, a study has shown.
In October 2008, a team of investigators in China led by Zhilun Zhang of the Tianjin Center for Disease Control and Prevention, randomly assigned 332 children aged 18-60 months with prevaccination anti-HAV antibody titers of less than 20 mIU/mL to receive either one dose of inactivated hepatitis A vaccine or one dose of live, attenuated hepatitis A vaccine. Both groups were followed through December 2013, with assessments of anti-HAV antibody concentrations at years 1, 2, and 5 post vaccination. In all, 182 successfully completed the study, meeting all requirements, including providing serum samples at each time point.
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Titer levels were 76.3% mIU/mL and 66.8mIU/mL for the inactivated and live vaccines at 5 years, respectively. No clinical hepatitis A case was reported.
The study appears online in Human Vaccines & Immunotherapeutics (doi: 10.1080/21645515.2016.1278329).
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