Comparison of Micronized Tretinoin Gel 0.05% and Tretinoin Gel Microsphere 0.1% in Young Adolescents with Acne: A Post Hoc Analysis of Efficacy and Tolerability Data

Acne vulgaris is common in young adolescents. Retinoids are widely used but may be associated with poor tolerability. This post hoc analysis of 483 participants aged 10 to 14 years with mild to moderate acne compared efficacy and tolerability of once-daily treatment with micronized tretinoin gel 0.05%, tretinoin gel microsphere 0.1%, and vehicle over 12 weeks.
In study 1, inflammatory and noninflammatory lesion reduction and treatment success was comparable between tretinoin gel 0.05% and tretinoin gel microsphere 0.1%. Inflammatory (46.3%) and noninflammatory (45.7%) lesion reductions with tretinoin gel 0.05% were significantly greater than vehicle (37.1% and 27.9%, respectively) (both P<.001 in study inflammatory and noninflammatory lesion reductions treatment success with tretinoin gel respectively were significantly greater than vehicle class="article_abstract_nonital">P<.001 and class="article_abstract_nonital">P=.008], respectively).
Tretinoin gel 0.05% was significantly better tolerated than tretinoin gel microsphere 0.1% (P<.001 the majority of adverse events were mild occurring in first weeks. fourteen percent participants reported dry skin burning sensation erythema and dermatitis exfoliative with tretinoin gel compared respectively microsphere class="article_abstract_nonital">P<.001 except skin burning sensation>In this secondary analysis of acne in young adolescents aged 10 to 14 years, micronized tretinoin gel 0.05% provided a comparable lesion reduction and treatment success versus tretinoin gel microsphere 0.1%, with a better cutaneous tolerability profile.