Clinical Edge Journal Scan

Diphenhydramine and Prochlorperazine Combo Not Associated With Migraine Treatment Failure


 

Key clinical point: The odds of treatment failure were not increased, and no extrapyramidal adverse events were reported in pediatric patients with migraine when diphenhydramine was coadministered with prochlorperazine in an emergency department (ED) setting.

Major finding: The administration of diphenhydramine plus prochlorperazine vs prochlorperazine alone was not associated with increased odds of additional migraine therapy (P = .347), hospitalization rates (P = .425), and 72-hour return visit rates (P = .271). None of the patients in the diphenhydramine plus prochlorperazine group experienced extrapyramidal adverse events, while 2.4% of patients in prochlorperazine group experienced extrapyramidal adverse events.

Study details: Findings are from a retrospective cohort study that included 1683 pediatric patients with migraine presenting to the ED who received diphenhydramine plus prochlorperazine (n = 1215) or prochlorperazine only (n = 468).

Disclosures: This study did not disclose any funding source. The authors declared no conflicts of interest.

Source: Naeem S, Lozano JM, Ruiz Castaneda AM, Lowe D. Diphenhydramine and migraine treatment failure in pediatric patients receiving prochlorperazine. Pediatr Emerg Care. 2024 (May 9). doi: 10.1097/PEC.0000000000003202 Source

Recommended Reading

Migraine Treatment Outcomes
Migraine ICYMI
Migraine Tied to Higher Vascular Dementia Risk
Migraine ICYMI
Photophobia Impairs Sleep Quality in Migraine
Migraine ICYMI
Migraine Diagnosis Shortens Exclusive Breastfeeding Period in Women
Migraine ICYMI
Meta-analysis Compares Effectiveness of Parenteral Agents for Migraine Pain in ED
Migraine ICYMI
Rimegepant Effective and Well Tolerated for Acute Migraine
Migraine ICYMI
Meta-analysis Shows Inverse Correlation Between PACAP and Migraine Duration
Migraine ICYMI
Study Shows Reciprocal Causal Association Between Migraine and Venous Thromboembolism
Migraine ICYMI
Severe Headache or Migraine Raises Risk for Erectile Dysfunction
Migraine ICYMI
Amitriptyline May Be a Better Treatment Choice Than Cinnarizine for Pediatric Migraine
Migraine ICYMI