Key clinical point: Prepregnancy migraine history was associated with a higher risk for adverse pregnancy outcomes, including preterm delivery, preeclampsia, and gestational hypertension.
Major finding: Participants with vs without a history of prepregnancy migraine were at a 17% increased risk for preterm delivery (adjusted relative risk [aRR] 1.17; 95% CI 1.05-1.30), 28% higher risk for gestational hypertension (aRR 1.28; 95% CI 1.11-1.48), and 40% greater risk for preeclampsia (aRR 1.40; 95% CI 1.19-1.65).
Study details: This prospective cohort study evaluated 30,555 incident pregnancies in 19,694 participants, of which 11.3% of participants reported a history of physician-diagnosed migraine with or without aura.
Disclosures: This study was supported by the US National Institutes of Health (NIH). Six authors declared receiving support from NIH unrelated to this study and reported ties with various sources.
Source: Purdue-Smithe AC et al. Prepregnancy migraine, migraine phenotype, and risk of adverse pregnancy outcomes. Neurology. 2023 (Jan 19). Doi: 10.1212/WNL.0000000000206831