Ezetimibe plus atorvastatin lowers cholesterol

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Ezetimibe plus atorvastatin lowers cholesterol
PRACTICE RECOMMENDATIONS

Ezetimibe plus atorvastatin lowers low-density lipoprotein (LDL) cholesterol more than either alone. When combined with low-dose atorvastatin (10 mg), ezetimibe achieves reductions similar to those seen with atorvastatin (80 mg) alone in LDL cholesterol, the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, and triglycerides.

Despite these modest reductions in cholesterol, this study does not provide evidence that this combination lessens cardiovascular morbidity or mortality. With this caveat, adding ezetimibe to atorvastatin may be a reasonable alternative for patients already on high-dose atorvastatin who either can’t reach target cholesterol levels or experience significant side effects.

 
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Ballantyne CM, Houri J, Notarbartolo A, et al. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003; 107:2409–2415.

Wendy S. Madigosky, MD
Kevin Y. Kane, MD, MSPH
Department of Family and Community Medicine, University of Missouri–Columbia. E-mail: madigoskyw@health.missouri.edu.

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The Journal of Family Practice - 52(9)
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664-688
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Author and Disclosure Information

Ballantyne CM, Houri J, Notarbartolo A, et al. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003; 107:2409–2415.

Wendy S. Madigosky, MD
Kevin Y. Kane, MD, MSPH
Department of Family and Community Medicine, University of Missouri–Columbia. E-mail: madigoskyw@health.missouri.edu.

Author and Disclosure Information

Ballantyne CM, Houri J, Notarbartolo A, et al. Effect of ezetimibe coadministered with atorvastatin in 628 patients with primary hypercholesterolemia: a prospective, randomized, double-blind trial. Circulation 2003; 107:2409–2415.

Wendy S. Madigosky, MD
Kevin Y. Kane, MD, MSPH
Department of Family and Community Medicine, University of Missouri–Columbia. E-mail: madigoskyw@health.missouri.edu.

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PRACTICE RECOMMENDATIONS

Ezetimibe plus atorvastatin lowers low-density lipoprotein (LDL) cholesterol more than either alone. When combined with low-dose atorvastatin (10 mg), ezetimibe achieves reductions similar to those seen with atorvastatin (80 mg) alone in LDL cholesterol, the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, and triglycerides.

Despite these modest reductions in cholesterol, this study does not provide evidence that this combination lessens cardiovascular morbidity or mortality. With this caveat, adding ezetimibe to atorvastatin may be a reasonable alternative for patients already on high-dose atorvastatin who either can’t reach target cholesterol levels or experience significant side effects.

 
PRACTICE RECOMMENDATIONS

Ezetimibe plus atorvastatin lowers low-density lipoprotein (LDL) cholesterol more than either alone. When combined with low-dose atorvastatin (10 mg), ezetimibe achieves reductions similar to those seen with atorvastatin (80 mg) alone in LDL cholesterol, the ratio of total cholesterol to high-density lipoprotein (HDL) cholesterol, and triglycerides.

Despite these modest reductions in cholesterol, this study does not provide evidence that this combination lessens cardiovascular morbidity or mortality. With this caveat, adding ezetimibe to atorvastatin may be a reasonable alternative for patients already on high-dose atorvastatin who either can’t reach target cholesterol levels or experience significant side effects.

 
Issue
The Journal of Family Practice - 52(9)
Issue
The Journal of Family Practice - 52(9)
Page Number
664-688
Page Number
664-688
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Ezetimibe plus atorvastatin lowers cholesterol
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