Clindamycin for vaginosis reduces prematurity and late miscarriage

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Clindamycin for vaginosis reduces prematurity and late miscarriage
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Using oral clindamycin to treat women with asymptomatic bacterial vaginosis during their second trimester (between 12 and 22 weeks estimated gestational age) reduces the number of premature births and late miscarriages. The study did not demonstrate a difference in the number of neonatal intensive care unit admissions, mean birth weight, or gestational age.

This is the first study demonstrating benefits in treating asymptomatic bacterial vaginosis early in pregnancy. It still needs to be determined, in larger trials, whether generalized screening and treatment for asymptomatic bacterial vaginosis in the early second trimester is beneficial and cost-effective.

 
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Practice Recommendations from Key Studies

Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomized controlled trial. Lancet 2003; 361:983–988.

Aimo Berger, , MD
Kevin Y. Kane, MD, MSPH
Department of Family Medicine, University of Missouri–Columbia.

bergera@health.missouri.edu

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The Journal of Family Practice - 52(8)
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587-604
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Practice Recommendations from Key Studies

Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomized controlled trial. Lancet 2003; 361:983–988.

Aimo Berger, , MD
Kevin Y. Kane, MD, MSPH
Department of Family Medicine, University of Missouri–Columbia.

bergera@health.missouri.edu

Author and Disclosure Information

Practice Recommendations from Key Studies

Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: a randomized controlled trial. Lancet 2003; 361:983–988.

Aimo Berger, , MD
Kevin Y. Kane, MD, MSPH
Department of Family Medicine, University of Missouri–Columbia.

bergera@health.missouri.edu

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PRACTICE RECOMMENDATIONS

Using oral clindamycin to treat women with asymptomatic bacterial vaginosis during their second trimester (between 12 and 22 weeks estimated gestational age) reduces the number of premature births and late miscarriages. The study did not demonstrate a difference in the number of neonatal intensive care unit admissions, mean birth weight, or gestational age.

This is the first study demonstrating benefits in treating asymptomatic bacterial vaginosis early in pregnancy. It still needs to be determined, in larger trials, whether generalized screening and treatment for asymptomatic bacterial vaginosis in the early second trimester is beneficial and cost-effective.

 
PRACTICE RECOMMENDATIONS

Using oral clindamycin to treat women with asymptomatic bacterial vaginosis during their second trimester (between 12 and 22 weeks estimated gestational age) reduces the number of premature births and late miscarriages. The study did not demonstrate a difference in the number of neonatal intensive care unit admissions, mean birth weight, or gestational age.

This is the first study demonstrating benefits in treating asymptomatic bacterial vaginosis early in pregnancy. It still needs to be determined, in larger trials, whether generalized screening and treatment for asymptomatic bacterial vaginosis in the early second trimester is beneficial and cost-effective.

 
Issue
The Journal of Family Practice - 52(8)
Issue
The Journal of Family Practice - 52(8)
Page Number
587-604
Page Number
587-604
Publications
Publications
Topics
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Clindamycin for vaginosis reduces prematurity and late miscarriage
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Clindamycin for vaginosis reduces prematurity and late miscarriage
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