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HDAC/aromatase inhibitor combo shows promise for HR+/HER2- advanced breast cancer
MUNICH – Chidamide + exemestane combination therapy increased PFS by about 4 months, compared with exemestane...
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Moderate hypofractionation preferred in new guideline for localized PC
A new ASTRO/ASCO/AUA guideline recommends moderate hypofractionation over conventional fractionation for patients with localized prostate cancer...
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Crizanlizumab appears effective across subgroups
Crizanlizumab can reduce vaso-occlusive crises (VOCs) across subgroups of patients with sickle cell disease (SCD), according to a post-hoc...
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Crizanlizumab relieves sickle cell crises across subgroups
The post hoc analysis of the SUSTAIN trial showed a significant decrease in painful vaso-occlusive crises.
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Genomic findings may predict outcomes in MPN patients
New research suggests genomic characteristics of patients with myeloproliferative neoplasms (MPNs) can predict clinical outcomes. Investigators...
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Genomic profiling predicts outcomes in patients with MPN
In blood cancers, there is a shift away from clinical and morphologic classification and toward genomic classification.
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Virus-specific T-cell infusion may resolve progressive multifocal leukoencephalopathy
One patient fully recovered and a second improved but had speech and mobility problems.
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Short-term NSAIDs appear safe for high-risk patients
The findings challenge the Choosing Wisely campaign of the American Society of Nephrology, which recommends against NSAIDs for high-risk patients...
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Weighing the costs of CAR T-cell therapy
The cost-effectiveness of tisagenlecleucel (Kymriah) depends on long-term clinical outcomes, which are presently unknown, according to...
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Antibiotics trigger proteolytic activity that leads to chronic colitis
Antibiotics cause increased proteolytic activity in the large intestine that disrupts the gut barrier, increasing risk of chronic colitis.
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Autologous fecal transplant restores microbiota after allo-HSCT
The therapy could help stave off graft-versus-host disease in stem cell transplant patients.
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First reported case of induced resistance to tisagenlecleucel
The CAR gene was unintentionally introduced into a single leukemic B cell during T-cell manufacturing.
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Brentuximab improves survival in older HL patients
Older patients with untreated Hodgkin lymphoma (HL) can achieve significantly improved survival by adding brentuximab vedotin to their treatment...
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Autologous fecal transplant restores microbiota after allo-HSCT
The therapy could help stave off graft-versus-host disease in stem cell transplant patients.