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TOPLINE:
and could serve as preventive, diagnostic, and therapeutic targets.
METHODOLOGY:
- The study population was drawn from patients who underwent surgical resection of the primary colorectal tumor at a single center from 2000 to 2020.
- yoCRC was defined as CRC diagnosed before age 50 years, and aoCRC was defined as CRC diagnosed after age 60 years. Patients aged between 50 and 60 years at diagnosis were excluded to ensure two distinct cohorts for meaningful comparison.
- Researchers used various gene sequencing technologies to compare tissue samples from 136 patients with yoCRC against samples from 140 patients with aoCRC.
TAKEAWAY:
- Patients with yoCRC vs those with aoCRC were more likely to have left-sided (72.8% vs 54.3%), rectal (36.7% vs 25%), and stage IV (28% vs 15%) tumors.
- yoCRC and aoCRC tumors had distinct microbial profiles associated with tumor location, sidedness, and stage, and obesity.
- yoCRC tumors had significantly higher microbial alpha diversity and varied beta diversity than aoCRC tumors.
- yoCRC tumors were enriched with Akkermansia and Bacteroides, whereas aoCRC tumors showed greater relative abundances of Bacillus, Staphylococcus, Listeria, Enterococcus, Pseudomonas, Fusobacterium, and Escherichia/Shigella.
- In yoCRC, Fusobacterium and Akkermansia abundance correlated with overall survival.
IN PRACTICE:
“[O]ur findings help to comprehensively define the microbial community that may play a role in young-onset colorectal oncogenesis [and] should encourage the evaluation of environmental and lifestyle risk factors that might contribute to microbial dysbiosis in this patient population,” the authors wrote.
SOURCE:
The study, led by Shimoli V. Barot, MD, Cleveland Clinic, Ohio was published online in eBioMedicine.
LIMITATIONS:
The study had several limitations. It was a single-institution retrospective study with limited diversity in terms of race/ethnicity. Smoking and aspirin use were higher among older participants, whereas the yoCRC group had higher rates of neoadjuvant therapy and metastesectomy. Data on factors affecting the microbiome around the time of specimen collection, such as diet, stress, and antibiotic and probiotic use, were limited and not adjusted for in the analysis.
DISCLOSURES:
The study was funded by the Sondra and Stephen Hardis Chair in Oncology Research. Two coauthors report fees and research funding from industry. Barot and the other coauthors report no conflicts of interest.
A version of this article appeared on Medscape.com.
TOPLINE:
and could serve as preventive, diagnostic, and therapeutic targets.
METHODOLOGY:
- The study population was drawn from patients who underwent surgical resection of the primary colorectal tumor at a single center from 2000 to 2020.
- yoCRC was defined as CRC diagnosed before age 50 years, and aoCRC was defined as CRC diagnosed after age 60 years. Patients aged between 50 and 60 years at diagnosis were excluded to ensure two distinct cohorts for meaningful comparison.
- Researchers used various gene sequencing technologies to compare tissue samples from 136 patients with yoCRC against samples from 140 patients with aoCRC.
TAKEAWAY:
- Patients with yoCRC vs those with aoCRC were more likely to have left-sided (72.8% vs 54.3%), rectal (36.7% vs 25%), and stage IV (28% vs 15%) tumors.
- yoCRC and aoCRC tumors had distinct microbial profiles associated with tumor location, sidedness, and stage, and obesity.
- yoCRC tumors had significantly higher microbial alpha diversity and varied beta diversity than aoCRC tumors.
- yoCRC tumors were enriched with Akkermansia and Bacteroides, whereas aoCRC tumors showed greater relative abundances of Bacillus, Staphylococcus, Listeria, Enterococcus, Pseudomonas, Fusobacterium, and Escherichia/Shigella.
- In yoCRC, Fusobacterium and Akkermansia abundance correlated with overall survival.
IN PRACTICE:
“[O]ur findings help to comprehensively define the microbial community that may play a role in young-onset colorectal oncogenesis [and] should encourage the evaluation of environmental and lifestyle risk factors that might contribute to microbial dysbiosis in this patient population,” the authors wrote.
SOURCE:
The study, led by Shimoli V. Barot, MD, Cleveland Clinic, Ohio was published online in eBioMedicine.
LIMITATIONS:
The study had several limitations. It was a single-institution retrospective study with limited diversity in terms of race/ethnicity. Smoking and aspirin use were higher among older participants, whereas the yoCRC group had higher rates of neoadjuvant therapy and metastesectomy. Data on factors affecting the microbiome around the time of specimen collection, such as diet, stress, and antibiotic and probiotic use, were limited and not adjusted for in the analysis.
DISCLOSURES:
The study was funded by the Sondra and Stephen Hardis Chair in Oncology Research. Two coauthors report fees and research funding from industry. Barot and the other coauthors report no conflicts of interest.
A version of this article appeared on Medscape.com.
TOPLINE:
and could serve as preventive, diagnostic, and therapeutic targets.
METHODOLOGY:
- The study population was drawn from patients who underwent surgical resection of the primary colorectal tumor at a single center from 2000 to 2020.
- yoCRC was defined as CRC diagnosed before age 50 years, and aoCRC was defined as CRC diagnosed after age 60 years. Patients aged between 50 and 60 years at diagnosis were excluded to ensure two distinct cohorts for meaningful comparison.
- Researchers used various gene sequencing technologies to compare tissue samples from 136 patients with yoCRC against samples from 140 patients with aoCRC.
TAKEAWAY:
- Patients with yoCRC vs those with aoCRC were more likely to have left-sided (72.8% vs 54.3%), rectal (36.7% vs 25%), and stage IV (28% vs 15%) tumors.
- yoCRC and aoCRC tumors had distinct microbial profiles associated with tumor location, sidedness, and stage, and obesity.
- yoCRC tumors had significantly higher microbial alpha diversity and varied beta diversity than aoCRC tumors.
- yoCRC tumors were enriched with Akkermansia and Bacteroides, whereas aoCRC tumors showed greater relative abundances of Bacillus, Staphylococcus, Listeria, Enterococcus, Pseudomonas, Fusobacterium, and Escherichia/Shigella.
- In yoCRC, Fusobacterium and Akkermansia abundance correlated with overall survival.
IN PRACTICE:
“[O]ur findings help to comprehensively define the microbial community that may play a role in young-onset colorectal oncogenesis [and] should encourage the evaluation of environmental and lifestyle risk factors that might contribute to microbial dysbiosis in this patient population,” the authors wrote.
SOURCE:
The study, led by Shimoli V. Barot, MD, Cleveland Clinic, Ohio was published online in eBioMedicine.
LIMITATIONS:
The study had several limitations. It was a single-institution retrospective study with limited diversity in terms of race/ethnicity. Smoking and aspirin use were higher among older participants, whereas the yoCRC group had higher rates of neoadjuvant therapy and metastesectomy. Data on factors affecting the microbiome around the time of specimen collection, such as diet, stress, and antibiotic and probiotic use, were limited and not adjusted for in the analysis.
DISCLOSURES:
The study was funded by the Sondra and Stephen Hardis Chair in Oncology Research. Two coauthors report fees and research funding from industry. Barot and the other coauthors report no conflicts of interest.
A version of this article appeared on Medscape.com.