Deborah Ross, MSN, ANP

The Patient Needing Transition to Multiple Daily Insulin Injections

A 29‐year‐old male with T1DM, on CSII, was admitted for fever and chills. His latest glycated hemoglobin (HbA_1c) level was 6.8%. His glucose levels started rising, and he wished to be taken off the insulin pump. He was started by the primary team on multiple daily insulin injections (MDII) with insulin glargine and insulin lispro. His glucose levels continued to rise, so an intravenous (IV) insulin infusion was started. Endocrinology was then consulted. The patient's condition was concerning for the potential development of DKA, so he was kept on IV insulin. When he was ready for transitioning to subcutaneous insulin, the pump had been taken home by a family member, and the patient could not recall his CSII basal rates but knew his total basal insulin dose, carbohydrate ratio, and sensitivity factor. Endocrinology assisted in transitioning him from the insulin infusion to MDII based on these recalled doses. When the insulin pump was available, the pump settings were interrogated, and he was transitioned back to it.

Key points:

• Having key hospital personnel trained on CSII, including interrogating the pump's settings, facilitates the transitioning of these patients from one hospital unit, or level of care, to another.
• Accessing the pump's settings involves pushing several buttons on the insulin pump. Because key hospital personnel will encounter patients on different insulin pumps, it may be helpful to keep menu maps handy as a quick reference. A menu map will show at a glance where certain information can be found, such as the basal insulin rate or the sensitivity factor (see examples in Figures 1 and 2).[12, 13]
• Knowing the HbA_1c will help determine if pump use has been effective.

Figure 1

Figure 2

The Patient With Technical Problems

An 84‐year‐old gentleman with T2DM was admitted for heart failure and aortic valve replacement. His HbA_1c was 6.2%, and he had had several outpatient hypoglycemic events. While on CSII in the hospital, his point of care testing (POCT) glucose readings ranged from 105 to 260 mg/dL. On the afternoon of the third hospital day, POCT readings stayed above 220 mg/dL and rose to 348 mg/dL on the fourth hospital morning, despite multiple blousing and changing the insulin, insertion site, reservoir cartridge, and pump tubing. There was no evidence of infection and no medication change that would have impacted glucose levels. Review of his procedures revealed that he had undergone computed tomography (CT) on the morning of hospital day 3 and wore his pump while being scanned. The pump company was notified.

Key points:

• Patients, and medical and nursing staff, should be reminded to remove insulin pumps for CT scans, magnetic resonance imaging, x‐rays, or other tests with high electromagnetic fields.
• If there is a suspicion of pump malfunction from such a procedure, notify the pump company.

The Patient Who Can Benefit From Inpatient Education

A 70‐year‐old female with T1DM was admitted for heart failure. The patient had been using CSII for 20 years. Her latest HbA_1c was 6.9%. She had 1 hypoglycemic event every 1 to 2 weeks. In the hospital, she experienced 2 hypoglycemic events within 3 days, both around bedtime. It was discovered that the patient was giving a bolus of insulin for elevated glucose levels based on the hospital POCT, and when the meal arrived (3060 minutes later), she again delivered a bolus based on her own glucometer reading plus insulin based on the carbohydrates in her meal. The patient was then instructed to request the POCT when her meal tray arrived, and she was taught how to use the pump's built‐in calculator. Glucose excursions improved.

Key points:

• Patients on CSII, though able to exercise autonomy in managing their insulin doses, may also need assistance in dosing insulin properly.
• Although pump education is ideally done on an outpatient basis, hospital‐based providers may encounter patients who need reinforcement of their training while hospitalized. Hospital personnel trained on insulin pumps (such as physicians, nurse practitioners, physician assistants, and certified diabetes educators) can help augment the patient's knowledge while in the hospital. In the absence of such key personnel, patient safety has to be addressed with re‐evaluation of the need to discontinue the pump and switch to multiple doses of subcutaneous insulin.

Initial Patient Assessment

On admission, patients are asked whether they use an insulin pump. This is included in the nursing assessment form. If they do, the physician is notified.

The insulin pump might be missed unless specifically asked for because (1) the insulin pump may be thought of more as a device rather than a medication, and (2) the insulin pump may be worn in less obvious areas, not only on the abdomen where providers are more apt to detect it.

Hospital Policy and Insulin Orders

Written hospital policies on how to safely manage patients presenting with an insulin pump will delineate patients who can safely be allowed to continue on the pump, and the responsibilities that come along with this. Our institution has such a policy. Experts from both the legal and biomedical engineering departments were consulted when the policy was crafted. Patients must be fully alert, able, and willing to self‐manage the pump. General contraindications to pump use in the hospital, such as altered mental status or DKA, are listed in Table 1. In addition, patients in the intensive care units are best managed on an IV insulin infusion during their critical illness, in keeping with several society guidelines.[14] Controlling severe hyperglycemia and DKA with multiple boluses through the insulin pump can potentially lead to stacking of insulin with subsequent hypoglycemia.

In our institution, a computerized insulin pump order set has to be activated. Apart from insulin, POCT, and hypoglycemia‐management orders, this order set contains documents aimed at balancing patient autonomy with delivery of appropriate and safe medical care that the bedside nurse goes over with the patient (Table 2). By policy at our institution, insulin should be dispensed from the hospital's pharmacy (except for that already in the pump), so the order set is linked to the pharmacy and a 3‐mL insulin vial is delivered to the hospital floor and stored in the patient‐specific medication bin. The order set triggers an Endocrinology consult so that the patient can be assessed by key trained personnel.

Patient Diagnosis

It is important to try to distinguish T1DM vs T2DM, as patients with T1DM are prone to ketoacidosis when the pump is disconnected.

Patient Assessment by the Endocrinology Consult Service

Hospitalized patients on the pump have varying degrees of pump knowledge and skill sets. We have encountered highly trained patients who meticulously count their carbohydrates and double‐check the insulin doses calculated by the built‐in pump calculator, and those who have knowledge gaps because their physicians, and not they themselves, change pump settings at the clinic visits.

Therefore, the Endocrinology consult team members (comprising physicians, nurse practitioners, and certified diabetes educators) go through the following items to be able to order the insulin correctly, assess whether patients are still able and willing to continue on their pump despite their illness, formulate alternative insulin regimens as needed, or help empower patients who may have forgotten some aspects of pump management:

• Insulin pump manufacturer/model.
• Insulin used in the pump.
• Often fast‐acting insulin (lispro, aspart, or glulisine).
• Some patients use regular insulin.
• A few patients use U500 insulin (5 more potent than other insulins).
• Insulin doses/pump settings.

Patients are assessed for:

• Hypoglycemia awareness.
• Previous glucose control.
• Bolus calculation (either using the built‐in calculator, computing this mentally, or using a different calculator).
• Ability to deliver a bolus (including vision and dexterity challenges).
• Ability to change the basal rate, or set a temporary rate, and suspend insulin delivery.

Discussion on Options for Inpatient Management

After assessment, education is provided as needed. If there are concerns on the part of the patient, the primary team, or the Endocrinology team about safe continuation of CSII during the hospitalization, then alternative insulin regimens are discussed. Patients who cannot access their basal rates and cannot adjust the doses are not able to self‐manage; they should be taken off the pump and treated with multiple subcutaneous insulin doses. Conversion to MDII is discussed under Interruption of Continuous Subcutaneous Insulin Infusion for Short and Prolonged Periods.

Provision of Pump Information for Hospital Healthcare Providers

Users of CSII, even if perfectly competent using their pumps in the ambulatory setting, may need assistance in the hospital for various reasons. They may not know what to do for surgical or radiologic procedures (discussed below) and may not be familiar with hospital policies involving CSII. Hospital providers trained on insulin pumps may need a refresher on locating a particular pump setting.

The provider can call the toll‐free number on the back of the pump for assistance (Table 3). Insulin‐pump companies also have menu maps to aid in finding information on pump settings (samples shown in Figures 1 and 2).[12, 13] Documentation of the patient's pump settings will assist in CSII dose changes during the acute illness or assist in switching to MDII if needed. The following information need to be collected:

Point‐of‐Care Testing for Glucose Monitoring

Our policy specifies that the hospital glucose meter is the meter of record upon which dose adjustments are based. Point‐of‐care testing is performed by our patient care nursing assistants or bedside nurses. The timing is typically before meals, at bedtime, between 2 and 3 AM, and with allowance for other times that patients are used to checking when they were at home, such as after meals. Frequent POCT has to be especially borne in mind for patients with hypoglycemia unawareness. Some patients are used to checking with their own home glucose meters in between these times, and we do work with them with the understanding that dose‐change decisions are based on the hospital glucose meter readings.

Dose Adjustments

Continuous subcutaneous insulin infusion dose adjustments for hypoglycemia and hyperglycemia are usually done in 10% to 20% decrements/emncrements. Our Endocrinology team discusses these with the patients and ensures that the new settings are entered into the pump and into the order set.

Basal Dose

In most cases, these situations stretch for greater than 24 hours, such as surgery and the anticipated recovery from anesthesia. We favor long‐acting insulin for basal needs, given 2 hours before discontinuing the pump. The total basal insulin dose per day can be given as the starting long‐acting insulin dose and then adjusted as needed. The total daily basal insulin dose can be retrieved from the insulin pump. In one study on T1DM patients using insulin lispro on the pump, total daily basal dose was given as insulin glargine without adverse effects.[16] If there is concern for hypoglycemia, then the dose can be reduced by 10% to 20%. Care should be made to ascertain that the basal insulin delivered via the pump is appropriate.

There are several ways to estimate this:

• If the daily total basal and the total prandial insulin requirements approximate a 50:50 ratio, then the basal rate via the pump is appropriate.
• If the daily total basal rate via the pump is similar to a weight‐based estimate of the basal dose (often 0.150.2 units/kg/day in patients with T1DM, 0.20.3 units/kg/day for T2DM, and higher in both cases with longer duration of DM or greater insulin resistance), then the basal rate via the pump is appropriate.

Bolus Dose

Patients can still continue to calculate their sensitivity factor and carbohydrate ratio and request for the equivalent dose of insulin. In the ideal situation, bedside nurses would be taught how to calculate this ratio and dose rapid‐acting insulin accordingly should the patient need to come off the insulin pump. Because of the logistic difficulties of making this uniform in our institution, we have worked instead on providing patients with information on the carbohydrate content of their meal tray. If the pump is discontinued, the patient would continue to calculate their prandial insulin based on their carbohydrates ratio and indicate to the nurse how much he/she would need. Our subcutaneous insulin orders for MDII allow for us to put a range of insulin doses based on the patient's typical insulin needs for mealtime.

Pump Removal for Certain Hospital Procedures

Patients may not remember that the pump has to be removed before entering high‐radiation areas. The pump owner manuals tell patients not to use the pump when going for magnetic resonance imaging, CT scans, or x‐rays, or near equipment with high electromagnetic fields.

Interrogation of the Pump

If there is concern about pump malfunction, patients should be switched to MDII. The pump company can be contacted for pump interrogation and provision of a temporary pump (Table 3).

Pump Disconnection

In our institution, the Radiology department has signage instructing patients to inform the technician if they are wearing an insulin pump. The pump is handed off to a family member or stored until the procedure is over. Another option is to leave it with the bedside nurse or the floor nurse manager for safekeeping. This is less ideal, because the wait for the radiologic procedure might take longer than expected and the patient is left without any insulin on board.

Interruption of Continuous Subcutaneous Insulin Infusion for Surgical Procedures

In our institution, the anesthesiology department has worked with the Endocrinology, Surgery and Medicine departments regarding patients with insulin pumps. Discontinuation of CSII is recommended for surgical procedures longer than 1 hour; patients are asked to continue on the insulin pump until they are taken to the preoperative suite, at which point they are placed on IV insulin infusion. Ideally, there should be an overlap of 1530 minutes. Providing an alternative continuous source of insulin during pump interruption is important, especially for patients with T1DM.[17]

Pump Resumption

Once the patient is ready to resume the pump, any subcutaneous insulin that was delivered and might still be active has to be accounted for and subtracted from the basal pump dose so that hypoglycemia is avoided. An alternative would be to wait until the last basal subcutaneous insulin dose is expected to be cleared before restarting CSII.

The Patient Needing Transition to Multiple Daily Insulin Injections

A 29‐year‐old male with T1DM, on CSII, was admitted for fever and chills. His latest glycated hemoglobin (HbA_1c) level was 6.8%. His glucose levels started rising, and he wished to be taken off the insulin pump. He was started by the primary team on multiple daily insulin injections (MDII) with insulin glargine and insulin lispro. His glucose levels continued to rise, so an intravenous (IV) insulin infusion was started. Endocrinology was then consulted. The patient's condition was concerning for the potential development of DKA, so he was kept on IV insulin. When he was ready for transitioning to subcutaneous insulin, the pump had been taken home by a family member, and the patient could not recall his CSII basal rates but knew his total basal insulin dose, carbohydrate ratio, and sensitivity factor. Endocrinology assisted in transitioning him from the insulin infusion to MDII based on these recalled doses. When the insulin pump was available, the pump settings were interrogated, and he was transitioned back to it.

Key points:

• Having key hospital personnel trained on CSII, including interrogating the pump's settings, facilitates the transitioning of these patients from one hospital unit, or level of care, to another.
• Accessing the pump's settings involves pushing several buttons on the insulin pump. Because key hospital personnel will encounter patients on different insulin pumps, it may be helpful to keep menu maps handy as a quick reference. A menu map will show at a glance where certain information can be found, such as the basal insulin rate or the sensitivity factor (see examples in Figures 1 and 2).[12, 13]
• Knowing the HbA_1c will help determine if pump use has been effective.

Figure 1

Figure 2

The Patient With Technical Problems

An 84‐year‐old gentleman with T2DM was admitted for heart failure and aortic valve replacement. His HbA_1c was 6.2%, and he had had several outpatient hypoglycemic events. While on CSII in the hospital, his point of care testing (POCT) glucose readings ranged from 105 to 260 mg/dL. On the afternoon of the third hospital day, POCT readings stayed above 220 mg/dL and rose to 348 mg/dL on the fourth hospital morning, despite multiple blousing and changing the insulin, insertion site, reservoir cartridge, and pump tubing. There was no evidence of infection and no medication change that would have impacted glucose levels. Review of his procedures revealed that he had undergone computed tomography (CT) on the morning of hospital day 3 and wore his pump while being scanned. The pump company was notified.

Key points:

• Patients, and medical and nursing staff, should be reminded to remove insulin pumps for CT scans, magnetic resonance imaging, x‐rays, or other tests with high electromagnetic fields.
• If there is a suspicion of pump malfunction from such a procedure, notify the pump company.

The Patient Who Can Benefit From Inpatient Education

A 70‐year‐old female with T1DM was admitted for heart failure. The patient had been using CSII for 20 years. Her latest HbA_1c was 6.9%. She had 1 hypoglycemic event every 1 to 2 weeks. In the hospital, she experienced 2 hypoglycemic events within 3 days, both around bedtime. It was discovered that the patient was giving a bolus of insulin for elevated glucose levels based on the hospital POCT, and when the meal arrived (3060 minutes later), she again delivered a bolus based on her own glucometer reading plus insulin based on the carbohydrates in her meal. The patient was then instructed to request the POCT when her meal tray arrived, and she was taught how to use the pump's built‐in calculator. Glucose excursions improved.

Key points:

• Patients on CSII, though able to exercise autonomy in managing their insulin doses, may also need assistance in dosing insulin properly.
• Although pump education is ideally done on an outpatient basis, hospital‐based providers may encounter patients who need reinforcement of their training while hospitalized. Hospital personnel trained on insulin pumps (such as physicians, nurse practitioners, physician assistants, and certified diabetes educators) can help augment the patient's knowledge while in the hospital. In the absence of such key personnel, patient safety has to be addressed with re‐evaluation of the need to discontinue the pump and switch to multiple doses of subcutaneous insulin.

Initial Patient Assessment

On admission, patients are asked whether they use an insulin pump. This is included in the nursing assessment form. If they do, the physician is notified.

The insulin pump might be missed unless specifically asked for because (1) the insulin pump may be thought of more as a device rather than a medication, and (2) the insulin pump may be worn in less obvious areas, not only on the abdomen where providers are more apt to detect it.

Hospital Policy and Insulin Orders

Written hospital policies on how to safely manage patients presenting with an insulin pump will delineate patients who can safely be allowed to continue on the pump, and the responsibilities that come along with this. Our institution has such a policy. Experts from both the legal and biomedical engineering departments were consulted when the policy was crafted. Patients must be fully alert, able, and willing to self‐manage the pump. General contraindications to pump use in the hospital, such as altered mental status or DKA, are listed in Table 1. In addition, patients in the intensive care units are best managed on an IV insulin infusion during their critical illness, in keeping with several society guidelines.[14] Controlling severe hyperglycemia and DKA with multiple boluses through the insulin pump can potentially lead to stacking of insulin with subsequent hypoglycemia.

In our institution, a computerized insulin pump order set has to be activated. Apart from insulin, POCT, and hypoglycemia‐management orders, this order set contains documents aimed at balancing patient autonomy with delivery of appropriate and safe medical care that the bedside nurse goes over with the patient (Table 2). By policy at our institution, insulin should be dispensed from the hospital's pharmacy (except for that already in the pump), so the order set is linked to the pharmacy and a 3‐mL insulin vial is delivered to the hospital floor and stored in the patient‐specific medication bin. The order set triggers an Endocrinology consult so that the patient can be assessed by key trained personnel.

Patient Diagnosis

It is important to try to distinguish T1DM vs T2DM, as patients with T1DM are prone to ketoacidosis when the pump is disconnected.

Patient Assessment by the Endocrinology Consult Service

Hospitalized patients on the pump have varying degrees of pump knowledge and skill sets. We have encountered highly trained patients who meticulously count their carbohydrates and double‐check the insulin doses calculated by the built‐in pump calculator, and those who have knowledge gaps because their physicians, and not they themselves, change pump settings at the clinic visits.

Therefore, the Endocrinology consult team members (comprising physicians, nurse practitioners, and certified diabetes educators) go through the following items to be able to order the insulin correctly, assess whether patients are still able and willing to continue on their pump despite their illness, formulate alternative insulin regimens as needed, or help empower patients who may have forgotten some aspects of pump management:

• Insulin pump manufacturer/model.
• Insulin used in the pump.
• Often fast‐acting insulin (lispro, aspart, or glulisine).
• Some patients use regular insulin.
• A few patients use U500 insulin (5 more potent than other insulins).
• Insulin doses/pump settings.

Patients are assessed for:

• Hypoglycemia awareness.
• Previous glucose control.
• Bolus calculation (either using the built‐in calculator, computing this mentally, or using a different calculator).
• Ability to deliver a bolus (including vision and dexterity challenges).
• Ability to change the basal rate, or set a temporary rate, and suspend insulin delivery.

Discussion on Options for Inpatient Management

After assessment, education is provided as needed. If there are concerns on the part of the patient, the primary team, or the Endocrinology team about safe continuation of CSII during the hospitalization, then alternative insulin regimens are discussed. Patients who cannot access their basal rates and cannot adjust the doses are not able to self‐manage; they should be taken off the pump and treated with multiple subcutaneous insulin doses. Conversion to MDII is discussed under Interruption of Continuous Subcutaneous Insulin Infusion for Short and Prolonged Periods.

Provision of Pump Information for Hospital Healthcare Providers

Users of CSII, even if perfectly competent using their pumps in the ambulatory setting, may need assistance in the hospital for various reasons. They may not know what to do for surgical or radiologic procedures (discussed below) and may not be familiar with hospital policies involving CSII. Hospital providers trained on insulin pumps may need a refresher on locating a particular pump setting.

The provider can call the toll‐free number on the back of the pump for assistance (Table 3). Insulin‐pump companies also have menu maps to aid in finding information on pump settings (samples shown in Figures 1 and 2).[12, 13] Documentation of the patient's pump settings will assist in CSII dose changes during the acute illness or assist in switching to MDII if needed. The following information need to be collected:

Point‐of‐Care Testing for Glucose Monitoring

Our policy specifies that the hospital glucose meter is the meter of record upon which dose adjustments are based. Point‐of‐care testing is performed by our patient care nursing assistants or bedside nurses. The timing is typically before meals, at bedtime, between 2 and 3 AM, and with allowance for other times that patients are used to checking when they were at home, such as after meals. Frequent POCT has to be especially borne in mind for patients with hypoglycemia unawareness. Some patients are used to checking with their own home glucose meters in between these times, and we do work with them with the understanding that dose‐change decisions are based on the hospital glucose meter readings.

Dose Adjustments

Continuous subcutaneous insulin infusion dose adjustments for hypoglycemia and hyperglycemia are usually done in 10% to 20% decrements/emncrements. Our Endocrinology team discusses these with the patients and ensures that the new settings are entered into the pump and into the order set.

Basal Dose

In most cases, these situations stretch for greater than 24 hours, such as surgery and the anticipated recovery from anesthesia. We favor long‐acting insulin for basal needs, given 2 hours before discontinuing the pump. The total basal insulin dose per day can be given as the starting long‐acting insulin dose and then adjusted as needed. The total daily basal insulin dose can be retrieved from the insulin pump. In one study on T1DM patients using insulin lispro on the pump, total daily basal dose was given as insulin glargine without adverse effects.[16] If there is concern for hypoglycemia, then the dose can be reduced by 10% to 20%. Care should be made to ascertain that the basal insulin delivered via the pump is appropriate.

There are several ways to estimate this:

• If the daily total basal and the total prandial insulin requirements approximate a 50:50 ratio, then the basal rate via the pump is appropriate.
• If the daily total basal rate via the pump is similar to a weight‐based estimate of the basal dose (often 0.150.2 units/kg/day in patients with T1DM, 0.20.3 units/kg/day for T2DM, and higher in both cases with longer duration of DM or greater insulin resistance), then the basal rate via the pump is appropriate.

Bolus Dose

Patients can still continue to calculate their sensitivity factor and carbohydrate ratio and request for the equivalent dose of insulin. In the ideal situation, bedside nurses would be taught how to calculate this ratio and dose rapid‐acting insulin accordingly should the patient need to come off the insulin pump. Because of the logistic difficulties of making this uniform in our institution, we have worked instead on providing patients with information on the carbohydrate content of their meal tray. If the pump is discontinued, the patient would continue to calculate their prandial insulin based on their carbohydrates ratio and indicate to the nurse how much he/she would need. Our subcutaneous insulin orders for MDII allow for us to put a range of insulin doses based on the patient's typical insulin needs for mealtime.

Pump Removal for Certain Hospital Procedures

Patients may not remember that the pump has to be removed before entering high‐radiation areas. The pump owner manuals tell patients not to use the pump when going for magnetic resonance imaging, CT scans, or x‐rays, or near equipment with high electromagnetic fields.

Interrogation of the Pump

If there is concern about pump malfunction, patients should be switched to MDII. The pump company can be contacted for pump interrogation and provision of a temporary pump (Table 3).

Pump Disconnection

In our institution, the Radiology department has signage instructing patients to inform the technician if they are wearing an insulin pump. The pump is handed off to a family member or stored until the procedure is over. Another option is to leave it with the bedside nurse or the floor nurse manager for safekeeping. This is less ideal, because the wait for the radiologic procedure might take longer than expected and the patient is left without any insulin on board.

Interruption of Continuous Subcutaneous Insulin Infusion for Surgical Procedures

In our institution, the anesthesiology department has worked with the Endocrinology, Surgery and Medicine departments regarding patients with insulin pumps. Discontinuation of CSII is recommended for surgical procedures longer than 1 hour; patients are asked to continue on the insulin pump until they are taken to the preoperative suite, at which point they are placed on IV insulin infusion. Ideally, there should be an overlap of 1530 minutes. Providing an alternative continuous source of insulin during pump interruption is important, especially for patients with T1DM.[17]

Pump Resumption

Once the patient is ready to resume the pump, any subcutaneous insulin that was delivered and might still be active has to be accounted for and subtracted from the basal pump dose so that hypoglycemia is avoided. An alternative would be to wait until the last basal subcutaneous insulin dose is expected to be cleared before restarting CSII.

The Patient Needing Transition to Multiple Daily Insulin Injections

A 29‐year‐old male with T1DM, on CSII, was admitted for fever and chills. His latest glycated hemoglobin (HbA_1c) level was 6.8%. His glucose levels started rising, and he wished to be taken off the insulin pump. He was started by the primary team on multiple daily insulin injections (MDII) with insulin glargine and insulin lispro. His glucose levels continued to rise, so an intravenous (IV) insulin infusion was started. Endocrinology was then consulted. The patient's condition was concerning for the potential development of DKA, so he was kept on IV insulin. When he was ready for transitioning to subcutaneous insulin, the pump had been taken home by a family member, and the patient could not recall his CSII basal rates but knew his total basal insulin dose, carbohydrate ratio, and sensitivity factor. Endocrinology assisted in transitioning him from the insulin infusion to MDII based on these recalled doses. When the insulin pump was available, the pump settings were interrogated, and he was transitioned back to it.

Key points:

• Having key hospital personnel trained on CSII, including interrogating the pump's settings, facilitates the transitioning of these patients from one hospital unit, or level of care, to another.
• Accessing the pump's settings involves pushing several buttons on the insulin pump. Because key hospital personnel will encounter patients on different insulin pumps, it may be helpful to keep menu maps handy as a quick reference. A menu map will show at a glance where certain information can be found, such as the basal insulin rate or the sensitivity factor (see examples in Figures 1 and 2).[12, 13]
• Knowing the HbA_1c will help determine if pump use has been effective.

Figure 1

Figure 2

The Patient With Technical Problems

An 84‐year‐old gentleman with T2DM was admitted for heart failure and aortic valve replacement. His HbA_1c was 6.2%, and he had had several outpatient hypoglycemic events. While on CSII in the hospital, his point of care testing (POCT) glucose readings ranged from 105 to 260 mg/dL. On the afternoon of the third hospital day, POCT readings stayed above 220 mg/dL and rose to 348 mg/dL on the fourth hospital morning, despite multiple blousing and changing the insulin, insertion site, reservoir cartridge, and pump tubing. There was no evidence of infection and no medication change that would have impacted glucose levels. Review of his procedures revealed that he had undergone computed tomography (CT) on the morning of hospital day 3 and wore his pump while being scanned. The pump company was notified.

Key points:

• Patients, and medical and nursing staff, should be reminded to remove insulin pumps for CT scans, magnetic resonance imaging, x‐rays, or other tests with high electromagnetic fields.
• If there is a suspicion of pump malfunction from such a procedure, notify the pump company.

The Patient Who Can Benefit From Inpatient Education

A 70‐year‐old female with T1DM was admitted for heart failure. The patient had been using CSII for 20 years. Her latest HbA_1c was 6.9%. She had 1 hypoglycemic event every 1 to 2 weeks. In the hospital, she experienced 2 hypoglycemic events within 3 days, both around bedtime. It was discovered that the patient was giving a bolus of insulin for elevated glucose levels based on the hospital POCT, and when the meal arrived (3060 minutes later), she again delivered a bolus based on her own glucometer reading plus insulin based on the carbohydrates in her meal. The patient was then instructed to request the POCT when her meal tray arrived, and she was taught how to use the pump's built‐in calculator. Glucose excursions improved.

Key points:

• Patients on CSII, though able to exercise autonomy in managing their insulin doses, may also need assistance in dosing insulin properly.
• Although pump education is ideally done on an outpatient basis, hospital‐based providers may encounter patients who need reinforcement of their training while hospitalized. Hospital personnel trained on insulin pumps (such as physicians, nurse practitioners, physician assistants, and certified diabetes educators) can help augment the patient's knowledge while in the hospital. In the absence of such key personnel, patient safety has to be addressed with re‐evaluation of the need to discontinue the pump and switch to multiple doses of subcutaneous insulin.

Initial Patient Assessment

On admission, patients are asked whether they use an insulin pump. This is included in the nursing assessment form. If they do, the physician is notified.

The insulin pump might be missed unless specifically asked for because (1) the insulin pump may be thought of more as a device rather than a medication, and (2) the insulin pump may be worn in less obvious areas, not only on the abdomen where providers are more apt to detect it.

Hospital Policy and Insulin Orders

Written hospital policies on how to safely manage patients presenting with an insulin pump will delineate patients who can safely be allowed to continue on the pump, and the responsibilities that come along with this. Our institution has such a policy. Experts from both the legal and biomedical engineering departments were consulted when the policy was crafted. Patients must be fully alert, able, and willing to self‐manage the pump. General contraindications to pump use in the hospital, such as altered mental status or DKA, are listed in Table 1. In addition, patients in the intensive care units are best managed on an IV insulin infusion during their critical illness, in keeping with several society guidelines.[14] Controlling severe hyperglycemia and DKA with multiple boluses through the insulin pump can potentially lead to stacking of insulin with subsequent hypoglycemia.

In our institution, a computerized insulin pump order set has to be activated. Apart from insulin, POCT, and hypoglycemia‐management orders, this order set contains documents aimed at balancing patient autonomy with delivery of appropriate and safe medical care that the bedside nurse goes over with the patient (Table 2). By policy at our institution, insulin should be dispensed from the hospital's pharmacy (except for that already in the pump), so the order set is linked to the pharmacy and a 3‐mL insulin vial is delivered to the hospital floor and stored in the patient‐specific medication bin. The order set triggers an Endocrinology consult so that the patient can be assessed by key trained personnel.

Patient Diagnosis

It is important to try to distinguish T1DM vs T2DM, as patients with T1DM are prone to ketoacidosis when the pump is disconnected.

Patient Assessment by the Endocrinology Consult Service

Hospitalized patients on the pump have varying degrees of pump knowledge and skill sets. We have encountered highly trained patients who meticulously count their carbohydrates and double‐check the insulin doses calculated by the built‐in pump calculator, and those who have knowledge gaps because their physicians, and not they themselves, change pump settings at the clinic visits.

Therefore, the Endocrinology consult team members (comprising physicians, nurse practitioners, and certified diabetes educators) go through the following items to be able to order the insulin correctly, assess whether patients are still able and willing to continue on their pump despite their illness, formulate alternative insulin regimens as needed, or help empower patients who may have forgotten some aspects of pump management:

• Insulin pump manufacturer/model.
• Insulin used in the pump.
• Often fast‐acting insulin (lispro, aspart, or glulisine).
• Some patients use regular insulin.
• A few patients use U500 insulin (5 more potent than other insulins).
• Insulin doses/pump settings.

Patients are assessed for:

• Hypoglycemia awareness.
• Previous glucose control.
• Bolus calculation (either using the built‐in calculator, computing this mentally, or using a different calculator).
• Ability to deliver a bolus (including vision and dexterity challenges).
• Ability to change the basal rate, or set a temporary rate, and suspend insulin delivery.

Discussion on Options for Inpatient Management

After assessment, education is provided as needed. If there are concerns on the part of the patient, the primary team, or the Endocrinology team about safe continuation of CSII during the hospitalization, then alternative insulin regimens are discussed. Patients who cannot access their basal rates and cannot adjust the doses are not able to self‐manage; they should be taken off the pump and treated with multiple subcutaneous insulin doses. Conversion to MDII is discussed under Interruption of Continuous Subcutaneous Insulin Infusion for Short and Prolonged Periods.

Provision of Pump Information for Hospital Healthcare Providers

Users of CSII, even if perfectly competent using their pumps in the ambulatory setting, may need assistance in the hospital for various reasons. They may not know what to do for surgical or radiologic procedures (discussed below) and may not be familiar with hospital policies involving CSII. Hospital providers trained on insulin pumps may need a refresher on locating a particular pump setting.

The provider can call the toll‐free number on the back of the pump for assistance (Table 3). Insulin‐pump companies also have menu maps to aid in finding information on pump settings (samples shown in Figures 1 and 2).[12, 13] Documentation of the patient's pump settings will assist in CSII dose changes during the acute illness or assist in switching to MDII if needed. The following information need to be collected:

Point‐of‐Care Testing for Glucose Monitoring

Our policy specifies that the hospital glucose meter is the meter of record upon which dose adjustments are based. Point‐of‐care testing is performed by our patient care nursing assistants or bedside nurses. The timing is typically before meals, at bedtime, between 2 and 3 AM, and with allowance for other times that patients are used to checking when they were at home, such as after meals. Frequent POCT has to be especially borne in mind for patients with hypoglycemia unawareness. Some patients are used to checking with their own home glucose meters in between these times, and we do work with them with the understanding that dose‐change decisions are based on the hospital glucose meter readings.

Dose Adjustments

Continuous subcutaneous insulin infusion dose adjustments for hypoglycemia and hyperglycemia are usually done in 10% to 20% decrements/emncrements. Our Endocrinology team discusses these with the patients and ensures that the new settings are entered into the pump and into the order set.

Basal Dose

In most cases, these situations stretch for greater than 24 hours, such as surgery and the anticipated recovery from anesthesia. We favor long‐acting insulin for basal needs, given 2 hours before discontinuing the pump. The total basal insulin dose per day can be given as the starting long‐acting insulin dose and then adjusted as needed. The total daily basal insulin dose can be retrieved from the insulin pump. In one study on T1DM patients using insulin lispro on the pump, total daily basal dose was given as insulin glargine without adverse effects.[16] If there is concern for hypoglycemia, then the dose can be reduced by 10% to 20%. Care should be made to ascertain that the basal insulin delivered via the pump is appropriate.

There are several ways to estimate this:

• If the daily total basal and the total prandial insulin requirements approximate a 50:50 ratio, then the basal rate via the pump is appropriate.
• If the daily total basal rate via the pump is similar to a weight‐based estimate of the basal dose (often 0.150.2 units/kg/day in patients with T1DM, 0.20.3 units/kg/day for T2DM, and higher in both cases with longer duration of DM or greater insulin resistance), then the basal rate via the pump is appropriate.

Bolus Dose

Patients can still continue to calculate their sensitivity factor and carbohydrate ratio and request for the equivalent dose of insulin. In the ideal situation, bedside nurses would be taught how to calculate this ratio and dose rapid‐acting insulin accordingly should the patient need to come off the insulin pump. Because of the logistic difficulties of making this uniform in our institution, we have worked instead on providing patients with information on the carbohydrate content of their meal tray. If the pump is discontinued, the patient would continue to calculate their prandial insulin based on their carbohydrates ratio and indicate to the nurse how much he/she would need. Our subcutaneous insulin orders for MDII allow for us to put a range of insulin doses based on the patient's typical insulin needs for mealtime.

Pump Removal for Certain Hospital Procedures

Patients may not remember that the pump has to be removed before entering high‐radiation areas. The pump owner manuals tell patients not to use the pump when going for magnetic resonance imaging, CT scans, or x‐rays, or near equipment with high electromagnetic fields.

Interrogation of the Pump

If there is concern about pump malfunction, patients should be switched to MDII. The pump company can be contacted for pump interrogation and provision of a temporary pump (Table 3).

Pump Disconnection

In our institution, the Radiology department has signage instructing patients to inform the technician if they are wearing an insulin pump. The pump is handed off to a family member or stored until the procedure is over. Another option is to leave it with the bedside nurse or the floor nurse manager for safekeeping. This is less ideal, because the wait for the radiologic procedure might take longer than expected and the patient is left without any insulin on board.

Interruption of Continuous Subcutaneous Insulin Infusion for Surgical Procedures

In our institution, the anesthesiology department has worked with the Endocrinology, Surgery and Medicine departments regarding patients with insulin pumps. Discontinuation of CSII is recommended for surgical procedures longer than 1 hour; patients are asked to continue on the insulin pump until they are taken to the preoperative suite, at which point they are placed on IV insulin infusion. Ideally, there should be an overlap of 1530 minutes. Providing an alternative continuous source of insulin during pump interruption is important, especially for patients with T1DM.[17]

Pump Resumption

Once the patient is ready to resume the pump, any subcutaneous insulin that was delivered and might still be active has to be accounted for and subtracted from the basal pump dose so that hypoglycemia is avoided. An alternative would be to wait until the last basal subcutaneous insulin dose is expected to be cleared before restarting CSII.