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A member of the Lamiaceae family, Salvia rosmarinus (rosemary),* an aromatic plant native to the Mediterranean region and now cultivated globally, has been used for centuries in cuisine and medicine, with several well-established biological activities.1-3 Thought to contribute to preventing hair loss, rosemary oil was also used for hundreds of years in hair rinses in the Mediterranean area.4 In traditional Iranian medicine, rosemary essential oil has been topically applied as an analgesic, anti-inflammatory, and anti-acne remedy.5 Rosemary is known to absorb UV light well and to impart antibacterial and antifungal activity, as well as help maintain skin homeostasis.3 It is also used and under further study for its anti-inflammatory, antioxidant, anti-infective, and anticancer activity.2,6-9 The health benefits of rosemary are typically ascribed to its constituent carnosol/carnosic and ursolic acids.7.
Chemical Constituents
The key chemical components of S. rosmarinus include bitter principle, resin, tannic acid, flavonoids, and volatile oils (made up of borneol, bornyl acetate, camphene, cineol, pinene, and camphor).10 Other important constituents of rosemary oil, in particular, include p-Cymene, linalool, gamma-terpinene, thymol, beta-pinene, alpha-pinene, eucalyptol, and carnosic acid.9 Volatile oils of rosemary have been used in various oils and lotions to treat wounds and with the intention of stimulating hair growth.10
Wound Healing
In a 2022 study in 60 adult male rats, Bulhões and colleagues found that the use of rosemary leaf essential oil-based ointments on skin lesions spurred wound healing, decreased inflammation, and enhanced angiogenesis as well as collagen fiber density.11
Three years earlier, Labib and colleagues studied the wound healing capacity of three chitosan-based topical formulations containing either tea tree essential oil, rosemary essential oil, or a mixture of both oils in an excision wound model in rats.
The combination preparation was found to be the most effective in fostering various stages of wound healing, with significant increases in wound contraction percentage observed in the combination group compared with either group treated using individual essential oils or the untreated animals.12
A 2010 in vivo study by Abu-Al-Basal using BALB/c mice with diabetes revealed that the topical application of rosemary essential oil for three days reduced inflammation, enhanced wound contraction and re-epithelialization, and promoted angiogenesis, granulation tissue regeneration, and collagen deposition.13
Anticancer Activity
Using a 7,12-dimethlybenz(a)anthracene (DMBA)-initiated and croton oil-promoted model in 2006, Sancheti and Goyal determined that rosemary extract administered orally at a dose rate of 500 mg/kg body weight/mouse significantly inhibited two-stage skin tumorigenesis in mice.14 Nearly a decade later, Cattaneo and colleagues determined that a rosemary hydroalcoholic extract displayed antiproliferative effects on the human melanoma A375 cell line.8
The polyphenols carnosic acid and rosmarinic acid are most often cited as the sources of the reputed anticancer effects of rosemary.15
Hair Health
Early in 2023, Begum and colleagues developed a 1% hair lotion including a methanolic extract of the aerial part of S. rosmarinus that they assessed for potential hair growth activity in C57BL/6 mice. Using water as a control and 2% minoxidil hair lotion as standard, the investigators determined that their rosemary hair lotion demonstrated significant hair growth promotion, exceeding that seen in the mice treated with the drug standard.1
In a randomized controlled study in C57BL/6NCrSlc mice a decade earlier, Murata and colleagues evaluated the anti-androgenic activity and hair growth potential imparted by topical rosemary oil compared with finasteride and minoxidil. Rosemary oil leaf extract, with 12-O-methylcarnosic acid as its most active component, robustly suppressed 5alpha-reductase and stimulated hair growth in vivo in both the androgenetic alopecia/testosterone-treated mouse model, as well as the hair growth activating mouse model as compared with minoxidil. Further, the inhibitory activity of rosemary was 82.4% and 94.6% at 200 mcg/mL and 500 mcg/mL, respectively, whereas finasteride demonstrated 81.9% at 250 nM.16
A human study two years later was even more encouraging. Panahi and colleagues conducted a randomized comparative trial with 100 patients to investigate the effects of rosemary oil as opposed to minoxidil 2% for the treatment of androgenetic alopecia over 6 months. By 6 months, significantly greater hair counts were observed in both groups compared with baseline and 3-month readings, but no significant variations between groups. No differences were found in the frequency of dryness, greasiness, or dandruff at any time point or between groups. Scalp itching was significantly greater at the 3- and 6-month points in both groups, particularly in the minoxidil group at both of those time points. The investigators concluded that rosemary oil compared well with minoxidil as androgenetic alopecia therapy.17
Conclusion
Rosemary has been used in traditional medicine for hundreds of years and it has been a common ingredient in cosmetic and cosmeceutical formulations for more than 20 years. Recent findings suggest a broad array of applications in modern medicine, particularly dermatology. The next column will focus on the most recent studies pertaining to the antioxidant and anti-aging activity of this aromatic shrub.
Dr. Baumann is a private practice dermatologist, researcher, author, and entrepreneur in Miami. She founded the division of cosmetic dermatology at the University of Miami in 1997. The third edition of her bestselling textbook, “Cosmetic Dermatology,” was published in 2022. Dr. Baumann has received funding for advisory boards and/or clinical research trials from Allergan, Galderma, Johnson & Johnson, and Burt’s Bees. She is the CEO of Skin Type Solutions Inc., a SaaS company used to generate skin care routines in office and as a ecommerce solution. Write to her at dermnews@mdedge.com.
References
1. Begum A et al. Adv Biomed Res. 2023 Mar 21;12:60.
2. de Oliveira JR et al. J Biomed Sci. 2019 Jan 9;26(1):5.
3. González-Minero FJ et al. Cosmetics. 2020 Oct 3;7(4):77.
4. Dinkins J et al. Int J Dermatol. 2023 Aug;62(8):980-5.
5. Akbari J et al. Pharm Biol. 2015;53(10):1442-7.
6. Allegra A et al. Nutrients. 2020 Jun 10;12(6):1739.
7. de Macedo LM et al. Plants (Basel). 2020 May 21;9(5):651.
8. Cattaneo L et al. PLoS One. 2015 Jul 15;10(7):e0132439.
9. Borges RS et al. J Ethnopharmacol. 2019 Jan 30;229:29-45.
10. Begum A et al. Acta Sci Pol Technol Aliment. 2013 Jan-Mar;12(1):61-73.
11. Bulhões AAVC et al. Acta Cir Bras. 2022 Apr 8;37(1):e370104.
12. Labib RM et al. PLoS One. 2019 Sep 16;14(9):e0219561.
13. Abu-Al-Basal MA. J Ethnopharmacol. 2010 Sep 15;131(2):443-50.
14. Sancheti G and Goyal PK. Phytother Res. 2006 Nov;20(11):981-6.
15. Moore J et al. Nutrients. 2016 Nov 17;8(11):731.
16. Murata K et al. Phytother Res. 2013 Feb;27(2):212-7.
17. Panahi Y et al. Skinmed. 2015 Jan-Feb;13(1):15-21.
*Correction, 2/27: This column was updated with the more recent name for rosemary, Salvia rosmarinus.
A member of the Lamiaceae family, Salvia rosmarinus (rosemary),* an aromatic plant native to the Mediterranean region and now cultivated globally, has been used for centuries in cuisine and medicine, with several well-established biological activities.1-3 Thought to contribute to preventing hair loss, rosemary oil was also used for hundreds of years in hair rinses in the Mediterranean area.4 In traditional Iranian medicine, rosemary essential oil has been topically applied as an analgesic, anti-inflammatory, and anti-acne remedy.5 Rosemary is known to absorb UV light well and to impart antibacterial and antifungal activity, as well as help maintain skin homeostasis.3 It is also used and under further study for its anti-inflammatory, antioxidant, anti-infective, and anticancer activity.2,6-9 The health benefits of rosemary are typically ascribed to its constituent carnosol/carnosic and ursolic acids.7.
Chemical Constituents
The key chemical components of S. rosmarinus include bitter principle, resin, tannic acid, flavonoids, and volatile oils (made up of borneol, bornyl acetate, camphene, cineol, pinene, and camphor).10 Other important constituents of rosemary oil, in particular, include p-Cymene, linalool, gamma-terpinene, thymol, beta-pinene, alpha-pinene, eucalyptol, and carnosic acid.9 Volatile oils of rosemary have been used in various oils and lotions to treat wounds and with the intention of stimulating hair growth.10
Wound Healing
In a 2022 study in 60 adult male rats, Bulhões and colleagues found that the use of rosemary leaf essential oil-based ointments on skin lesions spurred wound healing, decreased inflammation, and enhanced angiogenesis as well as collagen fiber density.11
Three years earlier, Labib and colleagues studied the wound healing capacity of three chitosan-based topical formulations containing either tea tree essential oil, rosemary essential oil, or a mixture of both oils in an excision wound model in rats.
The combination preparation was found to be the most effective in fostering various stages of wound healing, with significant increases in wound contraction percentage observed in the combination group compared with either group treated using individual essential oils or the untreated animals.12
A 2010 in vivo study by Abu-Al-Basal using BALB/c mice with diabetes revealed that the topical application of rosemary essential oil for three days reduced inflammation, enhanced wound contraction and re-epithelialization, and promoted angiogenesis, granulation tissue regeneration, and collagen deposition.13
Anticancer Activity
Using a 7,12-dimethlybenz(a)anthracene (DMBA)-initiated and croton oil-promoted model in 2006, Sancheti and Goyal determined that rosemary extract administered orally at a dose rate of 500 mg/kg body weight/mouse significantly inhibited two-stage skin tumorigenesis in mice.14 Nearly a decade later, Cattaneo and colleagues determined that a rosemary hydroalcoholic extract displayed antiproliferative effects on the human melanoma A375 cell line.8
The polyphenols carnosic acid and rosmarinic acid are most often cited as the sources of the reputed anticancer effects of rosemary.15
Hair Health
Early in 2023, Begum and colleagues developed a 1% hair lotion including a methanolic extract of the aerial part of S. rosmarinus that they assessed for potential hair growth activity in C57BL/6 mice. Using water as a control and 2% minoxidil hair lotion as standard, the investigators determined that their rosemary hair lotion demonstrated significant hair growth promotion, exceeding that seen in the mice treated with the drug standard.1
In a randomized controlled study in C57BL/6NCrSlc mice a decade earlier, Murata and colleagues evaluated the anti-androgenic activity and hair growth potential imparted by topical rosemary oil compared with finasteride and minoxidil. Rosemary oil leaf extract, with 12-O-methylcarnosic acid as its most active component, robustly suppressed 5alpha-reductase and stimulated hair growth in vivo in both the androgenetic alopecia/testosterone-treated mouse model, as well as the hair growth activating mouse model as compared with minoxidil. Further, the inhibitory activity of rosemary was 82.4% and 94.6% at 200 mcg/mL and 500 mcg/mL, respectively, whereas finasteride demonstrated 81.9% at 250 nM.16
A human study two years later was even more encouraging. Panahi and colleagues conducted a randomized comparative trial with 100 patients to investigate the effects of rosemary oil as opposed to minoxidil 2% for the treatment of androgenetic alopecia over 6 months. By 6 months, significantly greater hair counts were observed in both groups compared with baseline and 3-month readings, but no significant variations between groups. No differences were found in the frequency of dryness, greasiness, or dandruff at any time point or between groups. Scalp itching was significantly greater at the 3- and 6-month points in both groups, particularly in the minoxidil group at both of those time points. The investigators concluded that rosemary oil compared well with minoxidil as androgenetic alopecia therapy.17
Conclusion
Rosemary has been used in traditional medicine for hundreds of years and it has been a common ingredient in cosmetic and cosmeceutical formulations for more than 20 years. Recent findings suggest a broad array of applications in modern medicine, particularly dermatology. The next column will focus on the most recent studies pertaining to the antioxidant and anti-aging activity of this aromatic shrub.
Dr. Baumann is a private practice dermatologist, researcher, author, and entrepreneur in Miami. She founded the division of cosmetic dermatology at the University of Miami in 1997. The third edition of her bestselling textbook, “Cosmetic Dermatology,” was published in 2022. Dr. Baumann has received funding for advisory boards and/or clinical research trials from Allergan, Galderma, Johnson & Johnson, and Burt’s Bees. She is the CEO of Skin Type Solutions Inc., a SaaS company used to generate skin care routines in office and as a ecommerce solution. Write to her at dermnews@mdedge.com.
References
1. Begum A et al. Adv Biomed Res. 2023 Mar 21;12:60.
2. de Oliveira JR et al. J Biomed Sci. 2019 Jan 9;26(1):5.
3. González-Minero FJ et al. Cosmetics. 2020 Oct 3;7(4):77.
4. Dinkins J et al. Int J Dermatol. 2023 Aug;62(8):980-5.
5. Akbari J et al. Pharm Biol. 2015;53(10):1442-7.
6. Allegra A et al. Nutrients. 2020 Jun 10;12(6):1739.
7. de Macedo LM et al. Plants (Basel). 2020 May 21;9(5):651.
8. Cattaneo L et al. PLoS One. 2015 Jul 15;10(7):e0132439.
9. Borges RS et al. J Ethnopharmacol. 2019 Jan 30;229:29-45.
10. Begum A et al. Acta Sci Pol Technol Aliment. 2013 Jan-Mar;12(1):61-73.
11. Bulhões AAVC et al. Acta Cir Bras. 2022 Apr 8;37(1):e370104.
12. Labib RM et al. PLoS One. 2019 Sep 16;14(9):e0219561.
13. Abu-Al-Basal MA. J Ethnopharmacol. 2010 Sep 15;131(2):443-50.
14. Sancheti G and Goyal PK. Phytother Res. 2006 Nov;20(11):981-6.
15. Moore J et al. Nutrients. 2016 Nov 17;8(11):731.
16. Murata K et al. Phytother Res. 2013 Feb;27(2):212-7.
17. Panahi Y et al. Skinmed. 2015 Jan-Feb;13(1):15-21.
*Correction, 2/27: This column was updated with the more recent name for rosemary, Salvia rosmarinus.
A member of the Lamiaceae family, Salvia rosmarinus (rosemary),* an aromatic plant native to the Mediterranean region and now cultivated globally, has been used for centuries in cuisine and medicine, with several well-established biological activities.1-3 Thought to contribute to preventing hair loss, rosemary oil was also used for hundreds of years in hair rinses in the Mediterranean area.4 In traditional Iranian medicine, rosemary essential oil has been topically applied as an analgesic, anti-inflammatory, and anti-acne remedy.5 Rosemary is known to absorb UV light well and to impart antibacterial and antifungal activity, as well as help maintain skin homeostasis.3 It is also used and under further study for its anti-inflammatory, antioxidant, anti-infective, and anticancer activity.2,6-9 The health benefits of rosemary are typically ascribed to its constituent carnosol/carnosic and ursolic acids.7.
Chemical Constituents
The key chemical components of S. rosmarinus include bitter principle, resin, tannic acid, flavonoids, and volatile oils (made up of borneol, bornyl acetate, camphene, cineol, pinene, and camphor).10 Other important constituents of rosemary oil, in particular, include p-Cymene, linalool, gamma-terpinene, thymol, beta-pinene, alpha-pinene, eucalyptol, and carnosic acid.9 Volatile oils of rosemary have been used in various oils and lotions to treat wounds and with the intention of stimulating hair growth.10
Wound Healing
In a 2022 study in 60 adult male rats, Bulhões and colleagues found that the use of rosemary leaf essential oil-based ointments on skin lesions spurred wound healing, decreased inflammation, and enhanced angiogenesis as well as collagen fiber density.11
Three years earlier, Labib and colleagues studied the wound healing capacity of three chitosan-based topical formulations containing either tea tree essential oil, rosemary essential oil, or a mixture of both oils in an excision wound model in rats.
The combination preparation was found to be the most effective in fostering various stages of wound healing, with significant increases in wound contraction percentage observed in the combination group compared with either group treated using individual essential oils or the untreated animals.12
A 2010 in vivo study by Abu-Al-Basal using BALB/c mice with diabetes revealed that the topical application of rosemary essential oil for three days reduced inflammation, enhanced wound contraction and re-epithelialization, and promoted angiogenesis, granulation tissue regeneration, and collagen deposition.13
Anticancer Activity
Using a 7,12-dimethlybenz(a)anthracene (DMBA)-initiated and croton oil-promoted model in 2006, Sancheti and Goyal determined that rosemary extract administered orally at a dose rate of 500 mg/kg body weight/mouse significantly inhibited two-stage skin tumorigenesis in mice.14 Nearly a decade later, Cattaneo and colleagues determined that a rosemary hydroalcoholic extract displayed antiproliferative effects on the human melanoma A375 cell line.8
The polyphenols carnosic acid and rosmarinic acid are most often cited as the sources of the reputed anticancer effects of rosemary.15
Hair Health
Early in 2023, Begum and colleagues developed a 1% hair lotion including a methanolic extract of the aerial part of S. rosmarinus that they assessed for potential hair growth activity in C57BL/6 mice. Using water as a control and 2% minoxidil hair lotion as standard, the investigators determined that their rosemary hair lotion demonstrated significant hair growth promotion, exceeding that seen in the mice treated with the drug standard.1
In a randomized controlled study in C57BL/6NCrSlc mice a decade earlier, Murata and colleagues evaluated the anti-androgenic activity and hair growth potential imparted by topical rosemary oil compared with finasteride and minoxidil. Rosemary oil leaf extract, with 12-O-methylcarnosic acid as its most active component, robustly suppressed 5alpha-reductase and stimulated hair growth in vivo in both the androgenetic alopecia/testosterone-treated mouse model, as well as the hair growth activating mouse model as compared with minoxidil. Further, the inhibitory activity of rosemary was 82.4% and 94.6% at 200 mcg/mL and 500 mcg/mL, respectively, whereas finasteride demonstrated 81.9% at 250 nM.16
A human study two years later was even more encouraging. Panahi and colleagues conducted a randomized comparative trial with 100 patients to investigate the effects of rosemary oil as opposed to minoxidil 2% for the treatment of androgenetic alopecia over 6 months. By 6 months, significantly greater hair counts were observed in both groups compared with baseline and 3-month readings, but no significant variations between groups. No differences were found in the frequency of dryness, greasiness, or dandruff at any time point or between groups. Scalp itching was significantly greater at the 3- and 6-month points in both groups, particularly in the minoxidil group at both of those time points. The investigators concluded that rosemary oil compared well with minoxidil as androgenetic alopecia therapy.17
Conclusion
Rosemary has been used in traditional medicine for hundreds of years and it has been a common ingredient in cosmetic and cosmeceutical formulations for more than 20 years. Recent findings suggest a broad array of applications in modern medicine, particularly dermatology. The next column will focus on the most recent studies pertaining to the antioxidant and anti-aging activity of this aromatic shrub.
Dr. Baumann is a private practice dermatologist, researcher, author, and entrepreneur in Miami. She founded the division of cosmetic dermatology at the University of Miami in 1997. The third edition of her bestselling textbook, “Cosmetic Dermatology,” was published in 2022. Dr. Baumann has received funding for advisory boards and/or clinical research trials from Allergan, Galderma, Johnson & Johnson, and Burt’s Bees. She is the CEO of Skin Type Solutions Inc., a SaaS company used to generate skin care routines in office and as a ecommerce solution. Write to her at dermnews@mdedge.com.
References
1. Begum A et al. Adv Biomed Res. 2023 Mar 21;12:60.
2. de Oliveira JR et al. J Biomed Sci. 2019 Jan 9;26(1):5.
3. González-Minero FJ et al. Cosmetics. 2020 Oct 3;7(4):77.
4. Dinkins J et al. Int J Dermatol. 2023 Aug;62(8):980-5.
5. Akbari J et al. Pharm Biol. 2015;53(10):1442-7.
6. Allegra A et al. Nutrients. 2020 Jun 10;12(6):1739.
7. de Macedo LM et al. Plants (Basel). 2020 May 21;9(5):651.
8. Cattaneo L et al. PLoS One. 2015 Jul 15;10(7):e0132439.
9. Borges RS et al. J Ethnopharmacol. 2019 Jan 30;229:29-45.
10. Begum A et al. Acta Sci Pol Technol Aliment. 2013 Jan-Mar;12(1):61-73.
11. Bulhões AAVC et al. Acta Cir Bras. 2022 Apr 8;37(1):e370104.
12. Labib RM et al. PLoS One. 2019 Sep 16;14(9):e0219561.
13. Abu-Al-Basal MA. J Ethnopharmacol. 2010 Sep 15;131(2):443-50.
14. Sancheti G and Goyal PK. Phytother Res. 2006 Nov;20(11):981-6.
15. Moore J et al. Nutrients. 2016 Nov 17;8(11):731.
16. Murata K et al. Phytother Res. 2013 Feb;27(2):212-7.
17. Panahi Y et al. Skinmed. 2015 Jan-Feb;13(1):15-21.
*Correction, 2/27: This column was updated with the more recent name for rosemary, Salvia rosmarinus.
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BAUMANN, MD</bylineFull> <bylineTitleText/> <USOrGlobal/> <wireDocType/> <newsDocType>Column</newsDocType> <journalDocType/> <linkLabel/> <pageRange/> <citation/> <quizID/> <indexIssueDate/> <itemClass qcode="ninat:text"/> <provider qcode="provider:imng"> <name>IMNG Medical Media</name> <rightsInfo> <copyrightHolder> <name>Frontline Medical News</name> </copyrightHolder> <copyrightNotice>Copyright (c) 2015 Frontline Medical News, a Frontline Medical Communications Inc. company. All rights reserved. This material may not be published, broadcast, copied, or otherwise reproduced or distributed without the prior written permission of Frontline Medical Communications Inc.</copyrightNotice> </rightsInfo> </provider> <abstract/> <metaDescription>In part 1 of this update on rosemary, the focus will be on chemical constituents, wound healing, anticancer activity, and hair care potential</metaDescription> <articlePDF/> <teaserImage>299986</teaserImage> <title>Rosemary, Part 1</title> <deck/> <disclaimer/> <AuthorList/> <articleURL/> <doi/> <pubMedID/> <publishXMLStatus/> <publishXMLVersion>1</publishXMLVersion> <useEISSN>0</useEISSN> <urgency/> <pubPubdateYear/> <pubPubdateMonth/> <pubPubdateDay/> <pubVolume/> <pubNumber/> <wireChannels/> <primaryCMSID/> <CMSIDs/> <keywords/> <seeAlsos/> <publications_g> <publicationData> <publicationCode>skin</publicationCode> <pubIssueName/> <pubArticleType/> <pubTopics/> <pubCategories/> <pubSections/> </publicationData> </publications_g> <publications> <term canonical="true">13</term> </publications> <sections> <term>52</term> <term canonical="true">27928</term> </sections> <topics> <term>177</term> <term canonical="true">219</term> <term>313</term> </topics> <links> <link> <itemClass qcode="ninat:picture"/> <altRep contenttype="image/jpeg">images/240125be.jpg</altRep> <description role="drol:caption"/> <description role="drol:credit">HUIZENG HU/Moment/Getty Images</description> </link> <link> <itemClass qcode="ninat:picture"/> <altRep contenttype="image/jpeg">images/2400b666.jpg</altRep> <description role="drol:caption">Dr. Leslie S. Baumann</description> <description role="drol:credit">Baumann Cosmetic & Research Institute</description> </link> </links> </header> <itemSet> <newsItem> <itemMeta> <itemRole>Main</itemRole> <itemClass>text</itemClass> <title>Rosemary, Part 1</title> <deck/> </itemMeta> <itemContent> <p>A member of the Lamiaceae family, <em>Rosmarinus officinalis</em> (rosemary), an aromatic plant native to the Mediterranean region and now cultivated globally, has been used for centuries in cuisine and medicine, with several well-established biological activities.<sup>1-3</sup> Thought to contribute to preventing hair loss, rosemary oil was also used for hundreds of years in hair rinses in the Mediterranean area.<sup>4</sup> In traditional Iranian medicine, rosemary essential oil has been topically applied as an analgesic, anti-inflammatory, and anti-acne remedy.<sup>5</sup> Rosemary is known to absorb UV light well and to impart antibacterial and antifungal activity, as well as help maintain skin homeostasis.<sup>3</sup> It is also used and under further study for its anti-inflammatory, antioxidant, anti-infective, and anticancer activity.<sup>2,6-9</sup> The health benefits of rosemary are typically ascribed to its constituent carnosol/carnosic and ursolic acids.<sup>7</sup> <span class="tag metaDescription">In part 1 of this update on rosemary, the focus will be on chemical constituents, wound healing, anticancer activity, and hair care potential</span>.</p> <h2>Chemical Constituents</h2> <p>The key chemical components of <em>R. officinalis</em> include bitter principle, resin, tannic acid, flavonoids, and volatile oils (made up of borneol, bornyl acetate, camphene, cineol, pinene, and camphor).<sup>10</sup> Other important constituents of rosemary oil, in particular, include p-Cymene, linalool, gamma-terpinene, thymol, beta-pinene, alpha-pinene, eucalyptol, and carnosic acid.<sup>9</sup> Volatile oils of rosemary have been used in various oils and lotions to treat wounds and with the intention of stimulating hair growth.<sup>10</sup></p> <h2>Wound Healing</h2> <p>In a 2022 study in 60 adult male rats, Bulhões and colleagues found that the use of rosemary leaf essential oil-based ointments on skin lesions spurred wound healing, decreased inflammation, and enhanced angiogenesis as well as collagen fiber density.<sup>11</sup><br/><br/>Three years earlier, Labib and colleagues studied the wound healing capacity of three chitosan-based topical formulations containing either tea tree essential oil, rosemary essential oil, or a mixture of both oils in an excision wound model in rats. [[{"fid":"299986","view_mode":"medstat_image_flush_right","fields":{"format":"medstat_image_flush_right","field_file_image_alt_text[und][0][value]":"Rosemary essential oil and fresh twig.","field_file_image_credit[und][0][value]":"HUIZENG HU/Moment/Getty Images","field_file_image_caption[und][0][value]":""},"type":"media","attributes":{"class":"media-element file-medstat_image_flush_right"}}]]The combination preparation was found to be the most effective in fostering various stages of wound healing, with significant increases in wound contraction percentage observed in the combination group compared with either group treated using individual essential oils or the untreated animals.<sup>12</sup><br/><br/>A 2010 in vivo study by Abu-Al-Basal using BALB/c mice with diabetes revealed that the topical application of rosemary essential oil for three days reduced inflammation, enhanced wound contraction and re-epithelialization, and promoted angiogenesis, granulation tissue regeneration, and collagen deposition.<sup>13</sup></p> <h2>Anticancer Activity</h2> <p>Using a 7,12-dimethlybenz(a)anthracene (DMBA)-initiated and croton oil-promoted model in 2006, Sancheti and Goyal determined that rosemary extract administered orally at a dose rate of 500 mg/kg body weight/mouse significantly inhibited two-stage skin tumorigenesis in mice.<sup>14</sup> Nearly a decade later, Cattaneo and colleagues determined that a rosemary hydroalcoholic extract displayed antiproliferative effects on the human melanoma A375 cell line.<sup>8</sup> <br/><br/>The polyphenols carnosic acid and rosmarinic acid are most often cited as the sources of the reputed anticancer effects of rosemary.<sup>15</sup></p> <h2>Hair Health</h2> <p>Early in 2023, Begum and colleagues developed a 1% hair lotion including a methanolic extract of the aerial part of <em>R. officinalis</em> that they assessed for potential hair growth activity in C57BL/6 mice. Using water as a control and 2% minoxidil hair lotion as standard, the investigators determined that their rosemary hair lotion demonstrated significant hair growth promotion, exceeding that seen in the mice treated with the drug standard.<sup>1</sup><br/><br/>[[{"fid":"239756","view_mode":"medstat_image_flush_left","fields":{"format":"medstat_image_flush_left","field_file_image_alt_text[und][0][value]":"Dr. Leslie S. Baumann, a dermatologist, researcher, author, and entrepreneur who practices in Miami.","field_file_image_credit[und][0][value]":"Baumann Cosmetic & Research Institute","field_file_image_caption[und][0][value]":"Dr. Leslie S. Baumann"},"type":"media","attributes":{"class":"media-element file-medstat_image_flush_left"}}]]In a randomized controlled study in C57BL/6NCrSlc mice a decade earlier, Murata and colleagues evaluated the anti-androgenic activity and hair growth potential imparted by topical rosemary oil compared with finasteride and minoxidil. Rosemary oil leaf extract, with 12-O-methylcarnosic acid as its most active component, robustly suppressed 5alpha-reductase and stimulated hair growth in vivo in both the androgenetic alopecia/testosterone-treated mouse model, as well as the hair growth activating mouse model as compared with minoxidil. Further, the inhibitory activity of rosemary was 82.4% and 94.6% at 200 mcg/mL and 500 mcg/mL, respectively, whereas finasteride demonstrated 81.9% at 250 nM.<sup>16</sup><br/><br/>A human study two years later was even more encouraging. Panahi and colleagues conducted a randomized comparative trial with 100 patients to investigate the effects of rosemary oil as opposed to minoxidil 2% for the treatment of androgenetic alopecia over 6 months. By 6 months, significantly greater hair counts were observed in both groups compared with baseline and 3-month readings, but no significant variations between groups. No differences were found in the frequency of dryness, greasiness, or dandruff at any time point or between groups. Scalp itching was significantly greater at the 3- and 6-month points in both groups, particularly in the minoxidil group at both of those time points. The investigators concluded that rosemary oil compared well with minoxidil as androgenetic alopecia therapy.<sup>17</sup></p> <h2>Conclusion</h2> <p>Rosemary has been used in traditional medicine for hundreds of years and it has been a common ingredient in cosmetic and cosmeceutical formulations for more than 20 years. Recent findings suggest a broad array of applications in modern medicine, particularly dermatology. The next column will focus on the most recent studies pertaining to the antioxidant and anti-aging activity of this aromatic shrub.</p> <p> <em><span class="Hyperlink"><a href="https://lesliebaumannmd.com/">Dr. Baumann</a></span> is a private practice dermatologist, researcher, author, and entrepreneur in Miami. She founded the division of cosmetic dermatology at the University of Miami in 1997. The third edition of her bestselling textbook, “Cosmetic Dermatology,” was published in 2022. Dr. Baumann has received funding for advisory boards and/or clinical research trials from Allergan, Galderma, Johnson & Johnson, and Burt’s Bees. She is the CEO of Skin Type Solutions Inc., a SaaS company used to generate skin care routines in office and as a ecommerce solution. Write to her at <span class="Hyperlink"><a href="mailto:dermnews%40mdedge.com?subject=">dermnews@mdedge.com</a></span>.</em> </p> <h2>References</h2> <p>1. Begum A et al. <span class="Hyperlink"><a href="https://journals.lww.com/adbm/fulltext/2023/03210/evaluation_of_herbal_hair_lotion_loaded_with.60.aspx">Adv Biomed Res. 2023 Mar 21;12:60</a>.</span><br/><br/>2. de Oliveira JR et al. <span class="Hyperlink"><a href="https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-019-0499-8">J Biomed Sci. 2019 Jan 9;26(1):5</a></span>.<br/><br/>3. González-Minero FJ et al. <span class="Hyperlink"><a href="https://www.mdpi.com/2079-9284/7/4/77">Cosmetics. 2020 Oct 3;7(4):77</a></span>.<br/><br/>4. Dinkins J et al. <span class="Hyperlink"><a href="https://onlinelibrary.wiley.com/doi/10.1111/ijd.16657">Int J Dermatol. 2023 Aug;62(8):980-5</a></span>.<br/><br/>5. Akbari J et al. <span class="Hyperlink"><a href="https://www.tandfonline.com/doi/full/10.3109/13880209.2014.984855">Pharm Biol. 2015;53(10):1442-7</a></span>.<br/><br/>6. Allegra A et al. <span class="Hyperlink"><a href="https://www.mdpi.com/2072-6643/12/6/1739">Nutrients. 2020 Jun 10;12(6):1739</a></span>.<br/><br/>7. de Macedo LM et al. <span class="Hyperlink"><a href="https://www.mdpi.com/2223-7747/9/5/651">Plants (Basel). 2020 May 21;9(5):651</a></span>.<br/><br/>8. Cattaneo L et al. <span class="Hyperlink"><a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0132439">PLoS One. 2015 Jul 15;10(7):e0132439</a></span>.<br/><br/>9. Borges RS et al. <span class="Hyperlink"><a href="https://www.sciencedirect.com/science/article/pii/S0378874118314107?via%3Dihub">J Ethnopharmacol. 2019 Jan 30;229:29-45</a></span>.<br/><br/>10. Begum A et al. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/24584866/">Acta Sci Pol Technol Aliment. 2013 Jan-Mar;12(1):61-73</a></span>.<br/><br/>11. Bulhões AAVC et al. <span class="Hyperlink"><a href="https://www.scielo.br/j/acb/a/3q4xdwv7cL3V6rSxrSgSCMG/?lang=en">Acta Cir Bras. 2022 Apr 8;37(1):e370104</a></span>.<br/><br/>12. Labib RM et al. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/31525200/">PLoS One. 2019 Sep 16;14(9):e0219561</a></span>.<br/><br/>13. Abu-Al-Basal MA. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/20633625/">J Ethnopharmacol. 2010 Sep 15;131(2):443-50.</a></span><br/><br/>14. Sancheti G and Goyal PK. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/16927448/">Phytother Res. 2006 Nov;20(11):981-6</a></span>.<br/><br/>15. Moore J et al. <span class="Hyperlink"><a href="https://www.mdpi.com/2072-6643/8/11/731">Nutrients. 2016 Nov 17;8(11):731</a></span>.<br/><br/>16. Murata K et al. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/22517595/">Phytother Res. 2013 Feb;27(2):212-7.</a></span><br/><br/>17. Panahi Y et al. <span class="Hyperlink"><a href="https://pubmed.ncbi.nlm.nih.gov/25842469/">Skinmed. 2015 Jan-Feb;13(1):15-21</a></span>.</p> </itemContent> </newsItem> <newsItem> <itemMeta> <itemRole>teaser</itemRole> <itemClass>text</itemClass> <title/> <deck/> </itemMeta> <itemContent> <p>Recent findings suggest a broad array of applications in modern medicine, particularly dermatology.</p> </itemContent> </newsItem> </itemSet></root>
