Pseudo-Ludwig angina

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Pseudo-Ludwig angina
Author(s)
Andrew Tiu, MD
Kamolyut Lapumnuaypol, MD

An 83-year-old woman with hypertension, hypothyroidism, and a history of depression presented to the emergency department with acute shortness of breath and hypoxia. She was found to have submassive pulmonary embolism, and a heparin infusion was started immediately.

tiu_pseudo-ludwigangina_f1.jpg
%3Cp%3EFigure%201.%20(A)%20After%2048%20hours%20of%20heparin%20infusion%2C%20the%20patient%20developed%20violaceous%20swelling%20at%20the%20floor%20of%20the%20oral%20cavity.%20(B)%20At%202%20months%20after%20anticoagulation%20was%20stopped%2C%20the%20sublingual%20hematoma%20had%20completely%20resolved.%3C%2Fp%3E
After 48 hours, she developed uncontrolled drooling and hoarseness. Physical examination at that time revealed inspiratory stridor and violaceous swelling at the floor of the oral cavity (Figure 1), and laboratory testing revealed a supratherapeutic activated partial thromboplastin time (aPTT) of 240 seconds (therapeutic range 76–112 for a patient on heparin for pulmonary embolism).

Urgent nasopharyngeal laryngoscopy revealed a hematoma at the base of her tongue that extended into the vallecula, piriform sinuses, and aryepiglottic fold, causing acute airway obstruction. These features combined with the supratherapeutic aPTT led to the diagnosis of pseudo-Ludwig angina.

DANGER OF RAPID AIRWAY COMPROMISE

Pseudo-Ludwig angina is a rare condition in which over-anticoagulation causes sublingual swelling leading to airway obstruction, whereas true Ludwig angina is an infectious regional suppuration of the neck.

Most reported cases of pseudo-Ludwig angina have resulted from overanticogulation with warfarin or warfarin-like substances (rodenticides), or from coagulopathy due to liver disease.1–3 Early recognition is essential to avoid airway compromise.

In our patient, all anticoagulation was discontinued, and she was intubated until the hematoma began to resolve, the aPTT returned to normal, and respiratory compromise improved. At follow-up 2 months later, the sublingual hematoma had completely resolved (Figure 1). And at a 6-month follow-up visit, the pulmonary embolism had resolved, and pulmonary pressures by 2-dimensional echocardiography were normal.

References
  1. Lovallo E, Patterson S, Erickson M, Chin C, Blanc P, Durrani TS. When is “pseudo-Ludwig’s angina” associated with coagulopathy also a “pseudo” hemorrhage? J Investig Med High Impact Case Rep 2013; 1(2):2324709613492503. doi:10.1177/2324709613492503
  2. Smith RG, Parker TJ, Anderson TA. Noninfectious acute upper airway obstruction (pseudo-Ludwig phenomenon): report of a case. J Oral Maxillofac Surg 1987; 45(8):701–704. pmid:3475442
  3. Zacharia GS, Kandiyil S, Thomas V. Pseudo-Ludwig's phenomenon: a rare clinical manifestation in liver cirrhosis. ACG Case Rep J 2014; 2(1):53–54. doi:10.14309/crj.2014.83
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tiu_pseudo-ludwigangina.pdf
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Andrew Tiu, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Kamolyut Lapumnuaypol, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Address: Andrew Tiu, MD, Department of Medicine, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141; tiuandre@einstein.edu

Issue
Cleveland Clinic Journal of Medicine - 86(9)
Publications
Cleveland Clinic Journal of Medicine
Topics
Drug Therapy
Vascular
Pulmonology
Hospital Medicine
Geriatrics
Page Number
577-578
Legacy Keywords
hematoma, heparin, pulmonary embolism, PE, venous thromboembolism, VTE, anticoagulation, sublingual, mouth, bleeding, over-anticoagulation, side effect, pseudo-Ludwig angina, airway compromise, Andrew Tieu, Kamolyut Lapumnuaypol
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Kamolyut Lapumnuaypol, MD
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Kamolyut Lapumnuaypol, MD
Author and Disclosure Information

Andrew Tiu, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Kamolyut Lapumnuaypol, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Address: Andrew Tiu, MD, Department of Medicine, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141; tiuandre@einstein.edu

Author and Disclosure Information

Andrew Tiu, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Kamolyut Lapumnuaypol, MD
Department of Medicine, Einstein Medical Center, Philadelphia, PA

Address: Andrew Tiu, MD, Department of Medicine, Einstein Medical Center, 5501 Old York Road, Philadelphia, PA 19141; tiuandre@einstein.edu

Article PDF
tiu_pseudo-ludwigangina.pdf
Article PDF
tiu_pseudo-ludwigangina.pdf
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An 83-year-old woman with hypertension, hypothyroidism, and a history of depression presented to the emergency department with acute shortness of breath and hypoxia. She was found to have submassive pulmonary embolism, and a heparin infusion was started immediately.

tiu_pseudo-ludwigangina_f1.jpg
%3Cp%3EFigure%201.%20(A)%20After%2048%20hours%20of%20heparin%20infusion%2C%20the%20patient%20developed%20violaceous%20swelling%20at%20the%20floor%20of%20the%20oral%20cavity.%20(B)%20At%202%20months%20after%20anticoagulation%20was%20stopped%2C%20the%20sublingual%20hematoma%20had%20completely%20resolved.%3C%2Fp%3E
After 48 hours, she developed uncontrolled drooling and hoarseness. Physical examination at that time revealed inspiratory stridor and violaceous swelling at the floor of the oral cavity (Figure 1), and laboratory testing revealed a supratherapeutic activated partial thromboplastin time (aPTT) of 240 seconds (therapeutic range 76–112 for a patient on heparin for pulmonary embolism).

Urgent nasopharyngeal laryngoscopy revealed a hematoma at the base of her tongue that extended into the vallecula, piriform sinuses, and aryepiglottic fold, causing acute airway obstruction. These features combined with the supratherapeutic aPTT led to the diagnosis of pseudo-Ludwig angina.

DANGER OF RAPID AIRWAY COMPROMISE

Pseudo-Ludwig angina is a rare condition in which over-anticoagulation causes sublingual swelling leading to airway obstruction, whereas true Ludwig angina is an infectious regional suppuration of the neck.

Most reported cases of pseudo-Ludwig angina have resulted from overanticogulation with warfarin or warfarin-like substances (rodenticides), or from coagulopathy due to liver disease.1–3 Early recognition is essential to avoid airway compromise.

In our patient, all anticoagulation was discontinued, and she was intubated until the hematoma began to resolve, the aPTT returned to normal, and respiratory compromise improved. At follow-up 2 months later, the sublingual hematoma had completely resolved (Figure 1). And at a 6-month follow-up visit, the pulmonary embolism had resolved, and pulmonary pressures by 2-dimensional echocardiography were normal.

An 83-year-old woman with hypertension, hypothyroidism, and a history of depression presented to the emergency department with acute shortness of breath and hypoxia. She was found to have submassive pulmonary embolism, and a heparin infusion was started immediately.

tiu_pseudo-ludwigangina_f1.jpg
%3Cp%3EFigure%201.%20(A)%20After%2048%20hours%20of%20heparin%20infusion%2C%20the%20patient%20developed%20violaceous%20swelling%20at%20the%20floor%20of%20the%20oral%20cavity.%20(B)%20At%202%20months%20after%20anticoagulation%20was%20stopped%2C%20the%20sublingual%20hematoma%20had%20completely%20resolved.%3C%2Fp%3E
After 48 hours, she developed uncontrolled drooling and hoarseness. Physical examination at that time revealed inspiratory stridor and violaceous swelling at the floor of the oral cavity (Figure 1), and laboratory testing revealed a supratherapeutic activated partial thromboplastin time (aPTT) of 240 seconds (therapeutic range 76–112 for a patient on heparin for pulmonary embolism).

Urgent nasopharyngeal laryngoscopy revealed a hematoma at the base of her tongue that extended into the vallecula, piriform sinuses, and aryepiglottic fold, causing acute airway obstruction. These features combined with the supratherapeutic aPTT led to the diagnosis of pseudo-Ludwig angina.

DANGER OF RAPID AIRWAY COMPROMISE

Pseudo-Ludwig angina is a rare condition in which over-anticoagulation causes sublingual swelling leading to airway obstruction, whereas true Ludwig angina is an infectious regional suppuration of the neck.

Most reported cases of pseudo-Ludwig angina have resulted from overanticogulation with warfarin or warfarin-like substances (rodenticides), or from coagulopathy due to liver disease.1–3 Early recognition is essential to avoid airway compromise.

In our patient, all anticoagulation was discontinued, and she was intubated until the hematoma began to resolve, the aPTT returned to normal, and respiratory compromise improved. At follow-up 2 months later, the sublingual hematoma had completely resolved (Figure 1). And at a 6-month follow-up visit, the pulmonary embolism had resolved, and pulmonary pressures by 2-dimensional echocardiography were normal.

References
  1. Lovallo E, Patterson S, Erickson M, Chin C, Blanc P, Durrani TS. When is “pseudo-Ludwig’s angina” associated with coagulopathy also a “pseudo” hemorrhage? J Investig Med High Impact Case Rep 2013; 1(2):2324709613492503. doi:10.1177/2324709613492503
  2. Smith RG, Parker TJ, Anderson TA. Noninfectious acute upper airway obstruction (pseudo-Ludwig phenomenon): report of a case. J Oral Maxillofac Surg 1987; 45(8):701–704. pmid:3475442
  3. Zacharia GS, Kandiyil S, Thomas V. Pseudo-Ludwig's phenomenon: a rare clinical manifestation in liver cirrhosis. ACG Case Rep J 2014; 2(1):53–54. doi:10.14309/crj.2014.83
References
  1. Lovallo E, Patterson S, Erickson M, Chin C, Blanc P, Durrani TS. When is “pseudo-Ludwig’s angina” associated with coagulopathy also a “pseudo” hemorrhage? J Investig Med High Impact Case Rep 2013; 1(2):2324709613492503. doi:10.1177/2324709613492503
  2. Smith RG, Parker TJ, Anderson TA. Noninfectious acute upper airway obstruction (pseudo-Ludwig phenomenon): report of a case. J Oral Maxillofac Surg 1987; 45(8):701–704. pmid:3475442
  3. Zacharia GS, Kandiyil S, Thomas V. Pseudo-Ludwig's phenomenon: a rare clinical manifestation in liver cirrhosis. ACG Case Rep J 2014; 2(1):53–54. doi:10.14309/crj.2014.83
Issue
Cleveland Clinic Journal of Medicine - 86(9)
Issue
Cleveland Clinic Journal of Medicine - 86(9)
Page Number
577-578
Page Number
577-578
Publications
Cleveland Clinic Journal of Medicine
Publications
Cleveland Clinic Journal of Medicine
Topics
Drug Therapy
Vascular
Pulmonology
Hospital Medicine
Geriatrics
Article Type
Article
Display Headline
Pseudo-Ludwig angina
Display Headline
Pseudo-Ludwig angina
Legacy Keywords
hematoma, heparin, pulmonary embolism, PE, venous thromboembolism, VTE, anticoagulation, sublingual, mouth, bleeding, over-anticoagulation, side effect, pseudo-Ludwig angina, airway compromise, Andrew Tieu, Kamolyut Lapumnuaypol
Legacy Keywords
hematoma, heparin, pulmonary embolism, PE, venous thromboembolism, VTE, anticoagulation, sublingual, mouth, bleeding, over-anticoagulation, side effect, pseudo-Ludwig angina, airway compromise, Andrew Tieu, Kamolyut Lapumnuaypol
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