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Gleason grade 4 at positive surgical margin is predictive of aggressive prostate cancer
Key clinical point: Gleason grade 4 (GG4) at a positive surgical margin (PSM) after radical prostatectomy is a feature of aggressive prostate cancer that is associated with an increased risk of biochemical recurrence (BCR).
Major finding: GG4 at a PSM had a significant association with BCR compared with GG3 (pooled hazard ratio, 1.87; 95% confidence interval, 1.53-2.28; z = 5.87).
Study details: A meta-analysis of 6 studies, comprising 1,863 patients.
Disclosures: The authors declared no conflict of interest.
Citation:
Lysenko I et al. Clin Genitourin Cancer. 2020 Mar 4. doi: 10.1016/j.clgc.2020.02.011.