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TOPLINE:
People with polycystic ovary syndrome (PCOS) may score lower on cognitive tests than people without the condition, a research showed. They also may have worse integrity of brain tissue as evident on an MRI.
METHODOLOGY:
- Researchers used data from the Coronary Artery Risk Development in Young Adults Women’s Study; individuals were 18-30 years old at the beginning of the study and were followed over 30 years.
- A little over 900 women were included in the study, of which 66 had PCOS, which was defined as having elevated androgen levels or self-reported hirsutism and irregular menstrual cycles more than 32 days apart.
- Study participants completed tests measuring verbal learning and memory, processing speed and executive function, attention and cognitive control, and semantics and attention.
- Researchers analyzed brain white matter integrity for 291 of the individuals, including 25 with PCOS, who underwent MRI.
TAKEAWAY:
- Individuals with PCOS had worse memory, attention, and verbal ability scores than those without the disorder.
- MRI scans showed that those with PCOS had lower white matter integrity, an indicator of cognitive deficits, including poorer decision-making abilities.
- Those in the PCOS group were more likely to be White and have diabetes than those in the control group.
IN PRACTICE:
“This report of midlife cognition in PCOS raises a new concern about another potential comorbidity for individuals with this common disorder; given that up to 10% of women may be affected by PCOS, these results have important implications for public health at large,” the authors concluded.
SOURCE:
Heather G. Huddleston, MD, director of the PCOS Clinic at the UCSF Health, San Francisco, California, is the lead author of the study published in Neurology.
LIMITATIONS:
PCOS was determined on the basis of serum androgen levels and self-reporting of hirsutism and oligomenorrhea, so some cases may have been misclassified without the official diagnosis of a clinician.
DISCLOSURES:
The authors did not report any relevant financial conflicts. The study was funded by a grant from the University of California, San Francisco, California.
A version of this article appeared on Medscape.com.
TOPLINE:
People with polycystic ovary syndrome (PCOS) may score lower on cognitive tests than people without the condition, a research showed. They also may have worse integrity of brain tissue as evident on an MRI.
METHODOLOGY:
- Researchers used data from the Coronary Artery Risk Development in Young Adults Women’s Study; individuals were 18-30 years old at the beginning of the study and were followed over 30 years.
- A little over 900 women were included in the study, of which 66 had PCOS, which was defined as having elevated androgen levels or self-reported hirsutism and irregular menstrual cycles more than 32 days apart.
- Study participants completed tests measuring verbal learning and memory, processing speed and executive function, attention and cognitive control, and semantics and attention.
- Researchers analyzed brain white matter integrity for 291 of the individuals, including 25 with PCOS, who underwent MRI.
TAKEAWAY:
- Individuals with PCOS had worse memory, attention, and verbal ability scores than those without the disorder.
- MRI scans showed that those with PCOS had lower white matter integrity, an indicator of cognitive deficits, including poorer decision-making abilities.
- Those in the PCOS group were more likely to be White and have diabetes than those in the control group.
IN PRACTICE:
“This report of midlife cognition in PCOS raises a new concern about another potential comorbidity for individuals with this common disorder; given that up to 10% of women may be affected by PCOS, these results have important implications for public health at large,” the authors concluded.
SOURCE:
Heather G. Huddleston, MD, director of the PCOS Clinic at the UCSF Health, San Francisco, California, is the lead author of the study published in Neurology.
LIMITATIONS:
PCOS was determined on the basis of serum androgen levels and self-reporting of hirsutism and oligomenorrhea, so some cases may have been misclassified without the official diagnosis of a clinician.
DISCLOSURES:
The authors did not report any relevant financial conflicts. The study was funded by a grant from the University of California, San Francisco, California.
A version of this article appeared on Medscape.com.
TOPLINE:
People with polycystic ovary syndrome (PCOS) may score lower on cognitive tests than people without the condition, a research showed. They also may have worse integrity of brain tissue as evident on an MRI.
METHODOLOGY:
- Researchers used data from the Coronary Artery Risk Development in Young Adults Women’s Study; individuals were 18-30 years old at the beginning of the study and were followed over 30 years.
- A little over 900 women were included in the study, of which 66 had PCOS, which was defined as having elevated androgen levels or self-reported hirsutism and irregular menstrual cycles more than 32 days apart.
- Study participants completed tests measuring verbal learning and memory, processing speed and executive function, attention and cognitive control, and semantics and attention.
- Researchers analyzed brain white matter integrity for 291 of the individuals, including 25 with PCOS, who underwent MRI.
TAKEAWAY:
- Individuals with PCOS had worse memory, attention, and verbal ability scores than those without the disorder.
- MRI scans showed that those with PCOS had lower white matter integrity, an indicator of cognitive deficits, including poorer decision-making abilities.
- Those in the PCOS group were more likely to be White and have diabetes than those in the control group.
IN PRACTICE:
“This report of midlife cognition in PCOS raises a new concern about another potential comorbidity for individuals with this common disorder; given that up to 10% of women may be affected by PCOS, these results have important implications for public health at large,” the authors concluded.
SOURCE:
Heather G. Huddleston, MD, director of the PCOS Clinic at the UCSF Health, San Francisco, California, is the lead author of the study published in Neurology.
LIMITATIONS:
PCOS was determined on the basis of serum androgen levels and self-reporting of hirsutism and oligomenorrhea, so some cases may have been misclassified without the official diagnosis of a clinician.
DISCLOSURES:
The authors did not report any relevant financial conflicts. The study was funded by a grant from the University of California, San Francisco, California.
A version of this article appeared on Medscape.com.
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All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>People with polycystic ovary syndrome (PCOS) may score lower on cognitive tests than people without the condition, a research showed. They also may have worse i</metaDescription> <articlePDF/> <teaserImage/> <teaser>Individuals with PCOS had worse memory, attention, and verbal ability scores than those without the disorder.</teaser> <title>Polycystic Ovary Syndrome Associated With Midlife Memory, Thinking Problems</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>cpn</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>fp</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>im</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>ob</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> <publicationData> <publicationCode>nr</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> <journalTitle>Neurology Reviews</journalTitle> <journalFullTitle>Neurology Reviews</journalFullTitle> <copyrightStatement>2018 Frontline Medical Communications Inc.,</copyrightStatement> </publicationData> </publications_g> <publications> <term>9</term> <term>15</term> <term>21</term> <term canonical="true">23</term> <term>22</term> </publications> <sections> <term>27970</term> <term canonical="true">39313</term> </sections> <topics> <term>180</term> <term>230</term> <term>322</term> <term>258</term> <term canonical="true">218</term> </topics> <links/> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Polycystic Ovary Syndrome Associated With Midlife Memory, Thinking Problems</title> <deck/> </itemMeta> <itemContent> <h2>TOPLINE:</h2> <p>People with <span class="Hyperlink"><a href="https://emedicine.medscape.com/article/256806-overview">polycystic ovary syndrome</a></span> (PCOS) may score lower on cognitive tests than people without the condition, a research showed. They also may have worse integrity of brain tissue as evident on an MRI.</p> <h2>METHODOLOGY:</h2> <ul class="body"> <li>Researchers used data from the Coronary Artery Risk Development in Young Adults Women’s Study; individuals were 18-30 years old at the beginning of the study and were followed over 30 years.</li> <li>A little over 900 women were included in the study, of which 66 had PCOS, which was defined as having elevated androgen levels or self-reported <a href="https://emedicine.medscape.com/article/121038-overview">hirsutism</a> and irregular menstrual cycles more than 32 days apart.</li> <li>Study participants completed tests measuring verbal learning and memory, processing speed and executive function, attention and cognitive control, and semantics and attention.</li> <li>Researchers analyzed brain white matter integrity for 291 of the individuals, including 25 with PCOS, who underwent MRI.</li> </ul> <h2>TAKEAWAY:</h2> <ul class="body"> <li>Individuals with PCOS had worse memory, attention, and verbal ability scores than those without the disorder.</li> <li>MRI scans showed that those with PCOS had lower white matter integrity, an indicator of <a href="https://emedicine.medscape.com/article/917629-overview">cognitive deficits</a>, including poorer decision-making abilities.</li> <li>Those in the PCOS group were more likely to be White and have diabetes than those in the control group.</li> </ul> <h2>IN PRACTICE:</h2> <p>“This report of midlife cognition in PCOS raises a new concern about another potential comorbidity for individuals with this common disorder; given that up to 10% of women may be affected by PCOS, these results have important implications for public health at large,” the authors concluded.</p> <h2>SOURCE:</h2> <p>Heather G. Huddleston, MD, director of the PCOS Clinic at the UCSF Health, San Francisco, California, is the lead author of the study <span class="Hyperlink"><a href="https://www.neurology.org/doi/10.1212/WNL.0000000000208104">published in Neurology</a></span>.</p> <h2>LIMITATIONS:</h2> <p>PCOS was determined on the basis of serum androgen levels and self-reporting of hirsutism and oligomenorrhea, so some cases may have been misclassified without the official diagnosis of a clinician.</p> <h2>DISCLOSURES:</h2> <p>The authors did not report any relevant financial conflicts. The study was funded by a grant from the University of California, San Francisco, California.<span class="end"/></p> <p> <em>A version of this article appeared on <span class="Hyperlink"><a href="https://www.medscape.com/viewarticle/polycystic-ovary-syndrome-associated-midlife-memory-thinking-2024a100028m">Medscape.com</a></span>.</em> </p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> </itemContent> </newsItem> </itemSet></root>