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Sertraline effective for children and adolescents with major depression
PRACTICE RECOMMENDATIONS

Sertraline (Zoloft) is effective and generally well tolerated for the short-term treatment of major depressive disorder in both children and adolescents.

Although the studies were not powered to detect a difference in efficacy and safety between age groups, decreased efficacy and increased side effects were seen in children ages 6 to 11 years. Because treatment with sertraline was only studied for 10 weeks, the efficacy and safety of long-term treatment remain unknown.

 
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Practice Recommendations from Key Studies

Wagner KD, Ambrosini P, Rynn M, et al. Efficacy of sertra-line in the treatment of children and adolescents with major depressive disorder. Two randomized controlled trials. JAMA 2003; 290:1033–1041.

Kimberly Hritzak, PharmD, Resident
Nicole S. Culhane, PharmD, BCPS
Wilkes University, Nesbitt School of Pharmacy, Wyoming Valley Family Practice Residency, Wilkes-Barre, Pa. E-mail: sparano@wilkes.edu.

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The Journal of Family Practice - 53(1)
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Practice Recommendations from Key Studies

Wagner KD, Ambrosini P, Rynn M, et al. Efficacy of sertra-line in the treatment of children and adolescents with major depressive disorder. Two randomized controlled trials. JAMA 2003; 290:1033–1041.

Kimberly Hritzak, PharmD, Resident
Nicole S. Culhane, PharmD, BCPS
Wilkes University, Nesbitt School of Pharmacy, Wyoming Valley Family Practice Residency, Wilkes-Barre, Pa. E-mail: sparano@wilkes.edu.

Author and Disclosure Information

Practice Recommendations from Key Studies

Wagner KD, Ambrosini P, Rynn M, et al. Efficacy of sertra-line in the treatment of children and adolescents with major depressive disorder. Two randomized controlled trials. JAMA 2003; 290:1033–1041.

Kimberly Hritzak, PharmD, Resident
Nicole S. Culhane, PharmD, BCPS
Wilkes University, Nesbitt School of Pharmacy, Wyoming Valley Family Practice Residency, Wilkes-Barre, Pa. E-mail: sparano@wilkes.edu.

Article PDF
Article PDF
PRACTICE RECOMMENDATIONS

Sertraline (Zoloft) is effective and generally well tolerated for the short-term treatment of major depressive disorder in both children and adolescents.

Although the studies were not powered to detect a difference in efficacy and safety between age groups, decreased efficacy and increased side effects were seen in children ages 6 to 11 years. Because treatment with sertraline was only studied for 10 weeks, the efficacy and safety of long-term treatment remain unknown.

 
PRACTICE RECOMMENDATIONS

Sertraline (Zoloft) is effective and generally well tolerated for the short-term treatment of major depressive disorder in both children and adolescents.

Although the studies were not powered to detect a difference in efficacy and safety between age groups, decreased efficacy and increased side effects were seen in children ages 6 to 11 years. Because treatment with sertraline was only studied for 10 weeks, the efficacy and safety of long-term treatment remain unknown.

 
Issue
The Journal of Family Practice - 53(1)
Issue
The Journal of Family Practice - 53(1)
Page Number
8-24
Page Number
8-24
Publications
Publications
Topics
Article Type
Display Headline
Sertraline effective for children and adolescents with major depression
Display Headline
Sertraline effective for children and adolescents with major depression
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