Key clinical point: Higher dietary intakes of vitamin B 6 and folate were significantly associated with a lower risk for severe headaches or migraines, with a synergistic interaction observed between vitamin B 6 and folate intake and reduced migraine risk.
Major finding: Compared with the lowest quintile of dietary vitamin B 6 (≤1.13 mg/day) and folate (≤240 μg/day) intake, the risk for severe headache or migraine was lower in the highest quintile of vitamin B 6 (≥2.39 mg/day; adjusted odds ratio [aOR] 0.66; P = .01) and folate (≥502.01 μg/day; aOR 0.57; P = .002) intake. A synergistic interaction was observed between the high mass of vitamin B 6 and folate intake and a lower risk for severe headache or migraine (synergy index 0.58; 95% CI 0.40-0.83).
Study details: This cross-sectional study included 7017 adult participants (age ≥ 20 years), of whom 1350 (19.23%) had migraine.
Disclosures: This study was supported by the National Natural Science Foundation of China, Natural Science Foundation of Jiangxi Province, and others. No conflicts of interests were declared.
Source: Tian S et al. Vitamin B 6 and folate intake are associated with lower risk of severe headache or migraine in adults: An analysis based on NHANES 1999-2004. Nutr Res. 2023;121:51-60 (Nov 15). doi: 10.1016/j.nutres.2023.11.008