Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Genome study examines heritability of psoriatic disease subtypes

Publish date:: April 2, 2020

Key clinical point: Cutaneous psoriasis shows greater heritability than psoriatic arthritis or psoriasis vulgaris.

Major finding: Genetic variants make a greater contribution to phenotypic variation in cutaneous psoriasis.

Study details: An analysis of a genome-wide association study involving 2,938 people with psoriasis vulgaris, 1,155 with cutaneous psoriasis, 715 with psoriatic arthritis, and 3,117 unaffected controls.

Disclosures: The study was supported by the Atlantic Innovation Fund. The authors reported having no conflicts of interest.

Citation:

Li Q et al. Sci Rep. 2020 Mar 18. doi: 10.1038/s41598-020-61981-5

This Week's Must Reads

Synovial, skin gene expression differences may explain PsA treatment responses,

Guselkumab improvements for psoriatic arthritis persist through 1 year,

Biologics may delay psoriatic arthritis, study finds,

PASDAS beats DAS28 in measuring psoriatic arthritis treat-to-target success,

Entheseal lesions, bone density linked with incident PsA in psoriasis patients,

Must Reads in Psoriasis

Synovial, skin gene expression differences may explain PsA treatment responses,

Biologics may delay psoriatic arthritis, study finds,

Biologics yield low rates of skin clearance in real-world psoriasis study,

Financial incentives affect the adoption of biosimilars,

Genome study examines heritability of psoriatic disease subtypes,