Compared with sleeve gastrectomy (SG) or adjustable gastric banding (AGB) procedures, adults lost more weight with Roux-en-Y gastric bypass (RYGB) at 1, 3, and 5 years; however, RYGB had the highest 30-day rate of major adverse events (AEs). This according to results from a retrospective cohort study that compared weight loss and safety among bariatric procedures. A total of 65,093 patients aged 20‒79 with body mass index (BMI) of ≥35 kg/m² who had bariatric procedures were included. Researchers estimated total weight loss (TWL) at 1, 3, and 5 years and measured 30-day rates of major AEs. They found:

• Total numbers of eligible patients with weight measures at 1, 3, and 5 years were 44,978 (84%), 20,783 (68%), and 7,159 (69%), respectively.
• 30-day rates of major AEs were 5.0% for RYGB, 2.6% for SG, and 2.9% for AGB.
• 1-year mean TWLs were 31.2% for RYGB, 25.2% for SG, and 13.7% for AGB.
• 5-year TWLs were 25.5% for RYGB, 18.8% for SG, and 11.7% for AGB.
• At 1 year, RYGB patients lost 5.9 percentage points more weight than SG patients and 17.7 percentage points more than AGB patients, while SG patients lost 12.0 percentage points more than AGB patients.