Clinical Review

Alzheimer Disease: A Pragmatic Approach

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END-OF-LIFE CARE MUST BE ADDRESSED
Perhaps the most important aspect of end-of-life care in AD is assuring that families (or health care proxies) understand that AD is a fatal illness, with most patients dying within four to eight years of diagnosis.1 Evidence indicates that patients whose proxies have a clear recognition of this are less likely to experience “burdensome” interventions such as parenteral therapy, emergency department visits, hospital admissions, and tube feedings in their last three months of life.37

Overall, decisions regarding discontinuing medical treatments in advanced AD should be made by balancing the likelihood of benefit with the potential for adverse effects.38 For example, the American Geriatrics Society recently recommended against feeding tubes because they often result in discomfort due to agitation, use of restraints, and worsening pressure ulcers.39

Unfortunately, only a minority of families receives straightforward information on the course and prognosis of AD, including the fact that patients eventually stop eating and that the natural cause of death is often an acute infection. Studies also show that patients with dementia are at risk for inadequate treatment of pain.40 Assuring adequate pain control is an essential component of end-of-life care.

Hospice.
End-of-life care can often be improved with hospice care. This service is underused by ­patients with dementia, even though hospice care is available at no cost through Medicare. Hospice ­eligibility criteria for patients with AD are shown in Table 3.41,42

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