Erythematous Scaly Papules on the Shins and Calves

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Erythematous Scaly Papules on the Shins and Calves

The Diagnosis: Hyperkeratosis Lenticularis Perstans

A shave biopsy of a lesion on the right leg was performed. Histopathology revealed a discrete papule with overlying compact hyperkeratosis. There was parakeratosis with an absent granular layer and a lichenoid lymphocytic infiltrate within the papillary dermis (Figure). Given the clinical context, these changes were consistent with a diagnosis of hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease.

Discrete papule with overlying compact hyperkeratosis and an accompanying lichenoid inflammatory infiltrate (A)(H&E, original magnification ×2). Higher power view highlighting the lichenoid inflammation and loss of the granular layer with overlying parakeratosis (B)(H&E, original magnification ×10).

The patient was started on tretinoin cream 0.1% nightly for 3 months and triamcinolone ointment 0.1% as needed for pruritus but showed no clinical response. Given the benign nature of the condition and because the lesions were asymptomatic, additional treatment options were not pursued.

Originally described by Flegel1 in 1958, HLP is a rare skin disorder commonly seen in white individuals with onset in the fourth or fifth decades of life.1,2 While most cases are sporadic,3-6 HLP also has been associated with autosomal dominant inheritance.7-10

Patients with HLP typically present with multiple 1- to 5-mm reddish-brown, hyperkeratotic, scaly papules that reveal a moist, erythematous base with pinpoint bleeding upon removal of the scale. Lesions usually are distributed symmetrically and most commonly present on the extensor surfaces of the lower legs and dorsal feet.1,2,7 Lesions also may appear on the extensor surfaces of the arms, pinna, periocular region, antecubital and popliteal fossae, and oral mucosa and also may present as pits on the palms and soles.2,4,7,8 Furthermore, unilateral and localized variants of HLP have been described.11,12 Hyperkeratosis lenticularis perstans usually is asymptomatic but can present with mild pruritus or burning.3,5,13

The etiology and pathogenesis of HLP are unknown. Exposure to UV light has been implicated as an inciting factor14; however, reports of spontaneous resolution in the summer13 and upon treatment with psoralen plus UVA therapy15 make the role of UV light unclear. Furthermore, investigators disagree as to whether the primary pathogenic event in HLP is an inflammatory process or one of abnormal keratinization.1,3,7,10 Fernandez-Flores and Manjon16 suggested HLP is an inflammatory process with periods of exacerbations and remissions after finding mounds of parakeratosis with neutrophils arranged in different strata in the stratum corneum.

Histologically, compact hyperkeratosis usually is noted, often with associated parakeratosis, epidermal atrophy with thinning or absence of the granular layer, and a bandlike lymphohistiocytic infiltrate in the papillary dermis.1-3 Histopathologic differences between recent-onset versus longstanding lesions have been found, with old lesions lacking an inflammatory infiltrate.3 Furthermore, new lesions often show abnormalities in quantity and/or morphology of membrane-coating granules, also known as Odland bodies, in keratinocytes on electron microscopy,3,10,17 while old lesions do not.3 Odland bodies are involved in normal desquamation, leading some to speculate on their role in HLP.10 Currently, it is unclear whether abnormalities in these organelles cause the retention hyperkeratosis seen in HLP or if such abnormalities are a secondary phenomenon.3,17

There are questionable associations between HLP and diabetes mellitus type 2, hyperthyroidism, basal and squamous cell carcinomas of the skin, and gastrointestinal malignancy.4,9,18 Our patient had a history of basal cell carcinoma on the face, diet-controlled diabetes mellitus, and hypothyroidism. Given the high prevalence of these diseases in the general population, however, it is difficult to ascertain whether a true association with HLP exists.

While HLP can slowly progress to involve additional body sites, it is overall a benign condition that does not require treatment. Therapeutic options are based on case reports, with no single treatment showing a consistent response. From review of the literature, therapies that have been most effective include dermabrasion, excision,19 topical 5-fluorouracil,2,17,20 and oral retinoids.8 Hyperkeratosis lenticularis perstans generally is resistant to topical steroids, retinoids, and vitamin D3 analogs, although success with betamethasone dipropionate,5 isotretinoin  
gel 0.05%,11 and calcipotriol have been reported.6 A case of HLP with clinical response to psoralen plus UVA therapy also has been described.15

References
  1. Flegel H. Hyperkeratosis lenticularis perstans. Hautarzt. 1958;9:363-364.
  2. Pearson LH, Smith JG, Chalker DK. Hyperkeratosis lenticularis perstans (Flegel’s disease). J Am Acad Dermatol. 1987;16:190-195.
  3. Ando K, Hattori H, Yamauchi Y. Histopathological differences between early and old lesions of hyperkeratosis lenticularis perstans (Flegel’s disease). Am J Dermatopathol. 2006;28:122-126.
  4. Fernández-Crehuet P, Rodríguez-Rey E, Ríos-Martín JJ, et al. Hyperkeratosis lenticularis perstans, or Flegel disease, with palmoplantar involvement. Actas Dermosifiliogr. 2009;100:157-159.
  5. Sterneberg-Vos H, van Marion AM, Frank J, et al. Hyperkeratosis lenticularis perstans (Flegel’s disease)—successful treatment with topical corticosteroids. Int J Dermatol. 2008;47:38-41.
  6. Bayramgürler D, Apaydin R, Dökmeci S, et al. Flegel’s disease: treatment with topical calcipotriol. Clin Exp Dermatol. 2002;27:161-162.
  7. Price ML, Jones EW, MacDonald DM. A clinicopathological study of Flegel’s disease (hyperkeratosis lenticularis perstans). Br J Dermatol. 1987;116:681-691.
  8. Krishnan A, Kar S. Photoletter to the editor: hyperkeratosis lenticularis perstans (Flegel’s disease) with unusual clinical presentation. response to isotretinoin therapy. J Dermatol Case Rep. 2012;6:93-95.
  9. Beveridge GW, Langlands AO. Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. Br J Dermatol. 1973;88:453-458.
  10. Frenk E, Tapernoux B. Hyperkeratosis lenticularis perstans (Flegel): a biological model for keratinization occurring in the absence of Odland bodies? Dermatologica. 1976;153:253-262.
  11. Miranda-Romero A, Sánchez Sambucety P, Bajo del Pozo C, et al. Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). J Am Acad Dermatol. 1998;39:655-657.
  12. Gutiérrez MC, Hasson A, Arias MD, et al. Localized hyperkeratosis lenticularis perstans (Flegel's disease). Cutis. 1991;48:201-204.
  13. Fathy S, Azadeh B. Hyperkeratosis lenticularis perstans. Int J Dermatol. 1988;27:120-121.
  14. Rosdahl I, Rosen K. Hyperkeratosis lenticularis perstans: report on two cases. Acta Derm Venerol. 1985;65:562-564.
  15. Cooper SM, George S. Flegel's disease treated with psoralen ultraviolet A. Br J Dermatol. 2000;142:340-342.
  16. Fernandez-Flores A, Manjon JA. Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. Acta Dermatovenerol Croat. 2009;17:16-19.
  17. Langer K, Zonzits E, Konrad K. Hyperkeratosis lenticularis perstans (Flegel's disease). ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. J Am Acad Dermatol. 1992;27:812-816.
  18. Ishibashi A, Tsuboi R, Fujita K. Familial hyperkeratosis lenticularis perstans. associated with cancers of the digestive organs. J Dermatol. 1984;11:407-409.
  19. Cunha Filho RR, Almeida Jr HL. Hyperkeratosis lenticularis perstans. An Bras Dermatol. 2011;86(4 suppl 1):S76-S77.
  20. Blaheta HJ, Metzler G, Rassner G, et al. Hyperkeratosis lenticularis perstans (Flegel's disease)—lack of response to treatment with tacalcitol and calcipotriol. Dermatology. 2001;202:255-258.
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From the University of Virginia, Charlottesville. Dr. Gosis is from the School of Medicine. Drs. Daniel and Wilson are from the Department of Dermatology. Dr. Daniel also is from the Department of Dermatopathology.

The authors report no conflict of interest.

Correspondence: Barbara B. Wilson, MD, PO Box 800718, University of Virginia Health System, Charlottesville, VA 22908 (BLW7U@hscmail.mcc.virginia.edu).

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hyperkeratosis lenticularis perstans;flegel's disease;Odland bodies;membrane coating granules;Keratosis;leg dermatoses;skin disease, papulosquamous;skin disease
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From the University of Virginia, Charlottesville. Dr. Gosis is from the School of Medicine. Drs. Daniel and Wilson are from the Department of Dermatology. Dr. Daniel also is from the Department of Dermatopathology.

The authors report no conflict of interest.

Correspondence: Barbara B. Wilson, MD, PO Box 800718, University of Virginia Health System, Charlottesville, VA 22908 (BLW7U@hscmail.mcc.virginia.edu).

Author and Disclosure Information

From the University of Virginia, Charlottesville. Dr. Gosis is from the School of Medicine. Drs. Daniel and Wilson are from the Department of Dermatology. Dr. Daniel also is from the Department of Dermatopathology.

The authors report no conflict of interest.

Correspondence: Barbara B. Wilson, MD, PO Box 800718, University of Virginia Health System, Charlottesville, VA 22908 (BLW7U@hscmail.mcc.virginia.edu).

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The Diagnosis: Hyperkeratosis Lenticularis Perstans

A shave biopsy of a lesion on the right leg was performed. Histopathology revealed a discrete papule with overlying compact hyperkeratosis. There was parakeratosis with an absent granular layer and a lichenoid lymphocytic infiltrate within the papillary dermis (Figure). Given the clinical context, these changes were consistent with a diagnosis of hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease.

Discrete papule with overlying compact hyperkeratosis and an accompanying lichenoid inflammatory infiltrate (A)(H&E, original magnification ×2). Higher power view highlighting the lichenoid inflammation and loss of the granular layer with overlying parakeratosis (B)(H&E, original magnification ×10).

The patient was started on tretinoin cream 0.1% nightly for 3 months and triamcinolone ointment 0.1% as needed for pruritus but showed no clinical response. Given the benign nature of the condition and because the lesions were asymptomatic, additional treatment options were not pursued.

Originally described by Flegel1 in 1958, HLP is a rare skin disorder commonly seen in white individuals with onset in the fourth or fifth decades of life.1,2 While most cases are sporadic,3-6 HLP also has been associated with autosomal dominant inheritance.7-10

Patients with HLP typically present with multiple 1- to 5-mm reddish-brown, hyperkeratotic, scaly papules that reveal a moist, erythematous base with pinpoint bleeding upon removal of the scale. Lesions usually are distributed symmetrically and most commonly present on the extensor surfaces of the lower legs and dorsal feet.1,2,7 Lesions also may appear on the extensor surfaces of the arms, pinna, periocular region, antecubital and popliteal fossae, and oral mucosa and also may present as pits on the palms and soles.2,4,7,8 Furthermore, unilateral and localized variants of HLP have been described.11,12 Hyperkeratosis lenticularis perstans usually is asymptomatic but can present with mild pruritus or burning.3,5,13

The etiology and pathogenesis of HLP are unknown. Exposure to UV light has been implicated as an inciting factor14; however, reports of spontaneous resolution in the summer13 and upon treatment with psoralen plus UVA therapy15 make the role of UV light unclear. Furthermore, investigators disagree as to whether the primary pathogenic event in HLP is an inflammatory process or one of abnormal keratinization.1,3,7,10 Fernandez-Flores and Manjon16 suggested HLP is an inflammatory process with periods of exacerbations and remissions after finding mounds of parakeratosis with neutrophils arranged in different strata in the stratum corneum.

Histologically, compact hyperkeratosis usually is noted, often with associated parakeratosis, epidermal atrophy with thinning or absence of the granular layer, and a bandlike lymphohistiocytic infiltrate in the papillary dermis.1-3 Histopathologic differences between recent-onset versus longstanding lesions have been found, with old lesions lacking an inflammatory infiltrate.3 Furthermore, new lesions often show abnormalities in quantity and/or morphology of membrane-coating granules, also known as Odland bodies, in keratinocytes on electron microscopy,3,10,17 while old lesions do not.3 Odland bodies are involved in normal desquamation, leading some to speculate on their role in HLP.10 Currently, it is unclear whether abnormalities in these organelles cause the retention hyperkeratosis seen in HLP or if such abnormalities are a secondary phenomenon.3,17

There are questionable associations between HLP and diabetes mellitus type 2, hyperthyroidism, basal and squamous cell carcinomas of the skin, and gastrointestinal malignancy.4,9,18 Our patient had a history of basal cell carcinoma on the face, diet-controlled diabetes mellitus, and hypothyroidism. Given the high prevalence of these diseases in the general population, however, it is difficult to ascertain whether a true association with HLP exists.

While HLP can slowly progress to involve additional body sites, it is overall a benign condition that does not require treatment. Therapeutic options are based on case reports, with no single treatment showing a consistent response. From review of the literature, therapies that have been most effective include dermabrasion, excision,19 topical 5-fluorouracil,2,17,20 and oral retinoids.8 Hyperkeratosis lenticularis perstans generally is resistant to topical steroids, retinoids, and vitamin D3 analogs, although success with betamethasone dipropionate,5 isotretinoin  
gel 0.05%,11 and calcipotriol have been reported.6 A case of HLP with clinical response to psoralen plus UVA therapy also has been described.15

The Diagnosis: Hyperkeratosis Lenticularis Perstans

A shave biopsy of a lesion on the right leg was performed. Histopathology revealed a discrete papule with overlying compact hyperkeratosis. There was parakeratosis with an absent granular layer and a lichenoid lymphocytic infiltrate within the papillary dermis (Figure). Given the clinical context, these changes were consistent with a diagnosis of hyperkeratosis lenticularis perstans (HLP), also known as Flegel disease.

Discrete papule with overlying compact hyperkeratosis and an accompanying lichenoid inflammatory infiltrate (A)(H&E, original magnification ×2). Higher power view highlighting the lichenoid inflammation and loss of the granular layer with overlying parakeratosis (B)(H&E, original magnification ×10).

The patient was started on tretinoin cream 0.1% nightly for 3 months and triamcinolone ointment 0.1% as needed for pruritus but showed no clinical response. Given the benign nature of the condition and because the lesions were asymptomatic, additional treatment options were not pursued.

Originally described by Flegel1 in 1958, HLP is a rare skin disorder commonly seen in white individuals with onset in the fourth or fifth decades of life.1,2 While most cases are sporadic,3-6 HLP also has been associated with autosomal dominant inheritance.7-10

Patients with HLP typically present with multiple 1- to 5-mm reddish-brown, hyperkeratotic, scaly papules that reveal a moist, erythematous base with pinpoint bleeding upon removal of the scale. Lesions usually are distributed symmetrically and most commonly present on the extensor surfaces of the lower legs and dorsal feet.1,2,7 Lesions also may appear on the extensor surfaces of the arms, pinna, periocular region, antecubital and popliteal fossae, and oral mucosa and also may present as pits on the palms and soles.2,4,7,8 Furthermore, unilateral and localized variants of HLP have been described.11,12 Hyperkeratosis lenticularis perstans usually is asymptomatic but can present with mild pruritus or burning.3,5,13

The etiology and pathogenesis of HLP are unknown. Exposure to UV light has been implicated as an inciting factor14; however, reports of spontaneous resolution in the summer13 and upon treatment with psoralen plus UVA therapy15 make the role of UV light unclear. Furthermore, investigators disagree as to whether the primary pathogenic event in HLP is an inflammatory process or one of abnormal keratinization.1,3,7,10 Fernandez-Flores and Manjon16 suggested HLP is an inflammatory process with periods of exacerbations and remissions after finding mounds of parakeratosis with neutrophils arranged in different strata in the stratum corneum.

Histologically, compact hyperkeratosis usually is noted, often with associated parakeratosis, epidermal atrophy with thinning or absence of the granular layer, and a bandlike lymphohistiocytic infiltrate in the papillary dermis.1-3 Histopathologic differences between recent-onset versus longstanding lesions have been found, with old lesions lacking an inflammatory infiltrate.3 Furthermore, new lesions often show abnormalities in quantity and/or morphology of membrane-coating granules, also known as Odland bodies, in keratinocytes on electron microscopy,3,10,17 while old lesions do not.3 Odland bodies are involved in normal desquamation, leading some to speculate on their role in HLP.10 Currently, it is unclear whether abnormalities in these organelles cause the retention hyperkeratosis seen in HLP or if such abnormalities are a secondary phenomenon.3,17

There are questionable associations between HLP and diabetes mellitus type 2, hyperthyroidism, basal and squamous cell carcinomas of the skin, and gastrointestinal malignancy.4,9,18 Our patient had a history of basal cell carcinoma on the face, diet-controlled diabetes mellitus, and hypothyroidism. Given the high prevalence of these diseases in the general population, however, it is difficult to ascertain whether a true association with HLP exists.

While HLP can slowly progress to involve additional body sites, it is overall a benign condition that does not require treatment. Therapeutic options are based on case reports, with no single treatment showing a consistent response. From review of the literature, therapies that have been most effective include dermabrasion, excision,19 topical 5-fluorouracil,2,17,20 and oral retinoids.8 Hyperkeratosis lenticularis perstans generally is resistant to topical steroids, retinoids, and vitamin D3 analogs, although success with betamethasone dipropionate,5 isotretinoin  
gel 0.05%,11 and calcipotriol have been reported.6 A case of HLP with clinical response to psoralen plus UVA therapy also has been described.15

References
  1. Flegel H. Hyperkeratosis lenticularis perstans. Hautarzt. 1958;9:363-364.
  2. Pearson LH, Smith JG, Chalker DK. Hyperkeratosis lenticularis perstans (Flegel’s disease). J Am Acad Dermatol. 1987;16:190-195.
  3. Ando K, Hattori H, Yamauchi Y. Histopathological differences between early and old lesions of hyperkeratosis lenticularis perstans (Flegel’s disease). Am J Dermatopathol. 2006;28:122-126.
  4. Fernández-Crehuet P, Rodríguez-Rey E, Ríos-Martín JJ, et al. Hyperkeratosis lenticularis perstans, or Flegel disease, with palmoplantar involvement. Actas Dermosifiliogr. 2009;100:157-159.
  5. Sterneberg-Vos H, van Marion AM, Frank J, et al. Hyperkeratosis lenticularis perstans (Flegel’s disease)—successful treatment with topical corticosteroids. Int J Dermatol. 2008;47:38-41.
  6. Bayramgürler D, Apaydin R, Dökmeci S, et al. Flegel’s disease: treatment with topical calcipotriol. Clin Exp Dermatol. 2002;27:161-162.
  7. Price ML, Jones EW, MacDonald DM. A clinicopathological study of Flegel’s disease (hyperkeratosis lenticularis perstans). Br J Dermatol. 1987;116:681-691.
  8. Krishnan A, Kar S. Photoletter to the editor: hyperkeratosis lenticularis perstans (Flegel’s disease) with unusual clinical presentation. response to isotretinoin therapy. J Dermatol Case Rep. 2012;6:93-95.
  9. Beveridge GW, Langlands AO. Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. Br J Dermatol. 1973;88:453-458.
  10. Frenk E, Tapernoux B. Hyperkeratosis lenticularis perstans (Flegel): a biological model for keratinization occurring in the absence of Odland bodies? Dermatologica. 1976;153:253-262.
  11. Miranda-Romero A, Sánchez Sambucety P, Bajo del Pozo C, et al. Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). J Am Acad Dermatol. 1998;39:655-657.
  12. Gutiérrez MC, Hasson A, Arias MD, et al. Localized hyperkeratosis lenticularis perstans (Flegel's disease). Cutis. 1991;48:201-204.
  13. Fathy S, Azadeh B. Hyperkeratosis lenticularis perstans. Int J Dermatol. 1988;27:120-121.
  14. Rosdahl I, Rosen K. Hyperkeratosis lenticularis perstans: report on two cases. Acta Derm Venerol. 1985;65:562-564.
  15. Cooper SM, George S. Flegel's disease treated with psoralen ultraviolet A. Br J Dermatol. 2000;142:340-342.
  16. Fernandez-Flores A, Manjon JA. Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. Acta Dermatovenerol Croat. 2009;17:16-19.
  17. Langer K, Zonzits E, Konrad K. Hyperkeratosis lenticularis perstans (Flegel's disease). ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. J Am Acad Dermatol. 1992;27:812-816.
  18. Ishibashi A, Tsuboi R, Fujita K. Familial hyperkeratosis lenticularis perstans. associated with cancers of the digestive organs. J Dermatol. 1984;11:407-409.
  19. Cunha Filho RR, Almeida Jr HL. Hyperkeratosis lenticularis perstans. An Bras Dermatol. 2011;86(4 suppl 1):S76-S77.
  20. Blaheta HJ, Metzler G, Rassner G, et al. Hyperkeratosis lenticularis perstans (Flegel's disease)—lack of response to treatment with tacalcitol and calcipotriol. Dermatology. 2001;202:255-258.
References
  1. Flegel H. Hyperkeratosis lenticularis perstans. Hautarzt. 1958;9:363-364.
  2. Pearson LH, Smith JG, Chalker DK. Hyperkeratosis lenticularis perstans (Flegel’s disease). J Am Acad Dermatol. 1987;16:190-195.
  3. Ando K, Hattori H, Yamauchi Y. Histopathological differences between early and old lesions of hyperkeratosis lenticularis perstans (Flegel’s disease). Am J Dermatopathol. 2006;28:122-126.
  4. Fernández-Crehuet P, Rodríguez-Rey E, Ríos-Martín JJ, et al. Hyperkeratosis lenticularis perstans, or Flegel disease, with palmoplantar involvement. Actas Dermosifiliogr. 2009;100:157-159.
  5. Sterneberg-Vos H, van Marion AM, Frank J, et al. Hyperkeratosis lenticularis perstans (Flegel’s disease)—successful treatment with topical corticosteroids. Int J Dermatol. 2008;47:38-41.
  6. Bayramgürler D, Apaydin R, Dökmeci S, et al. Flegel’s disease: treatment with topical calcipotriol. Clin Exp Dermatol. 2002;27:161-162.
  7. Price ML, Jones EW, MacDonald DM. A clinicopathological study of Flegel’s disease (hyperkeratosis lenticularis perstans). Br J Dermatol. 1987;116:681-691.
  8. Krishnan A, Kar S. Photoletter to the editor: hyperkeratosis lenticularis perstans (Flegel’s disease) with unusual clinical presentation. response to isotretinoin therapy. J Dermatol Case Rep. 2012;6:93-95.
  9. Beveridge GW, Langlands AO. Familial hyperkeratosis lenticularis perstans associated with tumours of the skin. Br J Dermatol. 1973;88:453-458.
  10. Frenk E, Tapernoux B. Hyperkeratosis lenticularis perstans (Flegel): a biological model for keratinization occurring in the absence of Odland bodies? Dermatologica. 1976;153:253-262.
  11. Miranda-Romero A, Sánchez Sambucety P, Bajo del Pozo C, et al. Unilateral hyperkeratosis lenticularis perstans (Flegel's disease). J Am Acad Dermatol. 1998;39:655-657.
  12. Gutiérrez MC, Hasson A, Arias MD, et al. Localized hyperkeratosis lenticularis perstans (Flegel's disease). Cutis. 1991;48:201-204.
  13. Fathy S, Azadeh B. Hyperkeratosis lenticularis perstans. Int J Dermatol. 1988;27:120-121.
  14. Rosdahl I, Rosen K. Hyperkeratosis lenticularis perstans: report on two cases. Acta Derm Venerol. 1985;65:562-564.
  15. Cooper SM, George S. Flegel's disease treated with psoralen ultraviolet A. Br J Dermatol. 2000;142:340-342.
  16. Fernandez-Flores A, Manjon JA. Morphological evidence of periodical exacerbation of hyperkeratosis lenticularis perstans. Acta Dermatovenerol Croat. 2009;17:16-19.
  17. Langer K, Zonzits E, Konrad K. Hyperkeratosis lenticularis perstans (Flegel's disease). ultrastructural study of lesional and perilesional skin and therapeutic trial of topical tretinoin versus 5-fluorouracil. J Am Acad Dermatol. 1992;27:812-816.
  18. Ishibashi A, Tsuboi R, Fujita K. Familial hyperkeratosis lenticularis perstans. associated with cancers of the digestive organs. J Dermatol. 1984;11:407-409.
  19. Cunha Filho RR, Almeida Jr HL. Hyperkeratosis lenticularis perstans. An Bras Dermatol. 2011;86(4 suppl 1):S76-S77.
  20. Blaheta HJ, Metzler G, Rassner G, et al. Hyperkeratosis lenticularis perstans (Flegel's disease)—lack of response to treatment with tacalcitol and calcipotriol. Dermatology. 2001;202:255-258.
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Erythematous Scaly Papules on the Shins and Calves
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Erythematous Scaly Papules on the Shins and Calves
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hyperkeratosis lenticularis perstans;flegel's disease;Odland bodies;membrane coating granules;Keratosis;leg dermatoses;skin disease, papulosquamous;skin disease
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hyperkeratosis lenticularis perstans;flegel's disease;Odland bodies;membrane coating granules;Keratosis;leg dermatoses;skin disease, papulosquamous;skin disease
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A 73-year-old white woman presented to the dermatology clinic with a mildly pruritic, slowly progressive rash on the shins and calves of 10 years’ duration. She had been using triamcinolone ointment 0.1% prescribed by her primary care physician once daily for several weeks without improvement. On physical examination, multiple 1- to 4-mm erythematous, scaly papules were noted on the anterior and posterior aspects of the lower legs. No similar lesions were noted elsewhere on the body. Her medical history was remarkable for basal cell carcinoma on the face, diet-controlled diabetes mellitus, and hypothyroidism. Her family history was unremarkable.

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