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Methotrexate plus leflunomide proves effective for PsA
The combination therapy outperformed methotrexate monotherapy as a treatment option for patients with psoriatic arthritis (PsA), though it did...
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EULAR CVD management guidance focuses on gout, lupus, vasculitis
The recommendations advise on managing cardiovascular health in patients with gout, vasculitis, systemic sclerosis, myositis, Sjögren syndrome,...
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PACAP38- and VIP-induced cluster headache attacks do not appear to alter CGRP levels
Is CGRP the missing link for patients who begin a cluster attack, or should we be looking elsewhere?
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Updated guidance for COVID vaccination in rheumatology patients arrives amid continued hesitancy
A fifth update to the American College of Rheumatology’s guidelines makes new recommendations on supplemental and booster doses in patients with...
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A range of healthy dietary patterns can reduce risk of gout in women
A study of four different healthy eating patterns in women found that all reduced the risk of new-onset gout in women, compared with a traditional...
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Ketamine nasal spray provides slow-acting relief for cluster headache attacks
This proof-of-concept trial provides “critical information and paves the way for subsequent placebo-controlled studies.”
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Proactive infliximab monitoring found best for sustaining control of inflammatory diseases
Proactive therapeutic drug monitoring with maintenance infliximab proved more effective in sustaining disease control than did standard care in...
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Guselkumab’s efficacy, safety confirmed in patients with psoriatic arthritis and prior TNFi exposure
COSMOS trial results in patients with psoriatic arthritis fit with the expectation that “people who’ve previously failed a TNF inhibitor might be...
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Largest ever review of new daily persistent headache assesses its clinical features
“Future prospective studies are needed to better understand this disabling disorder.”
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PT may lower risk of long-term opioid use after knee replacement
When patients who have undergone total knee replacement also undergo physical therapy soon after, the likelihood of long-term opioid use after...
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PRP injections don’t top placebo for ankle osteoarthritis
Results from a double-blind, randomized clinical trial provide the first high-level evidence showing a lack of efficacy for platelet-rich plasma...
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Few JAK inhibitor users have diminished immune response to COVID-19 vaccines
Most patients taking JAK inhibitors had seemingly adequate immune responses based on serologic assessment of detectable antibodies, but those...
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Study of biologics’ impact on psoriasis-to-PsA transition contradicts previous findings
Differing patient selection criteria and other biases may be why results from a large EHR administrative database study contradict those from...
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Assessing headache severity via migraine symptoms can help predict outcomes
“Our hope is that this work serves as foundational basis for better understanding the complexity of headache as a symptom-based condition.”
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Researchers describe first reports of breakthrough COVID infections, booster shots in rheumatology patients
The first published results of breakthrough SARS-CoV-2 infection in fully or partially vaccinated patients with RMDs hint at encouraging low rates...