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Liver Stiffness in HIV/HCV-Coinfected Patients

BMC Infect Dis; ePub 2018 Apr 11; Pérez-Latorre, et al

Transient elastography (TE) is not useful for assessing the prognosis of HIV-infected patients with decompensated hepatitis C virus (HCV)-related cirrhosis, a recent study suggests. Researchers analyzed 65 HIV-HCV-coinfected patients with decompressed cirrhosis (DC) who underwent TE as pair of their routine follow-up between 2006 and 2015. They also calculated the liver stiffness spleen diameter-to-platelet score (LSPS), FIB-4 index, albumin, MELD score, and Child-Pugh score. The primary outcome was death. Among the findings:

  • After a median follow-up of 32 months after the first TE, 17 patients had received anti-HCV therapy and 31 patients had died.
  • Albumin concentration and Child-Pugh scores were the most consistent predictors of death in the study group.
  • In the univariate Cox regression analysis, albumin, FIB-4, Child-Pugh score, and MELD score, but not TE, were associated with death.

Citation:

Pérez-Latorre L, Sánchez-Conde M, Miralles P, et al. Prognostic value of liver stiffness in HIV/HCV-coinfected patients with decompensated cirrhosis. [Published online ahead of print April 11, 2018]. BMC Infect Dis. doi:10.1186/s12879-018-3067-z.