CAVEATS
Lack of comparison with other treatments
Data were insufficient to compare the efficacy of aspirin with zolmitriptan, other NSAIDs alone, or acetaminophen plus codeine. Aspirin should be used with caution in patients who have chronic renal disease and/or a history of peptic ulcer disease.
CHALLENGES TO IMPLEMENTATION
Patients want a prescription
Patients often expect a prescription when they present with complaints of migraine headache and may feel shortchanged if they’re told to take an aspirin. Providing a prescription for the antiemetic metoclopramide, as well as a brief explanation of the evidence indicating that aspirin is effective for migraine, may adequately address such expectations.
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