fat group.
Based on glucose tolerance test results, carbohydrate metabolism improved in both groups. The investigators observed no adverse effects of the HPLC diet.
Dr. Krebs said she has submitted her study for publication and has no relevant conflicts of interest.
Teens on the HPLC diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg.
Source DR. KREBS
SAN FRANCISCO — Obese adolescents lost significantly more weight on a high-protein, low-carbohydrate diet than on a standard low-fat diet, according to a randomized study involving 46 teens.
At the end of 12 weeks, the teens on the high-protein, low-carbohydrate (HPLC) diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg, a significant difference, Dr. Nancy F. Krebs of the University of Colorado, Denver, said at a meeting on clinical pediatrics sponsored by the University of California, San Francisco.
Moreover, adolescents in both groups tended to maintain their weight loss over an additional 24 weeks of follow-up. “My hypothesis was that [the HPLC diet] would get them to 12 weeks but they'd rebound,” possibly even ending up heavier than before.
In fact, while adolescents in the HPLC group tended to gain back a little weight within the first 3 months after the end of the diet, they still weighed less than those in the low-fat group. And the HPLC group appeared to maintain that difference for another 3 months, although those differences did not reach statistical significance.
All the adolescents in the study were severely overweight, weighing at least 175% of their ideal body weight. The teens in the HPLC group were placed on a diet limiting them to 20 g/day of carbohydrates. To ensure that they were compliant with this diet, the investigators measured ketone levels twice daily. People on HPLC diets tend to become ketonic quickly, something that can be measured easily with a urine dipstick.
Both groups of adolescents lost equivalent amounts of fat and protein and showed similar improvements in their lipid profiles, but those on the HPLC diet lowered their triglyceride levels significantly more than the low-fat group.
Based on glucose tolerance test results, carbohydrate metabolism improved in both groups. The investigators observed no adverse effects of the HPLC diet.
Dr. Krebs said she has submitted her study for publication and has no relevant conflicts of interest.
Teens on the HPLC diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg.
Source DR. KREBS
SAN FRANCISCO — Obese adolescents lost significantly more weight on a high-protein, low-carbohydrate diet than on a standard low-fat diet, according to a randomized study involving 46 teens.
At the end of 12 weeks, the teens on the high-protein, low-carbohydrate (HPLC) diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg, a significant difference, Dr. Nancy F. Krebs of the University of Colorado, Denver, said at a meeting on clinical pediatrics sponsored by the University of California, San Francisco.
Moreover, adolescents in both groups tended to maintain their weight loss over an additional 24 weeks of follow-up. “My hypothesis was that [the HPLC diet] would get them to 12 weeks but they'd rebound,” possibly even ending up heavier than before.
In fact, while adolescents in the HPLC group tended to gain back a little weight within the first 3 months after the end of the diet, they still weighed less than those in the low-fat group. And the HPLC group appeared to maintain that difference for another 3 months, although those differences did not reach statistical significance.
All the adolescents in the study were severely overweight, weighing at least 175% of their ideal body weight. The teens in the HPLC group were placed on a diet limiting them to 20 g/day of carbohydrates. To ensure that they were compliant with this diet, the investigators measured ketone levels twice daily. People on HPLC diets tend to become ketonic quickly, something that can be measured easily with a urine dipstick.
Both groups of adolescents lost equivalent amounts of fat and protein and showed similar improvements in their lipid profiles, but those on the HPLC diet lowered their triglyceride levels significantly more than the low-fat group.
Based on glucose tolerance test results, carbohydrate metabolism improved in both groups. The investigators observed no adverse effects of the HPLC diet.
Dr. Krebs said she has submitted her study for publication and has no relevant conflicts of interest.
Teens on the HPLC diet lost an average of 9.0 kg, while those on the low-fat diet lost an average of 5.6 kg.
Source DR. KREBS