High Vitamin D Intake May Prevent Fractures

Major Finding: People taking 792–2,000 IU/day of vitamin D had a statistically significant, 14% reduced rate of any nonvertebral fracture and a significant, 30% reduced rate of hip fractures compared with control subjects who did not receive a vitamin D supplement.

Data Source: Meta-analysis of 11 double-blind, randomized, controlled trials with individual participant data available for 31,022 subjects with an average age of 76.

Disclosures: Dr. Bischoff-Ferrari said that she had no disclosures.

TORONTO — A daily vitamin D dose of at least 792 IU was linked with significantly reduced rates of nonvertebral fractures and hip fractures in a meta-analysis of data from 11 randomized, controlled trials.

But the benefit from vitamin D appeared blunted when combined with a higher calcium dose, or when patients received vitamin D once yearly, Dr. Heike A. Bischoff-Ferrari reported.

In the meta-analysis, patients in the highest quartile for daily vitamin D intake, 792–2000 IU, had a statistically significant 14% reduced rate of any nonvertebral fracture and a significant 30% reduced rate of hip fractures after adjusting for age, gender, and type of dwelling, said Dr. Bischoff-Ferrari, a rheumatologist at the University of Zurich.

Her meta-analysis pooled individual participant data from 12 double-blind, randomized, controlled trials that examined the impact of vitamin D supplements on fracture rate in people aged 65 years or older published through June 2010, and for which she could obtain individual participant data. The primary analysis focused on the 11 studies of the 12 in which participants received the supplement at least monthly, with 31,022 people enrolled. The twelfth study tested once annual dosing, and the researchers included those data in a separate analysis. The participants' average age was 76 years, and about 90% were women.

The analysis divided the study subjects into the control group, with more than 15,000 people, and then into quartiles of their received amount of vitamin D, including both their study-treatment dose and any additional vitamin D intake. The analysis also took into account adherence to treatment. Each vitamin D quartile contained nearly 4,000 people, with a daily dose range of 792–2,000 IU forming the top quartile. Only the top quartile of vitamin intake linked with statistically significant differences, compared with the controls, for any nonvertebral fracture and for hip fracture.

An additional analysis that looked at the interaction of calcium supplements along with vitamin D showed that, with a daily calcium dose below 1,000 mg/day, a high-dose vitamin D supplement (792–2,000 IU/day) linked with a statistically significant reduction in nonvertebral fractures, but when the daily calcium supplement delivered 1,000 mg or more, this amount of vitamin D did not associate with any significant change in fracture rate, suggesting an adverse effect from higher calcium intake.

Vitals

Source ©Joss/Fotolia.com

Major Finding: People taking 792–2,000 IU/day of vitamin D had a statistically significant, 14% reduced rate of any nonvertebral fracture and a significant, 30% reduced rate of hip fractures compared with control subjects who did not receive a vitamin D supplement.

Data Source: Meta-analysis of 11 double-blind, randomized, controlled trials with individual participant data available for 31,022 subjects with an average age of 76.

Disclosures: Dr. Bischoff-Ferrari said that she had no disclosures.

TORONTO — A daily vitamin D dose of at least 792 IU was linked with significantly reduced rates of nonvertebral fractures and hip fractures in a meta-analysis of data from 11 randomized, controlled trials.

But the benefit from vitamin D appeared blunted when combined with a higher calcium dose, or when patients received vitamin D once yearly, Dr. Heike A. Bischoff-Ferrari reported.

In the meta-analysis, patients in the highest quartile for daily vitamin D intake, 792–2000 IU, had a statistically significant 14% reduced rate of any nonvertebral fracture and a significant 30% reduced rate of hip fractures after adjusting for age, gender, and type of dwelling, said Dr. Bischoff-Ferrari, a rheumatologist at the University of Zurich.

Her meta-analysis pooled individual participant data from 12 double-blind, randomized, controlled trials that examined the impact of vitamin D supplements on fracture rate in people aged 65 years or older published through June 2010, and for which she could obtain individual participant data. The primary analysis focused on the 11 studies of the 12 in which participants received the supplement at least monthly, with 31,022 people enrolled. The twelfth study tested once annual dosing, and the researchers included those data in a separate analysis. The participants' average age was 76 years, and about 90% were women.

The analysis divided the study subjects into the control group, with more than 15,000 people, and then into quartiles of their received amount of vitamin D, including both their study-treatment dose and any additional vitamin D intake. The analysis also took into account adherence to treatment. Each vitamin D quartile contained nearly 4,000 people, with a daily dose range of 792–2,000 IU forming the top quartile. Only the top quartile of vitamin intake linked with statistically significant differences, compared with the controls, for any nonvertebral fracture and for hip fracture.

An additional analysis that looked at the interaction of calcium supplements along with vitamin D showed that, with a daily calcium dose below 1,000 mg/day, a high-dose vitamin D supplement (792–2,000 IU/day) linked with a statistically significant reduction in nonvertebral fractures, but when the daily calcium supplement delivered 1,000 mg or more, this amount of vitamin D did not associate with any significant change in fracture rate, suggesting an adverse effect from higher calcium intake.

Vitals

Source ©Joss/Fotolia.com

Major Finding: People taking 792–2,000 IU/day of vitamin D had a statistically significant, 14% reduced rate of any nonvertebral fracture and a significant, 30% reduced rate of hip fractures compared with control subjects who did not receive a vitamin D supplement.

Data Source: Meta-analysis of 11 double-blind, randomized, controlled trials with individual participant data available for 31,022 subjects with an average age of 76.

Disclosures: Dr. Bischoff-Ferrari said that she had no disclosures.

TORONTO — A daily vitamin D dose of at least 792 IU was linked with significantly reduced rates of nonvertebral fractures and hip fractures in a meta-analysis of data from 11 randomized, controlled trials.

But the benefit from vitamin D appeared blunted when combined with a higher calcium dose, or when patients received vitamin D once yearly, Dr. Heike A. Bischoff-Ferrari reported.

In the meta-analysis, patients in the highest quartile for daily vitamin D intake, 792–2000 IU, had a statistically significant 14% reduced rate of any nonvertebral fracture and a significant 30% reduced rate of hip fractures after adjusting for age, gender, and type of dwelling, said Dr. Bischoff-Ferrari, a rheumatologist at the University of Zurich.

Her meta-analysis pooled individual participant data from 12 double-blind, randomized, controlled trials that examined the impact of vitamin D supplements on fracture rate in people aged 65 years or older published through June 2010, and for which she could obtain individual participant data. The primary analysis focused on the 11 studies of the 12 in which participants received the supplement at least monthly, with 31,022 people enrolled. The twelfth study tested once annual dosing, and the researchers included those data in a separate analysis. The participants' average age was 76 years, and about 90% were women.

The analysis divided the study subjects into the control group, with more than 15,000 people, and then into quartiles of their received amount of vitamin D, including both their study-treatment dose and any additional vitamin D intake. The analysis also took into account adherence to treatment. Each vitamin D quartile contained nearly 4,000 people, with a daily dose range of 792–2,000 IU forming the top quartile. Only the top quartile of vitamin intake linked with statistically significant differences, compared with the controls, for any nonvertebral fracture and for hip fracture.

An additional analysis that looked at the interaction of calcium supplements along with vitamin D showed that, with a daily calcium dose below 1,000 mg/day, a high-dose vitamin D supplement (792–2,000 IU/day) linked with a statistically significant reduction in nonvertebral fractures, but when the daily calcium supplement delivered 1,000 mg or more, this amount of vitamin D did not associate with any significant change in fracture rate, suggesting an adverse effect from higher calcium intake.

Vitals

Source ©Joss/Fotolia.com