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CTPA may not rule out VTE in high-risk patients
Clinical question: Does a negative computed tomography pulmonary angiography rule out venous thromboembolism (VTE)?
Background: Computed tomography pulmonary angiography (CTPA) is the most common diagnostic modality used to diagnose pulmonary embolism (PE) and has a high negative predictive value in patients with a low 3-month risk of VTE. In patients with higher pretest probability of PE, it is unknown whether CTPA is sufficient to rule out VTE.
Study design: Meta-analysis.
Setting: Published prospective outcome studies of patients with suspected PE using CTPA as a diagnostic strategy.
Synopsis: The authors reviewed 3,143 publications from MEDLINE, EMBASE, and the Cochrane Library and identified 22 prospective outcome studies to include in their meta-analysis. A VTE was diagnosed in 3,923 out of 11,872 participants (33%) using CTPA. Of the 7,863 patients with a negative CTPA, 148 patients had an acute VTE confirmed by venous ultrasound, ventilation/perfusion scan, or angiography, and 74 patients experienced VTE during a 3-month follow-up period, yielding an overall proportion of 2.4% of patients (95% confidence interval, 1.3%-3.8%).
Subgroup analysis showed that cumulative occurrence of VTE was related to pretest prevalence. In the subgroup of patients with a VTE prevalence greater than 40%, VTE was observed in 8.1% of patients with a negative CTPA (95% CI, 3.4%-14.5%).
Bottom line: CTPA may be insufficient to rule out VTE in patients with a high pretest probability of PE.
Citation: Belzile D et al. Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta-analysisof the management outcome studies. J Thromb Haemost. 2018 Jun;16(6):1107-20.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.
Clinical question: Does a negative computed tomography pulmonary angiography rule out venous thromboembolism (VTE)?
Background: Computed tomography pulmonary angiography (CTPA) is the most common diagnostic modality used to diagnose pulmonary embolism (PE) and has a high negative predictive value in patients with a low 3-month risk of VTE. In patients with higher pretest probability of PE, it is unknown whether CTPA is sufficient to rule out VTE.
Study design: Meta-analysis.
Setting: Published prospective outcome studies of patients with suspected PE using CTPA as a diagnostic strategy.
Synopsis: The authors reviewed 3,143 publications from MEDLINE, EMBASE, and the Cochrane Library and identified 22 prospective outcome studies to include in their meta-analysis. A VTE was diagnosed in 3,923 out of 11,872 participants (33%) using CTPA. Of the 7,863 patients with a negative CTPA, 148 patients had an acute VTE confirmed by venous ultrasound, ventilation/perfusion scan, or angiography, and 74 patients experienced VTE during a 3-month follow-up period, yielding an overall proportion of 2.4% of patients (95% confidence interval, 1.3%-3.8%).
Subgroup analysis showed that cumulative occurrence of VTE was related to pretest prevalence. In the subgroup of patients with a VTE prevalence greater than 40%, VTE was observed in 8.1% of patients with a negative CTPA (95% CI, 3.4%-14.5%).
Bottom line: CTPA may be insufficient to rule out VTE in patients with a high pretest probability of PE.
Citation: Belzile D et al. Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta-analysisof the management outcome studies. J Thromb Haemost. 2018 Jun;16(6):1107-20.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.
Clinical question: Does a negative computed tomography pulmonary angiography rule out venous thromboembolism (VTE)?
Background: Computed tomography pulmonary angiography (CTPA) is the most common diagnostic modality used to diagnose pulmonary embolism (PE) and has a high negative predictive value in patients with a low 3-month risk of VTE. In patients with higher pretest probability of PE, it is unknown whether CTPA is sufficient to rule out VTE.
Study design: Meta-analysis.
Setting: Published prospective outcome studies of patients with suspected PE using CTPA as a diagnostic strategy.
Synopsis: The authors reviewed 3,143 publications from MEDLINE, EMBASE, and the Cochrane Library and identified 22 prospective outcome studies to include in their meta-analysis. A VTE was diagnosed in 3,923 out of 11,872 participants (33%) using CTPA. Of the 7,863 patients with a negative CTPA, 148 patients had an acute VTE confirmed by venous ultrasound, ventilation/perfusion scan, or angiography, and 74 patients experienced VTE during a 3-month follow-up period, yielding an overall proportion of 2.4% of patients (95% confidence interval, 1.3%-3.8%).
Subgroup analysis showed that cumulative occurrence of VTE was related to pretest prevalence. In the subgroup of patients with a VTE prevalence greater than 40%, VTE was observed in 8.1% of patients with a negative CTPA (95% CI, 3.4%-14.5%).
Bottom line: CTPA may be insufficient to rule out VTE in patients with a high pretest probability of PE.
Citation: Belzile D et al. Outcomes following a negative computed tomography pulmonary angiography according to pulmonary embolism prevalence: a meta-analysisof the management outcome studies. J Thromb Haemost. 2018 Jun;16(6):1107-20.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.
Intramuscular midazolam superior in sedating acutely agitated adults
Clinical question: How effective are intramuscular midazolam, olanzapine, ziprasidone, and haloperidol at sedating acutely agitated adults in the emergency department?
Background: Acute agitation is commonly seen in the ED and sometimes requires parenteral medications to keep patients and staff safe. Although many medications, including benzodiazepines and antipsychotics, are used, there is no consensus regarding which medications are most effective and safe for acute agitation.
Study design: Prospective observational study.
Setting: Emergency department of an inner-city Level 1 adult and pediatric trauma center.
Synopsis: This study enrolled 737 adults in the ED who presented with acute agitation and treated them with either haloperidol 5 mg, ziprasidone 20 mg, olanzapine 10 mg, midazolam 5 mg, or haloperidol 10 mg intramuscularly, based on predetermined 3-week blocks. The main outcome was the proportion of patients adequately sedated at 15 minutes, based on Altered Mental Status Scale score less than 1. A total of 650 patients (88%) were agitated from alcohol intoxication.
Midazolam resulted in a statistically higher proportion of patients adequately sedated, compared with ziprasidone (difference, 18%; 95% confidence interval, 6%-29%), haloperidol 5 mg (difference, 30%; 95% CI, 19%-41%), and haloperidol 10 mg (difference, 28%; 95% CI,17%-39%). Midazolam resulted in a higher proportion of patients adequately sedated, compared with olanzapine (difference 9%), but this difference was not statistically significant because the confidence interval crossed 1 (95% CI, –1%-20%). Olanzapine resulted in a statistically higher proportion of patients adequately sedated, compared with haloperidol 5 mg (difference 20%; 95% CI, 10%-31%) and 10 mg (difference 18%; 95% CI, 7%-29%). Adverse effects were rare.
Bottom line: Intramuscular midazolam is safe and may be more effective for treating acute agitation in the emergency department than standard antipsychotics.
Citation: Klein LR et al. Intramuscular midazolam, olanzapine, ziprasidone, or haloperidol for treating acute agitation in the emergency department. Ann Emerg Med. 2018 Jun 6. doi: https://doi.org/10.1016/j.annemergmed.2018.04.027.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.
Clinical question: How effective are intramuscular midazolam, olanzapine, ziprasidone, and haloperidol at sedating acutely agitated adults in the emergency department?
Background: Acute agitation is commonly seen in the ED and sometimes requires parenteral medications to keep patients and staff safe. Although many medications, including benzodiazepines and antipsychotics, are used, there is no consensus regarding which medications are most effective and safe for acute agitation.
Study design: Prospective observational study.
Setting: Emergency department of an inner-city Level 1 adult and pediatric trauma center.
Synopsis: This study enrolled 737 adults in the ED who presented with acute agitation and treated them with either haloperidol 5 mg, ziprasidone 20 mg, olanzapine 10 mg, midazolam 5 mg, or haloperidol 10 mg intramuscularly, based on predetermined 3-week blocks. The main outcome was the proportion of patients adequately sedated at 15 minutes, based on Altered Mental Status Scale score less than 1. A total of 650 patients (88%) were agitated from alcohol intoxication.
Midazolam resulted in a statistically higher proportion of patients adequately sedated, compared with ziprasidone (difference, 18%; 95% confidence interval, 6%-29%), haloperidol 5 mg (difference, 30%; 95% CI, 19%-41%), and haloperidol 10 mg (difference, 28%; 95% CI,17%-39%). Midazolam resulted in a higher proportion of patients adequately sedated, compared with olanzapine (difference 9%), but this difference was not statistically significant because the confidence interval crossed 1 (95% CI, –1%-20%). Olanzapine resulted in a statistically higher proportion of patients adequately sedated, compared with haloperidol 5 mg (difference 20%; 95% CI, 10%-31%) and 10 mg (difference 18%; 95% CI, 7%-29%). Adverse effects were rare.
Bottom line: Intramuscular midazolam is safe and may be more effective for treating acute agitation in the emergency department than standard antipsychotics.
Citation: Klein LR et al. Intramuscular midazolam, olanzapine, ziprasidone, or haloperidol for treating acute agitation in the emergency department. Ann Emerg Med. 2018 Jun 6. doi: https://doi.org/10.1016/j.annemergmed.2018.04.027.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.
Clinical question: How effective are intramuscular midazolam, olanzapine, ziprasidone, and haloperidol at sedating acutely agitated adults in the emergency department?
Background: Acute agitation is commonly seen in the ED and sometimes requires parenteral medications to keep patients and staff safe. Although many medications, including benzodiazepines and antipsychotics, are used, there is no consensus regarding which medications are most effective and safe for acute agitation.
Study design: Prospective observational study.
Setting: Emergency department of an inner-city Level 1 adult and pediatric trauma center.
Synopsis: This study enrolled 737 adults in the ED who presented with acute agitation and treated them with either haloperidol 5 mg, ziprasidone 20 mg, olanzapine 10 mg, midazolam 5 mg, or haloperidol 10 mg intramuscularly, based on predetermined 3-week blocks. The main outcome was the proportion of patients adequately sedated at 15 minutes, based on Altered Mental Status Scale score less than 1. A total of 650 patients (88%) were agitated from alcohol intoxication.
Midazolam resulted in a statistically higher proportion of patients adequately sedated, compared with ziprasidone (difference, 18%; 95% confidence interval, 6%-29%), haloperidol 5 mg (difference, 30%; 95% CI, 19%-41%), and haloperidol 10 mg (difference, 28%; 95% CI,17%-39%). Midazolam resulted in a higher proportion of patients adequately sedated, compared with olanzapine (difference 9%), but this difference was not statistically significant because the confidence interval crossed 1 (95% CI, –1%-20%). Olanzapine resulted in a statistically higher proportion of patients adequately sedated, compared with haloperidol 5 mg (difference 20%; 95% CI, 10%-31%) and 10 mg (difference 18%; 95% CI, 7%-29%). Adverse effects were rare.
Bottom line: Intramuscular midazolam is safe and may be more effective for treating acute agitation in the emergency department than standard antipsychotics.
Citation: Klein LR et al. Intramuscular midazolam, olanzapine, ziprasidone, or haloperidol for treating acute agitation in the emergency department. Ann Emerg Med. 2018 Jun 6. doi: https://doi.org/10.1016/j.annemergmed.2018.04.027.
Dr. Jenkins is assistant professor of medicine and an academic hospitalist, University of Utah, Salt Lake City.