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Painful Skin Lesions on the Hands Following Black Henna Application
Author(s)
Canting Guo, BS
Ryan Sato, MD
Ilene Rothman, MD

The Diagnosis: Allergic Contact Dermatitis to 
Para-phenylenediamine

To darken the color of henna and increase penetrance and staining, para-phenylenediamine (PPD) is added.1 Allergic contact dermatitis is the most common type of hypersensitivity to PPD.2 A retrospective study that examined severe adverse events from applying henna dyes in children found that angioedema of mucosal tissues was the most common severe adverse event; others included renal failure and shock.3

Black henna is associated with multiple cultural practices. For example, Indian weddings contain a henna decoration ceremony for the bride based on the belief that the longer the henna lasts, the longer the marriage lasts. Black henna is favored for this practice, as it lasts longer than red henna.

 

Red henna tattoo on the palmar surfaces of the hands.
Red henna tattoo on the palmar surfaces of the hands.

Henna (Lawsonia inermis) is a plant that contains the molecule lawsone (naphthoquinone). Lawsone has an intense affinity for keratin; as a result, lawsone is frequently added to temporary body tattoos and hair dyes to create a relatively permanent change in skin or hair color.4 Henna is mixed with hennotannic acid to release the lawsone from the plant. Lawsone and hennotannic acid rarely cause allergic reactions.1,5-7 Once applied to skin, henna takes a few hours to dry, and the resulting color is orange to red.8 Often, PPD is added to henna paste to create a black color, to speed up the drying process, and to increase its longevity.

Para-phenylenediamine has been repeatedly reported to cause allergic contact dermatitis. We describe a case of allergic contact dermatitis secondary to PPD in black henna. Our patient is a clear example that PPD is the allergen in black henna given that there was no reaction to the natural red henna tattoo that was applied at the same time to the palmar surfaces of the hands (Figure). Aside from the bullous reaction to black henna dye described here, other reported presentations include erythema multiforme–like and exudative erythema reactions.9,10

Contact dermatitis lesions from black henna dye can be treated with topical corticosteroids. Patients may develop residual postinflammatory hyperpigmentation or hypopigmentation, leukoderma, keloids, or scars.1,11,12

References
  1. Onder M, Atahan CA, Oztas P, et al. Temporary henna tattoo reactions in children. Int J Dermatol. 2001;40:577-579.
  2. Marcoux D, Couture-Trudel PM, Rboulet-Delmas G, 
et al. Sensitization to paraphenylenediame from a streetside temporary tattoo. Pediatr Dermatol. 2002;19:498-502.
  3. Hashim S, Hamza Y, Yahia B, et al. Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum. Ann Trop Paediatr. 1992;12:3-6.
  4. Hijji Y, Barare B, Zhang Y. Lawsone (2- hydroxy-1, 
4-naphthoquinone) as a sensitive cyanide and acetate sensor. Sensors and Actuators B: Chemical. 2012;169:106-112.
  5. Neri I, Guareschi E, Savoia F, et al. Childhood allergic contact dermatitis from henna tattoo. Pediatr Dermatol. 2002;19:503-505.
  6. Evans CC, Fleming JD. Allergic contact dermatitis from a henna tattoo. N Engl J Med. 2008;359:627.
  7. Belhadjali H, Akkari H, Youssef M, et al. Bullous allergic contact dermatitis to pure henna in a 3-year-old girl. 
Pediatr Dermatol. 2011;28:580-581.
  8. Najem N, Bagher Zadeh V. Allergic contact dermatitis to black henna. Acta Dermatovenerol Alp Pannonica Adriat. 2011;20:87-88.
  9. Sidwell RU, Francis ND, Basarab T, et al. Vesicular erythema multiforme-like reaction to para-phenylenediamine in a henna tattoo. Pediatr Dermatol. 2008;25:201-204.
  10. Jovanovic DL, Slavkovic-Jovanovic MR. Allergic contact dermatitis from temporary henna tattoo. J Dermatol. 2009;36:63-65.
  11. Valsecchi R, Leghissa P, Di Landro A, et al. 
Persistent leukoderma after henna tattoo. Contact 
Dermatitis. 2007;56:108-109.
  12. Gunasti S, Aksungur VL. Severe inflammatory and keloidal, allergic reaction due to para-phenylenediamine in temporary tattoos. Indian J Dermatol Venereol Leprol. 2010;76:165-167.
Article PDF
CT096090005-e.pdf
Author and Disclosure Information

Dr. Guo is from the Department of Internal Medicine, Brown University, Providence, Rhode Island. Dr. Sato is from Sato Dermatology, Honolulu, Hawaii. Dr. Rothman is from the Department of Pediatric Dermatology, Women & Children’s Hospital of Buffalo, New York.

The authors report no conflict of interest.

Correspondence: Canting Guo, MD, Rhode Island Hospital, Jane Brown Building, 593 Eddy St, Providence, RI 02903 (cantingg@gmail.com).
 

Issue
Cutis - 96(3)
Publications
Cutis
MDedge Dermatology
Topics
Contact Dermatitis
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E5-E6
Legacy Keywords
black henna, para-phenylenediamine, allergic contact dermatitis
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Author(s)
Canting Guo, BS
Ryan Sato, MD
Ilene Rothman, MD
Author(s)
Canting Guo, BS
Ryan Sato, MD
Ilene Rothman, MD
Author and Disclosure Information

Dr. Guo is from the Department of Internal Medicine, Brown University, Providence, Rhode Island. Dr. Sato is from Sato Dermatology, Honolulu, Hawaii. Dr. Rothman is from the Department of Pediatric Dermatology, Women & Children’s Hospital of Buffalo, New York.

The authors report no conflict of interest.

Correspondence: Canting Guo, MD, Rhode Island Hospital, Jane Brown Building, 593 Eddy St, Providence, RI 02903 (cantingg@gmail.com).
 

Author and Disclosure Information

Dr. Guo is from the Department of Internal Medicine, Brown University, Providence, Rhode Island. Dr. Sato is from Sato Dermatology, Honolulu, Hawaii. Dr. Rothman is from the Department of Pediatric Dermatology, Women & Children’s Hospital of Buffalo, New York.

The authors report no conflict of interest.

Correspondence: Canting Guo, MD, Rhode Island Hospital, Jane Brown Building, 593 Eddy St, Providence, RI 02903 (cantingg@gmail.com).
 

Article PDF
CT096090005-e.pdf
Article PDF
CT096090005-e.pdf

The Diagnosis: Allergic Contact Dermatitis to 
Para-phenylenediamine

To darken the color of henna and increase penetrance and staining, para-phenylenediamine (PPD) is added.1 Allergic contact dermatitis is the most common type of hypersensitivity to PPD.2 A retrospective study that examined severe adverse events from applying henna dyes in children found that angioedema of mucosal tissues was the most common severe adverse event; others included renal failure and shock.3

Black henna is associated with multiple cultural practices. For example, Indian weddings contain a henna decoration ceremony for the bride based on the belief that the longer the henna lasts, the longer the marriage lasts. Black henna is favored for this practice, as it lasts longer than red henna.

 

Red henna tattoo on the palmar surfaces of the hands.
Red henna tattoo on the palmar surfaces of the hands.

Henna (Lawsonia inermis) is a plant that contains the molecule lawsone (naphthoquinone). Lawsone has an intense affinity for keratin; as a result, lawsone is frequently added to temporary body tattoos and hair dyes to create a relatively permanent change in skin or hair color.4 Henna is mixed with hennotannic acid to release the lawsone from the plant. Lawsone and hennotannic acid rarely cause allergic reactions.1,5-7 Once applied to skin, henna takes a few hours to dry, and the resulting color is orange to red.8 Often, PPD is added to henna paste to create a black color, to speed up the drying process, and to increase its longevity.

Para-phenylenediamine has been repeatedly reported to cause allergic contact dermatitis. We describe a case of allergic contact dermatitis secondary to PPD in black henna. Our patient is a clear example that PPD is the allergen in black henna given that there was no reaction to the natural red henna tattoo that was applied at the same time to the palmar surfaces of the hands (Figure). Aside from the bullous reaction to black henna dye described here, other reported presentations include erythema multiforme–like and exudative erythema reactions.9,10

Contact dermatitis lesions from black henna dye can be treated with topical corticosteroids. Patients may develop residual postinflammatory hyperpigmentation or hypopigmentation, leukoderma, keloids, or scars.1,11,12

The Diagnosis: Allergic Contact Dermatitis to 
Para-phenylenediamine

To darken the color of henna and increase penetrance and staining, para-phenylenediamine (PPD) is added.1 Allergic contact dermatitis is the most common type of hypersensitivity to PPD.2 A retrospective study that examined severe adverse events from applying henna dyes in children found that angioedema of mucosal tissues was the most common severe adverse event; others included renal failure and shock.3

Black henna is associated with multiple cultural practices. For example, Indian weddings contain a henna decoration ceremony for the bride based on the belief that the longer the henna lasts, the longer the marriage lasts. Black henna is favored for this practice, as it lasts longer than red henna.

 

Red henna tattoo on the palmar surfaces of the hands.
Red henna tattoo on the palmar surfaces of the hands.

Henna (Lawsonia inermis) is a plant that contains the molecule lawsone (naphthoquinone). Lawsone has an intense affinity for keratin; as a result, lawsone is frequently added to temporary body tattoos and hair dyes to create a relatively permanent change in skin or hair color.4 Henna is mixed with hennotannic acid to release the lawsone from the plant. Lawsone and hennotannic acid rarely cause allergic reactions.1,5-7 Once applied to skin, henna takes a few hours to dry, and the resulting color is orange to red.8 Often, PPD is added to henna paste to create a black color, to speed up the drying process, and to increase its longevity.

Para-phenylenediamine has been repeatedly reported to cause allergic contact dermatitis. We describe a case of allergic contact dermatitis secondary to PPD in black henna. Our patient is a clear example that PPD is the allergen in black henna given that there was no reaction to the natural red henna tattoo that was applied at the same time to the palmar surfaces of the hands (Figure). Aside from the bullous reaction to black henna dye described here, other reported presentations include erythema multiforme–like and exudative erythema reactions.9,10

Contact dermatitis lesions from black henna dye can be treated with topical corticosteroids. Patients may develop residual postinflammatory hyperpigmentation or hypopigmentation, leukoderma, keloids, or scars.1,11,12

References
  1. Onder M, Atahan CA, Oztas P, et al. Temporary henna tattoo reactions in children. Int J Dermatol. 2001;40:577-579.
  2. Marcoux D, Couture-Trudel PM, Rboulet-Delmas G, 
et al. Sensitization to paraphenylenediame from a streetside temporary tattoo. Pediatr Dermatol. 2002;19:498-502.
  3. Hashim S, Hamza Y, Yahia B, et al. Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum. Ann Trop Paediatr. 1992;12:3-6.
  4. Hijji Y, Barare B, Zhang Y. Lawsone (2- hydroxy-1, 
4-naphthoquinone) as a sensitive cyanide and acetate sensor. Sensors and Actuators B: Chemical. 2012;169:106-112.
  5. Neri I, Guareschi E, Savoia F, et al. Childhood allergic contact dermatitis from henna tattoo. Pediatr Dermatol. 2002;19:503-505.
  6. Evans CC, Fleming JD. Allergic contact dermatitis from a henna tattoo. N Engl J Med. 2008;359:627.
  7. Belhadjali H, Akkari H, Youssef M, et al. Bullous allergic contact dermatitis to pure henna in a 3-year-old girl. 
Pediatr Dermatol. 2011;28:580-581.
  8. Najem N, Bagher Zadeh V. Allergic contact dermatitis to black henna. Acta Dermatovenerol Alp Pannonica Adriat. 2011;20:87-88.
  9. Sidwell RU, Francis ND, Basarab T, et al. Vesicular erythema multiforme-like reaction to para-phenylenediamine in a henna tattoo. Pediatr Dermatol. 2008;25:201-204.
  10. Jovanovic DL, Slavkovic-Jovanovic MR. Allergic contact dermatitis from temporary henna tattoo. J Dermatol. 2009;36:63-65.
  11. Valsecchi R, Leghissa P, Di Landro A, et al. 
Persistent leukoderma after henna tattoo. Contact 
Dermatitis. 2007;56:108-109.
  12. Gunasti S, Aksungur VL. Severe inflammatory and keloidal, allergic reaction due to para-phenylenediamine in temporary tattoos. Indian J Dermatol Venereol Leprol. 2010;76:165-167.
References
  1. Onder M, Atahan CA, Oztas P, et al. Temporary henna tattoo reactions in children. Int J Dermatol. 2001;40:577-579.
  2. Marcoux D, Couture-Trudel PM, Rboulet-Delmas G, 
et al. Sensitization to paraphenylenediame from a streetside temporary tattoo. Pediatr Dermatol. 2002;19:498-502.
  3. Hashim S, Hamza Y, Yahia B, et al. Poisoning from henna dye and para-phenylenediamine mixtures in children in Khartoum. Ann Trop Paediatr. 1992;12:3-6.
  4. Hijji Y, Barare B, Zhang Y. Lawsone (2- hydroxy-1, 
4-naphthoquinone) as a sensitive cyanide and acetate sensor. Sensors and Actuators B: Chemical. 2012;169:106-112.
  5. Neri I, Guareschi E, Savoia F, et al. Childhood allergic contact dermatitis from henna tattoo. Pediatr Dermatol. 2002;19:503-505.
  6. Evans CC, Fleming JD. Allergic contact dermatitis from a henna tattoo. N Engl J Med. 2008;359:627.
  7. Belhadjali H, Akkari H, Youssef M, et al. Bullous allergic contact dermatitis to pure henna in a 3-year-old girl. 
Pediatr Dermatol. 2011;28:580-581.
  8. Najem N, Bagher Zadeh V. Allergic contact dermatitis to black henna. Acta Dermatovenerol Alp Pannonica Adriat. 2011;20:87-88.
  9. Sidwell RU, Francis ND, Basarab T, et al. Vesicular erythema multiforme-like reaction to para-phenylenediamine in a henna tattoo. Pediatr Dermatol. 2008;25:201-204.
  10. Jovanovic DL, Slavkovic-Jovanovic MR. Allergic contact dermatitis from temporary henna tattoo. J Dermatol. 2009;36:63-65.
  11. Valsecchi R, Leghissa P, Di Landro A, et al. 
Persistent leukoderma after henna tattoo. Contact 
Dermatitis. 2007;56:108-109.
  12. Gunasti S, Aksungur VL. Severe inflammatory and keloidal, allergic reaction due to para-phenylenediamine in temporary tattoos. Indian J Dermatol Venereol Leprol. 2010;76:165-167.
Issue
Cutis - 96(3)
Issue
Cutis - 96(3)
Page Number
E5-E6
Page Number
E5-E6
Publications
Cutis
MDedge Dermatology
Publications
Cutis
MDedge Dermatology
Topics
Contact Dermatitis
Article Type
Quiz
Display Headline
Painful Skin Lesions on the Hands Following Black Henna Application
Display Headline
Painful Skin Lesions on the Hands Following Black Henna Application
Legacy Keywords
black henna, para-phenylenediamine, allergic contact dermatitis
Legacy Keywords
black henna, para-phenylenediamine, allergic contact dermatitis
Sections
Photo Challenge
Questionnaire Body

Red henna tattoo on the palmar surfaces of the hands.
Red henna tattoo on the palmar surfaces of the hands.

A 14-year-old adolescent girl presented with painful skin lesions on the dorsal aspect of the hands of 10 days’ duration. She reported having received red henna tattoo on the palmar surface of the hands and black henna tattoo on the dorsal surface of the hands 1 day prior to development of the lesions. Within 1 day of receiving the tattoo, she developed pruritus, blisters, and pain on the dorsal aspect of the hands. The palms were unaffected. Physical examination revealed erythematous, brown to black bullae and crusts that followed the contours of the henna design on the dorsal aspect of the hands. There were orange and brown henna designs on the patient’s palms, but no erythema, bullae, or induration was noted.

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