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Single-Nucleotide Polymorphisms Sequencing Identifies Candidate Functional Variants at PCa Risk Loci
Key clinical point: The experimental data along with bioinformatic tools provides a strategy for identifying candidate functional elements at prostate cancer susceptibility loci to help guide subsequent laboratory studies.
Major finding: Clinical association analysis of the 2 candidate genes showed that CTBP2 was upregulated, while NCOA4 was downregulated in prostate cancer.
Study details: Allele-dependent protein binding at 903 SNP sites covering 28 genomic regions were tested.
Citation:
Zhang P, et al. Genes (Basel). 2019 Jul 18;10(7). doi: 10.3390/genes10070547.