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Hematologic Malignancies of the Breast Studied
South Med J; 2017 Oct; Alsadi, Lin, Alnajar, et al
Primary hematological malignancies of the breast occur more frequently than secondary malignancies, according to a retrospective review involving 52 hematologic neoplasms. Investigators looked at hematologic neoplasms diagnosed in breast tissue over a 22-year period ending in 2014, analyzing clinical characteristics, patient history, histologic subtype, and outcomes. There were 46 lymphomas, 4 plasmacytomas, and 2 myeloid sarcomas. 30 cases were primary and 22 secondary to the breast. Lymphoma breakdown was:
- Diffuse large B-cell lymphomas: 15.
- Follicular lymphomas (FL): 14.
- Marginal zone lymphomas (MZL): 8.
- Anaplastic large T-cell lymphomas and peripheral T-cell lymphomas-not otherwise specified: 2 each.
- Small lymphocytic lymphoma, Burkitt lymphoma, mantle cell lymphoma, B-cell lymphoblastic lymphoma, and T-cell lymphoblastic lymphoma: 1 each.
Primary lymphomas accounted for 6 in every 10 of lymphomas. Most FLs and almost all MZLs were primary.
Alsadi A, Lin D, Alnajar H, Brickman A, Martyn C, Gattuso P. Hematologic malignancies discovered on investigation of breast abnormalities. South Med J. 2017;110(10):614-620. doi:10.14423/SMJ.0000000000000710.
This Week's Must Reads
Must Reads in Hematologic Malignancies
Long-term ibrutinib data in older patients, Barr PM et al. Haematologica. 2018;103(9):1502-10
Prognostic Score System for Patients with PMF, J Clin Oncol; ePub 2017 Dec 9; Gugliemelli, et al
These Patients Are More Apt to Be Depressed, Ann Hematol; ePub 2017 Dec 7; Shreders, et al
Survival Length Shortest in These Patients with MF, Eur J Haematol; ePub 2017 Dec 11; Masarova, et al
The Value of Ruxolitinib Before and After AlloSCT, Blood; ePub 2017 Dec 7; Poulose, Malysz, et al